WO1999047557A3 - Identification of factors which mediate the interaction of heterotrimeric g proteins and monomeric g proteins - Google Patents

Identification of factors which mediate the interaction of heterotrimeric g proteins and monomeric g proteins Download PDF

Info

Publication number
WO1999047557A3
WO1999047557A3 PCT/US1999/006051 US9906051W WO9947557A3 WO 1999047557 A3 WO1999047557 A3 WO 1999047557A3 US 9906051 W US9906051 W US 9906051W WO 9947557 A3 WO9947557 A3 WO 9947557A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
heterotrimeric
monomeric
mediate
interaction
Prior art date
Application number
PCT/US1999/006051
Other languages
French (fr)
Other versions
WO1999047557A2 (en
Inventor
Gideon Bollag
Matthew J Hart
William Roscoe
Paul Polakis
Paul Sternweis
Tohru Kozasa
Xuejun Jiang
Original Assignee
Onyx Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Onyx Pharma Inc filed Critical Onyx Pharma Inc
Priority to CA002319037A priority Critical patent/CA2319037A1/en
Priority to AU31038/99A priority patent/AU3103899A/en
Priority to JP2000536748A priority patent/JP2002509862A/en
Priority to EP99912727A priority patent/EP1064373A2/en
Publication of WO1999047557A2 publication Critical patent/WO1999047557A2/en
Publication of WO1999047557A3 publication Critical patent/WO1999047557A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4722—G-proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Monomeric GTPase guanine nucleotide exchange factor (GEF) have been identified which also contain an RGS region analogous to those of GTPase activating proteins (GAP). One of these GEF proteins, a Rho GEF has been demonstrated to contain an RGS sequence that has GAP activity toward a α subunit of a heterotrimeric G prote in.
PCT/US1999/006051 1998-03-18 1999-03-18 Identification of factors which mediate the interaction of heterotrimeric g proteins and monomeric g proteins WO1999047557A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002319037A CA2319037A1 (en) 1998-03-18 1999-03-18 Identification of factors which mediate the interaction of heterotrimeric g proteins and monomeric g proteins
AU31038/99A AU3103899A (en) 1998-03-18 1999-03-18 Identification of factors which mediate the interaction of heterotrimeric g proteins and monomeric g proteins
JP2000536748A JP2002509862A (en) 1998-03-18 1999-03-18 Identification of factors mediating the interaction between heterotrimeric G protein and monomeric G protein
EP99912727A EP1064373A2 (en) 1998-03-18 1999-03-18 Identification of factors which mediate the interaction of heterotrimeric g proteins and monomeric g proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7863498P 1998-03-18 1998-03-18
US60/078,634 1998-03-18

Publications (2)

Publication Number Publication Date
WO1999047557A2 WO1999047557A2 (en) 1999-09-23
WO1999047557A3 true WO1999047557A3 (en) 1999-11-18

Family

ID=22145305

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/006051 WO1999047557A2 (en) 1998-03-18 1999-03-18 Identification of factors which mediate the interaction of heterotrimeric g proteins and monomeric g proteins

Country Status (6)

Country Link
EP (1) EP1064373A2 (en)
JP (1) JP2002509862A (en)
CN (1) CN1293709A (en)
AU (1) AU3103899A (en)
CA (1) CA2319037A1 (en)
WO (1) WO1999047557A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2385460A1 (en) * 1999-09-21 2001-03-29 Forsyth Dental Infirmary For Children Rgs10b, a g-protein regulator expressed in osteoclasts
HUP0302548A2 (en) * 2000-05-11 2003-11-28 Wyeth Structure of g-protein (rgs4) and methods of identifying agonists and antagonists using same
WO2004035614A1 (en) * 2001-07-11 2004-04-29 Karo Bio Ab Synthetic or partially purified peptides which can bind to specific subunits of g proteins and uses thereof
JP2003024078A (en) * 2001-07-18 2003-01-28 Japan Science & Technology Corp Active monitor molecule for trimer type protein
WO2003016345A1 (en) * 2001-08-16 2003-02-27 Bayer Healthcare Ag Regulation of human regulator of g-protein signaling
CN105126079B (en) * 2015-09-29 2019-03-01 武汉大学 G-protein signal transduction regulatory protein 14(RGS14) treating function and application in myocardial hypertrophy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998020127A1 (en) * 1996-11-06 1998-05-14 Onyx Pharmaceuticals, Inc. Guanine exchange factor of rho gtpase and nucleic acid encoding it
WO1998057990A2 (en) * 1997-06-17 1998-12-23 Onyx Pharmaceuticals, Inc. Methods and compositions for treating abnormal cell growth related to unwanted guanine nucleotide exchange factor activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998020127A1 (en) * 1996-11-06 1998-05-14 Onyx Pharmaceuticals, Inc. Guanine exchange factor of rho gtpase and nucleic acid encoding it
WO1998057990A2 (en) * 1997-06-17 1998-12-23 Onyx Pharmaceuticals, Inc. Methods and compositions for treating abnormal cell growth related to unwanted guanine nucleotide exchange factor activity

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ALAN HALL: "G proteins and small GTPases: Distant relatives keep in touch", SCIENCE, vol. 280, 26 June 1998 (1998-06-26), DC, pages 2074 - 2075, XP002111128 *
DAVID M. BERMAN ET AL.: "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits", CELL, vol. 86, no. 3, 9 August 1996 (1996-08-09), NA US, pages 445 - 452, XP002111126 *
FUKUHARA S ET AL: "A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho.", JOURNAL OF BIOLOGICAL CHEMISTRY, (1999 FEB 26) 274 (9) 5868-79., XP002111131 *
HART M J ET AL: "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13 [see comments].", SCIENCE, (1998 JUN 26) 280 (5372) 2112-4., XP002111129 *
KOZASA T ET AL: "p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13 [see comments].", SCIENCE, (1998 JUN 26) 280 (5372) 2109-11., XP002111127 *
MAO J ET AL: "Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein alpha subunit Galpha13.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1998 OCT 27) 95 (22) 12973-6., XP002111130 *
MATTHEW J. HART ET AL.: "Identification of a novel Guanine nucleotide exchange factor for the Rho GTPase", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 41, 11 October 1996 (1996-10-11), MD US, pages 25452 - 25458, XP002057776 *

Also Published As

Publication number Publication date
WO1999047557A2 (en) 1999-09-23
JP2002509862A (en) 2002-04-02
CA2319037A1 (en) 1999-09-23
AU3103899A (en) 1999-10-11
CN1293709A (en) 2001-05-02
EP1064373A2 (en) 2001-01-03

Similar Documents

Publication Publication Date Title
ZA972439B (en) Amino acid fermentation processes.
EP0679716A4 (en) Gene signature.
HK1019074A1 (en) Protein having phospholipase activity.
ZA983930B (en) Excitatory amino acid receptor modulators.
CA2315274A1 (en) Polypeptides having aminopeptidase activity and nucleic acids encoding same
ID26517A (en) PROTEIN GENE MEMBRANE ISOLATED DENRIT CELLS
IL135688A0 (en) Human checkpoint kinase, hcds1, compositions and methods
ZA9710288B (en) Novel genes encoding telomerase proteins.
EP2283852A3 (en) Porphorymonas gingivalis polypeptides and polynucleotides
CA2281206A1 (en) Geranyl diphosphate synthase genes
ZA975588B (en) Isolated nucleic acid molecules which code for gage tumor rejection antigen, the tumor rejection antigen, and uses thereof.
WO1999047557A3 (en) Identification of factors which mediate the interaction of heterotrimeric g proteins and monomeric g proteins
HUP0104825A3 (en) Genes and proteins, and their use
HK1041686A1 (en) N-arylsulfonyl amino acid omega amedes.
NO963487D0 (en) Isolated tyrosinase-derived peptides, and uses thereof
ZA974286B (en) The spindly gene, methods of identification and use.
EP0622464A3 (en) Nucleic acid assay procedure.
CA2406884A1 (en) Novel collectins
ZA99677B (en) Placental protein 13.
AU6260796A (en) Isolated formylated bacterial peptides, nucleic acid molecul es and uses thereof
NO20004648L (en) Nucleic acid transfer vectors, their use and preparations containing the vectors
AP2006003504A0 (en) Outer surface proteins, their genes, and their use.
EP1118659A4 (en) Expression systems for functional nucleic acid expression
AU6483896A (en) Nucleotide and amino acid sequence and uses thereof
CA2244928A1 (en) Dna coding for serine/threonine kinase

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 99804014.2

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref document number: 2319037

Country of ref document: CA

Ref document number: 2319037

Country of ref document: CA

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 31038/99

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 1999912727

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2000 536748

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: KR

WWP Wipo information: published in national office

Ref document number: 1999912727

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 1999912727

Country of ref document: EP