CN117425654A - 2,8-二氮杂螺[4.5]癸烷化合物 - Google Patents

2,8-二氮杂螺[4.5]癸烷化合物 Download PDF

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Publication number
CN117425654A
CN117425654A CN202280039813.4A CN202280039813A CN117425654A CN 117425654 A CN117425654 A CN 117425654A CN 202280039813 A CN202280039813 A CN 202280039813A CN 117425654 A CN117425654 A CN 117425654A
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CN
China
Prior art keywords
alkyl
compound
substituted
group
substituent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280039813.4A
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English (en)
Chinese (zh)
Inventor
S·J·麦克拉尔
A·R·王
J·J·克劳福德
W·李
赖光华
G·佩尔蒂埃
S·罗伊
D·K·温特
M·奥库穆拉
R·多雷尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
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Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CN117425654A publication Critical patent/CN117425654A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pens And Brushes (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
CN202280039813.4A 2021-06-04 2022-06-03 2,8-二氮杂螺[4.5]癸烷化合物 Pending CN117425654A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2021098358 2021-06-04
CNPCT/CN2021/098358 2021-06-04
PCT/CN2022/097025 WO2022253341A1 (en) 2021-06-04 2022-06-03 2, 8-diazaspiro [4.5] decane compounds

Publications (1)

Publication Number Publication Date
CN117425654A true CN117425654A (zh) 2024-01-19

Family

ID=84322789

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280039813.4A Pending CN117425654A (zh) 2021-06-04 2022-06-03 2,8-二氮杂螺[4.5]癸烷化合物

Country Status (11)

Country Link
US (1) US20240174696A1 (https=)
EP (1) EP4347594A4 (https=)
JP (1) JP2024521929A (https=)
KR (1) KR20240016977A (https=)
CN (1) CN117425654A (https=)
AR (1) AR126078A1 (https=)
AU (1) AU2022284188A1 (https=)
BR (1) BR112023025393A2 (https=)
CA (1) CA3222054A1 (https=)
TW (1) TW202313608A (https=)
WO (1) WO2022253341A1 (https=)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101679418A (zh) * 2007-04-06 2010-03-24 诺瓦提斯公司 用作蛋白质激酶抑制剂的[2,6]萘啶类化合物
JP2011529932A (ja) * 2008-08-05 2011-12-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換ナフチリジン及び医薬としてのその使用
WO2012167423A1 (en) * 2011-06-08 2012-12-13 Hutchison Medipharma Limited Substituted pyridopyrazines as novel syk inhibitors
KR20140048216A (ko) * 2011-06-29 2014-04-23 오츠카 세이야쿠 가부시키가이샤 치료 화합물로서의 퀴나졸린 및 관련된 사용 방법
TWI675836B (zh) * 2014-03-25 2019-11-01 美商伊格尼塔公司 非典型蛋白質激酶ｃ之氮雜喹唑啉抑制劑
JOP20190257A1 (ar) * 2017-04-28 2019-10-28 Novartis Ag مركبات أريل غير متجانسة ثنائية الحلقة مندمجة 6-6 واستخدامها كمثبطات lats
KR102328435B1 (ko) * 2018-09-11 2021-11-18 재단법인 대구경북첨단의료산업진흥재단 신규 피리도-피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 단백질 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물
WO2021050059A1 (en) * 2019-09-11 2021-03-18 Provincial Health Services Authority Dna-pk inhibiting compounds

Also Published As

Publication number Publication date
TW202313608A (zh) 2023-04-01
AU2022284188A1 (en) 2023-11-30
WO2022253341A1 (en) 2022-12-08
AR126078A1 (es) 2023-09-06
EP4347594A1 (en) 2024-04-10
BR112023025393A2 (pt) 2024-02-27
KR20240016977A (ko) 2024-02-06
US20240174696A1 (en) 2024-05-30
JP2024521929A (ja) 2024-06-04
EP4347594A4 (en) 2025-06-18
CA3222054A1 (en) 2022-12-08

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