AU2020222080C1 - Hydroxypyridoxazepines as Nrf2 activators - Google Patents
Hydroxypyridoxazepines as Nrf2 activators Download PDFInfo
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- AU2020222080C1 AU2020222080C1 AU2020222080A AU2020222080A AU2020222080C1 AU 2020222080 C1 AU2020222080 C1 AU 2020222080C1 AU 2020222080 A AU2020222080 A AU 2020222080A AU 2020222080 A AU2020222080 A AU 2020222080A AU 2020222080 C1 AU2020222080 C1 AU 2020222080C1
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- oxazepin
- triazol
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962806201P | 2019-02-15 | 2019-02-15 | |
| US62/806,201 | 2019-02-15 | ||
| US201962931877P | 2019-11-07 | 2019-11-07 | |
| US62/931,877 | 2019-11-07 | ||
| PCT/IB2020/051100 WO2020165776A1 (en) | 2019-02-15 | 2020-02-11 | Hydroxypyridoxazepines as nrf2 activators |
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| AU2020222080A1 AU2020222080A1 (en) | 2021-09-02 |
| AU2020222080B2 AU2020222080B2 (en) | 2022-05-19 |
| AU2020222080C1 true AU2020222080C1 (en) | 2022-09-29 |
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Family Applications (1)
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|---|---|---|---|
| AU2020222080A Active AU2020222080C1 (en) | 2019-02-15 | 2020-02-11 | Hydroxypyridoxazepines as Nrf2 activators |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US11945826B2 (es) |
| EP (1) | EP3924356A1 (es) |
| JP (1) | JP2022520442A (es) |
| KR (1) | KR20210126676A (es) |
| CN (1) | CN113474349B (es) |
| AU (1) | AU2020222080C1 (es) |
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| UA126950C2 (uk) | 2018-08-20 | 2023-02-22 | Янссен Фармацевтика Нв | Інгібітори міжбілкової взаємодії keap1-nrf2 |
| AR118050A1 (es) | 2019-02-15 | 2021-09-15 | Bristol Myers Squibb Co | Compuestos bicíclicos sustituidos como moduladores del receptor farnesoide x |
| TW202404984A (zh) * | 2022-04-28 | 2024-02-01 | 日商第一三共股份有限公司 | 苯并三唑化合物 |
| TW202345792A (zh) * | 2022-04-28 | 2023-12-01 | 日商第一三共股份有限公司 | 苯并噻吩化合物 |
| WO2024047248A1 (en) * | 2022-09-02 | 2024-03-07 | Institut National de la Santé et de la Recherche Médicale | Use of nrf2 activators for the treatment of cerebral small vessel disease |
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| WO2015092713A1 (en) * | 2013-12-18 | 2015-06-25 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
| WO2016203400A1 (en) * | 2015-06-15 | 2016-12-22 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
| WO2016202253A1 (en) * | 2015-06-15 | 2016-12-22 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
| WO2016203401A1 (en) * | 2015-06-15 | 2016-12-22 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
| WO2018104766A1 (en) * | 2016-12-06 | 2018-06-14 | Glaxosmithkline Intellectual Property Development Limited | 3-(2,3-dihydro-1h-inden-5-yl)propanoic acid derivatives and their use as nrf2 regulators |
| WO2018109646A1 (en) * | 2016-12-15 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 compounds |
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| US7714012B2 (en) * | 2006-11-17 | 2010-05-11 | Trustees Of Dartmouth University | Synthesis and biological activities of new tricyclic-bis-enones (TBEs) |
| CA2995325A1 (en) * | 2015-08-12 | 2017-02-16 | Mochida Pharmaceutical Co., Ltd. | Isothiazole derivative |
| JP2018529745A (ja) * | 2015-10-06 | 2018-10-11 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | Ｎｒｆ２レギュレーターとしてのビアリールピラゾール |
| WO2018109642A1 (en) * | 2016-12-12 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | N-aryl pyrazoles as nrf2 regulators |
| US11078216B2 (en) * | 2016-12-14 | 2021-08-03 | Glaxosmithkline Intellectual Property Development Limited | Bisaryl amides as NRF2 activators |
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015092713A1 (en) * | 2013-12-18 | 2015-06-25 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
| WO2016203400A1 (en) * | 2015-06-15 | 2016-12-22 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
| WO2016202253A1 (en) * | 2015-06-15 | 2016-12-22 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
| WO2016203401A1 (en) * | 2015-06-15 | 2016-12-22 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
| WO2018104766A1 (en) * | 2016-12-06 | 2018-06-14 | Glaxosmithkline Intellectual Property Development Limited | 3-(2,3-dihydro-1h-inden-5-yl)propanoic acid derivatives and their use as nrf2 regulators |
| WO2018109646A1 (en) * | 2016-12-15 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 compounds |
Also Published As
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| MA54939A (fr) | 2021-12-22 |
| IL285438A (en) | 2021-09-30 |
| CN113474349B (zh) | 2024-03-01 |
| US20220204526A1 (en) | 2022-06-30 |
| KR20210126676A (ko) | 2021-10-20 |
| SG11202108257TA (en) | 2021-08-30 |
| MX2021009659A (es) | 2021-09-08 |
| AU2020222080B2 (en) | 2022-05-19 |
| TW202045514A (zh) | 2020-12-16 |
| JP2022520442A (ja) | 2022-03-30 |
| AU2020222080A1 (en) | 2021-09-02 |
| CL2021002110A1 (es) | 2022-02-11 |
| CO2021010930A2 (es) | 2021-09-09 |
| CN113474349A (zh) | 2021-10-01 |
| EP3924356A1 (en) | 2021-12-22 |
| BR112021016042A2 (pt) | 2021-10-05 |
| WO2020165776A1 (en) | 2020-08-20 |
| CA3129955A1 (en) | 2020-08-20 |
| US11945826B2 (en) | 2024-04-02 |
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