AU2022429647A1 - Process for preparing (5s)-{[2-(4-carboxyphenyl)ethyl] |2-(2-{|3-chloro-4'-(trifluoromethyl)biphenyl-4- yl]methoxy}phenyl)ethyl]aminol-5,6,7,8-tetrahydroquinoline-2-carboxylic acid and its crystalline forms for use as pharmaceutically active compound - Google Patents
Process for preparing (5s)-{[2-(4-carboxyphenyl)ethyl] |2-(2-{|3-chloro-4'-(trifluoromethyl)biphenyl-4- yl]methoxy}phenyl)ethyl]aminol-5,6,7,8-tetrahydroquinoline-2-carboxylic acid and its crystalline forms for use as pharmaceutically active compound Download PDFInfo
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- AU2022429647A1 AU2022429647A1 AU2022429647A AU2022429647A AU2022429647A1 AU 2022429647 A1 AU2022429647 A1 AU 2022429647A1 AU 2022429647 A AU2022429647 A AU 2022429647A AU 2022429647 A AU2022429647 A AU 2022429647A AU 2022429647 A1 AU2022429647 A1 AU 2022429647A1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21218163.0 | 2021-12-29 | ||
| EP21218163 | 2021-12-29 | ||
| PCT/EP2022/087952 WO2023126436A1 (en) | 2021-12-29 | 2022-12-28 | Process for preparing (5s)-{[2-(4-carboxyphenyl)ethyl] |2-(2-{|3-chloro-4'-(trifluoromethyl)biphenyl-4- yl]methoxy}phenyl)ethyl]aminol-5,6,7,8-tetrahydroquinoline-2-carboxylic acid and its crystalline forms for use as pharmaceutically active compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2022429647A1 true AU2022429647A1 (en) | 2024-07-04 |
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ID=79185525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2022429647A Pending AU2022429647A1 (en) | 2021-12-29 | 2022-12-28 | Process for preparing (5s)-{[2-(4-carboxyphenyl)ethyl] |2-(2-{|3-chloro-4'-(trifluoromethyl)biphenyl-4- yl]methoxy}phenyl)ethyl]aminol-5,6,7,8-tetrahydroquinoline-2-carboxylic acid and its crystalline forms for use as pharmaceutically active compound |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US12202805B2 (https=) |
| EP (1) | EP4457215A1 (https=) |
| JP (1) | JP2025502842A (https=) |
| KR (1) | KR20240144177A (https=) |
| CN (1) | CN118765272A (https=) |
| AR (1) | AR128147A1 (https=) |
| AU (1) | AU2022429647A1 (https=) |
| CA (1) | CA3244893A1 (https=) |
| IL (1) | IL313922A (https=) |
| MX (1) | MX2024008172A (https=) |
| TW (1) | TW202342012A (https=) |
| WO (1) | WO2023126436A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118765199A (zh) | 2021-12-29 | 2024-10-11 | 拜耳股份公司 | 心肺病症的治疗 |
| TW202342012A (zh) | 2021-12-29 | 2023-11-01 | 德商拜耳廠股份有限公司 | 製備用作醫藥活性化合物的（５ｓ）－｛［２－（４－羧基苯基）乙基］［２－（２－｛［３－氯－４＇－（三氟甲基）聯苯－４－基］甲氧基｝苯基）乙基］胺基｝－５，６，７，８－四氫喹啉－２－羧酸及其結晶形式之方法 |
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| US20230183181A1 (en) | 2020-05-20 | 2023-06-15 | Bayer Aktiengesellschaft | Process of preparing butyl-(5s)-5-({2-[4-(butoxycarbonyl)phenyl]ethyl}[2-(2-{[3-chloro-4'-(trifluoromethyl)[biphenyl]-4-yl]methoxy}phenyl)ethyl]amino)-5,6,7,8-tetrahydroquinoline-2-carboxylate |
| TW202342012A (zh) | 2021-12-29 | 2023-11-01 | 德商拜耳廠股份有限公司 | 製備用作醫藥活性化合物的（５ｓ）－｛［２－（４－羧基苯基）乙基］［２－（２－｛［３－氯－４＇－（三氟甲基）聯苯－４－基］甲氧基｝苯基）乙基］胺基｝－５，６，７，８－四氫喹啉－２－羧酸及其結晶形式之方法 |
| CN118765199A (zh) | 2021-12-29 | 2024-10-11 | 拜耳股份公司 | 心肺病症的治疗 |
| US20250281480A1 (en) | 2021-12-29 | 2025-09-11 | Bayer Aktiengesellschaft | Pharmaceutical dry powder inhalation formulation |
-
2022
- 2022-12-28 TW TW111150499A patent/TW202342012A/zh unknown
- 2022-12-28 EP EP22844516.9A patent/EP4457215A1/en active Pending
- 2022-12-28 AR ARP220103632A patent/AR128147A1/es unknown
- 2022-12-28 CA CA3244893A patent/CA3244893A1/en active Pending
- 2022-12-28 WO PCT/EP2022/087952 patent/WO2023126436A1/en not_active Ceased
- 2022-12-28 AU AU2022429647A patent/AU2022429647A1/en active Pending
- 2022-12-28 KR KR1020247025651A patent/KR20240144177A/ko active Pending
- 2022-12-28 CN CN202280092729.9A patent/CN118765272A/zh active Pending
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Also Published As
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|---|---|
| US20240116874A1 (en) | 2024-04-11 |
| US20250263381A1 (en) | 2025-08-21 |
| TW202342012A (zh) | 2023-11-01 |
| MX2024008172A (es) | 2025-04-02 |
| CN118765272A (zh) | 2024-10-11 |
| US12202805B2 (en) | 2025-01-21 |
| IL313922A (en) | 2024-08-01 |
| JP2025502842A (ja) | 2025-01-28 |
| AR128147A1 (es) | 2024-03-27 |
| KR20240144177A (ko) | 2024-10-02 |
| CA3244893A1 (en) | 2023-07-06 |
| EP4457215A1 (en) | 2024-11-06 |
| WO2023126436A1 (en) | 2023-07-06 |
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