AU2022284188A1 - 2, 8-diazaspiro [4.5] decane compounds - Google Patents

2, 8-diazaspiro [4.5] decane compounds Download PDF

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Publication number
AU2022284188A1
AU2022284188A1 AU2022284188A AU2022284188A AU2022284188A1 AU 2022284188 A1 AU2022284188 A1 AU 2022284188A1 AU 2022284188 A AU2022284188 A AU 2022284188A AU 2022284188 A AU2022284188 A AU 2022284188A AU 2022284188 A1 AU2022284188 A1 AU 2022284188A1
Authority
AU
Australia
Prior art keywords
alkyl
compound
optionally substituted
independently selected
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2022284188A
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English (en)
Inventor
James John CRAWFORD
Ruth DOREL
Kwong Wah LAI
Wendy Lee
Steven John MCKERRALL
Mikiko OKUMURA
Guillaume Pelletier
Stéphanie ROY
Dana Krystin WINTER
Alice Rose WONG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AU2022284188A1 publication Critical patent/AU2022284188A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pens And Brushes (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
AU2022284188A 2021-06-04 2022-06-03 2, 8-diazaspiro [4.5] decane compounds Pending AU2022284188A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2021098358 2021-06-04
CNPCT/CN2021/098358 2021-06-04
PCT/CN2022/097025 WO2022253341A1 (en) 2021-06-04 2022-06-03 2, 8-diazaspiro [4.5] decane compounds

Publications (1)

Publication Number Publication Date
AU2022284188A1 true AU2022284188A1 (en) 2023-11-30

Family

ID=84322789

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2022284188A Pending AU2022284188A1 (en) 2021-06-04 2022-06-03 2, 8-diazaspiro [4.5] decane compounds

Country Status (11)

Country Link
US (1) US20240174696A1 (https=)
EP (1) EP4347594A4 (https=)
JP (1) JP2024521929A (https=)
KR (1) KR20240016977A (https=)
CN (1) CN117425654A (https=)
AR (1) AR126078A1 (https=)
AU (1) AU2022284188A1 (https=)
BR (1) BR112023025393A2 (https=)
CA (1) CA3222054A1 (https=)
TW (1) TW202313608A (https=)
WO (1) WO2022253341A1 (https=)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101679418A (zh) * 2007-04-06 2010-03-24 诺瓦提斯公司 用作蛋白质激酶抑制剂的[2,6]萘啶类化合物
JP2011529932A (ja) * 2008-08-05 2011-12-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換ナフチリジン及び医薬としてのその使用
WO2012167423A1 (en) * 2011-06-08 2012-12-13 Hutchison Medipharma Limited Substituted pyridopyrazines as novel syk inhibitors
KR20140048216A (ko) * 2011-06-29 2014-04-23 오츠카 세이야쿠 가부시키가이샤 치료 화합물로서의 퀴나졸린 및 관련된 사용 방법
TWI675836B (zh) * 2014-03-25 2019-11-01 美商伊格尼塔公司 非典型蛋白質激酶ｃ之氮雜喹唑啉抑制劑
JOP20190257A1 (ar) * 2017-04-28 2019-10-28 Novartis Ag مركبات أريل غير متجانسة ثنائية الحلقة مندمجة 6-6 واستخدامها كمثبطات lats
KR102328435B1 (ko) * 2018-09-11 2021-11-18 재단법인 대구경북첨단의료산업진흥재단 신규 피리도-피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 단백질 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물
WO2021050059A1 (en) * 2019-09-11 2021-03-18 Provincial Health Services Authority Dna-pk inhibiting compounds

Also Published As

Publication number Publication date
CN117425654A (zh) 2024-01-19
TW202313608A (zh) 2023-04-01
WO2022253341A1 (en) 2022-12-08
AR126078A1 (es) 2023-09-06
EP4347594A1 (en) 2024-04-10
BR112023025393A2 (pt) 2024-02-27
KR20240016977A (ko) 2024-02-06
US20240174696A1 (en) 2024-05-30
JP2024521929A (ja) 2024-06-04
EP4347594A4 (en) 2025-06-18
CA3222054A1 (en) 2022-12-08

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