AU2022320699A1 - Substituted pyridine derivatives as sarm1 inhibitors - Google Patents
Substituted pyridine derivatives as sarm1 inhibitors Download PDFInfo
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- AU2022320699A1 AU2022320699A1 AU2022320699A AU2022320699A AU2022320699A1 AU 2022320699 A1 AU2022320699 A1 AU 2022320699A1 AU 2022320699 A AU2022320699 A AU 2022320699A AU 2022320699 A AU2022320699 A AU 2022320699A AU 2022320699 A1 AU2022320699 A1 AU 2022320699A1
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- Australia
- Prior art keywords
- imidazol
- methyl
- compound
- pyridin
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000003222 pyridines Chemical class 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title description 15
- 150000001875 compounds Chemical class 0.000 claims abstract description 307
- 238000000034 method Methods 0.000 claims abstract description 45
- 101000685982 Homo sapiens NAD(+) hydrolase SARM1 Proteins 0.000 claims abstract description 44
- 102100023356 NAD(+) hydrolase SARM1 Human genes 0.000 claims abstract description 44
- 230000007850 degeneration Effects 0.000 claims abstract description 38
- 230000003376 axonal effect Effects 0.000 claims abstract description 30
- 208000012902 Nervous system disease Diseases 0.000 claims abstract description 25
- BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 claims abstract description 21
- 210000003050 axon Anatomy 0.000 claims abstract description 14
- 230000009467 reduction Effects 0.000 claims abstract description 7
- -1 CXalkoxy Chemical group 0.000 claims description 404
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 179
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 144
- 150000003839 salts Chemical class 0.000 claims description 139
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 131
- 125000005843 halogen group Chemical group 0.000 claims description 110
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 65
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 37
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- 125000006568 (C4-C7) heterocycloalkyl group Chemical group 0.000 claims description 30
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- 125000000041 C6-C10 aryl group Chemical group 0.000 claims description 22
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 19
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- 229910052938 sodium sulfate Inorganic materials 0.000 description 36
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
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| US202163226557P | 2021-07-28 | 2021-07-28 | |
| US63/226,557 | 2021-07-28 | ||
| US202263305103P | 2022-01-31 | 2022-01-31 | |
| US63/305,103 | 2022-01-31 | ||
| US202263368034P | 2022-07-08 | 2022-07-08 | |
| US63/368,034 | 2022-07-08 | ||
| PCT/US2022/038577 WO2023009663A1 (en) | 2021-07-28 | 2022-07-27 | Substituted pyridine derivatives as sarm1 inhibitors |
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| US12404265B2 (en) | 2020-08-04 | 2025-09-02 | Nura Bio, Inc. | Substituted pyridine derivatives as SARM1 inhibitors |
| CN116438171A (zh) | 2020-09-16 | 2023-07-14 | 努拉生物公司 | 作为sarm1抑制剂的取代的吡啶衍生物 |
| EP4304586A4 (en) | 2021-03-10 | 2025-04-02 | Jnana Therapeutics Inc. | SMALL MOLECULE INHIBITORS OF MAMMALIAN SLC6A19 FUNCTION |
| EP4376840A4 (en) * | 2021-07-28 | 2025-05-21 | Nura Bio, Inc. | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS |
| CN113655155A (zh) * | 2021-07-28 | 2021-11-16 | 任贤金 | 一种测定sph3127有关物质的方法 |
| EP4562001A1 (en) * | 2022-07-27 | 2025-06-04 | Nura Bio, Inc. | Substituted pyridine derivatives as sarm1 inhibitors |
| CN120424050A (zh) * | 2024-02-05 | 2025-08-05 | 科辉智药(深圳)新药研究中心有限公司 | 作为sarm1酶活性抑制剂的吡啶类化合物及其应用 |
| WO2025179205A1 (en) * | 2024-02-23 | 2025-08-28 | Nura Bio, Inc. | Methods for the treatment of neurological disorders |
| WO2026080488A1 (en) | 2024-10-09 | 2026-04-16 | Genentech, Inc. | Heterocyclic compounds for the treatment of neurodegenerative diseases |
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| AU9781098A (en) * | 1997-10-02 | 1999-04-27 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| CA2460345A1 (en) * | 2001-09-13 | 2003-03-20 | Synta Pharmaceuticals Corp. | 2-aroylimidazole compounds for treating cancer |
| DE102004009933A1 (de) | 2004-02-26 | 2005-09-15 | Merck Patent Gmbh | Verwendung von Thiadiazolharnstoffderivaten |
| WO2005105780A2 (en) | 2004-04-28 | 2005-11-10 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of rock and other protein kinases |
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| US8236824B2 (en) | 2007-10-09 | 2012-08-07 | MERCK Patent Gesellschaft mit beschränkter Haftung | N-(pyrazole-3-yl)-benzamide derivatives as glucokinase activators |
| WO2009114552A1 (en) | 2008-03-10 | 2009-09-17 | The Board Of Trustees Of The Leland Stanford Junior University | Heteroaryl compounds, compositions, and methods of use in cancer treatment |
| US8785468B2 (en) | 2009-02-13 | 2014-07-22 | Amgen Inc. | Phenylalanine amide derivatives useful for treating insulin-related diseases and conditions |
| WO2012049161A1 (en) | 2010-10-13 | 2012-04-19 | Glaxo Group Limited | 3 -amino- pyrazole derivatives useful against tuberculosis |
| WO2012050141A1 (ja) | 2010-10-14 | 2012-04-19 | 住友化学株式会社 | ヘテロ芳香環化合物およびその有害生物防除用途 |
| JP6282721B2 (ja) | 2013-03-14 | 2018-02-21 | ダート・ニューロサイエンス・（ケイマン）・リミテッド | Ｐｄｅ４阻害剤としての置換ピリジン及びピラジン化合物 |
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| WO2015175704A1 (en) * | 2014-05-14 | 2015-11-19 | The Regents Of The University Of California | Inhibitors of bacterial dna gyrase with efficacy against gram-negative bacteria |
| CA2955872A1 (en) | 2014-07-24 | 2016-01-28 | Bayer Pharma Aktiengesellschaft | Glucose transport inhibitors |
| JP2018515623A (ja) | 2015-05-18 | 2018-06-14 | トランスレイショナル・ドラッグ・ディベロップメント・エルエルシー | キナーゼ阻害剤としての複素環式化合物 |
| US20170355708A1 (en) | 2016-06-09 | 2017-12-14 | Cadent Therapeutics, Inc. | Potassium channel modulators |
| EP3541806A4 (en) | 2016-11-21 | 2020-07-01 | Translational Drug Development, LLC | HETEROCYCLIC COMPOUNDS FOR USE AS KINASE INHIBITORS |
| CA3108669A1 (en) | 2018-06-07 | 2019-12-12 | Disarm Therapeutics, Inc. | Inhibitors of sarm1 |
| KR20210143783A (ko) * | 2019-02-28 | 2021-11-29 | 케자르 라이프 사이언스 | 단백질 분비 저해제로서 티아졸 유도체 |
| JP7289375B2 (ja) * | 2019-06-06 | 2023-06-09 | ディスアーム セラピューティクス， インコーポレイテッド | Ｓａｒｍ１の阻害剤 |
| US12595252B2 (en) | 2019-06-14 | 2026-04-07 | Disarm Therapeutics, Inc. | Inhibitors of SARM1 |
| CA3150878A1 (en) * | 2019-09-12 | 2021-03-18 | Jonathan Bentley | Inhibitors of sarm1 |
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| US12435084B2 (en) | 2020-04-09 | 2025-10-07 | Eli Lilly And Company | Indazole derivatives as inhibitors of SARM1 |
| US12404265B2 (en) | 2020-08-04 | 2025-09-02 | Nura Bio, Inc. | Substituted pyridine derivatives as SARM1 inhibitors |
| TWI904906B (zh) | 2020-08-24 | 2025-11-11 | 美商達薩瑪治療公司 | Sarm1之抑制劑 |
| CN116438171A (zh) | 2020-09-16 | 2023-07-14 | 努拉生物公司 | 作为sarm1抑制剂的取代的吡啶衍生物 |
| EP4376840A4 (en) | 2021-07-28 | 2025-05-21 | Nura Bio, Inc. | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS |
| EP4562001A1 (en) | 2022-07-27 | 2025-06-04 | Nura Bio, Inc. | Substituted pyridine derivatives as sarm1 inhibitors |
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| JP2024528036A (ja) | 2024-07-26 |
| KR20240041987A (ko) | 2024-04-01 |
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| WO2023009663A1 (en) | 2023-02-02 |
| CL2024000239A1 (es) | 2024-06-07 |
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| US20230286941A1 (en) | 2023-09-14 |
| EP4376840A1 (en) | 2024-06-05 |
| IL310403A (en) | 2024-03-01 |
| CA3226869A1 (en) | 2023-02-02 |
| TW202313009A (zh) | 2023-04-01 |
| MX2024001322A (es) | 2024-04-30 |
| EP4376840A4 (en) | 2025-05-21 |
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