JP2024543272A - マルチモチーフデンドロン及びその超分子構造ならびにその使用 - Google Patents

マルチモチーフデンドロン及びその超分子構造ならびにその使用 Download PDF

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JP2024543272A
JP2024543272A JP2024531667A JP2024531667A JP2024543272A JP 2024543272 A JP2024543272 A JP 2024543272A JP 2024531667 A JP2024531667 A JP 2024531667A JP 2024531667 A JP2024531667 A JP 2024531667A JP 2024543272 A JP2024543272 A JP 2024543272A
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フィザル カーン，オマー
ティルストラ，グレイソン
マーガレット マニング，アランナ
ミン アンソン ラウ，ヤン
クチュール－セネカル，ジュリアン
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University of Toronto
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    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
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    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
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JP2024531667A 2021-11-29 2022-11-29 マルチモチーフデンドロン及びその超分子構造ならびにその使用 Pending JP2024543272A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163283588P 2021-11-29 2021-11-29
US63/283,588 2021-11-29
US202263398936P 2022-08-18 2022-08-18
US63/398,936 2022-08-18
PCT/CA2022/051745 WO2023092242A1 (en) 2021-11-29 2022-11-29 Multi-motif dendrons and their supramolecular structures and uses thereof

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JP2024543272A true JP2024543272A (ja) 2024-11-20
JP2024543272A5 JP2024543272A5 (https=) 2025-12-19

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US (2) US20240294714A1 (https=)
EP (1) EP4441030A4 (https=)
JP (1) JP2024543272A (https=)
KR (1) KR20240117084A (https=)
AU (1) AU2022396084A1 (https=)
CA (1) CA3232690A1 (https=)
IL (1) IL313225A (https=)
WO (1) WO2023092242A1 (https=)

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CN117623978B (zh) * 2023-10-23 2026-03-20 山东大学 可生物降解的氨基酸衍生可电离脂质及其制备方法与应用
US12539279B2 (en) 2023-12-11 2026-02-03 The Governing Council Of The University Of Toronto Supramolecular ionizable lipid molecules with heteroatomic tuning for nucleic acid delivery

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AU2003279807A1 (en) * 2002-10-03 2004-04-23 The Board Of Trustees Of The University Of Arkansas Nanocrystals in ligand boxes exhibiting enhanced chemical, photochemical, and thermal stability, and methods of making the same
CN101220119A (zh) * 2008-01-23 2008-07-16 中国科学院化学研究所 一种超支化共聚物及其制备方法
US9102938B2 (en) * 2010-04-01 2015-08-11 Alnylam Pharmaceuticals, Inc. 2′ and 5′ modified monomers and oligonucleotides
CN104292129B (zh) * 2014-06-16 2018-03-02 中国石油化工集团公司 一种树枝状单体、采用该单体的处理剂及其制备方法
WO2017048789A1 (en) * 2015-09-14 2017-03-23 The Board Of Regents Of The University Of Texas System Lipocationic dendrimers and uses thereof
GB201600289D0 (en) * 2016-01-07 2016-02-24 Univ Liverpool Polydendrons
CA3040337A1 (en) * 2016-10-26 2018-05-03 Curevac Ag Lipid nanoparticle mrna vaccines
CN106519139A (zh) * 2016-11-10 2017-03-22 江苏苏博特新材料股份有限公司 一种早强型外加剂及其制备方法和应用
AU2021269137A1 (en) * 2020-05-08 2022-12-15 Orna Therapeutics, Inc. Circular RNA compositions and methods
WO2022168085A1 (en) * 2021-02-02 2022-08-11 Ramot At Tel-Aviv University Ltd. Lipids suitable for nucleic acid delivery
WO2022218295A1 (en) * 2021-04-13 2022-10-20 Chengdu Westgene Biopharm Co., Ltd Ionizable lipids and compositions for nucleic acid delivery
CN113402404B (zh) * 2021-04-30 2022-03-11 苏州科锐迈德生物医药科技有限公司 脂质化合物及包含其的脂质载体、核酸脂质纳米粒组合物和药物制剂
CN113264842B (zh) * 2021-07-21 2022-03-01 苏州科锐迈德生物医药科技有限公司 一种脂质化合物及包含其的脂质载体、核酸脂质纳米粒组合物和药物制剂
CN114262275B (zh) * 2021-12-15 2023-09-29 华中师范大学 一种高效低毒性dna及rna脂质递送载体

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WO2023092242A1 (en) 2023-06-01
EP4441030A1 (en) 2024-10-09
CA3232690A1 (en) 2023-06-01
AU2022396084A1 (en) 2024-04-04
US20240294714A1 (en) 2024-09-05
KR20240117084A (ko) 2024-07-31
EP4441030A4 (en) 2025-10-22
IL313225A (en) 2024-07-01
US20240247109A1 (en) 2024-07-25

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