IL297951A - Engineered relaxins and methods of use thereof - Google Patents
Engineered relaxins and methods of use thereofInfo
- Publication number
- IL297951A IL297951A IL297951A IL29795122A IL297951A IL 297951 A IL297951 A IL 297951A IL 297951 A IL297951 A IL 297951A IL 29795122 A IL29795122 A IL 29795122A IL 297951 A IL297951 A IL 297951A
- Authority
- IL
- Israel
- Prior art keywords
- amino acid
- acid sequence
- seq
- fusion protein
- peptide
- Prior art date
Links
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- 230000003389 potentiating effect Effects 0.000 description 1
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
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- 229960003387 progesterone Drugs 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
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- JSDRRTOADPPCHY-HSQYWUDLSA-N quinapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 JSDRRTOADPPCHY-HSQYWUDLSA-N 0.000 description 1
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- 235000011803 sesame oil Nutrition 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2221—Relaxins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063021814P | 2020-05-08 | 2020-05-08 | |
| PCT/US2021/031260 WO2021226439A2 (en) | 2020-05-08 | 2021-05-07 | Engineered relaxins and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL297951A true IL297951A (en) | 2023-01-01 |
Family
ID=78468429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL297951A IL297951A (en) | 2020-05-08 | 2021-05-07 | Engineered relaxins and methods of use thereof |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230174610A1 (https=) |
| EP (1) | EP4146681A4 (https=) |
| JP (1) | JP2023524981A (https=) |
| KR (1) | KR20230008791A (https=) |
| CN (1) | CN115768801A (https=) |
| AU (1) | AU2021268355A1 (https=) |
| CA (1) | CA3180662A1 (https=) |
| IL (1) | IL297951A (https=) |
| MX (1) | MX2022013770A (https=) |
| WO (1) | WO2021226439A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118510536A (zh) | 2021-11-11 | 2024-08-16 | 泰克托尼治疗股份有限公司 | 松弛素-2融合蛋白类似物及其使用方法 |
| AU2022410335A1 (en) * | 2021-12-15 | 2024-07-18 | Medimmune Limited | Treatment using heterodimeric relaxin fusions |
| AU2024270919A1 (en) * | 2023-05-18 | 2026-01-15 | Tectonic Operating Company, Inc. | Relaxin-2 fusion protein analogs and methods of using same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4835251A (en) * | 1986-06-23 | 1989-05-30 | Genetech, Inc. | Method of chain combination |
| US20110243943A1 (en) * | 2010-04-02 | 2011-10-06 | Athena Discovery, Inc. | Treatment using relaxin-fusion proteins with extended in vivo half-lives |
| US9567386B2 (en) * | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| RU2014103288A (ru) * | 2011-07-01 | 2015-08-10 | Байер Интеллектчуал Проперти Гмбх | Слитые полипептиды релаксина и их применение |
| JP6822839B2 (ja) * | 2013-09-13 | 2021-01-27 | ザ・スクリップス・リサーチ・インスティテュート | 修飾された治療剤、及びその組成物 |
| IL263079B2 (en) * | 2016-05-18 | 2024-05-01 | Modernatx Inc | Polynucleotides encoding relaxin |
| EP3574004A1 (en) * | 2017-01-25 | 2019-12-04 | Medimmune, LLC | Relaxin fusion polypeptides and uses thereof |
| PE20191716A1 (es) * | 2017-02-08 | 2019-12-05 | Bristol Myers Squibb Co | Polipeptidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos |
-
2021
- 2021-05-07 CN CN202180033724.4A patent/CN115768801A/zh active Pending
- 2021-05-07 WO PCT/US2021/031260 patent/WO2021226439A2/en not_active Ceased
- 2021-05-07 CA CA3180662A patent/CA3180662A1/en active Pending
- 2021-05-07 JP JP2022567283A patent/JP2023524981A/ja active Pending
- 2021-05-07 EP EP21800239.2A patent/EP4146681A4/en active Pending
- 2021-05-07 IL IL297951A patent/IL297951A/en unknown
- 2021-05-07 US US17/998,057 patent/US20230174610A1/en active Pending
- 2021-05-07 KR KR1020227042680A patent/KR20230008791A/ko active Pending
- 2021-05-07 AU AU2021268355A patent/AU2021268355A1/en active Pending
- 2021-05-07 MX MX2022013770A patent/MX2022013770A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021226439A2 (en) | 2021-11-11 |
| CN115768801A (zh) | 2023-03-07 |
| CA3180662A1 (en) | 2021-11-11 |
| MX2022013770A (es) | 2023-04-03 |
| KR20230008791A (ko) | 2023-01-16 |
| EP4146681A2 (en) | 2023-03-15 |
| WO2021226439A8 (en) | 2021-12-23 |
| WO2021226439A3 (en) | 2022-02-10 |
| US20230174610A1 (en) | 2023-06-08 |
| JP2023524981A (ja) | 2023-06-14 |
| EP4146681A4 (en) | 2024-06-26 |
| AU2021268355A1 (en) | 2022-11-24 |
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