AU2020263577B2 - Methods and compositions for treating chronic inflammatory injury, metaplasia, dysplasia and cancers of epithelial tissues - Google Patents

Methods and compositions for treating chronic inflammatory injury, metaplasia, dysplasia and cancers of epithelial tissues

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Publication number
AU2020263577B2
AU2020263577B2 AU2020263577A AU2020263577A AU2020263577B2 AU 2020263577 B2 AU2020263577 B2 AU 2020263577B2 AU 2020263577 A AU2020263577 A AU 2020263577A AU 2020263577 A AU2020263577 A AU 2020263577A AU 2020263577 B2 AU2020263577 B2 AU 2020263577B2
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Prior art keywords
pesc
agent
certain embodiments
pyrazol
phenyl
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AU2020263577A
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English (en)
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AU2020263577A1 (en
Inventor
Marcin DULEBA
Frank Mckeon
Matthew Vincent
Wa Xian
Jingzhong XIE
Yanting Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tract Pharmaceuticals Inc
University of Texas System
University of Houston System
Original Assignee
Tract Pharmaceuticals Inc
University of Texas System
University of Houston System
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0693Tumour cells; Cancer cells
    • C12N5/0695Stem cells; Progenitor cells; Precursor cells
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    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61K31/351Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/53751,4-Oxazines, e.g. morpholine
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AU2020263577A 2019-04-26 2020-04-24 Methods and compositions for treating chronic inflammatory injury, metaplasia, dysplasia and cancers of epithelial tissues Active AU2020263577B2 (en)

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