AU2021268355A1 - Engineered relaxins and methods of use thereof - Google Patents

Engineered relaxins and methods of use thereof Download PDF

Info

Publication number
AU2021268355A1
AU2021268355A1 AU2021268355A AU2021268355A AU2021268355A1 AU 2021268355 A1 AU2021268355 A1 AU 2021268355A1 AU 2021268355 A AU2021268355 A AU 2021268355A AU 2021268355 A AU2021268355 A AU 2021268355A AU 2021268355 A1 AU2021268355 A1 AU 2021268355A1
Authority
AU
Australia
Prior art keywords
amino acid
acid sequence
seq
fusion protein
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2021268355A
Other languages
English (en)
Inventor
Sarah Cecilia ERLANDSON
Andrew KRUSE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard University filed Critical Harvard University
Publication of AU2021268355A1 publication Critical patent/AU2021268355A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2221—Relaxins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2021268355A 2020-05-08 2021-05-07 Engineered relaxins and methods of use thereof Pending AU2021268355A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063021814P 2020-05-08 2020-05-08
US63/021,814 2020-05-08
PCT/US2021/031260 WO2021226439A2 (en) 2020-05-08 2021-05-07 Engineered relaxins and methods of use thereof

Publications (1)

Publication Number Publication Date
AU2021268355A1 true AU2021268355A1 (en) 2022-11-24

Family

ID=78468429

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2021268355A Pending AU2021268355A1 (en) 2020-05-08 2021-05-07 Engineered relaxins and methods of use thereof

Country Status (10)

Country Link
US (1) US20230174610A1 (https=)
EP (1) EP4146681A4 (https=)
JP (1) JP2023524981A (https=)
KR (1) KR20230008791A (https=)
CN (1) CN115768801A (https=)
AU (1) AU2021268355A1 (https=)
CA (1) CA3180662A1 (https=)
IL (1) IL297951A (https=)
MX (1) MX2022013770A (https=)
WO (1) WO2021226439A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118510536A (zh) 2021-11-11 2024-08-16 泰克托尼治疗股份有限公司 松弛素-2融合蛋白类似物及其使用方法
AU2022410335A1 (en) * 2021-12-15 2024-07-18 Medimmune Limited Treatment using heterodimeric relaxin fusions
AU2024270919A1 (en) * 2023-05-18 2026-01-15 Tectonic Operating Company, Inc. Relaxin-2 fusion protein analogs and methods of using same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4835251A (en) * 1986-06-23 1989-05-30 Genetech, Inc. Method of chain combination
US20110243943A1 (en) * 2010-04-02 2011-10-06 Athena Discovery, Inc. Treatment using relaxin-fusion proteins with extended in vivo half-lives
US9567386B2 (en) * 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
RU2014103288A (ru) * 2011-07-01 2015-08-10 Байер Интеллектчуал Проперти Гмбх Слитые полипептиды релаксина и их применение
JP6822839B2 (ja) * 2013-09-13 2021-01-27 ザ・スクリップス・リサーチ・インスティテュート 修飾された治療剤、及びその組成物
IL263079B2 (en) * 2016-05-18 2024-05-01 Modernatx Inc Polynucleotides encoding relaxin
EP3574004A1 (en) * 2017-01-25 2019-12-04 Medimmune, LLC Relaxin fusion polypeptides and uses thereof
PE20191716A1 (es) * 2017-02-08 2019-12-05 Bristol Myers Squibb Co Polipeptidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos

Also Published As

Publication number Publication date
IL297951A (en) 2023-01-01
WO2021226439A2 (en) 2021-11-11
CN115768801A (zh) 2023-03-07
CA3180662A1 (en) 2021-11-11
MX2022013770A (es) 2023-04-03
KR20230008791A (ko) 2023-01-16
EP4146681A2 (en) 2023-03-15
WO2021226439A8 (en) 2021-12-23
WO2021226439A3 (en) 2022-02-10
US20230174610A1 (en) 2023-06-08
JP2023524981A (ja) 2023-06-14
EP4146681A4 (en) 2024-06-26

Similar Documents

Publication Publication Date Title
US20250282843A1 (en) Compositions comprising an interleukin construct
RU2433141C2 (ru) Оптимизированный слитый белок taci-fc
US20230174610A1 (en) Engineered relaxins and methods of use thereof
JP2022514465A (ja) 第ｉｘ因子を発現するレンチウイルスベクターの使用
CN107810195B (zh) 重组丛生蛋白及其在疾病治疗和预防中的应用
US20230340044A1 (en) Recombinant variants of r-spondin proteins and their use
KR20170138558A (ko) Hiv 융합을 표적으로 하는 폴리펩티드
KR20240110824A (ko) 릴랙신-2 융합 단백질 유사체 및 이의 사용 방법
US12589141B2 (en) DNA vaccine capable of effectively treating and/or preventing type 1 diabetes and use thereof
JP2023509189A (ja) Ｒｓｐｏ１タンパク質およびその使用
KR20250148592A (ko) R-스폰딘 단백질의 재조합 변이체 및 그의 용도
US20230091105A1 (en) Chimeric fusions between c4-binding protein c-terminal segment and angiopoietin-1 fibrinogen-like domain as angiopoietin mimetics and tie2 agonists to treat vascular diseases
CN117980323A (zh) R-spondin蛋白的重组变体及其用途
CN120897758A (zh) Covid-19融合蛋白的核衣壳抗原免疫疗法和使用方法
US20160122713A1 (en) Genetically-modified micro-organ secreting a therapeutic peptide and methods of use thereof