AU2020240069B2 - Compositions and methods to treat gastrointestinal diseases and disorders - Google Patents

Compositions and methods to treat gastrointestinal diseases and disorders

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Publication number
AU2020240069B2
AU2020240069B2 AU2020240069A AU2020240069A AU2020240069B2 AU 2020240069 B2 AU2020240069 B2 AU 2020240069B2 AU 2020240069 A AU2020240069 A AU 2020240069A AU 2020240069 A AU2020240069 A AU 2020240069A AU 2020240069 B2 AU2020240069 B2 AU 2020240069B2
Authority
AU
Australia
Prior art keywords
rifaximin
nac
mucolytic agent
dtt
ibs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2020240069A
Other languages
English (en)
Other versions
AU2020240069A1 (en
Inventor
Gabriela Guimaraes Sousa LEITE
Ruchi Mathur
Walter Morales
Mark Pimentel
Ali REZAIE
Stacy WEITSMAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cedars-Sinai Medical Center
Original Assignee
Cedars-Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cedars-Sinai Medical Center filed Critical Cedars-Sinai Medical Center
Publication of AU2020240069A1 publication Critical patent/AU2020240069A1/en
Application granted granted Critical
Publication of AU2020240069B2 publication Critical patent/AU2020240069B2/en
Priority to AU2025271108A priority Critical patent/AU2025271108A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2020240069A 2019-03-18 2020-03-18 Compositions and methods to treat gastrointestinal diseases and disorders Active AU2020240069B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2025271108A AU2025271108A1 (en) 2019-03-18 2025-11-20 Compositions and methods to treat gastrointestinal diseases and disorders

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962819986P 2019-03-18 2019-03-18
US62/819,986 2019-03-18
PCT/US2020/023396 WO2020191076A1 (en) 2019-03-18 2020-03-18 Compositions and methods to treat gastrointestinal diseases and disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2025271108A Division AU2025271108A1 (en) 2019-03-18 2025-11-20 Compositions and methods to treat gastrointestinal diseases and disorders

Publications (2)

Publication Number Publication Date
AU2020240069A1 AU2020240069A1 (en) 2021-10-28
AU2020240069B2 true AU2020240069B2 (en) 2025-08-28

Family

ID=72520533

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2020240069A Active AU2020240069B2 (en) 2019-03-18 2020-03-18 Compositions and methods to treat gastrointestinal diseases and disorders
AU2025271108A Pending AU2025271108A1 (en) 2019-03-18 2025-11-20 Compositions and methods to treat gastrointestinal diseases and disorders

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2025271108A Pending AU2025271108A1 (en) 2019-03-18 2025-11-20 Compositions and methods to treat gastrointestinal diseases and disorders

Country Status (7)

Country Link
US (1) US12642793B2 (cg-RX-API-DMAC10.html)
EP (1) EP3941461A4 (cg-RX-API-DMAC10.html)
JP (1) JP2022526495A (cg-RX-API-DMAC10.html)
CN (1) CN113645968A (cg-RX-API-DMAC10.html)
AU (2) AU2020240069B2 (cg-RX-API-DMAC10.html)
CA (2) CA3132400C (cg-RX-API-DMAC10.html)
WO (1) WO2020191076A1 (cg-RX-API-DMAC10.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3132400C (en) 2019-03-18 2026-05-12 Cedars-Sinai Medical Center Compositions and methods to treat gastrointestinal diseases and disorders
EP4510915A4 (en) * 2022-04-20 2026-01-21 Cedars Sinai Medical Center METHODS FOR DIAGNOSING IRRITABLE BOWEL SYNDROME WITH DIARRHEA (IBS-D) AND SELECTING AN ANTI-IBS-D TREATMENT
JP2025516807A (ja) * 2022-05-19 2025-05-30 シーダーズ－サイナイ メディカル センター リファキシミンとｎ－アセチルシステインの製剤

Citations (1)

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WO2016003536A1 (en) * 2014-06-30 2016-01-07 Salix Pharmaceuticals, Inc. Methods for retreating irritable bowel syndrome (ibs)

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Also Published As

Publication number Publication date
CA3132400A1 (en) 2020-09-24
EP3941461A4 (en) 2022-12-14
CA3132400C (en) 2026-05-12
AU2025271108A1 (en) 2025-12-18
JP2022526495A (ja) 2022-05-25
US20230038019A1 (en) 2023-02-09
US12642793B2 (en) 2026-06-02
EP3941461A1 (en) 2022-01-26
CA3293273A1 (en) 2026-03-02
WO2020191076A1 (en) 2020-09-24
CN113645968A (zh) 2021-11-12
AU2020240069A1 (en) 2021-10-28

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