AU2022301047A1 - Cdk2 inhibitors - Google Patents
Cdk2 inhibitors Download PDFInfo
- Publication number
- AU2022301047A1 AU2022301047A1 AU2022301047A AU2022301047A AU2022301047A1 AU 2022301047 A1 AU2022301047 A1 AU 2022301047A1 AU 2022301047 A AU2022301047 A AU 2022301047A AU 2022301047 A AU2022301047 A AU 2022301047A AU 2022301047 A1 AU2022301047 A1 AU 2022301047A1
- Authority
- AU
- Australia
- Prior art keywords
- group
- compound
- halo
- optionally substituted
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163215901P | 2021-06-28 | 2021-06-28 | |
| US63/215,901 | 2021-06-28 | ||
| PCT/US2022/035122 WO2023278326A1 (en) | 2021-06-28 | 2022-06-27 | Cdk2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2022301047A1 true AU2022301047A1 (en) | 2024-01-04 |
Family
ID=82655170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2022301047A Pending AU2022301047A1 (en) | 2021-06-28 | 2022-06-27 | Cdk2 inhibitors |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US11932648B2 (https=) |
| EP (1) | EP4363423A1 (https=) |
| JP (1) | JP2024524373A (https=) |
| KR (1) | KR20240046167A (https=) |
| CN (1) | CN117897384A (https=) |
| AR (1) | AR126251A1 (https=) |
| AU (1) | AU2022301047A1 (https=) |
| CA (1) | CA3223223A1 (https=) |
| CL (1) | CL2023003965A1 (https=) |
| CO (1) | CO2024000237A2 (https=) |
| CR (1) | CR20230598A (https=) |
| DO (1) | DOP2023000280A (https=) |
| EC (1) | ECSP24006831A (https=) |
| IL (1) | IL309118A (https=) |
| MX (1) | MX2024000230A (https=) |
| PE (1) | PE20250123A1 (https=) |
| TW (1) | TW202317574A (https=) |
| UY (1) | UY39832A (https=) |
| WO (1) | WO2023278326A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2022271290A1 (en) | 2021-05-07 | 2023-11-23 | Kymera Therapeutics, Inc. | Cdk2 degraders and uses thereof |
| US11932648B2 (en) | 2021-06-28 | 2024-03-19 | Blueprint Medicines Corporation | CDK2 inhibitors |
| JP2026500305A (ja) | 2022-12-16 | 2026-01-06 | アストラゼネカ・アクチエボラーグ | ２，６，９三置換プリン |
| CN120787231A (zh) * | 2023-01-04 | 2025-10-14 | 缆图药品公司 | Cdk2抑制剂的固体形式 |
| WO2024148091A1 (en) * | 2023-01-04 | 2024-07-11 | Blueprint Medicines Corporation | Cdk2 inhibitors |
| WO2024148089A1 (en) * | 2023-01-04 | 2024-07-11 | Blueprint Medicines Corporation | Cdk2 inhibitors |
| EP4646416A1 (en) * | 2023-01-04 | 2025-11-12 | Blueprint Medicines Corporation | Cdk2 inhibitors |
| EP4661874A1 (en) | 2023-02-10 | 2025-12-17 | Blueprint Medicines Corporation | The cdk2 inhibitor blu-222 for treatment of cancer |
| UY40638A (es) | 2023-02-17 | 2024-08-30 | Novartis Ag | Inhibidores de quinasa dependientes de ciclina (cdk2) |
| WO2025188779A1 (en) | 2024-03-04 | 2025-09-12 | Blueprint Medicines Corporation | Cdk2 inhibitors for treatment of cancer |
| WO2026024674A1 (en) | 2024-07-22 | 2026-01-29 | Genesis Therapeutics, Inc. | Methods of treating skp2-associated cancers |
| WO2026038120A1 (en) * | 2024-08-12 | 2026-02-19 | Novartis Ag | Synthesis and crystalline forms of a cdk2 inhibitor |
| WO2026050766A1 (en) * | 2024-09-02 | 2026-03-05 | Blueprint Medicines Corporation | Intermediate salts for synthesis of a cdk2 inhibitor |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL154016A0 (en) | 2000-08-31 | 2003-07-31 | Pfizer Prod Inc | Pyrazole derivatives and their use as protein kinase inhibitors |
| EP1317450B1 (en) | 2000-09-15 | 2006-11-22 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| NZ526472A (en) | 2000-12-21 | 2004-04-30 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors |
| AU2003286711A1 (en) | 2002-10-25 | 2004-05-13 | Vertex Pharmaceuticals Incorporated | Indazolinone compositions useful as kinase inhibitors |
| EP1706400A1 (en) | 2004-01-09 | 2006-10-04 | Novartis AG | Phenyl- 4-(3-phenyl-1h-pyrazol-4-yl)-pyrimidin-2-yl -amine derivatives as igf-ir inhibitors |
| US7405220B2 (en) * | 2004-06-09 | 2008-07-29 | Hoffmann-La Roche Inc. | Pyrazolopyrimidines |
| US8362031B2 (en) | 2004-08-20 | 2013-01-29 | University Of Kansas | Lonidamine analogues and treatment of polycystic kidney disease |
| CA2598076A1 (en) | 2005-02-16 | 2006-08-24 | Astrazeneca Ab | Chemical compounds |
| FR2889526B1 (fr) | 2005-08-04 | 2012-02-17 | Aventis Pharma Sa | 7-aza-indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
| EP1926734A1 (en) | 2005-08-22 | 2008-06-04 | Amgen Inc. | Pyrazolopyridine and pyrazolopyrimidine compounds useful as kinase enzymes modulators |
| WO2008117050A1 (en) | 2007-03-27 | 2008-10-02 | Astrazeneca Ab | Pyrazolyl-amino-substituted pyrazines and their use for the treatment of cancer |
| WO2008129255A1 (en) | 2007-04-18 | 2008-10-30 | Astrazeneca Ab | 5-aminopyrazol-3-yl-3h-imidazo [4,5-b] pyridine derivatives and their use for the treatment of cancer |
| MX2010005950A (es) * | 2007-11-28 | 2010-06-17 | Schering Corp | 2-fluoropirazolo[1,5-a]pirimidinas como inhibidores de proteina quinasa. |
| DE102008063992A1 (de) | 2008-12-19 | 2010-09-02 | Lerner, Zinoviy, Dipl.-Ing. | Neue aliphatisch substituierte Pyrazolopyridine und ihre Verwendung |
| KR20110049217A (ko) | 2009-11-04 | 2011-05-12 | 다우어드밴스드디스플레이머티리얼 유한회사 | 신규한 유기 발광 화합물 및 이를 채용하고 있는 유기 전계 발광 소자 |
| EP3795573B1 (en) | 2009-12-31 | 2022-07-06 | Hutchison Medipharma Limited | Certain triazolopyrazines, compositions thereof and methods of use therefor |
| JO3145B1 (ar) | 2010-11-08 | 2017-09-20 | Lilly Co Eli | مركبات مفيدة لتثبيط chk1 |
| KR20120063283A (ko) | 2010-12-07 | 2012-06-15 | 제일약품주식회사 | 신규한 피라졸로 피리딘 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 약학적 조성물 |
| WO2013026021A2 (en) | 2011-08-18 | 2013-02-21 | Buck Institute For Research On Aging | Trka as a target for inhibiting app cleavage and/or progression of alzheimer's disease |
| WO2014181287A1 (en) | 2013-05-09 | 2014-11-13 | Piramal Enterprises Limited | Heterocyclyl compounds and uses thereof |
| NZ714283A (en) | 2013-05-10 | 2020-04-24 | Karus Therapeutics Ltd | Novel histone deacetylase inhibitors |
| CA2918242C (en) | 2013-07-31 | 2022-06-21 | Merck Patent Gmbh | Pyridines, pyrimidines, and pyrazines, as btk inhibitors and uses thereof |
| WO2016057322A1 (en) | 2014-10-08 | 2016-04-14 | Salk Institute For Biological Studies | Ppar agonists and methods of use thereof |
| CA2987552A1 (en) | 2015-06-04 | 2016-12-08 | Aurigene Discovery Technologies Limited | Substituted heterocyclyl derivatives as cdk inhibitors |
| WO2018106667A1 (en) | 2016-12-05 | 2018-06-14 | Microbiotix, Inc. | Broad-spectrum inhibitors of filoviruses |
| WO2019183364A1 (en) | 2018-03-21 | 2019-09-26 | Relay Therapeutics, Inc. | Pyrazolo[3,4-b]pyrazine shp2 phosphatase inhibitors and methods of use thereof |
| GB201808093D0 (en) | 2018-05-18 | 2018-07-04 | Enterprise Therapeutics Ltd | Compounds |
| WO2020108516A1 (zh) | 2018-11-27 | 2020-06-04 | 江苏豪森药业集团有限公司 | 含氮杂芳类衍生物调节剂、其制备方法和应用 |
| JP2022510980A (ja) * | 2018-11-30 | 2022-01-28 | 江▲蘇▼豪森▲薬▼▲業▼集▲団▼有限公司 | ヘテロ芳香族誘導体調節因子、その製造方法及び使用 |
| CN113330000B (zh) | 2019-01-31 | 2024-12-24 | 辉瑞公司 | 具有对cdk2的抑制活性的3-羰基氨基-5-环戊基-1fi-吡咯化合物 |
| US20200316064A1 (en) | 2019-02-15 | 2020-10-08 | Incyte Corporation | Cyclin-dependent kinase 2 biomarkers and uses thereof |
| WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
| WO2020264420A1 (en) | 2019-06-28 | 2020-12-30 | Gb002, Inc. | Heterocyclic kinase inhibitors and products and uses thereof |
| AU2020364007A1 (en) | 2019-10-11 | 2022-04-28 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| US11634424B2 (en) | 2019-11-29 | 2023-04-25 | Medshine Discovery Inc. | Diazaindole derivative and use thereof as CHK1 inhibitor |
| CN113135896B (zh) | 2020-01-18 | 2024-12-06 | 正大天晴药业集团股份有限公司 | 作为ret抑制剂的甲基吡唑类衍生物 |
| CN114057733A (zh) | 2020-08-07 | 2022-02-18 | 海思科医药集团股份有限公司 | 一种并环杂环衍生物及其在医药上的应用 |
| WO2022061155A1 (en) | 2020-09-17 | 2022-03-24 | The Translational Genomics Research Institute | Imidazopyridazine and imidazopyrazine compounds as inhibitors of cdk7 |
| TW202246255A (zh) | 2021-02-12 | 2022-12-01 | 美商傳達治療有限公司 | Ｃｄｋ抑制劑及其使用方法 |
| CN115141195B (zh) | 2021-03-03 | 2024-02-06 | 成都先导药物开发股份有限公司 | 一种nuak抑制剂及其用途 |
| KR20240005751A (ko) | 2021-04-12 | 2024-01-12 | 에이2에이 파마수티칼스, 잉크. | 암 치료를 위한 조성물 및 방법 |
| WO2022245776A1 (en) | 2021-05-20 | 2022-11-24 | Saint John's Cancer Institute | Anti-cdk inhibitors for cancer treatment |
| US20240287040A1 (en) | 2021-06-16 | 2024-08-29 | Blueprint Medicines Corporation | Substituted pyrimidinyl-pyrazoles as cdk2 inhibitors |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| US11932648B2 (en) | 2021-06-28 | 2024-03-19 | Blueprint Medicines Corporation | CDK2 inhibitors |
| WO2023092088A1 (en) | 2021-11-19 | 2023-05-25 | Blueprint Medicines Corporation | Cdk2 inhibitors and methods of making and using same |
| WO2023249974A2 (en) | 2022-06-20 | 2023-12-28 | Incyclix Bio, Inc. | Cyclin-dependent kinase 2 inhibitors for medical treatment |
| CN117717565A (zh) | 2022-09-16 | 2024-03-19 | 北京悦康科创医药科技股份有限公司 | 反义寡核苷酸在制备治疗食管癌药物中的应用 |
| WO2024148089A1 (en) | 2023-01-04 | 2024-07-11 | Blueprint Medicines Corporation | Cdk2 inhibitors |
| WO2024148091A1 (en) | 2023-01-04 | 2024-07-11 | Blueprint Medicines Corporation | Cdk2 inhibitors |
| CN120787231A (zh) | 2023-01-04 | 2025-10-14 | 缆图药品公司 | Cdk2抑制剂的固体形式 |
| EP4646416A1 (en) | 2023-01-04 | 2025-11-12 | Blueprint Medicines Corporation | Cdk2 inhibitors |
| EP4661874A1 (en) | 2023-02-10 | 2025-12-17 | Blueprint Medicines Corporation | The cdk2 inhibitor blu-222 for treatment of cancer |
| TW202442234A (zh) | 2023-04-14 | 2024-11-01 | 美商纜圖藥品公司 | Ｃｄｋ２抑制劑 |
-
2022
- 2022-06-27 US US17/850,453 patent/US11932648B2/en active Active
- 2022-06-27 WO PCT/US2022/035122 patent/WO2023278326A1/en not_active Ceased
- 2022-06-27 KR KR1020247003175A patent/KR20240046167A/ko active Pending
- 2022-06-27 AU AU2022301047A patent/AU2022301047A1/en active Pending
- 2022-06-27 IL IL309118A patent/IL309118A/en unknown
- 2022-06-27 UY UY0001039832A patent/UY39832A/es unknown
- 2022-06-27 EP EP22744613.5A patent/EP4363423A1/en active Pending
- 2022-06-27 CN CN202280057725.7A patent/CN117897384A/zh active Pending
- 2022-06-27 TW TW111123974A patent/TW202317574A/zh unknown
- 2022-06-27 MX MX2024000230A patent/MX2024000230A/es unknown
- 2022-06-27 PE PE2023003487A patent/PE20250123A1/es unknown
- 2022-06-27 CR CR20230598A patent/CR20230598A/es unknown
- 2022-06-27 AR ARP220101677A patent/AR126251A1/es unknown
- 2022-06-27 JP JP2023580454A patent/JP2024524373A/ja active Pending
- 2022-06-27 CA CA3223223A patent/CA3223223A1/en active Pending
-
2023
- 2023-02-08 US US18/166,178 patent/US11970498B2/en active Active
- 2023-12-18 DO DO2023000280A patent/DOP2023000280A/es unknown
- 2023-12-28 CL CL2023003965A patent/CL2023003965A1/es unknown
-
2024
- 2024-01-12 CO CONC2024/0000237A patent/CO2024000237A2/es unknown
- 2024-01-25 EC ECSENADI20246831A patent/ECSP24006831A/es unknown
- 2024-03-14 US US18/605,248 patent/US12545684B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA3223223A1 (en) | 2023-01-05 |
| US12545684B2 (en) | 2026-02-10 |
| US20240383902A1 (en) | 2024-11-21 |
| ECSP24006831A (es) | 2024-07-31 |
| DOP2023000280A (es) | 2024-03-28 |
| US20230322791A1 (en) | 2023-10-12 |
| CN117897384A (zh) | 2024-04-16 |
| TW202317574A (zh) | 2023-05-01 |
| US11970498B2 (en) | 2024-04-30 |
| CR20230598A (es) | 2024-04-25 |
| UY39832A (es) | 2023-01-31 |
| US11932648B2 (en) | 2024-03-19 |
| EP4363423A1 (en) | 2024-05-08 |
| IL309118A (en) | 2024-02-01 |
| PE20250123A1 (es) | 2025-01-16 |
| JP2024524373A (ja) | 2024-07-05 |
| AR126251A1 (es) | 2023-10-04 |
| KR20240046167A (ko) | 2024-04-08 |
| MX2024000230A (es) | 2024-04-01 |
| US20230159535A1 (en) | 2023-05-25 |
| CO2024000237A2 (es) | 2024-02-05 |
| WO2023278326A1 (en) | 2023-01-05 |
| CL2023003965A1 (es) | 2024-12-06 |
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