AU3103899A - Identification of factors which mediate the interaction of heterotrimeric g proteins and monomeric g proteins - Google Patents

Identification of factors which mediate the interaction of heterotrimeric g proteins and monomeric g proteins Download PDF

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Publication number
AU3103899A
AU3103899A AU31038/99A AU3103899A AU3103899A AU 3103899 A AU3103899 A AU 3103899A AU 31038/99 A AU31038/99 A AU 31038/99A AU 3103899 A AU3103899 A AU 3103899A AU 3103899 A AU3103899 A AU 3103899A
Authority
AU
Australia
Prior art keywords
gef
protein
rgs
polypeptide
subunit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU31038/99A
Other languages
English (en)
Inventor
Gideon Bollag
Matthew J. Hart
Xuejun Jiang
Tohru Kozasa
Paul Polakis
William Roscoe
Paul Sternweis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Onyx Pharmaceuticals Inc
University of Texas System
Original Assignee
Onyx Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Onyx Pharmaceuticals Inc filed Critical Onyx Pharmaceuticals Inc
Publication of AU3103899A publication Critical patent/AU3103899A/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4722—G-proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU31038/99A 1998-03-18 1999-03-18 Identification of factors which mediate the interaction of heterotrimeric g proteins and monomeric g proteins Abandoned AU3103899A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7863498P 1998-03-18 1998-03-18
US60078634 1998-03-18
PCT/US1999/006051 WO1999047557A2 (en) 1998-03-18 1999-03-18 Identification of factors which mediate the interaction of heterotrimeric g proteins and monomeric g proteins

Publications (1)

Publication Number Publication Date
AU3103899A true AU3103899A (en) 1999-10-11

Family

ID=22145305

Family Applications (1)

Application Number Title Priority Date Filing Date
AU31038/99A Abandoned AU3103899A (en) 1998-03-18 1999-03-18 Identification of factors which mediate the interaction of heterotrimeric g proteins and monomeric g proteins

Country Status (6)

Country Link
EP (1) EP1064373A2 (ja)
JP (1) JP2002509862A (ja)
CN (1) CN1293709A (ja)
AU (1) AU3103899A (ja)
CA (1) CA2319037A1 (ja)
WO (1) WO1999047557A2 (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1214412A1 (en) * 1999-09-21 2002-06-19 Forsyth Dental Infirmary For Children Rgs10b, a g-protein regulator expressed in osteoclasts
PL359420A1 (en) * 2000-05-11 2004-08-23 Wyeth Structure of free regulator of g-protein signaling (rgs4) and methods of identifying agonists and antagonists using same
WO2004035614A1 (en) * 2001-07-11 2004-04-29 Karo Bio Ab Synthetic or partially purified peptides which can bind to specific subunits of g proteins and uses thereof
JP2003024078A (ja) * 2001-07-18 2003-01-28 Japan Science & Technology Corp 三量体型ｇ蛋白質の活性モニター分子
WO2003016345A1 (en) * 2001-08-16 2003-02-27 Bayer Healthcare Ag Regulation of human regulator of g-protein signaling
CN105126079B (zh) * 2015-09-29 2019-03-01 武汉大学 G蛋白信号转导调节蛋白14（rgs14）在治疗心肌肥厚中的功能及应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6238881B1 (en) * 1996-11-06 2001-05-29 Onyx Pharmaceuticals, Inc. Nucleic acids and polypeptides related to a guanine exchange factor of Rho GTPase
US6340575B1 (en) * 1997-06-17 2002-01-22 Onyx Pharmaceuticals, Inc. Methods and compositions for treating abnormal cell growth related to unwanted guanine nucleotide exchange factor activity

Also Published As

Publication number Publication date
CA2319037A1 (en) 1999-09-23
EP1064373A2 (en) 2001-01-03
CN1293709A (zh) 2001-05-02
WO1999047557A2 (en) 1999-09-23
WO1999047557A3 (en) 1999-11-18
JP2002509862A (ja) 2002-04-02

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Legal Events

Date Code Title Description
DA3 Amendments made section 104

Free format text: FT=THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE APPLICANT TO INCLUDE BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM

MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted