AU2022396084A1 - Multi-motif dendrons and their supramolecular structures and uses thereof - Google Patents

Multi-motif dendrons and their supramolecular structures and uses thereof Download PDF

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AU2022396084A1
AU2022396084A1 AU2022396084A AU2022396084A AU2022396084A1 AU 2022396084 A1 AU2022396084 A1 AU 2022396084A1 AU 2022396084 A AU2022396084 A AU 2022396084A AU 2022396084 A AU2022396084 A AU 2022396084A AU 2022396084 A1 AU2022396084 A1 AU 2022396084A1
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dendron
composition
terminal group
alkyl
peg
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Julien COUTURE-SENÉCAL
Omar Fizal KHAN
Yan Ming Anson LAU
Alanna Margaret MANNING
Grayson TILSTRA
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University of Toronto
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University of Toronto
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    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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AU2022396084A 2021-11-29 2022-11-29 Multi-motif dendrons and their supramolecular structures and uses thereof Pending AU2022396084A1 (en)

Applications Claiming Priority (5)

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US202163283588P 2021-11-29 2021-11-29
US63/283,588 2021-11-29
US202263398936P 2022-08-18 2022-08-18
US63/398,936 2022-08-18
PCT/CA2022/051745 WO2023092242A1 (en) 2021-11-29 2022-11-29 Multi-motif dendrons and their supramolecular structures and uses thereof

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EP (1) EP4441030A4 (https=)
JP (1) JP2024543272A (https=)
KR (1) KR20240117084A (https=)
AU (1) AU2022396084A1 (https=)
CA (1) CA3232690A1 (https=)
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CN117623978B (zh) * 2023-10-23 2026-03-20 山东大学 可生物降解的氨基酸衍生可电离脂质及其制备方法与应用
US12539279B2 (en) 2023-12-11 2026-02-03 The Governing Council Of The University Of Toronto Supramolecular ionizable lipid molecules with heteroatomic tuning for nucleic acid delivery

Family Cites Families (14)

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AU2003279807A1 (en) * 2002-10-03 2004-04-23 The Board Of Trustees Of The University Of Arkansas Nanocrystals in ligand boxes exhibiting enhanced chemical, photochemical, and thermal stability, and methods of making the same
CN101220119A (zh) * 2008-01-23 2008-07-16 中国科学院化学研究所 一种超支化共聚物及其制备方法
US9102938B2 (en) * 2010-04-01 2015-08-11 Alnylam Pharmaceuticals, Inc. 2′ and 5′ modified monomers and oligonucleotides
CN104292129B (zh) * 2014-06-16 2018-03-02 中国石油化工集团公司 一种树枝状单体、采用该单体的处理剂及其制备方法
WO2017048789A1 (en) * 2015-09-14 2017-03-23 The Board Of Regents Of The University Of Texas System Lipocationic dendrimers and uses thereof
GB201600289D0 (en) * 2016-01-07 2016-02-24 Univ Liverpool Polydendrons
CA3040337A1 (en) * 2016-10-26 2018-05-03 Curevac Ag Lipid nanoparticle mrna vaccines
CN106519139A (zh) * 2016-11-10 2017-03-22 江苏苏博特新材料股份有限公司 一种早强型外加剂及其制备方法和应用
AU2021269137A1 (en) * 2020-05-08 2022-12-15 Orna Therapeutics, Inc. Circular RNA compositions and methods
WO2022168085A1 (en) * 2021-02-02 2022-08-11 Ramot At Tel-Aviv University Ltd. Lipids suitable for nucleic acid delivery
WO2022218295A1 (en) * 2021-04-13 2022-10-20 Chengdu Westgene Biopharm Co., Ltd Ionizable lipids and compositions for nucleic acid delivery
CN113402404B (zh) * 2021-04-30 2022-03-11 苏州科锐迈德生物医药科技有限公司 脂质化合物及包含其的脂质载体、核酸脂质纳米粒组合物和药物制剂
CN113264842B (zh) * 2021-07-21 2022-03-01 苏州科锐迈德生物医药科技有限公司 一种脂质化合物及包含其的脂质载体、核酸脂质纳米粒组合物和药物制剂
CN114262275B (zh) * 2021-12-15 2023-09-29 华中师范大学 一种高效低毒性dna及rna脂质递送载体

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WO2023092242A1 (en) 2023-06-01
EP4441030A1 (en) 2024-10-09
CA3232690A1 (en) 2023-06-01
US20240294714A1 (en) 2024-09-05
KR20240117084A (ko) 2024-07-31
EP4441030A4 (en) 2025-10-22
IL313225A (en) 2024-07-01
US20240247109A1 (en) 2024-07-25

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