AU2022256048A1 - Dopaminergic precursor cells and methods of use - Google Patents

Dopaminergic precursor cells and methods of use Download PDF

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Publication number
AU2022256048A1
AU2022256048A1 AU2022256048A AU2022256048A AU2022256048A1 AU 2022256048 A1 AU2022256048 A1 AU 2022256048A1 AU 2022256048 A AU2022256048 A AU 2022256048A AU 2022256048 A AU2022256048 A AU 2022256048A AU 2022256048 A1 AU2022256048 A1 AU 2022256048A1
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cells
culture
inhibitor
signaling
smad
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AU2022256048A
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Carrie CHAVEZ
Randall LEARISH
Christopher MCMAHON
Cayla THOMPSON
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Fujifilm Cellular Dynamics Inc
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Fujifilm Cellular Dynamics Inc
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    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • G—PHYSICS
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/32—Polylysine, polyornithine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

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  • Urology & Nephrology (AREA)
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  • Wood Science & Technology (AREA)
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  • Developmental Biology & Embryology (AREA)
  • Animal Behavior & Ethology (AREA)
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  • General Physics & Mathematics (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
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  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
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AU2022256048A 2021-04-07 2022-04-07 Dopaminergic precursor cells and methods of use Pending AU2022256048A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163171837P 2021-04-07 2021-04-07
US63/171,837 2021-04-07
US202163275691P 2021-11-04 2021-11-04
US63/275,691 2021-11-04
PCT/US2022/023797 WO2022216911A1 (en) 2021-04-07 2022-04-07 Dopaminergic precursor cells and methods of use

Publications (1)

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AU2022256048A1 true AU2022256048A1 (en) 2023-10-05

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Country Status (7)

Country Link
US (1) US20240219375A1 (https=)
EP (1) EP4319876A1 (https=)
JP (1) JP2024513912A (https=)
KR (1) KR20230165846A (https=)
AU (1) AU2022256048A1 (https=)
CA (1) CA3213988A1 (https=)
WO (1) WO2022216911A1 (https=)

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US12565639B2 (en) 2023-06-13 2026-03-03 Aspen Neuroscience, Inc. Methods for differentiating dopaminergic neurons from stem cells
CN119269789B (zh) * 2023-07-06 2026-04-24 深圳华大生命科学研究院 多巴胺能神经元前体细胞的标志物及其应用
WO2025049336A2 (en) * 2023-08-25 2025-03-06 Bluerock Therapeutics Lp Methods and compositions of dopaminergic cells for treating parkinson's disease
US20250157580A1 (en) * 2023-11-13 2025-05-15 Aspen Neuroscience, Inc. Methods of predicting dopamine production capability of differentiated neuronal cells

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KR20230165846A (ko) 2023-12-05
WO2022216911A1 (en) 2022-10-13
JP2024513912A (ja) 2024-03-27
CA3213988A1 (en) 2022-10-13
US20240219375A1 (en) 2024-07-04
EP4319876A1 (en) 2024-02-14

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