AU3537893A - Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use - Google Patents

Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use

Info

Publication number
AU3537893A
AU3537893A AU35378/93A AU3537893A AU3537893A AU 3537893 A AU3537893 A AU 3537893A AU 35378/93 A AU35378/93 A AU 35378/93A AU 3537893 A AU3537893 A AU 3537893A AU 3537893 A AU3537893 A AU 3537893A
Authority
AU
Australia
Prior art keywords
group
pip
methyl
groups
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU35378/93A
Other languages
English (en)
Inventor
Nobuyoshi Iwata
Tsugio Kaneko
Yoshiki Matsui
Shunji Naruto
Yuichi Sugano
Toshiyuki Tonohiro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of AU3537893A publication Critical patent/AU3537893A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU35378/93A 1992-03-23 1993-03-23 Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use Abandoned AU3537893A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP6532392 1992-03-23
JP4-65323 1992-03-23
JP5-9156 1993-01-22
JP915693 1993-01-22

Publications (1)

Publication Number Publication Date
AU3537893A true AU3537893A (en) 1993-09-30

Family

ID=26343823

Family Applications (1)

Application Number Title Priority Date Filing Date
AU35378/93A Abandoned AU3537893A (en) 1992-03-23 1993-03-23 Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use

Country Status (11)

Country Link
EP (1) EP0562832A1 (enExample)
KR (1) KR930019661A (enExample)
CN (1) CN1081676A (enExample)
AU (1) AU3537893A (enExample)
CA (1) CA2092112A1 (enExample)
CZ (1) CZ47393A3 (enExample)
FI (1) FI931291L (enExample)
HU (1) HU9300828D0 (enExample)
IL (1) IL105139A0 (enExample)
NO (1) NO931040L (enExample)
TW (1) TW226019B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU667053B2 (en) * 1991-10-03 1996-03-07 Eisai Co. Ltd. Heteroaryl amines as novel acetyl cholinesterase inhibitors
AU684276B2 (en) * 1993-04-08 1997-12-11 Boehringer Ingelheim Italia S.P.A. Indole derivatives as 5-HT1A and/or 5-HT2 ligands

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9310582D0 (en) * 1993-05-22 1993-07-07 Smithkline Beecham Plc Pharmaceuticals
US5620973A (en) * 1993-11-30 1997-04-15 Takeda Chemical Industries, Ltd. Tetracyclic condensed heterocyclic compounds and their use
ES2098186B1 (es) * 1995-02-09 1998-02-01 Consejo Superior Investigacion Composiciones farmaceuticas a base de aminometilindoles para su aplicacion terapeutica como neuroprotectores en las enfermedades de parkinson y alzheimer.
DE19512639A1 (de) * 1995-04-05 1996-10-10 Merck Patent Gmbh Benzonitrile und -fluoride
GB2308362A (en) * 1995-12-19 1997-06-25 Lilly Industries Ltd Pharmaceutical indole derivatives
US6534496B1 (en) 1997-04-17 2003-03-18 Takeda Chemical Industries, Inc. Thermogenic composition and benzazepine thermogenics
HUP0104493A3 (en) 1998-09-30 2002-12-28 Takeda Pharmaceutical Drugs for improving vesical excretory strength
CN1317276C (zh) * 2000-09-29 2007-05-23 中国科学院上海药物研究所 一类吲哚基哌啶类化合物及其制备方法和用途
CA2471760A1 (en) * 2001-12-28 2003-07-17 Takeda Chemical Industries, Ltd. Preventives/remedies for urinary disturbance
TW200621237A (en) 2004-11-01 2006-07-01 Wyeth Corp [(1-h-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1h-indazol-3-yl)methanones
EA012245B1 (ru) 2004-11-29 2009-08-28 УОРНЕР-ЛАМБЕРТ КОМПАНИ Эд-Эл-Си Терапевтические пиразоло[3,4-b]пиридины и индазолы
JP2009523734A (ja) 2006-01-13 2009-06-25 ワイス ５−ヒドロキシトリプタミン受容体のためのリガンドとしてのスルホニル置換された１ｈ−インドール
KR20120117905A (ko) 2010-01-28 2012-10-24 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 프로테아좀 활성을 향상시키는 조성물 및 방법
JP2013526542A (ja) 2010-05-12 2013-06-24 アッヴィ・インコーポレイテッド キナーゼのインダゾール阻害薬
TR201906779T4 (tr) * 2011-05-12 2019-05-21 Proteostasis Therapeutics Inc Proteostaz regülatörleri.
WO2014116228A1 (en) 2013-01-25 2014-07-31 President And Fellows Of Harvard College Usp14 inhibitors for treating or preventing viral infections
WO2015073528A1 (en) 2013-11-12 2015-05-21 Proteostasis Therapeutics, Inc. Proteasome activity enhancing compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2334358A1 (fr) * 1975-12-12 1977-07-08 Sogeras Nouveaux medicaments derives de l'indole
FR2477544A1 (fr) * 1980-03-07 1981-09-11 Pharmindustrie Nouveaux derives de la chloro-3 quinoleine, procedes pour leur preparation, et leur utilisation comme medicaments

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU667053B2 (en) * 1991-10-03 1996-03-07 Eisai Co. Ltd. Heteroaryl amines as novel acetyl cholinesterase inhibitors
AU684276B2 (en) * 1993-04-08 1997-12-11 Boehringer Ingelheim Italia S.P.A. Indole derivatives as 5-HT1A and/or 5-HT2 ligands

Also Published As

Publication number Publication date
CN1081676A (zh) 1994-02-09
KR930019661A (ko) 1993-10-18
FI931291A7 (fi) 1993-09-24
FI931291A0 (fi) 1993-03-23
FI931291L (fi) 1993-09-24
HU9300828D0 (en) 1993-06-28
NO931040L (no) 1993-09-24
IL105139A0 (en) 1993-07-08
CA2092112A1 (en) 1993-09-24
EP0562832A1 (en) 1993-09-29
CZ47393A3 (en) 1993-11-17
TW226019B (enExample) 1994-07-01
NO931040D0 (no) 1993-03-23

Similar Documents

Publication Publication Date Title
IL116998A0 (en) Novel indoline compounds processes for their preparation and their use for the treatment of CNS disorders
AU6974996A (en) Compositions for the treatment of dermatological disorders and methods for their use
AU3548795A (en) Benzopyranopyrazolyl derivatives for the treatment of inflammation
NZ263084A (en) Dipeptide derivatives, treatment of immunomediated inflammatory disorders
IL110204A0 (en) Novel indolene derivatives, processes for their preparation and their use for the treatment of cns disorders
EP0884319A3 (en) [1,3]oxazino[3,2-A]indole derivative
HUP9901807A3 (en) Heterocycle substituted n-acyl benzenesulfonamide derivatives, process for their preparation and their use as prodrug for the preparation of pharmaceutical compositions treating inflammation or inflammation-associated disorders
AU3497295A (en) Compositions and methods for the treatment of body weight disorders, including obesity
AU2293992A (en) Indole derivatives, pharmaceutical compositions and methods of treating neurological and psychiatric disorders
FI931291A7 (fi) Indolin ja indatsolin johdannaiset aivosairauksien hoitoon ja ennaltaehkäisyyn, niiden valmistus ja käyttö
IL106737A0 (en) Indole and indoline derivatives, process for their preparation and use as medicament
AU4674797A (en) Phenylalaninol derivatives for the treatment of central nervous system disorders
AU4312593A (en) Use of indolone derivatives for the treatment of memory disorders, sexual dysfunction and Parkinson's disease
AU2490492A (en) Process for the preparation of beta-phenylisoserine derivatives and use thereof
AU4530989A (en) Pharmaceutical composition for the treatment of cerebral edema
AU4619893A (en) Substituted phenols, processes for their preparation and their use for the treatment of disorders caused by cell proliferation
MY110149A (en) Compounds for the treatment of neurodegenerative disorders
AU3695293A (en) Derivatives of adipogenesis inhibitory factor, their preparation and their use
CA2135709A1 (en) Melatonin derivatives for use in treating sleep disorders
EP0556671A3 (en) Triazolopyridine derivatives, process for their preparation and their use as microbicides
AUPN104895A0 (en) Methods of and preparations for the treatment of ailments and disorders
AU5201793A (en) Alpha, omega-diarylalkane derivatives, their preparation and their use in the treatment and prevention of circulatory diseases and psychosis
AU4476089A (en) Use of azepinone derivatives for the treatment of respiratory tract disorders
AU603375B2 (en) Therapeutic agent for the treatment of disorders associated with cerebral ischemia
ZA932062B (en) Indole and indazole derivatives, for the treatment and prophylaxis of cerabral disorders, their preparation and their use