AU3630093A - Helicobacter pylori proteins useful for vaccines and diagnostics - Google Patents

Helicobacter pylori proteins useful for vaccines and diagnostics

Info

Publication number
AU3630093A
AU3630093A AU36300/93A AU3630093A AU3630093A AU 3630093 A AU3630093 A AU 3630093A AU 36300/93 A AU36300/93 A AU 36300/93A AU 3630093 A AU3630093 A AU 3630093A AU 3630093 A AU3630093 A AU 3630093A
Authority
AU
Australia
Prior art keywords
vaccines
diagnostics
helicobacter pylori
proteins useful
pylori proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU36300/93A
Other languages
English (en)
Inventor
Massimo Bugnoli
Antonello Covacci
Giovanni Macchia
Rino Rappuoli
John Telford
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GSK Vaccines SRL
Original Assignee
Biocine Sclavo SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITFI920052A external-priority patent/IT1262895B/it
Application filed by Biocine Sclavo SpA filed Critical Biocine Sclavo SpA
Publication of AU3630093A publication Critical patent/AU3630093A/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/205Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/35Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/975Kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
AU36300/93A 1992-03-02 1993-03-02 Helicobacter pylori proteins useful for vaccines and diagnostics Abandoned AU3630093A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
ITFI92A0052 1992-03-02
ITFI920052A IT1262895B (it) 1992-03-02 1992-03-02 Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico.
EPPCT/EP93/00158 1993-01-25
WOEP9300158 1993-01-25
PCT/EP1993/000472 WO1993018150A1 (en) 1992-03-02 1993-03-02 Helicobacter pylori proteins useful for vaccines and diagnostics

Publications (1)

Publication Number Publication Date
AU3630093A true AU3630093A (en) 1993-10-05

Family

ID=26069992

Family Applications (1)

Application Number Title Priority Date Filing Date
AU36300/93A Abandoned AU3630093A (en) 1992-03-02 1993-03-02 Helicobacter pylori proteins useful for vaccines and diagnostics

Country Status (7)

Country Link
US (3) US6077706A (cg-RX-API-DMAC7.html)
EP (1) EP0967279B1 (cg-RX-API-DMAC7.html)
JP (4) JP3368902B2 (cg-RX-API-DMAC7.html)
AU (1) AU3630093A (cg-RX-API-DMAC7.html)
CA (2) CA2383007A1 (cg-RX-API-DMAC7.html)
DE (2) DE69334197T2 (cg-RX-API-DMAC7.html)
WO (1) WO1993018150A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU679542B2 (en) * 1993-07-27 1997-07-03 Csl Limited Treatment of (H. pylori) associated gastroduodenal disease

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866375A (en) * 1991-10-31 1999-02-02 Chiron S.P.A. Method for the culture of microorganisms of the genera helicobacter, campylobacter and arcobacter employing culture media comprising cyclodextrins
US5721349A (en) * 1992-02-26 1998-02-24 Vanderbilt University Vacuolating toxin-deficient H. pylori
AU3728293A (en) * 1992-02-26 1993-09-13 Vanderbilt University Purified vacuolating toxin from (helicobacter) pylori and methods to use same
US5928865A (en) * 1992-03-02 1999-07-27 Chiron S.P.A. Compositions comprising isolated Helicobacter pylori CagI polynucleotides and method of preparation thereof
IT1262896B (it) * 1992-03-06 1996-07-22 Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini.
MX9301706A (es) * 1992-04-13 1994-05-31 Oravax Inc Composicion de vacuna para el tratamiento de la infeccion por helicobacter.
US5733740A (en) * 1992-10-13 1998-03-31 Vanderbilt University Taga gene and methods for detecting predisposition to peptic ulceration and gastric carcinoma
US5403924A (en) * 1992-10-13 1995-04-04 Vanderbilt University Taga gene and methods for detecting predisposition to peptic ulceration
US5972336A (en) * 1992-11-03 1999-10-26 Oravax Merieux Co. Urease-based vaccine against helicobacter infection
US6290962B1 (en) * 1992-11-03 2001-09-18 Oravax, Inc. Urease-based vaccine and treatment for helicobacter infection
US6258359B1 (en) 1993-05-19 2001-07-10 Institut Pasteur Immunogenic compositions against helicobacter infection, polypeptides for use in the compositions, and nucleic acid sequences encoding said polypeptides
WO1995014093A1 (en) 1993-05-19 1995-05-26 Institut Pasteur Immunogenic compositions against helicobacter infection, polypeptides for use in the compositions and nucleic acid sequences encoding said polypeptides
GB9313279D0 (en) * 1993-06-28 1993-08-11 Medical Res Council Protection against infection with helicobacter pylori
US6406703B1 (en) 1993-07-27 2002-06-18 Csl Limited Treatment of H. pylori associated gastroduodenal disease
US5750119A (en) * 1994-01-13 1998-05-12 Mount Sinai School Of Medicine Of The City University Of New York Immunotherapeutic stress protein-peptide complexes against cancer
US5997873A (en) 1994-01-13 1999-12-07 Mount Sinai School Of Medicine Of The City University Of New York Method of preparation of heat shock protein 70-peptide complexes
US5961979A (en) * 1994-03-16 1999-10-05 Mount Sinai School Of Medicine Of The City University Of New York Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens
GB2290710B (en) * 1994-06-29 1998-03-25 Reckitt & Colmann Prod Ltd Protease from helicobacter pylori for use in vaccines/therapeutic compositions
AU695769B2 (en) * 1994-07-01 1998-08-20 Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin, The Helicobacter proteins and vaccines
GB9505438D0 (en) * 1995-03-17 1995-05-03 Sod Conseils Rech Applic Antisense oligonucleotides
AU6343696A (en) * 1995-07-07 1997-02-10 Oravax, Inc Helicobacter clpb
US5985270A (en) * 1995-09-13 1999-11-16 Fordham University Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes
US5837251A (en) * 1995-09-13 1998-11-17 Fordham University Compositions and methods using complexes of heat shock proteins and antigenic molecules for the treatment and prevention of neoplastic diseases
US5935576A (en) * 1995-09-13 1999-08-10 Fordham University Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens
EP0797585A1 (fr) * 1995-10-09 1997-10-01 Pasteur Merieux Serums Et Vaccins Recepteur lactoferrine d'helicobacter
DK0909323T3 (da) 1996-01-04 2007-05-21 Novartis Vaccines & Diagnostic Helicobacter pylori-bakterioferritin
JPH1033179A (ja) * 1996-07-24 1998-02-10 Fuso Yakuhin Kogyo Kk 感染症診断用プローブ
WO1998012562A1 (en) * 1996-09-20 1998-03-26 Cortecs International Limited Adhesins from heliobacter pylori and their diagnostic and therapeutic uses
ATE218709T1 (de) * 1996-12-19 2002-06-15 Chiron Corp Helicobacter pylori diagnostika
US6017540A (en) 1997-02-07 2000-01-25 Fordham University Prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases with heat shock/stress protein-peptide complexes
US5830464A (en) * 1997-02-07 1998-11-03 Fordham University Compositions and methods for the treatment and growth inhibition of cancer using heat shock/stress protein-peptide complexes in combination with adoptive immunotherapy
CA2289253A1 (en) * 1997-04-30 1998-11-05 Merieux Oravax Anti-helicobacter vaccine composition for use by the subdiaphragmatic systemic route, and combined mucosal/parenteral immunization method
FR2748477B1 (fr) * 1997-07-01 2001-07-13 Pasteur Merieux Serums Vacc Nouvelle proteine membranaire d'helicobacter pylori
US6914131B1 (en) 1998-10-09 2005-07-05 Chiron S.R.L. Neisserial antigens
CA2315880A1 (en) * 1997-12-31 1999-07-15 Stressgen Biotechnologies Corporation Streptococcal heat shock proteins of the hsp60 family
WO1999057278A2 (en) * 1998-04-30 1999-11-11 Chiron S.P.A. IMMUNIZATION AGAINST AND TREATMENT FOR INFECTION BY $i(H.PYLORI)
US6585975B1 (en) * 1998-04-30 2003-07-01 Acambis, Inc. Use of Salmonella vectors for vaccination against helicobacter infection
US6838553B1 (en) * 1999-10-05 2005-01-04 Academia Sinica Peptide repeat immunogens
GB9924060D0 (en) * 1999-10-11 1999-12-15 Chiron Spa VIP54 protein
PT2275551E (pt) 1999-10-29 2015-06-29 Novartis Vaccines & Diagnostic Péptidos antigénicos de neisseria
US8273360B2 (en) 2000-01-17 2012-09-25 Novartis Ag Outer membrane vesicle (OMV) vaccine comprising N. meningitidis serogroup B outer membrane proteins
JP2004505894A (ja) 2000-06-02 2004-02-26 ユニバーシティー オブ コネティカット ヘルス センター 免疫療法のためのα(2)マクログロブリンと抗原分子との複合体
US20020107368A1 (en) * 2000-12-07 2002-08-08 Jing-Hui Tian Helicobacter proteins, gene sequences and uses thereof
EP2332573A1 (en) 2001-05-31 2011-06-15 Novartis Vaccines and Diagnostics, Inc. Chimeric alphavirus replicon particles
GB0115176D0 (en) 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
GB0118249D0 (en) 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
GB0121591D0 (en) 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
WO2003015712A2 (en) 2001-08-20 2003-02-27 University Of Connecticut Health Center Methods for preparing compositions comprising heat shock proteins or alpha-2-macroglobulin
CA2476626A1 (en) 2002-02-20 2003-08-28 Chiron Corporation Microparticles with adsorbed polypeptide-containing molecules
US20050250175A1 (en) * 2002-08-02 2005-11-10 Takehiko Nomura Bacterial cell wall skeleton component preparaion
GB0220194D0 (en) 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
ATE352316T1 (de) 2002-11-01 2007-02-15 Glaxosmithkline Biolog Sa Immunogene zusammensetzung
US20070059329A1 (en) 2002-11-15 2007-03-15 Nathalie Norais Unexpected surface proteins in meningococcus
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
US8034378B2 (en) 2002-12-27 2011-10-11 Novartis Vaccines And Diagnostics, Inc Immunogenic compositions containing phospholipid
WO2004087153A2 (en) 2003-03-28 2004-10-14 Chiron Corporation Use of organic compounds for immunopotentiation
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
PL1631264T5 (pl) 2003-06-02 2018-09-28 Glaxosmithkline Biologicals Sa Kompozycje immunogenne oparte na biodegradowalnych mikrocząstkach zawierających toksoid błonicy i tężca
ATE516306T1 (de) 2003-08-13 2011-07-15 Novartis Vaccines & Diagnostic Verbessertes verfahren zur reinigung von tfpi und tfpi-analogen
EP1730171A1 (en) 2004-02-19 2006-12-13 Ramot at Tel Aviv University Ltd. Peptide mimotopes of mycobacterial mannosylated lipoglycans and uses thereof
JP5041279B2 (ja) * 2004-04-22 2012-10-03 株式会社 Mbr 細菌細胞壁骨格成分を含有する製剤
JP2008504292A (ja) 2004-06-24 2008-02-14 ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド 免疫増強用の化合物
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
US8147837B2 (en) 2004-06-24 2012-04-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of mycobacterial mannosylated lipoglycans peptide mimotopes for treating inflammation
US20090317420A1 (en) 2004-07-29 2009-12-24 Chiron Corporation Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae
JP5285278B2 (ja) 2004-12-22 2013-09-11 クリーブランド クリニック ファウンデイション フラゲリン関連ポリペプチドおよびその使用
EP2357000A1 (en) 2005-10-18 2011-08-17 Novartis Vaccines and Diagnostics, Inc. Mucosal and systemic immunizations with alphavirus replicon particles
JP5215865B2 (ja) 2005-11-22 2013-06-19 ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド ノロウイルス抗原およびサポウイルス抗原
ES2536426T3 (es) 2006-03-23 2015-05-25 Novartis Ag Compuestos de imidazoquinoxalina como inmunomoduladores
KR100846494B1 (ko) * 2006-09-26 2008-07-17 삼성전자주식회사 헬리코박터 파일로리의 표적 서열을 증폭하기 위한프라이머 세트, 상기 프라이머 세트를 이용하여 헬리코박터파일로리를 검출하는 방법 및 상기 프라이머 세트를포함하는 헬리코박터 파일로리를 검출하는 키트
GB0700562D0 (en) 2007-01-11 2007-02-21 Novartis Vaccines & Diagnostic Modified Saccharides
CA2699513C (en) 2007-09-12 2018-03-13 Novartis Ag Gas57 mutant antigens and gas57 antibodies
ES2391695T3 (es) 2007-12-21 2012-11-29 Novartis Ag Formas mutantes de estreptolisina O
ES2412237T3 (es) 2008-08-01 2013-07-10 Cleveland Biolabs, Inc. Métodos para tratar lesiones por reperfusión
WO2010032138A2 (en) 2008-09-18 2010-03-25 Novartis Ag Vaccine adjuvant combinations
MX2011007456A (es) 2009-01-12 2011-08-03 Novartis Ag Antigenos del dominio de proteina de superficie de union a colageno tipo b (can_b) en vacunas contra bacteria gram positiva.
JP2013503148A (ja) 2009-08-27 2013-01-31 ノバルティス アーゲー アルミニウム、オリゴヌクレオチドおよびポリカチオンを含むアジュバント
EA026401B1 (ru) 2009-09-02 2017-04-28 Новартис Аг Иммуногенные композиции, содержащие модуляторы активности tlr
KR20130121699A (ko) 2010-05-28 2013-11-06 테트리스 온라인, 인코포레이티드 상호작용 혼성 비동기 컴퓨터 게임 기반구조
ES2458355T3 (es) 2010-09-01 2014-05-05 Novartis Ag Adsorción de inmunopotenciadores sobre sales metálicas insolubles
US9618508B2 (en) 2010-12-14 2017-04-11 Glaxosmithkline Biologicals Sa Flow cytometry analysis of materials adsorbed to metal salts
CN103476458B (zh) 2011-01-10 2017-02-15 克利夫兰生物实验室公司 Toll样受体激动剂治疗癌症的用途
BR112013022397A2 (pt) 2011-03-02 2017-09-26 Derek O’Hagan vacinas combinadas com doses menores de antígeno e/ou adjuvante
RU2014140336A (ru) 2012-03-07 2016-04-27 Новартис Аг Иммунологически полезные соли аргинина
JP2015510872A (ja) 2012-03-07 2015-04-13 ノバルティス アーゲー Streptococcuspneumoniae抗原の増強された製剤
RU2014140521A (ru) 2012-03-08 2016-04-27 Новартис Аг Адъювантные составы бустерных вакцин
EP2877852B1 (en) * 2012-07-23 2022-05-25 Hermouet, Sylvie A protein microarray for characterizing the specificity of the monoclonal immunoglobulins of mgus or myeloma patients
KR20170031251A (ko) 2014-07-30 2017-03-20 클리브랜드 바이오랩스, 아이엔씨. 플라젤린 조성물 및 용도
WO2016109002A2 (en) 2014-10-16 2016-07-07 Cleveland Biolabs, Inc. Methods and compositions for the treatment of radiation-related disorders
SE541618C2 (en) * 2017-02-24 2019-11-12 Biotome Pty Ltd Novel peptides and their use in diagnosis

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3751307T2 (de) 1986-03-28 1995-09-21 The Board Of Trustees Of The University Of Illinois, Urbana, Ill. Zubereitungen und verfahren für klone, die, mit mehrfacharzneimittelresistenz assoziierte, dna-sequenzen in menschlichen zellen enthalten.
US5554372A (en) 1986-09-22 1996-09-10 Emory University Methods and vaccines comprising surface-active copolymers
US5459041A (en) * 1988-02-18 1995-10-17 Enteric Research Laboratories, Inc. Campylobacter pylori antigens and uses thereof for detection of Campylobacter pylori infection
US4882271A (en) * 1988-03-10 1989-11-21 Baylor College Of Medicine Process for preparation of high molecular weight cell-associated protein of campylobacter pylori and use for serological detection of campylobacter pylori infection
FR2637612B1 (fr) * 1988-10-06 1993-09-10 Pasteur Institut Sequences de nucleotides codant pour une proteine a activite ureasique
JP3436756B2 (ja) 1988-12-19 2003-08-18 アメリカン・サイアナミド・カンパニー 髄膜炎菌のクラスiの外膜タンパク質のワクチン
GB8928625D0 (en) * 1989-12-19 1990-02-21 3I Res Expl Ltd H.pylori dna probes
US5292658A (en) 1989-12-29 1994-03-08 University Of Georgia Research Foundation, Inc. Boyd Graduate Studies Research Center Cloning and expressions of Renilla luciferase
ES2198514T3 (es) 1991-08-27 2004-02-01 F. Hoffmann-La Roche Ag Cebadores y sondas para la deteccion de la hepatitis c.
US5354854A (en) 1991-11-07 1994-10-11 The Curators Of The University Of Missouri Expression system for use in plants to suppress foreign expression and method
US5721349A (en) * 1992-02-26 1998-02-24 Vanderbilt University Vacuolating toxin-deficient H. pylori
IT1262895B (it) 1992-03-02 1996-07-22 Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico.
US5733740A (en) 1992-10-13 1998-03-31 Vanderbilt University Taga gene and methods for detecting predisposition to peptic ulceration and gastric carcinoma
US5403924A (en) * 1992-10-13 1995-04-04 Vanderbilt University Taga gene and methods for detecting predisposition to peptic ulceration
US6019982A (en) * 1994-08-26 2000-02-01 The Administrators Of The Tulane Educational Fund Mutant enterotoxin effective as a non-toxic oral adjuvant
US6902903B1 (en) 1996-12-19 2005-06-07 Chiron Corporation Helicobacter pylori diagnostics
CA2408328C (en) 2000-05-10 2012-04-17 Aventis Pasteur Limited Immunogenic polypeptides encoded by mage minigenes and uses thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU679542B2 (en) * 1993-07-27 1997-07-03 Csl Limited Treatment of (H. pylori) associated gastroduodenal disease

Also Published As

Publication number Publication date
CA2131729C (en) 2008-02-12
CA2383007A1 (en) 1993-09-16
EP0967279B1 (en) 2008-01-02
DE69333110T2 (de) 2004-05-06
US7700755B2 (en) 2010-04-20
US20040048353A1 (en) 2004-03-11
JPH07504565A (ja) 1995-05-25
US6077706A (en) 2000-06-20
DE69334197T2 (de) 2008-12-11
JP2000350591A (ja) 2000-12-19
US20050276819A1 (en) 2005-12-15
CA2131729A1 (en) 1993-09-16
WO1993018150A1 (en) 1993-09-16
DE69334197D1 (de) 2008-02-14
JP2000333686A (ja) 2000-12-05
JP3408494B2 (ja) 2003-05-19
DE69333110D1 (de) 2003-08-28
JP3368902B2 (ja) 2003-01-20
JP2006055168A (ja) 2006-03-02
EP0967279A1 (en) 1999-12-29

Similar Documents

Publication Publication Date Title
AU3630093A (en) Helicobacter pylori proteins useful for vaccines and diagnostics
AU3736193A (en) Test for (helicobacter pylori)
AU3134893A (en) Micro-libraries and methods for making and manipulating them
AU7865591A (en) Method and means for extending the host range of insecticidal proteins
AU4777693A (en) Method and apparatus for obtaining cytology monolayers
IL122340A0 (en) Helicobacter pylori antigens and vaccine compositions
EP0440794A4 (en) Method and apparatus for reconstituting image
AU2285092A (en) Ending apparatus and method
AU7386694A (en) Stabilised immunoglobulin preparations and method for preparing same
AU5064990A (en) Improved strapping joint and method for forming same
AU2126495A (en) Recombinase-deficient (helicobacter pylori) and related methods
AU4924893A (en) Antibody treatment of (helicobacter pylori)
AU5160596A (en) Helicobacter pylori cagi region
AU3189795A (en) Mouse model for helicobacter pylori infection
AU2158292A (en) Cea-binding proteins and methods for their isolation and use
AU6524898A (en) Recombinant microorganisms expressing antigenic proteins of (helicobacter pylori)
AU7137896A (en) Helicobacter pylori protein
AU3883893A (en) (Haemophilus somnus) immunogenic proteins
AU3814395A (en) Helicobacter pylori diagnostic methods and kits
AU3814093A (en) Solid state disk emulator apparatus and method
AU5466694A (en) Method and device for effecting aesthesiometries
AU3458389A (en) Method and apparatus for image manipulation
AU2971692A (en) Flystrike antigen and vaccine and method for preparation
IL116541A0 (en) Helicobacter proteins and vaccines
ZA955499B (en) Helicobacter proteins and vaccines