AU2020342649B2 - Compositions and methods for the treatment of viral infections - Google Patents

Compositions and methods for the treatment of viral infections

Info

Publication number
AU2020342649B2
AU2020342649B2 AU2020342649A AU2020342649A AU2020342649B2 AU 2020342649 B2 AU2020342649 B2 AU 2020342649B2 AU 2020342649 A AU2020342649 A AU 2020342649A AU 2020342649 A AU2020342649 A AU 2020342649A AU 2020342649 B2 AU2020342649 B2 AU 2020342649B2
Authority
AU
Australia
Prior art keywords
compositions
treatment
methods
viral infections
infections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2020342649A
Other languages
English (en)
Other versions
AU2020342649A1 (en
Inventor
James M. Balkovec
Daniel C. BENSEN
Allen Borchardt
Thomas P. Brady
Zhi-yong CHEN
Jason Cole
Quyen-Quyen Thuy Do
Simon DOEHRMANN
Wanlong Jiang
Thanh Lam
Alain Noncovich
Leslie W. Tari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cidara Therapeutics Inc
Original Assignee
Cidara Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cidara Therapeutics Inc filed Critical Cidara Therapeutics Inc
Publication of AU2020342649A1 publication Critical patent/AU2020342649A1/en
Application granted granted Critical
Publication of AU2020342649B2 publication Critical patent/AU2020342649B2/en
Priority to AU2025263868A priority Critical patent/AU2025263868A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2020342649A 2019-09-06 2020-09-08 Compositions and methods for the treatment of viral infections Active AU2020342649B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2025263868A AU2025263868A1 (en) 2019-09-06 2025-11-07 Compositions and methods for the treatment of viral infections

Applications Claiming Priority (21)

Application Number Priority Date Filing Date Title
US201962897036P 2019-09-06 2019-09-06
US62/897,036 2019-09-06
US201962941405P 2019-11-27 2019-11-27
US62/941,405 2019-11-27
US201962948143P 2019-12-13 2019-12-13
US62/948,143 2019-12-13
US202062959857P 2020-01-10 2020-01-10
US62/959,857 2020-01-10
US202062966500P 2020-01-27 2020-01-27
US62/966,500 2020-01-27
US202062970491P 2020-02-05 2020-02-05
US62/970,491 2020-02-05
US202062984705P 2020-03-03 2020-03-03
US62/984,705 2020-03-03
US202062988304P 2020-03-11 2020-03-11
US62/988,304 2020-03-11
US202063032488P 2020-05-29 2020-05-29
US63/032,488 2020-05-29
US202063062377P 2020-08-06 2020-08-06
US63/062,377 2020-08-06
PCT/US2020/049772 WO2021046549A1 (en) 2019-09-06 2020-09-08 Compositions and methods for the treatment of viral infections

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2025263868A Division AU2025263868A1 (en) 2019-09-06 2025-11-07 Compositions and methods for the treatment of viral infections

Publications (2)

Publication Number Publication Date
AU2020342649A1 AU2020342649A1 (en) 2022-03-24
AU2020342649B2 true AU2020342649B2 (en) 2025-08-07

Family

ID=74852729

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2020342649A Active AU2020342649B2 (en) 2019-09-06 2020-09-08 Compositions and methods for the treatment of viral infections
AU2025263868A Pending AU2025263868A1 (en) 2019-09-06 2025-11-07 Compositions and methods for the treatment of viral infections

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2025263868A Pending AU2025263868A1 (en) 2019-09-06 2025-11-07 Compositions and methods for the treatment of viral infections

Country Status (18)

Country Link
US (4) US20210220478A1 (enExample)
EP (1) EP4025256A4 (enExample)
JP (2) JP7667139B2 (enExample)
KR (1) KR20220088527A (enExample)
CN (2) CN114980933B (enExample)
AU (2) AU2020342649B2 (enExample)
CA (1) CA3153359A1 (enExample)
CL (1) CL2022000531A1 (enExample)
CO (1) CO2022003078A2 (enExample)
CR (1) CR20220138A (enExample)
EC (1) ECSP22026797A (enExample)
IL (1) IL290792B1 (enExample)
MX (1) MX2022002728A (enExample)
PE (1) PE20221443A1 (enExample)
PH (1) PH12022550505A1 (enExample)
TW (1) TWI861205B (enExample)
WO (1) WO2021046549A1 (enExample)
ZA (1) ZA202203681B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112021004266A2 (pt) 2018-09-06 2021-08-03 Cidara Therapeutics, Inc. conjugados, população de conjugados, composição farmacêutica e métodos para o tratamento de um sujeito com uma infecção viral e para o tratamento profilático
TWI861205B (zh) 2019-09-06 2024-11-11 美商席達拉醫療有限公司 用於治療病毒感染之組合物及方法
JP2023511956A (ja) * 2020-01-24 2023-03-23 レゲネロン ファーマシューティカルス,インコーポレーテッド タンパク質-抗ウイルス化合物コンジュゲート
WO2022032188A1 (en) 2020-08-06 2022-02-10 Cidara Therapeutics, Inc. Methods for the synthesis of protein-drug conjugates
US20230364251A1 (en) 2020-08-06 2023-11-16 Cidara Therapeutics, Inc. Methods for the synthesis of protein-drug conjugates
CA3211494A1 (en) 2021-03-11 2022-09-15 Leslie W. Tari Protein-drug conjugates for antiviral therapy
US20250144220A1 (en) * 2021-12-30 2025-05-08 Suzhou Ark Biopharmaceutical Co., Ltd. Conjugate for preventing and treating viral infections and use thereof
KR20250048157A (ko) * 2022-07-05 2025-04-07 시다라 세라퓨틱스, 인코포레이티드 Cd73의 억제제를 포함하는 fc 컨쥬게이트 및 이의 용도
CN119215189A (zh) 2023-06-29 2024-12-31 上海爱科百发生物医药技术股份有限公司 用于预防和治疗病毒感染的偶联物及其用途
WO2025064869A2 (en) * 2023-09-20 2025-03-27 Cidara Therapeutics, Inc. Compositions and methods for the treatment of cancer
TW202527994A (zh) * 2023-12-08 2025-07-16 大陸商蘇州拓界醫藥有限公司 一種抗病毒偶聯物
WO2025157263A1 (zh) * 2024-01-26 2025-07-31 浙江养生堂天然药物研究所有限公司 偶联物及其制备方法和用途
WO2025230581A1 (en) * 2024-05-02 2025-11-06 Cidara Therapeutics, Inc. Fc conjugates and uses thereof
WO2026055183A1 (en) * 2024-09-03 2026-03-12 Vir Biotechnology, Inc Antiviral compositions and methods of using the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020051498A1 (en) * 2018-09-06 2020-03-12 Cidara Therapeutics, Inc. Compositions and methods for the treatment of viral infections

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU732916C (en) 1996-11-14 2002-06-06 Biota Scientific Management Pty Ltd Method and novel compounds for use therein
US6495580B1 (en) 1998-01-29 2002-12-17 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
AUPP913999A0 (en) 1999-03-12 1999-04-01 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
SI1196408T1 (en) 1999-06-28 2005-02-28 Janssen Pharmaceutica N.V. Respiratory syncytial virus replication inhibitors
AUPR001000A0 (en) * 2000-09-08 2000-10-05 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
AUPR879701A0 (en) * 2001-11-09 2001-12-06 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
WO2004014316A2 (en) 2002-08-09 2004-02-19 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
CA2556752C (en) 2004-02-23 2016-02-02 Genentech, Inc. Heterocyclic self-immolative linkers and conjugates
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
BRPI0615354A2 (pt) 2005-08-19 2011-05-17 Endocyte, Inc. conjugado de liberação de fármaco de ligação de receptor, composição farmacêutica que o compreende, bem como seu uso
EP2158318A2 (en) 2007-05-14 2010-03-03 Biogen Idec MA, Inc. Single-chain fc (scfc) regions, binding polypeptides comprising same, and methods related thereto
JP2012517447A (ja) 2009-02-10 2012-08-02 ザ スクリプス リサーチ インスティチュート 化学的にプログラムされたワクチン接種法
AU2011250970B2 (en) 2010-05-10 2016-12-15 Sinica, Academia Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses
PT3012258T (pt) 2010-06-24 2018-12-14 Gilead Sciences Inc Composição farmacêutica compreendendo um derivado de pirazolo[1,5-a]pirimidina como agente antiviral
EP3415528B1 (en) 2011-04-13 2021-05-26 Bristol-Myers Squibb Company Fc fusion proteins comprising novel linkers or arrangements
US8871756B2 (en) 2011-08-11 2014-10-28 Hoffmann-La Roche Inc. Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease
TW201817744A (zh) 2011-09-30 2018-05-16 日商中外製藥股份有限公司 具有促進抗原清除之FcRn結合域的治療性抗原結合分子
US9834597B2 (en) 2012-09-21 2017-12-05 The Regents Of The University Of California Modified FC polypeptides, FC conjugates, and methods of use thereof
MY172021A (en) 2012-10-16 2019-11-12 Janssen Sciences Ireland Uc Rsv antiviral compounds
WO2014145016A2 (en) 2013-03-15 2014-09-18 Genentech, Inc. Il-22 polypeptides and il-22 fc fusion proteins and methods of use
AR096891A1 (es) 2013-07-12 2016-02-03 Hanmi Pharm Ind Co Ltd Conjugado de monómero polipéptido biológicamente activo y conjugado de fragmento fc de inmunoglobulina, que muestra aclaramiento mediado por receptor reducido, y el método para la preparación del mismo
JP6211195B2 (ja) 2013-08-12 2017-10-11 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 呼吸器合胞体ウイルス感染症の処置および予防のための新規アザ−オキソ−インドール
TWI671299B (zh) 2014-04-14 2019-09-11 愛爾蘭商健生科學愛爾蘭無限公司 作為rsv抗病毒化合物之螺脲化合物
WO2017046625A1 (en) 2015-06-25 2017-03-23 Cube Biotech Gmbh New chelators for affinity purification of recombinant proteins
WO2018006063A1 (en) 2016-07-01 2018-01-04 Cidara Therapeutics, Inc. Compositions and methods for the treatment of bacterial infections
US20230190950A1 (en) * 2017-01-06 2023-06-22 Cidara Therapeutics, Inc. Compositions and methods for the treatment of bacterial infections
WO2020252396A1 (en) 2019-06-13 2020-12-17 Cidara Therapeutics, Inc. Compositions and methods for the treatment of respiratory syncytial virus
AU2020291469A1 (en) 2019-06-13 2022-02-10 Cidara Therapeutics, Inc. Compositions and methods for the treatment of human immunodeficiency virus
TWI861205B (zh) 2019-09-06 2024-11-11 美商席達拉醫療有限公司 用於治療病毒感染之組合物及方法
CA3211494A1 (en) * 2021-03-11 2022-09-15 Leslie W. Tari Protein-drug conjugates for antiviral therapy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020051498A1 (en) * 2018-09-06 2020-03-12 Cidara Therapeutics, Inc. Compositions and methods for the treatment of viral infections

Also Published As

Publication number Publication date
JP7667139B2 (ja) 2025-04-22
IL290792B1 (en) 2026-04-01
US20260108618A1 (en) 2026-04-23
CN114980933B (zh) 2025-01-07
WO2021046549A1 (en) 2021-03-11
PH12022550505A1 (en) 2023-08-23
KR20220088527A (ko) 2022-06-27
US11510992B1 (en) 2022-11-29
NZ785415A (en) 2024-07-26
EP4025256A4 (en) 2023-12-13
WO2021046549A8 (en) 2021-05-20
EP4025256A1 (en) 2022-07-13
US20230398226A1 (en) 2023-12-14
IL290792A (en) 2022-04-01
BR112022004058A2 (pt) 2022-05-31
CA3153359A1 (en) 2021-03-11
CN114980933A (zh) 2022-08-30
US20210220478A1 (en) 2021-07-22
CN120168655A (zh) 2025-06-20
PE20221443A1 (es) 2022-09-21
CR20220138A (es) 2022-07-28
TWI861205B (zh) 2024-11-11
CO2022003078A2 (es) 2022-07-08
MX2022002728A (es) 2022-08-04
AU2020342649A1 (en) 2022-03-24
TW202122117A (zh) 2021-06-16
US12427200B2 (en) 2025-09-30
AU2025263868A1 (en) 2025-11-27
JP2022546609A (ja) 2022-11-04
CL2022000531A1 (es) 2022-10-28
ECSP22026797A (es) 2022-05-31
ZA202203681B (en) 2023-11-29
JP2025108559A (ja) 2025-07-23

Similar Documents

Publication Publication Date Title
AU2020342649B2 (en) Compositions and methods for the treatment of viral infections
IL281277A (en) Preparations and methods for treating viral infections
EP3980400A4 (en) PEPTIDOMIMETICS FOR THE TREATMENT OF CORONAVIRUS AND PICORNAVIRUS INFECTIONS
ZA202002069B (en) Novel mek-inhibitor for the treatment of viral and bacterial infections
PL4157272T3 (pl) Remdesiwir do leczenia zakażeń wirusowych
EP4022072A4 (en) COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
EP4213820A4 (en) METHODS AND COMPOSITIONS FOR TREATING VIRAL INFECTIONS
EP3426671A4 (en) COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF INFECTIONS
EP3990472A4 (en) COMPOSITIONS AND METHODS FOR THE TREATMENT OF YEAST INFECTIONS
EP4367086A4 (en) COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF VIRUS INFECTIONS
EP4025258A4 (en) METHODS AND COMPOSITIONS FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS
HK40079133A (en) Compositions and methods for the treatment of viral infections
HK40052593A (en) Compositions and methods for the treatment of viral infections
PL3810625T3 (pl) Sposoby i kompozycje do leczenia zakażenia wirusem zapalenia wątroby typu b
HK40076807A (en) Compositions and methods for treating viral infections
AU2018904123A0 (en) Compositions and methods for treating viral infections
EP3511408A4 (en) COMPOSITION FOR THE TREATMENT OR PREVENTION OF VIRAL INFECTIONS
HK40101021A (en) Methods and compositions for treating viral infections
HK40094722A (en) Compositions and methods for treating viral infections
HK40069515A (en) Compositions and methods for treatment of fungal infections
HK40108955A (en) Compositions and methods for treating and preventing viral infections
HK40078268A (en) Compositions and methods for treatment
HK40073716A (en) Compositions and methods for the treatment of respiratory syncytial virus
AU2019901644A0 (en) Compositions for the Treatment of Diseases and Conditions
AU2019902892A0 (en) Compositions and methods for treatment

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)