AU2371400A - Vitronectin receptor antagonist pharmaceuticals - Google Patents
Vitronectin receptor antagonist pharmaceuticalsInfo
- Publication number
- AU2371400A AU2371400A AU23714/00A AU2371400A AU2371400A AU 2371400 A AU2371400 A AU 2371400A AU 23714/00 A AU23714/00 A AU 23714/00A AU 2371400 A AU2371400 A AU 2371400A AU 2371400 A AU2371400 A AU 2371400A
- Authority
- AU
- Australia
- Prior art keywords
- receptor antagonist
- vitronectin receptor
- antagonist pharmaceuticals
- pharmaceuticals
- vitronectin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11283198P | 1998-12-18 | 1998-12-18 | |
US60112831 | 1998-12-18 | ||
PCT/US1999/030311 WO2000035887A2 (en) | 1998-12-18 | 1999-12-17 | Vitronectin receptor antagonist pharmaceuticals |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2371400A true AU2371400A (en) | 2000-07-03 |
Family
ID=22346057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU23714/00A Abandoned AU2371400A (en) | 1998-12-18 | 1999-12-17 | Vitronectin receptor antagonist pharmaceuticals |
Country Status (6)
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6569402B1 (en) | 1998-12-18 | 2003-05-27 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
US6171578B1 (en) * | 1999-04-14 | 2001-01-09 | Diatide, Inc. | Benzodiazepine derivatives for imaging thrombi |
EP1311292A2 (en) * | 2000-06-21 | 2003-05-21 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
EP1420792A4 (en) * | 2001-08-01 | 2007-10-10 | Smithkline Beecham Corp | PRODUCTS AND EXCIPIENTS FOR THE ADMINISTRATION OF MEDICAMENTS |
JP4750360B2 (ja) | 2001-10-22 | 2011-08-17 | ザ スクリプス リサーチ インスティチュート | 抗体ターゲッティング化合物 |
MXPA04007188A (es) | 2002-01-24 | 2005-10-18 | Barnes Jewish Hospital | Agentes para imagen dirigidos a integrina. |
US7279150B2 (en) | 2002-01-24 | 2007-10-09 | Barnes-Jewish Hospital | Chelating agents with lipophilic carriers |
US20040224986A1 (en) | 2002-08-16 | 2004-11-11 | Bart De Corte | Piperidinyl targeting compounds that selectively bind integrins |
US20060217292A1 (en) * | 2003-05-12 | 2006-09-28 | Harris Thomas D | Vitronectin receptor antagonist compounds and their use in the preparation of diopharmaceuticals |
WO2005032599A1 (en) * | 2003-09-30 | 2005-04-14 | Semafore Pharmaceuticals Inc. | Chelate based scaffolds in tumor targeting |
US7504088B2 (en) | 2004-06-09 | 2009-03-17 | Kereos, Inc. | Lipophilic derivatives of chelate monoamides |
US8758723B2 (en) * | 2006-04-19 | 2014-06-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for cellular imaging and therapy |
JP2009534381A (ja) * | 2006-04-19 | 2009-09-24 | ボード オブ リージェンツ オブ ザ ユニバーシティ オブ テキサス システム | 細胞画像化および治療のための組成物および方法 |
US10925977B2 (en) * | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
LT2939538T (lt) | 2008-07-03 | 2019-03-12 | Monsanto Technology Llc | Sacharidų darinių paviršinio aktyvumo medžiagų ir eterio amino oksidų paviršinio aktyvumo medžiagų deriniai, kaip herbicidų adjuvantai |
US20100178245A1 (en) * | 2009-01-13 | 2010-07-15 | Arnsdorf Morton F | Biocompatible Microbubbles to Deliver Radioactive Compounds to Tumors, Atherosclerotic Plaques, Joints and Other Targeted Sites |
JP2012517447A (ja) | 2009-02-10 | 2012-08-02 | ザ スクリプス リサーチ インスティチュート | 化学的にプログラムされたワクチン接種法 |
FR2977892B1 (fr) * | 2011-07-13 | 2013-07-26 | Servier Lab | Nouveaux agents d'imagerie, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Family Cites Families (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4248802A (en) * | 1975-06-20 | 1981-02-03 | Rhone-Poulenc Industries | Catalytic hydroformylation of olefins |
WO1981001145A1 (en) | 1979-10-18 | 1981-04-30 | Univ Illinois | Hydrolytic enzyme-activatible pro-drugs |
US4859777A (en) | 1981-07-01 | 1989-08-22 | Eastman Kodak Company | Terpyridine chelating agents |
US4957939A (en) | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
DE3360633D1 (en) | 1982-02-12 | 1985-10-03 | Unitika Ltd | Anti-cancer device |
US4452774A (en) | 1982-04-30 | 1984-06-05 | President And Fellows Of Harvard College | Isonitrile radionuclide complexes for labelling and imaging agents |
US4472509A (en) | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
JPH07110815B2 (ja) | 1985-11-18 | 1995-11-29 | ボ−ド・オブ・リ−ジェンツ、ザ・ユニバ−シティ−・オブ・テキサス・システム | 画像及びスペクトル向上(およびスペクトルシフト)のためのポリキレ−ト剤 |
CA1305160C (en) | 1985-12-23 | 1992-07-14 | Paul Louis Bergstein | Ether isonitriles and radiolabeled complexes thereof |
MX174467B (es) | 1986-01-23 | 1994-05-17 | Squibb & Sons Inc | 1,4,7-triscarboximetil-1,4,7,10-tetraazaciclodo decano substituido en 1 y compuestos analogos |
US5567411A (en) | 1986-11-10 | 1996-10-22 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Dendritic amplifier molecules having multiple terminal active groups stemming from a benzyl core group |
US5252317A (en) | 1986-11-10 | 1993-10-12 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Amplifier molecules for diagnosis and therapy derived from 3,5-bis[1-(3-amino-2,2-bis (aminomethyl)-propyl) oxymethyl] benzoic acid |
US5064956A (en) | 1987-06-24 | 1991-11-12 | The Dow Chemical Company | Process for preparing mono-n-alkylated polyazamacrocycles |
US5135736A (en) | 1988-08-15 | 1992-08-04 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
IL91933A (en) | 1988-10-11 | 1994-12-29 | Univ Southern California | Their immuno-bracelet and isophiles which are beneficial in increasing vascular permeability or blood supply to tumor or otherwise damaged tissue |
JPH04501565A (ja) | 1988-11-14 | 1992-03-19 | ブリガム・アンド・ウイメンズ・ホスピタル | Elam―1に特異的な抗体およびその用途 |
US5376356A (en) | 1989-03-14 | 1994-12-27 | Neorx Corporation | Imaging tissue sites of inflammation |
IL94055A (en) | 1989-04-10 | 1995-11-27 | Oncogen | Oncostatin M Container Pharmaceuticals to Change Tissue Immunogenicity and Improve Implant Absorption |
US5272263A (en) | 1989-04-28 | 1993-12-21 | Biogen, Inc. | DNA sequences encoding vascular cell adhesion molecules (VCAMS) |
US5395609A (en) | 1989-06-19 | 1995-03-07 | Antisoma Limited | Synthetic peptides for use in tumor detection |
EP0436005B1 (en) | 1989-07-20 | 1995-03-29 | Sandoz Ltd. | Labeled polypeptide derivatives |
US5087440A (en) | 1989-07-31 | 1992-02-11 | Salutar, Inc. | Heterocyclic derivatives of DTPA used for magnetic resonance imaging |
GB8923843D0 (en) | 1989-10-23 | 1989-12-13 | Salutar Inc | Compounds |
US5679810A (en) | 1990-01-19 | 1997-10-21 | Salutar, Inc. | Linear oligomeric polychelant compounds |
GB9006977D0 (en) | 1990-03-28 | 1990-05-23 | Nycomed As | Compositions |
WO1992017215A1 (en) | 1990-03-28 | 1992-10-15 | Nycomed Salutar, Inc. | Contrast media |
TW212184B (US06818201-20041116-C00075.png) | 1990-04-02 | 1993-09-01 | Takeda Pharm Industry Co Ltd | |
IN172208B (US06818201-20041116-C00075.png) | 1990-04-02 | 1993-05-01 | Sint Sa | |
US5382654A (en) | 1992-02-05 | 1995-01-17 | Mallinckrodt Medical, Inc. | Radiolabelled peptide compounds |
EP0568631A4 (en) | 1991-01-24 | 1995-04-05 | Cytel Corp | MONOCLONAL ANTIBODIES FOR A CELL SURFACE RECEPTOR (ELAM-1) AND USES THEREOF. |
US5504064A (en) | 1991-04-10 | 1996-04-02 | Oklahoma Medical Research Foundation | Treatment of bleeding with modified tissue factor in combination with an activator of FVII |
AU667813B2 (en) | 1991-05-03 | 1996-04-18 | Rockefeller University, The | Amino-acid sequence homologies between selectins and B pertussis toxin-peptides derived therefrom antibodies thereto pharmaceutical compositions |
US5250679A (en) | 1991-10-18 | 1993-10-05 | Genentech, Inc. | Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor |
AU2861692A (en) | 1991-10-18 | 1993-05-21 | Beth Israel Hospital Association, The | Vascular permeability factor targeted compounds |
DK0627940T3 (da) | 1992-03-05 | 2003-09-01 | Univ Texas | Anvendelse af immunokonjugater til diagnose og/eller terapi af vaskulariserede tumorer |
US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
US5776427A (en) | 1992-03-05 | 1998-07-07 | Board Of Regents, The University Of Texas System | Methods for targeting the vasculature of solid tumors |
GB9209641D0 (en) | 1992-05-02 | 1992-06-17 | Johnson Matthey Plc | Improvements in radiolabelling |
AU5093593A (en) | 1992-08-28 | 1994-03-29 | Scripps Research Institute, The | Inhibition of tumor metastasis via neutralization of tissue factor function |
CN1173991C (zh) | 1992-11-13 | 2004-11-03 | 马克斯普朗克科学促进协会 | 作为血管内皮生长因子受体的f1k-1 |
US5342757A (en) | 1992-11-13 | 1994-08-30 | Ludwig Institute For Cancer Research | Monoclonal antibodies which specifically binds to endosialin, a 165 Kd glycoprotein found on tumor vascular endothelium, and uses thereof |
US5650134A (en) | 1993-01-12 | 1997-07-22 | Novartis Ag (Formerly Sandoz Ltd.) | Peptides |
DE4301871A1 (de) | 1993-01-13 | 1994-07-14 | Diagnostikforschung Inst | Neue Mittel zur Diagnose von Gefäßerkrankungen |
US5760191A (en) | 1993-02-05 | 1998-06-02 | Nycomed Imaging As | Macrocyclic complexing agents and targeting immunoreagents useful in therapeutic and diagnostic compositions and methods |
US5744120A (en) | 1993-03-30 | 1998-04-28 | The Dupont Merick Pharmaceutical Company | Ternary radiopharmaceutical complexes |
US5750088A (en) * | 1993-03-30 | 1998-05-12 | The Dupont Merck Pharmaceutical Company | Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals |
DE4311023C2 (de) | 1993-03-31 | 1996-05-02 | Diagnostikforschung Inst | Bifunktionelle chalkogenatom-unterbrochene Chelatbildner von Typ XN¶1¶S¶1¶O¶1¶ für radioaktive Isotope, deren Metallkomplexe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel |
MXPA94002323A (es) | 1993-03-31 | 2002-06-18 | Mallinckrodt Medical Inc | Formulaciones radiofarmaceuticas que tienen reductores no estanosos. |
ES2114209T3 (es) * | 1993-07-19 | 1998-05-16 | Resolution Pharm Inc | Queladores de radionuclidos de tipo hidrazino que tienen una configuracion n3s. |
US5417959A (en) | 1993-10-04 | 1995-05-23 | Mallinckrodt Medical, Inc. | Functionalized aza-crytand ligands for diagnostic imaging applications |
MA23420A1 (fr) | 1994-01-07 | 1995-10-01 | Smithkline Beecham Corp | Antagonistes bicycliques de fibrinogene. |
US5753230A (en) | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
WO1996000574A1 (en) | 1994-06-29 | 1996-01-11 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
NZ290008A (en) | 1994-06-29 | 1998-08-26 | Smithkline Beecham Corp | Vitronectin receptor antagonists, comprising a fibrinogen antagonist analogue linked to a heterocycle |
CA2194369C (en) | 1994-07-11 | 2004-08-31 | Philip E. Thorpe | Methods and compositions for the specific coagulation of vasculature |
US5556939A (en) | 1994-10-13 | 1996-09-17 | Merck Frosst Canada, Inc. | TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications |
US5520904A (en) | 1995-01-27 | 1996-05-28 | Mallinckrodt Medical, Inc. | Calcium/oxyanion-containing particles with a polymerical alkoxy coating for use in medical diagnostic imaging |
EP0727225A3 (en) | 1995-02-14 | 1997-01-15 | Sonus Pharma Inc | Compositions and methods for directed ultrasonic imaging |
SE515621C2 (sv) * | 1995-05-08 | 2001-09-10 | Ericsson Telefon Ab L M | Förfarande vid lägesbestämning |
US5801228A (en) | 1995-06-07 | 1998-09-01 | Nycomed Imaging As | Polymeric contrast agents for medical imaging |
GB9511989D0 (en) | 1995-06-13 | 1995-08-09 | Glaxo Group Ltd | Chemical compounds |
EP0850221B1 (en) | 1995-08-30 | 2001-07-18 | G.D. Searle & Co. | Meta-guanidine, urea, thiourea or azacyclic amino benzoic acid derivatives as integrin antagonists |
DE19536781A1 (de) | 1995-09-21 | 1997-03-27 | Diagnostikforschung Inst | Bifunktionelle sulfidhaltige Sulfonamid-Chelatbildner vom Typ XSNS für radioaktive Isotope |
DE19536785A1 (de) | 1995-09-21 | 1997-03-27 | Diagnostikforschung Inst | Bifunktionelle sulfidhaltige Sulfonamid-Chelatbildner vom Typ S¶2¶NY für radioaktive Isotope |
JP4018141B2 (ja) | 1995-11-01 | 2007-12-05 | ブラッコ・リサーチ・ソシエテ・アノニム | Nmr画像形成用の標的磁気標識分子マーカーシステム |
PL326714A1 (en) | 1995-11-14 | 1998-10-26 | Du Pont Merck Pharma | Novel macrocyclic compounds as inhibitors of metaloproteinases |
WO1997023480A1 (en) | 1995-12-22 | 1997-07-03 | The Du Pont Merck Pharmaceutical Company | Novel integrin receptor antagonists |
US5879659A (en) * | 1996-03-13 | 1999-03-09 | Dupont Pharmaceuticals Company | Ternary radiopharmaceutical complexes |
US5804161A (en) | 1996-05-14 | 1998-09-08 | Nycomed Salutar Inc. | Contrast agents |
ZA978758B (en) | 1996-10-02 | 1999-03-30 | Du Pont Merck Pharma | Technetium-99m-labeled chelator incorporated cyclic peptides that bind to the GPIIb/IIIa receptor as imaging agents |
US6056973A (en) | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
WO1998016256A1 (en) | 1996-10-16 | 1998-04-23 | The Burnham Institute | Magnetic resonance imaging of thrombi |
ES2206689T3 (es) | 1996-10-28 | 2004-05-16 | Amersham Health As | Agentes de contraste. |
GB9708265D0 (en) | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Contrast agents |
DE19725368A1 (de) * | 1997-06-16 | 1998-12-17 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren und deren Verwendung für bildgebende Verfahren |
WO1999006049A1 (en) | 1997-08-04 | 1999-02-11 | Smithkline Beecham Corporation | Integrin receptor antagonists |
JP2001516055A (ja) | 1997-09-10 | 2001-09-25 | ザ バーナム インスティチュート | 腫瘍中の血管形成血管系にホーミングする分子を同定する方法 |
EP1056773A2 (en) | 1998-02-11 | 2000-12-06 | Resolution Pharmaceuticals Inc. | Angiogenesis targeting molecules |
EP1100506A4 (en) | 1998-07-29 | 2002-06-26 | Merck & Co Inc | INTEGRIN RECEPTOR ANTAGONISTS |
JP2002536370A (ja) * | 1999-02-03 | 2002-10-29 | メルク エンド カムパニー インコーポレーテッド | α−Vインテグリン受容体拮抗薬としてのベンゾアゼピン誘導体 |
US6254852B1 (en) * | 1999-07-16 | 2001-07-03 | Dupont Pharmaceuticals Company | Porous inorganic targeted ultrasound contrast agents |
-
1999
- 1999-12-17 US US09/466,582 patent/US6558649B1/en not_active Expired - Fee Related
- 1999-12-17 TR TR2001/01757T patent/TR200101757T2/xx unknown
- 1999-12-17 AU AU23714/00A patent/AU2371400A/en not_active Abandoned
- 1999-12-17 WO PCT/US1999/030311 patent/WO2000035887A2/en active Application Filing
- 1999-12-17 EP EP99967441A patent/EP1140864A2/en not_active Withdrawn
- 1999-12-17 CA CA002349333A patent/CA2349333A1/en not_active Abandoned
-
2002
- 2002-11-26 US US10/306,244 patent/US6818201B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2000035887A2 (en) | 2000-06-22 |
WO2000035887A3 (en) | 2000-11-16 |
US20030143235A1 (en) | 2003-07-31 |
TR200101757T2 (tr) | 2001-12-21 |
US6558649B1 (en) | 2003-05-06 |
US6818201B2 (en) | 2004-11-16 |
CA2349333A1 (en) | 2000-06-22 |
EP1140864A2 (en) | 2001-10-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL142958A0 (en) | Vitronectin receptor antagonist pharmaceuticals | |
EP1000031A4 (en) | VITRONECTIN RECEPTOR ANTAGONISTS | |
AU4746297A (en) | Vitronectin receptor antagonists | |
AU8689798A (en) | Integrin receptor antagonists | |
AU2371400A (en) | Vitronectin receptor antagonist pharmaceuticals | |
IL130760A0 (en) | Vitronectin receptor antagonists | |
AU2001271435A1 (en) | Vitronectin receptor antagonist pharmaceuticals | |
IL135189A0 (en) | Vitronectin receptor antagonist | |
IL135188A0 (en) | Vitronectin receptor antagonist | |
IL138245A0 (en) | Vitronectin receptor antagonists | |
IL135028A0 (en) | Vitronectin receptor antagonists | |
AU6990000A (en) | Novel integrin receptor antagonists | |
EG24025A (en) | Vitronectin receptor antagonist | |
GC0000203A (en) | Vitronectin receptor antagonists | |
PL346157A1 (en) | Vitronectin receptor antagonists | |
AU2574801A (en) | Selective iGLUR5 receptor antagonists | |
AU6051200A (en) | Il-8 receptor antagonists | |
AU6826498A (en) | Endotholin receptor antagonists | |
SI1140203T1 (sl) | Viktronektin receptor farmacevtski antagonist | |
AU5748300A (en) | Il-8 receptor antagonists | |
AU5168900A (en) | Il-8 receptor antagonists | |
AU5622400A (en) | Il-8 receptor antagonists | |
AU2512800A (en) | Alpha1-adrenergic receptor antagonists | |
GB9822331D0 (en) | Vitronectin receptor antagonists | |
GB9815803D0 (en) | Vitronectin receptor antagonists |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |