AU2020203961A1 - DNA methylation biomarkers for early detection of cervical cancer - Google Patents

DNA methylation biomarkers for early detection of cervical cancer Download PDF

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Publication number
AU2020203961A1
AU2020203961A1 AU2020203961A AU2020203961A AU2020203961A1 AU 2020203961 A1 AU2020203961 A1 AU 2020203961A1 AU 2020203961 A AU2020203961 A AU 2020203961A AU 2020203961 A AU2020203961 A AU 2020203961A AU 2020203961 A1 AU2020203961 A1 AU 2020203961A1
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AU
Australia
Prior art keywords
seq
cervical cancer
dna methylation
cgids
methylation
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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AU2020203961A
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English (en)
Inventor
David CHEISHVILI
Mariam EL-ZEIN
Eduardo Franco
Moshe Szyf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hkg Epitherapeutics Ltd
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Hkg Epitherapeutics Ltd
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Publication date
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Publication of AU2020203961A1 publication Critical patent/AU2020203961A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2020203961A 2018-12-04 2020-02-04 DNA methylation biomarkers for early detection of cervical cancer Pending AU2020203961A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862774994P 2018-12-04 2018-12-04
US62/774,994 2018-12-04
PCT/IB2020/050885 WO2020115728A2 (en) 2018-12-04 2020-02-04 Dna methylation biomarkers for early detection of cervical cancer

Publications (1)

Publication Number Publication Date
AU2020203961A1 true AU2020203961A1 (en) 2021-06-17

Family

ID=70975630

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020203961A Pending AU2020203961A1 (en) 2018-12-04 2020-02-04 DNA methylation biomarkers for early detection of cervical cancer

Country Status (11)

Country Link
US (1) US20220073994A1 (ja)
EP (1) EP3891296A4 (ja)
JP (2) JP7489979B2 (ja)
KR (1) KR20210117262A (ja)
CN (1) CN113423843A (ja)
AU (1) AU2020203961A1 (ja)
BR (1) BR112021010640A2 (ja)
CA (1) CA3121886A1 (ja)
IL (1) IL283616A (ja)
SG (1) SG11202104288PA (ja)
WO (1) WO2020115728A2 (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202009222D0 (en) * 2020-06-17 2020-07-29 Ucl Business Plc Methods for detecting and predicting cancer
GB202009217D0 (en) * 2020-06-17 2020-07-29 Ucl Business Ltd Methods for detecting and predicting breast cancer
MX2022016097A (es) * 2020-06-17 2023-04-20 Ucl Business Ltd Procedimientos para detectar y predecir neoplasia epitelial cervical de grado 3 (cin3) y/o cáncer.
GB202009220D0 (en) * 2020-06-17 2020-07-29 Ucl Business Ltd Methods for detecting and predicting cancer
IL299142A (en) * 2020-06-17 2023-02-01 Ucl Business Ltd Methods for the diagnosis and prognosis of cancer and/or CIN3
CN112048561B (zh) * 2020-09-18 2021-11-26 北京起源聚禾生物科技有限公司 用于宫颈高级别病变和宫颈癌早期检测的组合物及试剂盒
JP2024509851A (ja) * 2021-03-05 2024-03-05 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 子宮頸癌の検出
CN113943817B (zh) * 2021-12-20 2022-04-19 北京迈基诺基因科技股份有限公司 宫颈癌癌化水平评估模型及构建方法
CN114214415A (zh) * 2021-12-29 2022-03-22 广州安必平医药科技股份有限公司 一种用于宫颈癌相关基因甲基化检测的引物探针组合及其应用
CN115612744A (zh) * 2022-12-14 2023-01-17 中国医学科学院肿瘤医院 人乳头瘤病毒分型及相关基因甲基化一体化检测模型及其构建方法
CN117265096A (zh) * 2023-09-07 2023-12-22 北京美康基因科学股份有限公司 用于宫颈高级别病变和宫颈癌早期检测的试剂盒

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10961590B2 (en) * 2015-09-17 2021-03-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cancer detection methods
CN107541565B (zh) 2016-06-23 2021-07-06 首都医科大学附属北京佑安医院 宿主外周血单个核细胞和t细胞的癌症dna甲基化标志物
US20190345559A1 (en) 2016-06-23 2019-11-14 Moshe Szyf Dna methylation signatures of cancer in host peripheral blood mononuclear cells and t cells
BR112019018743A2 (pt) * 2017-03-10 2020-05-05 Self-Screen B.V. classificador de metilação para detecção de cânceres invasivos induzidos por hpv, cânceres ginecológicos e anogenitais não induzidos por hpv e suas lesões precursoras de alto grau

Also Published As

Publication number Publication date
SG11202104288PA (en) 2021-05-28
JP7489979B2 (ja) 2024-05-24
WO2020115728A2 (en) 2020-06-11
BR112021010640A2 (pt) 2021-09-08
KR20210117262A (ko) 2021-09-28
CA3121886A1 (en) 2020-06-11
IL283616A (en) 2021-07-29
CN113423843A (zh) 2021-09-21
US20220073994A1 (en) 2022-03-10
JP2024056878A (ja) 2024-04-23
EP3891296A4 (en) 2022-11-16
EP3891296A2 (en) 2021-10-13
JP2022531637A (ja) 2022-07-08
WO2020115728A3 (en) 2020-09-24

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