AU2020303447A1 - Micellar nanoparticles and uses thereof - Google Patents

Micellar nanoparticles and uses thereof Download PDF

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Publication number
AU2020303447A1
AU2020303447A1 AU2020303447A AU2020303447A AU2020303447A1 AU 2020303447 A1 AU2020303447 A1 AU 2020303447A1 AU 2020303447 A AU2020303447 A AU 2020303447A AU 2020303447 A AU2020303447 A AU 2020303447A AU 2020303447 A1 AU2020303447 A1 AU 2020303447A1
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Australia
Prior art keywords
cationic carrier
micelle
aspects
carrier unit
moiety
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AU2020303447A
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English (en)
Inventor
Hyun-Jeong CHO
Dae Hoon Kim
Han Seok Koh
Yu Na Lim
Hyun Su Min
Jin-Hyeob RYU
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Biorchestra Co Ltd
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Biorchestra Co Ltd
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    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10844380B1 (en) 2019-06-17 2020-11-24 Biorchestra Co., Ltd. Uses for prevention or treatment of brain diseases using microrna
WO2021156833A1 (en) * 2020-02-07 2021-08-12 Biorchestra Co., Ltd. Use of mirna-485 inhibitors for treating tauopathy
US11761874B2 (en) * 2020-05-15 2023-09-19 Saudi Arabian Oil Company CMC-based method for surfactant concentration determination
KR20230084499A (ko) * 2020-10-09 2023-06-13 고쿠리츠다이가쿠호우진 도쿄다이가쿠 니코틴아미드 내포 미셀, 및 니코틴아미드 내포 미셀을 포함하는 임신 고혈압 증후군 치료용 조성물
CA3200622A1 (en) * 2020-12-30 2022-07-07 Jin-Hyeob RYU Micellar nanoparticles and uses thereof
CN116963722A (zh) * 2020-12-30 2023-10-27 生物欧赛加有限责任公司 胶束纳米粒子及其用途
US20250313835A1 (en) * 2022-07-07 2025-10-09 Biorchestra Co., Ltd. Micellar nanoparticles and uses thereof
CN115721608A (zh) * 2022-11-29 2023-03-03 陕西科技大学 一种靶向温度敏感性聚合物胶束、制备方法及应用
WO2024228119A1 (en) * 2023-05-01 2024-11-07 Biorchestra Co., Ltd. Mirna-485 inhibitors
WO2024228118A1 (en) * 2023-05-01 2024-11-07 Biorchestra Co., Ltd. Mirna-485 inhibitors
WO2025149946A1 (en) * 2024-01-10 2025-07-17 Biorchestra Co., Ltd. Micellar nanoparticles and uses thereof

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5219564A (en) * 1990-07-06 1993-06-15 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
US20040259247A1 (en) 2000-12-01 2004-12-23 Thomas Tuschl Rna interference mediating small rna molecules
WO2004002455A1 (en) * 2002-06-26 2004-01-08 Medigene Oncology Gmbh Novel method of stabilizing diagnostic and therapeutic compounds in a cationic carrier system
US7683036B2 (en) 2003-07-31 2010-03-23 Regulus Therapeutics Inc. Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
US20050142581A1 (en) 2003-09-04 2005-06-30 Griffey Richard H. Microrna as ligands and target molecules
EP1718667B1 (en) 2004-02-23 2013-01-09 Genentech, Inc. Heterocyclic self-immolative linkers and conjugates
US20080213891A1 (en) 2004-07-21 2008-09-04 Alnylam Pharmaceuticals, Inc. RNAi Agents Comprising Universal Nucleobases
AU2005328382C1 (en) 2004-07-21 2013-01-24 Alnylam Pharmaceuticals, Inc. Oligonucleotides comprising a modified or non-natural nucleobase
CA2574603C (en) 2004-08-04 2014-11-04 Alnylam Pharmaceuticals, Inc. Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase
WO2007021896A2 (en) 2005-08-10 2007-02-22 Alnylam Pharmaceuticals, Inc. Chemically modified oligonucleotides for use in modulating micro rna and uses thereof
US20070213292A1 (en) 2005-08-10 2007-09-13 The Rockefeller University Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
WO2007027894A2 (en) 2005-08-29 2007-03-08 Isis Pharmaceuticals, Inc. Antisense compounds having enhanced anti-microrna activity
CA2620856C (en) 2005-08-29 2017-11-28 Isis Pharmaceuticals, Inc. Methods for use in modulating mir-122a
EP1984499B1 (en) 2006-01-27 2015-05-27 Isis Pharmaceuticals, Inc. Oligomeric compounds and compositions for the use in modulation of micrornas
EP2666859B1 (en) 2006-04-03 2019-01-02 Roche Innovation Center Copenhagen A/S Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
CA2648132C (en) 2006-04-03 2019-05-28 Santaris Pharma A/S Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
WO2008046911A2 (en) 2006-10-20 2008-04-24 Exiqon A/S Novel human micrornas associated with cancer
US20090137504A1 (en) 2006-12-21 2009-05-28 Soren Morgenthaler Echwald Microrna target site blocking oligos and uses thereof
WO2008113832A2 (en) 2007-03-22 2008-09-25 Santaris Pharma A/S SHORT RNA ANTAGONIST COMPOUNDS FOR THE MODULATION OF TARGET mRNA
EP2623599B1 (en) 2007-10-04 2019-01-02 Roche Innovation Center Copenhagen A/S Micromirs
US20090156459A1 (en) * 2007-11-16 2009-06-18 Pharmain Corporation Cationic-Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same
US8541435B2 (en) * 2008-07-11 2013-09-24 Uday Saxena Niacin compositions for reduction of amyloid beta peptide 42 (abeta 42) production and for treatment of Alzheimer's disease (AD)
JP5622254B2 (ja) * 2009-03-31 2014-11-12 国立大学法人東京大学 二本鎖リボ核酸ポリイオンコンプレックス
ES2599979T3 (es) 2009-04-24 2017-02-06 Roche Innovation Center Copenhagen A/S Composiciones farmacéuticas para el tratamiento de pacientes de VHC que no responden al interferón
CN102573913B (zh) * 2009-07-31 2014-06-18 阿森迪斯药物股份有限公司 可生物降解的基于聚乙二醇的水不溶性水凝胶
CA2773737C (en) * 2009-09-09 2021-11-16 Pharmain Corporation Anionic-core composition for delivery of therapeutic agents, and methods of making and using the same
US20120005765A1 (en) * 2010-07-01 2012-01-05 Saint Louis University Animal model for parkinson's disease
BR112013006686A2 (pt) 2010-09-24 2017-11-14 Zoetis Llc isoxazolina oximas como agentes antiparasitários
EP2741780A1 (en) * 2011-08-10 2014-06-18 Ludwig-Maximilians-Universität München Method for the controlled intracellular delivery of nucleic acids
JP6646578B2 (ja) * 2013-12-05 2020-02-14 ウー, ニエンWU, Nian 薬物転送技術のための高分子−炭水化物共役体
KR20170003527A (ko) * 2014-02-24 2017-01-09 유리젠 파마슈티컬스, 인코포레이티드 경구 투여용 펜토산 폴리설페이트 염의 조성물
US20180334732A1 (en) * 2014-11-25 2018-11-22 Drexel University Compositions and methods for hiv quasi-species excision from hiv-1-infected patients
CN108289906B (zh) * 2015-11-19 2022-03-11 公立大学法人名古屋市立大学 抗肿瘤性药物递送制剂
WO2017212007A1 (en) * 2016-06-09 2017-12-14 Curevac Ag Cationic carriers for nucleic acid delivery
WO2018053316A1 (en) 2016-09-15 2018-03-22 The Regents Of The University Of California Improved hybrid telodendrimers
RU2016146594A (ru) * 2016-11-28 2018-05-28 Общество С Ограниченной Ответственностью "Биофарм-Меморейн" Средство для лечения деменции различной этиологии
CN110582301A (zh) 2016-12-14 2019-12-17 利甘达尔股份有限公司 用于核酸和蛋白质有效负载递送的方法和组合物
WO2018139759A1 (ko) * 2017-01-26 2018-08-02 주식회사 바이오오케스트라 마이크로 rna를 이용한 알츠하이머병 진단방법
US11123304B2 (en) 2017-02-03 2021-09-21 The Brigham And Women's Hospital, Inc. Nanoparticles having poly(ester amide) polymer cores as drug delivery vehicles
CN110156971A (zh) 2018-02-13 2019-08-23 上海时莱生物技术有限公司 一种两亲性嵌段共聚物及其制备方法和纳米胶束载药系统
US11857634B2 (en) 2018-04-20 2024-01-02 University of Pittsburgh—of the Commonwealth System of Higher Education Cationic amphiphilic polymers for codelivery of hydrophobic agents and nucleic acids
CN111632153B (zh) 2020-06-23 2023-02-24 宁夏医科大学 一种化学基因药物共载的靶向纳米递药系统及其制备方法
CA3200622A1 (en) 2020-12-30 2022-07-07 Jin-Hyeob RYU Micellar nanoparticles and uses thereof
JP2024503303A (ja) 2020-12-30 2024-01-25 バイオーケストラ カンパニー， リミテッド ミセルナノ粒子及びその使用

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