AU2020407089B2 - Novel DDR1 antibodies and uses thereof - Google Patents

Novel DDR1 antibodies and uses thereof Download PDF

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Publication number
AU2020407089B2
AU2020407089B2 AU2020407089A AU2020407089A AU2020407089B2 AU 2020407089 B2 AU2020407089 B2 AU 2020407089B2 AU 2020407089 A AU2020407089 A AU 2020407089A AU 2020407089 A AU2020407089 A AU 2020407089A AU 2020407089 B2 AU2020407089 B2 AU 2020407089B2
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seq
ddr1
amino acid
acid sequence
chain variable
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AU2020407089A1 (en
Inventor
Zhiqiang An
Hui Deng
Rong Li
Xiujie SUN
Ningyan Zhang
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George Washington University
University of Texas System
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George Washington University
University of Texas System
University of Texas at Austin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2020407089A 2019-12-17 2020-12-17 Novel DDR1 antibodies and uses thereof Active AU2020407089B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962949300P 2019-12-17 2019-12-17
US62/949,300 2019-12-17
PCT/US2020/065618 WO2021127185A1 (en) 2019-12-17 2020-12-17 Novel ddr1 antibodies and uses thereof

Publications (2)

Publication Number Publication Date
AU2020407089A1 AU2020407089A1 (en) 2022-06-30
AU2020407089B2 true AU2020407089B2 (en) 2023-06-01

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AU2020407089A Active AU2020407089B2 (en) 2019-12-17 2020-12-17 Novel DDR1 antibodies and uses thereof

Country Status (10)

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US (2) US20230130372A1 (https=)
EP (1) EP4076526A4 (https=)
JP (2) JP2023508277A (https=)
CN (1) CN115443150A (https=)
AU (1) AU2020407089B2 (https=)
BR (1) BR112022011037A2 (https=)
CA (1) CA3160181A1 (https=)
IL (1) IL294019A (https=)
MX (1) MX2022007353A (https=)
WO (1) WO2021127185A1 (https=)

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Publication number Priority date Publication date Assignee Title
CN115443150A (zh) * 2019-12-17 2022-12-06 德克萨斯大学系统董事会 新型ddr1抗体和其用途
CN116023497B (zh) * 2022-11-09 2024-06-21 四川大学华西医院 抗ddr1抗体及其用途
AU2023379587A1 (en) * 2022-11-16 2025-06-05 Incendia Therapeutics, Inc. Methods of treating cancer using anti-ddr1 antibodies and immune checkpoint inhibitors
CN120418294A (zh) * 2022-11-16 2025-08-01 英森迪亚治疗公司 使用抗ddr1抗体治疗癌症的方法
CN118909125B (zh) * 2024-10-10 2025-01-03 杭州美赛生物医药科技有限公司 抗ddr1抗体及其应用

Citations (2)

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US20140248282A1 (en) * 2011-08-23 2014-09-04 Chugai Seiyaku Kabushiki Kaisha Novel anti-ddr1 antibody having anti-tumor activity

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Patent Citations (2)

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Also Published As

Publication number Publication date
US12331130B2 (en) 2025-06-17
US20230235078A1 (en) 2023-07-27
WO2021127185A1 (en) 2021-06-24
JP2024164067A (ja) 2024-11-26
JP2023508277A (ja) 2023-03-02
US20230130372A1 (en) 2023-04-27
CA3160181A1 (en) 2021-06-24
CN115443150A (zh) 2022-12-06
AU2020407089A1 (en) 2022-06-30
BR112022011037A2 (pt) 2022-09-13
IL294019A (en) 2022-08-01
MX2022007353A (es) 2022-09-19
EP4076526A4 (en) 2024-07-03
EP4076526A1 (en) 2022-10-26

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