AU2019346417A1 - Auricular nerve stimulation to address patient disorders, and associated systems and methods - Google Patents
Auricular nerve stimulation to address patient disorders, and associated systems and methods Download PDFInfo
- Publication number
- AU2019346417A1 AU2019346417A1 AU2019346417A AU2019346417A AU2019346417A1 AU 2019346417 A1 AU2019346417 A1 AU 2019346417A1 AU 2019346417 A AU2019346417 A AU 2019346417A AU 2019346417 A AU2019346417 A AU 2019346417A AU 2019346417 A1 AU2019346417 A1 AU 2019346417A1
- Authority
- AU
- Australia
- Prior art keywords
- patient
- signal
- earpiece
- electrical
- electrical therapy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 97
- 230000007383 nerve stimulation Effects 0.000 title abstract description 7
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 110
- 210000005036 nerve Anatomy 0.000 claims abstract description 26
- 238000004891 communication Methods 0.000 claims abstract description 19
- 210000000613 ear canal Anatomy 0.000 claims abstract description 13
- 210000000883 ear external Anatomy 0.000 claims abstract description 11
- 230000001515 vagal effect Effects 0.000 claims abstract description 11
- 238000011282 treatment Methods 0.000 claims description 23
- 208000035824 paresthesia Diseases 0.000 claims description 20
- 230000004044 response Effects 0.000 claims description 19
- 210000005069 ears Anatomy 0.000 claims description 18
- 239000004020 conductor Substances 0.000 claims description 14
- 238000004519 manufacturing process Methods 0.000 claims description 12
- 208000019695 Migraine disease Diseases 0.000 claims description 11
- 206010027599 migraine Diseases 0.000 claims description 11
- 230000001953 sensory effect Effects 0.000 claims description 11
- 210000004556 brain Anatomy 0.000 claims description 10
- 230000016507 interphase Effects 0.000 claims description 6
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 6
- 230000000926 neurological effect Effects 0.000 claims description 5
- 238000011458 pharmacological treatment Methods 0.000 claims description 5
- 238000011269 treatment regimen Methods 0.000 claims description 5
- 230000001965 increasing effect Effects 0.000 claims description 4
- 230000004968 inflammatory condition Effects 0.000 claims description 4
- 206010019233 Headaches Diseases 0.000 claims description 3
- 201000009916 Postpartum depression Diseases 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims description 3
- 230000000996 additive effect Effects 0.000 claims description 3
- 231100000869 headache Toxicity 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 2
- 229920001940 conductive polymer Polymers 0.000 claims description 2
- 230000008878 coupling Effects 0.000 claims description 2
- 238000010168 coupling process Methods 0.000 claims description 2
- 238000005859 coupling reaction Methods 0.000 claims description 2
- 208000019116 sleep disease Diseases 0.000 claims description 2
- 208000020685 sleep-wake disease Diseases 0.000 claims description 2
- 230000030214 innervation Effects 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 description 34
- 230000000638 stimulation Effects 0.000 description 27
- 230000000694 effects Effects 0.000 description 22
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 238000011156 evaluation Methods 0.000 description 9
- 230000001537 neural effect Effects 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- 230000000241 respiratory effect Effects 0.000 description 9
- 229940079593 drug Drugs 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 230000001225 therapeutic effect Effects 0.000 description 7
- 208000035475 disorder Diseases 0.000 description 6
- 230000000144 pharmacologic effect Effects 0.000 description 6
- 210000001186 vagus nerve Anatomy 0.000 description 6
- 239000003435 antirheumatic agent Substances 0.000 description 5
- 208000006673 asthma Diseases 0.000 description 5
- 239000000090 biomarker Substances 0.000 description 5
- 239000013543 active substance Substances 0.000 description 4
- 206010003246 arthritis Diseases 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000000875 corresponding effect Effects 0.000 description 4
- 238000002599 functional magnetic resonance imaging Methods 0.000 description 4
- 230000001939 inductive effect Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000007958 sleep Effects 0.000 description 4
- 230000003356 anti-rheumatic effect Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000000747 cardiac effect Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 230000000737 periodic effect Effects 0.000 description 3
- 210000000578 peripheral nerve Anatomy 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 210000001679 solitary nucleus Anatomy 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- -1 !L-18 Proteins 0.000 description 2
- 108010074051 C-Reactive Protein Proteins 0.000 description 2
- 102100032752 C-reactive protein Human genes 0.000 description 2
- 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 description 2
- 102000004414 Calcitonin Gene-Related Peptide Human genes 0.000 description 2
- 241000746998 Tragus Species 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000002988 disease modifying antirheumatic drug Substances 0.000 description 2
- 230000001667 episodic effect Effects 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 210000003016 hypothalamus Anatomy 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 229940125389 long-acting beta agonist Drugs 0.000 description 2
- 210000001699 lower leg Anatomy 0.000 description 2
- 238000002595 magnetic resonance imaging Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 238000002610 neuroimaging Methods 0.000 description 2
- 238000006213 oxygenation reaction Methods 0.000 description 2
- 230000035479 physiological effects, processes and functions Effects 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 230000000770 proinflammatory effect Effects 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000002889 sympathetic effect Effects 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
- 230000001755 vocal effect Effects 0.000 description 2
- ASUGUQWIHMTFJL-QGZVFWFLSA-N (2r)-2-methyl-2-[[2-(1h-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-n-(2,2,2-trifluoroethyl)butanamide Chemical compound FC(F)(F)CNC(=O)[C@@](C)(CC)NC1=CC=NC(C=2C3=CC=CN=C3NC=2)=N1 ASUGUQWIHMTFJL-QGZVFWFLSA-N 0.000 description 1
- WYQFJHHDOKWSHR-MNOVXSKESA-N (3S,4R)-3-ethyl-4-(1,5,7,10-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),3,7,9,11-pentaen-12-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide Chemical compound CC[C@@H]1CN(C(=O)NCC(F)(F)F)C[C@@H]1C1=CN=C2N1C(C=CN1)=C1N=C2 WYQFJHHDOKWSHR-MNOVXSKESA-N 0.000 description 1
- HMLGSIZOMSVISS-ONJSNURVSA-N (7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2,2-dimethylpropanoyloxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound N([C@@H]1C(N2C(=C(C=C)CSC21)C(O)=O)=O)C(=O)\C(=N/OCOC(=O)C(C)(C)C)C1=CSC(N)=N1 HMLGSIZOMSVISS-ONJSNURVSA-N 0.000 description 1
- 206010052613 Allergic bronchitis Diseases 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 206010006482 Bronchospasm Diseases 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 208000006561 Cluster Headache Diseases 0.000 description 1
- 102000004420 Creatine Kinase Human genes 0.000 description 1
- 108010042126 Creatine kinase Proteins 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 108010008165 Etanercept Proteins 0.000 description 1
- 206010016334 Feeling hot Diseases 0.000 description 1
- 208000001640 Fibromyalgia Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000051628 Interleukin-1 receptor antagonist Human genes 0.000 description 1
- 108700021006 Interleukin-1 receptor antagonist Proteins 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 description 1
- 206010023232 Joint swelling Diseases 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- 208000019022 Mood disease Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 208000010411 REM Sleep Parasomnias Diseases 0.000 description 1
- 208000025535 REM sleep behavior disease Diseases 0.000 description 1
- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- 208000036366 Sensation of pressure Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 208000021386 Sjogren Syndrome Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 239000004012 Tofacitinib Substances 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102100040247 Tumor necrosis factor Human genes 0.000 description 1
- 229960003697 abatacept Drugs 0.000 description 1
- 239000003522 acrylic cement Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229960002964 adalimumab Drugs 0.000 description 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 210000004727 amygdala Anatomy 0.000 description 1
- 229960004238 anakinra Drugs 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000035045 associative learning Effects 0.000 description 1
- 229940098165 atrovent Drugs 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 230000002567 autonomic effect Effects 0.000 description 1
- 229950000971 baricitinib Drugs 0.000 description 1
- XUZMWHLSFXCVMG-UHFFFAOYSA-N baricitinib Chemical compound C1N(S(=O)(=O)CC)CC1(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 XUZMWHLSFXCVMG-UHFFFAOYSA-N 0.000 description 1
- 210000004227 basal ganglia Anatomy 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000002051 biphasic effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000002802 cardiorespiratory effect Effects 0.000 description 1
- 210000001159 caudate nucleus Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- KEWHKYJURDBRMN-XSAPEOHZSA-M chembl2134724 Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-XSAPEOHZSA-M 0.000 description 1
- DREIJXJRTLTGJC-ZLBJMMTISA-N chembl3137308 Chemical compound C([C@H]1C[C@@](O)(C2)C3)C2C[C@H]3[C@H]1NC1=C2C=CNC2=NC=C1C(=O)N DREIJXJRTLTGJC-ZLBJMMTISA-N 0.000 description 1
- 230000008867 communication pathway Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 230000009193 crawling Effects 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 238000013500 data storage Methods 0.000 description 1
- 229950008830 decernotinib Drugs 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000012938 design process Methods 0.000 description 1
- 230000009266 disease activity Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000000537 electroencephalography Methods 0.000 description 1
- 210000001353 entorhinal cortex Anatomy 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 229950006063 eptinezumab Drugs 0.000 description 1
- 229950001616 erenumab Drugs 0.000 description 1
- 229960000403 etanercept Drugs 0.000 description 1
- 230000002964 excitative effect Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 208000024695 exercise-induced bronchoconstriction Diseases 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229950006663 filgotinib Drugs 0.000 description 1
- 229950011509 fremanezumab Drugs 0.000 description 1
- 210000005153 frontal cortex Anatomy 0.000 description 1
- 229950000118 galcanezumab Drugs 0.000 description 1
- 230000003861 general physiology Effects 0.000 description 1
- 210000001905 globus pallidus Anatomy 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000001320 hippocampus Anatomy 0.000 description 1
- XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 description 1
- 229960004171 hydroxychloroquine Drugs 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 238000002847 impedance measurement Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229960000598 infliximab Drugs 0.000 description 1
- 229940125369 inhaled corticosteroids Drugs 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 229940124625 intravenous corticosteroids Drugs 0.000 description 1
- OEXHQOGQTVQTAT-JRNQLAHRSA-N ipratropium Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 OEXHQOGQTVQTAT-JRNQLAHRSA-N 0.000 description 1
- 229960001888 ipratropium Drugs 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 230000005722 itchiness Effects 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 150000002617 leukotrienes Chemical class 0.000 description 1
- 230000005980 lung dysfunction Effects 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 210000001595 mastoid Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000006993 memory improvement Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- RIJLVEAXPNLDTC-UHFFFAOYSA-N n-[5-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide Chemical compound C1CC1C(=O)NC(=NN12)N=C1C=CC=C2C(C=C1)=CC=C1CN1CCS(=O)(=O)CC1 RIJLVEAXPNLDTC-UHFFFAOYSA-N 0.000 description 1
- 230000006855 networking Effects 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 229960000470 omalizumab Drugs 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 210000001769 parahippocampal gyrus Anatomy 0.000 description 1
- 230000001734 parasympathetic effect Effects 0.000 description 1
- 229950005157 peficitinib Drugs 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000002360 prefrontal effect Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000002106 pulse oximetry Methods 0.000 description 1
- 210000002637 putamen Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 229960004641 rituximab Drugs 0.000 description 1
- 238000007788 roughening Methods 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- 229940125390 short-acting beta agonist Drugs 0.000 description 1
- 230000008054 signal transmission Effects 0.000 description 1
- 230000000392 somatic effect Effects 0.000 description 1
- 230000003238 somatosensory effect Effects 0.000 description 1
- 230000009159 somatosensory pathway Effects 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 1
- 229960001940 sulfasalazine Drugs 0.000 description 1
- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000003478 temporal lobe Anatomy 0.000 description 1
- 210000000516 tensor tympani Anatomy 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 230000000542 thalamic effect Effects 0.000 description 1
- 210000001103 thalamus Anatomy 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960003989 tocilizumab Drugs 0.000 description 1
- 229960001350 tofacitinib Drugs 0.000 description 1
- UJLAWZDWDVHWOW-YPMHNXCESA-N tofacitinib Chemical compound C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)C1=NC=NC2=C1C=CN2 UJLAWZDWDVHWOW-YPMHNXCESA-N 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 210000003901 trigeminal nerve Anatomy 0.000 description 1
- 210000000836 trigeminal nuclei Anatomy 0.000 description 1
- 210000003454 tympanic membrane Anatomy 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 229950000088 upadacitinib Drugs 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 229940099073 xolair Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
- A61N1/36034—Control systems specified by the stimulation parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36021—External stimulators, e.g. with patch electrodes for treatment of pain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36036—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the outer, middle or inner ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Social Psychology (AREA)
- Developmental Disabilities (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862735492P | 2018-09-24 | 2018-09-24 | |
| US62/735,492 | 2018-09-24 | ||
| US201862785205P | 2018-12-26 | 2018-12-26 | |
| US62/785,205 | 2018-12-26 | ||
| US201962891203P | 2019-08-23 | 2019-08-23 | |
| US62/891,203 | 2019-08-23 | ||
| PCT/US2019/052699 WO2020068830A1 (en) | 2018-09-24 | 2019-09-24 | Auricular nerve stimulation to address patient disorders, and associated systems and methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2019346417A1 true AU2019346417A1 (en) | 2021-04-15 |
Family
ID=69883864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2019346417A Abandoned AU2019346417A1 (en) | 2018-09-24 | 2019-09-24 | Auricular nerve stimulation to address patient disorders, and associated systems and methods |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US10835747B2 (https=) |
| EP (1) | EP3857916A4 (https=) |
| JP (1) | JP2022502139A (https=) |
| CN (1) | CN113711623A (https=) |
| AU (1) | AU2019346417A1 (https=) |
| WO (1) | WO2020068830A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12201427B2 (en) | 2012-06-14 | 2025-01-21 | Medibotics Llc | Headband with brain activity sensors |
| US12453853B2 (en) | 2013-01-21 | 2025-10-28 | Cala Health, Inc. | Multi-modal stimulation for treating tremor |
| EP3498332B1 (en) | 2013-01-21 | 2021-07-14 | Cala Health, Inc. | Devices for controlling tremor |
| US9662269B2 (en) | 2013-10-22 | 2017-05-30 | Innovative Health Solutions, Inc. | Systems and methods for auricular peripheral nerve field stimulation |
| US12447332B2 (en) | 2013-10-22 | 2025-10-21 | Neuraxis, Inc. | United states auricular nerve field stimulation device and methods for using the same |
| AU2015271774B2 (en) | 2014-06-02 | 2020-04-16 | Cala Health, Inc. | Systems and methods for peripheral nerve stimulation to treat tremor |
| CN119565022A (zh) | 2015-06-10 | 2025-03-07 | 卡拉健康公司 | 用于外周神经刺激以利用可拆卸治疗和监测单元治疗震颤的系统和方法 |
| WO2017023864A1 (en) | 2015-07-31 | 2017-02-09 | Cala Health, Inc. | Systems, devices, and method for the treatment of osteoarthritis |
| EP3352843B1 (en) | 2015-09-23 | 2021-06-23 | Cala Health, Inc. | Device for peripheral nerve stimulation in the finger to treat hand tremors |
| WO2017132067A2 (en) | 2016-01-21 | 2017-08-03 | Cala Health, Inc. | Systems, methods and devices for peripheral neuromodulation for treating diseases related to overactive bladder |
| CN109803717B (zh) | 2016-08-25 | 2024-01-09 | 卡拉健康公司 | 通过周围神经刺激治疗心脏机能障碍的系统和方法 |
| EP3606604A4 (en) | 2017-04-03 | 2020-12-16 | Cala Health, Inc. | PERIPHERAL NEUROMODULATION SYSTEMS, METHODS AND DEVICES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH BLADDER HYPERACTIVITY |
| US11857778B2 (en) | 2018-01-17 | 2024-01-02 | Cala Health, Inc. | Systems and methods for treating inflammatory bowel disease through peripheral nerve stimulation |
| US11369791B2 (en) * | 2018-04-26 | 2022-06-28 | Neuraxis, Inc. | Auricular nerve field stimulation device |
| WO2020068830A1 (en) | 2018-09-24 | 2020-04-02 | Vivek Sharma | Auricular nerve stimulation to address patient disorders, and associated systems and methods |
| US12251560B1 (en) | 2019-08-13 | 2025-03-18 | Cala Health, Inc. | Connection quality determination for wearable neurostimulation systems |
| US11890468B1 (en) | 2019-10-03 | 2024-02-06 | Cala Health, Inc. | Neurostimulation systems with event pattern detection and classification |
| US12390659B2 (en) * | 2019-11-12 | 2025-08-19 | Lew Lim | Apparatus and method for photobiomodulation-based alternative to electrical vagus nerve stimulation and deep brain stimulation related to movement disorders |
| GB202011522D0 (en) * | 2020-07-24 | 2020-09-09 | Afferent Medical Solutions Ltd | Neuromodulation for the treatment of circulatory system diseases |
| US11771895B2 (en) | 2020-08-06 | 2023-10-03 | The Feinstein Institutes For Medical Research | Compact auricular stimulation device |
| KR102438007B1 (ko) * | 2020-08-28 | 2022-08-30 | 고려대학교 산학협력단 | 맞춤형 신경 자극기 |
| KR102438009B1 (ko) * | 2020-08-28 | 2022-08-30 | 고려대학교 산학협력단 | 밀착형 신경 자극기 |
| TR202022374A1 (tr) * | 2020-12-30 | 2022-07-21 | Vagustim Saglik Teknolojileri Anonim Sirketi | Hastalik ve rahatsizliklarin tedavi̇si̇nde auri̇küler vagus si̇ni̇ri̇ni̇n kesi̇kli̇ doğru akim i̇le uyarildiği bi̇r si̇stem ve yöntem |
| US12324926B2 (en) | 2021-06-07 | 2025-06-10 | Neuraxis, Inc. | Device and method for eradicating pathogens in nasal passages |
| CN113577564B (zh) * | 2021-07-29 | 2024-03-08 | 英特格拉医疗保健仪器研发公司 | 耳部迷走神经刺激装置及刺激耳部迷走神经的方法 |
| KR102604276B1 (ko) * | 2021-11-26 | 2023-11-23 | 주식회사 뉴라이브 | 복합 자극의 제어 방법 및 복합 자극 장치 |
| KR102604287B1 (ko) * | 2021-11-26 | 2023-11-23 | 주식회사 뉴라이브 | 미주신경 자극 장치의 제어 방법 |
| US20250229086A1 (en) | 2022-01-20 | 2025-07-17 | Setpoint Medical Corporation | Treatment of inflammatory disorders |
| TR2022001477A1 (tr) * | 2022-02-04 | 2023-08-21 | Vagustim Saglik Teknolojileri Anonim Sirketi | Hastalik ve rahatsizliklarin tedavi̇si̇ni̇n si̇ni̇rleri̇n elektri̇ksel uyarimi i̇le gerçekleşti̇ri̇ldi̇ği̇ bi̇r si̇stem ve si̇stemi̇n çalişma yöntemi̇ |
| GB202211871D0 (en) * | 2022-08-14 | 2022-09-28 | Earswitch Ltd | Method and device effecting differential stimulation to locations of ear tissues |
| EP4583963A1 (en) * | 2022-08-14 | 2025-07-16 | Earswitch Ltd | Ear apparatus |
| WO2024071994A1 (ko) * | 2022-09-26 | 2024-04-04 | 주식회사 뉴라이브 | 멀미 예방 및 완화 전자 장치 |
| JP1753085S (ja) * | 2022-10-11 | 2023-09-14 | アイコン用画像 | |
| CO2022015061A1 (es) * | 2022-10-21 | 2023-02-06 | Fund Cardiovascular De Colombia | Dispositivo portátil de electroestimulación del nervio vago sincronizado con el ciclo respiratorio |
| WO2024164003A1 (en) * | 2023-02-03 | 2024-08-08 | Washington University | Transcutaneous auricular vagal nerve stimulation for enhanced learning |
| EP4578487A1 (en) * | 2023-12-28 | 2025-07-02 | Xana Stim Sárl | A system for bilateral auricular nerve stimulation of the vagus nerve |
| WO2025219826A1 (en) * | 2024-04-15 | 2025-10-23 | Universita' Degli Studi Di Milano | System for the transcutaneous auricular vagus nerve stimulation |
| EP4674467A1 (en) * | 2024-07-01 | 2026-01-07 | Aurimod GmbH | Device for transcutaneous auricular nerve stimulation |
Family Cites Families (143)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4867164A (en) | 1983-09-14 | 1989-09-19 | Jacob Zabara | Neurocybernetic prosthesis |
| US4702254A (en) | 1983-09-14 | 1987-10-27 | Jacob Zabara | Neurocybernetic prosthesis |
| US5025807A (en) | 1983-09-14 | 1991-06-25 | Jacob Zabara | Neurocybernetic prosthesis |
| US5263480A (en) | 1991-02-01 | 1993-11-23 | Cyberonics, Inc. | Treatment of eating disorders by nerve stimulation |
| US5269303A (en) | 1991-02-22 | 1993-12-14 | Cyberonics, Inc. | Treatment of dementia by nerve stimulation |
| US5299569A (en) | 1991-05-03 | 1994-04-05 | Cyberonics, Inc. | Treatment of neuropsychiatric disorders by nerve stimulation |
| US5335657A (en) | 1991-05-03 | 1994-08-09 | Cyberonics, Inc. | Therapeutic treatment of sleep disorder by nerve stimulation |
| US5215086A (en) | 1991-05-03 | 1993-06-01 | Cyberonics, Inc. | Therapeutic treatment of migraine symptoms by stimulation |
| US5231988A (en) | 1991-08-09 | 1993-08-03 | Cyberonics, Inc. | Treatment of endocrine disorders by nerve stimulation |
| US5330515A (en) | 1992-06-17 | 1994-07-19 | Cyberonics, Inc. | Treatment of pain by vagal afferent stimulation |
| US5458625A (en) | 1994-05-04 | 1995-10-17 | Kendall; Donald E. | Transcutaneous nerve stimulation device and method for using same |
| US5540730A (en) | 1995-06-06 | 1996-07-30 | Cyberonics, Inc. | Treatment of motility disorders by nerve stimulation |
| US5707400A (en) | 1995-09-19 | 1998-01-13 | Cyberonics, Inc. | Treating refractory hypertension by nerve stimulation |
| US5713923A (en) | 1996-05-13 | 1998-02-03 | Medtronic, Inc. | Techniques for treating epilepsy by brain stimulation and drug infusion |
| US6587719B1 (en) | 1999-07-01 | 2003-07-01 | Cyberonics, Inc. | Treatment of obesity by bilateral vagus nerve stimulation |
| US6610713B2 (en) | 2000-05-23 | 2003-08-26 | North Shore - Long Island Jewish Research Institute | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
| US8914114B2 (en) | 2000-05-23 | 2014-12-16 | The Feinstein Institute For Medical Research | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
| US20020090099A1 (en) * | 2001-01-08 | 2002-07-11 | Hwang Sung-Gul | Hands-free, wearable communication device for a wireless communication system |
| US6622041B2 (en) | 2001-08-21 | 2003-09-16 | Cyberonics, Inc. | Treatment of congestive heart failure and autonomic cardiovascular drive disorders |
| US7444183B2 (en) | 2003-02-03 | 2008-10-28 | Enteromedics, Inc. | Intraluminal electrode apparatus and method |
| CA2432810A1 (en) | 2003-06-19 | 2004-12-19 | Andres M. Lozano | Method of treating depression, mood disorders and anxiety disorders by brian infusion |
| US8729129B2 (en) | 2004-03-25 | 2014-05-20 | The Feinstein Institute For Medical Research | Neural tourniquet |
| US9764135B2 (en) | 2004-10-21 | 2017-09-19 | Advanced Neuromodulation Systems, Inc. | Stimulation design for neuromodulation |
| US8239029B2 (en) * | 2004-10-21 | 2012-08-07 | Advanced Neuromodulation Systems, Inc. | Stimulation of the amygdalohippocampal complex to treat neurological conditions |
| US20060100672A1 (en) | 2004-11-05 | 2006-05-11 | Litvak Leonid M | Method and system of matching information from cochlear implants in two ears |
| US9089691B2 (en) | 2004-12-07 | 2015-07-28 | Cardiac Pacemakers, Inc. | Stimulator for auricular branch of vagus nerve |
| CN102793972A (zh) | 2004-12-27 | 2012-11-28 | 范因斯坦医学研究院 | 通过电刺激迷走神经治疗炎症性疾病 |
| DE102005003735B4 (de) | 2005-01-26 | 2008-04-03 | Cerbomed Gmbh | Vorrichtung zur transkutanen Stimulation eines Nervs des menschlichen Körpers |
| US20110166624A1 (en) | 2005-01-26 | 2011-07-07 | Cerbomed Gmbh | Device for the transdermal stimulation of a nerve of the human body |
| US20060206165A1 (en) * | 2005-03-14 | 2006-09-14 | Jaax Kristen N | Occipital nerve stimulation to treat headaches and other conditions |
| US7784583B1 (en) | 2005-04-25 | 2010-08-31 | The United States Of America As Represented By The Secretary Of The Air Force | Deep insertion vented earpiece system |
| US20070027504A1 (en) | 2005-07-27 | 2007-02-01 | Cyberonics, Inc. | Cranial nerve stimulation to treat a hearing disorder |
| US20080077200A1 (en) | 2006-09-21 | 2008-03-27 | Aculight Corporation | Apparatus and method for stimulation of nerves and automated control of surgical instruments |
| WO2007056493A1 (en) | 2005-11-08 | 2007-05-18 | Schumann Daniel H | Device and method for the treatment of pain with electrical energy |
| US9174066B2 (en) | 2009-03-20 | 2015-11-03 | ElectroCore, LLC | Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient |
| US10537728B2 (en) | 2005-11-10 | 2020-01-21 | ElectroCore, LLC | Vagal nerve stimulation to avert or treat stroke or transient ischemic attack |
| US20110125203A1 (en) * | 2009-03-20 | 2011-05-26 | ElectroCore, LLC. | Magnetic Stimulation Devices and Methods of Therapy |
| US8676330B2 (en) | 2009-03-20 | 2014-03-18 | ElectroCore, LLC | Electrical and magnetic stimulators used to treat migraine/sinus headache and comorbid disorders |
| US9119953B2 (en) | 2005-11-10 | 2015-09-01 | ElectroCore, LLC | Non-invasive treatment of a medical condition by vagus nerve stimulation |
| US8874227B2 (en) | 2009-03-20 | 2014-10-28 | ElectroCore, LLC | Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient |
| US8874205B2 (en) | 2009-03-20 | 2014-10-28 | ElectroCore, LLC | Device and methods for non-invasive electrical stimulation and their use for vagal nerve stimulation |
| US10441780B2 (en) | 2005-11-10 | 2019-10-15 | Electrocore, Inc. | Systems and methods for vagal nerve stimulation |
| US8676324B2 (en) | 2005-11-10 | 2014-03-18 | ElectroCore, LLC | Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders |
| US8983628B2 (en) | 2009-03-20 | 2015-03-17 | ElectroCore, LLC | Non-invasive vagal nerve stimulation to treat disorders |
| US9037247B2 (en) | 2005-11-10 | 2015-05-19 | ElectroCore, LLC | Non-invasive treatment of bronchial constriction |
| US9339641B2 (en) | 2006-01-17 | 2016-05-17 | Emkinetics, Inc. | Method and apparatus for transdermal stimulation over the palmar and plantar surfaces |
| US20080051852A1 (en) | 2006-01-21 | 2008-02-28 | Cerbomed Gmbh | Device and method for the transdermal stimulation of a nerve of the human body |
| US7801601B2 (en) | 2006-01-27 | 2010-09-21 | Cyberonics, Inc. | Controlling neuromodulation using stimulus modalities |
| EP2026874B1 (en) * | 2006-03-29 | 2015-05-20 | Dignity Health | Vagus nerve stimulation system |
| US8209034B2 (en) | 2008-12-18 | 2012-06-26 | Electrocore Llc | Methods and apparatus for electrical stimulation treatment using esophageal balloon and electrode |
| DE102006023824B4 (de) | 2006-05-20 | 2010-01-28 | Cerbomed Gmbh | Vorrichtung zur transkutanen Aufbringung eines Reizes oder zur transkutanen Erfassung eines Parameters |
| DE102006033623B4 (de) | 2006-07-18 | 2010-04-08 | Cerbomed Gmbh | System zur transkutanen Stimulation eines Nervs des menschlichen Körpers |
| DE102006036069B4 (de) | 2006-07-18 | 2008-09-04 | Cerbomed Gmbh | Audiologisches Übertragungssystem |
| US7742828B2 (en) | 2006-09-29 | 2010-06-22 | Tyco Healthcare Group Lp | Medical electrode suitable for high-energy stimulation |
| WO2008112915A1 (en) | 2007-03-13 | 2008-09-18 | The Feinstein Institute For Medical Research | Treatment of inflammation by non-invasive stimulation |
| US8391970B2 (en) | 2007-08-27 | 2013-03-05 | The Feinstein Institute For Medical Research | Devices and methods for inhibiting granulocyte activation by neural stimulation |
| US20090204173A1 (en) | 2007-11-05 | 2009-08-13 | Zi-Ping Fang | Multi-Frequency Neural Treatments and Associated Systems and Methods |
| US9211409B2 (en) | 2008-03-31 | 2015-12-15 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation of T-cell activity |
| US9662490B2 (en) | 2008-03-31 | 2017-05-30 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug |
| ES2563634T3 (es) | 2008-05-13 | 2016-03-15 | Cerbomed Gmbh | Aparato para mejorar el funcionamiento del tejido neurológico |
| JP2011525133A (ja) | 2008-06-20 | 2011-09-15 | メドレリーフ インコーポレイテッド | 非経頭蓋電気治療を提供するためのシステム、装置および方法 |
| US9248286B2 (en) | 2009-03-20 | 2016-02-02 | ElectroCore, LLC | Medical self-treatment using non-invasive vagus nerve stimulation |
| US9403001B2 (en) | 2009-03-20 | 2016-08-02 | ElectroCore, LLC | Non-invasive magnetic or electrical nerve stimulation to treat gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders |
| US8918178B2 (en) | 2009-03-20 | 2014-12-23 | ElectroCore, LLC | Non-invasive vagal nerve stimulation to treat disorders |
| US10512769B2 (en) | 2009-03-20 | 2019-12-24 | Electrocore, Inc. | Non-invasive magnetic or electrical nerve stimulation to treat or prevent autism spectrum disorders and other disorders of psychological development |
| US10376696B2 (en) | 2009-03-20 | 2019-08-13 | Electrocore, Inc. | Medical self-treatment using non-invasive vagus nerve stimulation |
| US10232178B2 (en) | 2009-03-20 | 2019-03-19 | Electrocore, Inc. | Non-invasive magnetic or electrical nerve stimulation to treat or prevent dementia |
| US9254383B2 (en) | 2009-03-20 | 2016-02-09 | ElectroCore, LLC | Devices and methods for monitoring non-invasive vagus nerve stimulation |
| US9333347B2 (en) | 2010-08-19 | 2016-05-10 | ElectroCore, LLC | Devices and methods for non-invasive electrical stimulation and their use for vagal nerve stimulation on the neck of a patient |
| US8914122B2 (en) | 2009-03-20 | 2014-12-16 | ElectroCore, LLC | Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient |
| US8843210B2 (en) | 2009-03-20 | 2014-09-23 | ElectroCore, LLC | Non-invasive vagal nerve stimulation to treat disorders |
| US8983629B2 (en) | 2009-03-20 | 2015-03-17 | ElectroCore, LLC | Non-invasive vagal nerve stimulation to treat disorders |
| US8428719B2 (en) * | 2009-04-03 | 2013-04-23 | The General Hospital Corporation | Systems and methods for respiratory-gated auricular vagal afferent nerve stimulation |
| EP2586488B1 (en) * | 2009-04-22 | 2017-03-15 | Nevro Corporation | Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems |
| CA2771070C (en) * | 2009-09-03 | 2019-03-26 | Murdoch Childrens Research Institute | Transcutaneous stimulation method and system |
| DE202010014951U1 (de) | 2010-05-28 | 2011-11-25 | Cerbomed Gmbh | Elektrodenanordnung |
| US9358381B2 (en) | 2011-03-10 | 2016-06-07 | ElectroCore, LLC | Non-invasive vagal nerve stimulation to treat disorders |
| WO2012075192A2 (en) * | 2010-11-30 | 2012-06-07 | The Regents Of The University Of California | Pulse generator for cranial nerve stimulation |
| WO2012075198A2 (en) | 2010-11-30 | 2012-06-07 | Nevro Corporation | Extended pain relief via high frequency spinal cord modulation, and associated systems and methods |
| KR20140037803A (ko) | 2010-12-14 | 2014-03-27 | 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 | 의료 질환 치료용 장치, 시스템 및 방법 |
| US9399134B2 (en) | 2011-03-10 | 2016-07-26 | ElectroCore, LLC | Non-invasive vagal nerve stimulation to treat disorders |
| US10279163B2 (en) | 2011-03-10 | 2019-05-07 | Electrocore, Inc. | Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders |
| DE102011018228A1 (de) | 2011-04-19 | 2012-10-25 | Cerbomed Gmbh | Vorrichtung und Verfahren zur Aufbringung eines transkutanen elektrischen Stimulationsreizes auf die Oberfläche eines Abschnitts des menschlichen Ohrs |
| US8892207B2 (en) * | 2011-04-20 | 2014-11-18 | Medtronic, Inc. | Electrical therapy for facilitating inter-area brain synchronization |
| DE102011100065A1 (de) | 2011-04-30 | 2012-10-31 | Cerbomed Gmbh | Vorrichtung zur kombinierten Aufbringung eines transkutanen elektrischen Stimulationsreizes und Abgabe eines akustischen Signals |
| US9566426B2 (en) | 2011-08-31 | 2017-02-14 | ElectroCore, LLC | Systems and methods for vagal nerve stimulation |
| AU2012304370B2 (en) | 2011-09-08 | 2016-01-28 | Nevro Corporation | Selective high frequency spinal cord modulation for inhibiting pain, including cephalic and/or total body pain with reduced side effects, and associated systems and methods |
| WO2013055595A1 (en) * | 2011-10-11 | 2013-04-18 | Sequenta, Inc. | Determining responsiveness of autoimmune patients to dmard treatment |
| DE102012014727B4 (de) | 2012-03-02 | 2014-01-23 | Cerbomed Gmbh | Elektrodenanordnung |
| US9572983B2 (en) | 2012-03-26 | 2017-02-21 | Setpoint Medical Corporation | Devices and methods for modulation of bone erosion |
| US9415220B1 (en) | 2012-07-31 | 2016-08-16 | Synchromax, Inc. | Auricular stimulation for inflammatory parasympathetic diseases |
| US9440070B2 (en) | 2012-11-26 | 2016-09-13 | Thyne Global, Inc. | Wearable transdermal electrical stimulation devices and methods of using them |
| EP3498332B1 (en) | 2013-01-21 | 2021-07-14 | Cala Health, Inc. | Devices for controlling tremor |
| US12453853B2 (en) | 2013-01-21 | 2025-10-28 | Cala Health, Inc. | Multi-modal stimulation for treating tremor |
| US10220211B2 (en) * | 2013-01-22 | 2019-03-05 | Livanova Usa, Inc. | Methods and systems to diagnose depression |
| US9427581B2 (en) | 2013-04-28 | 2016-08-30 | ElectroCore, LLC | Devices and methods for treating medical disorders with evoked potentials and vagus nerve stimulation |
| US9179222B2 (en) * | 2013-06-06 | 2015-11-03 | Cochlear Limited | Signal processing for hearing prostheses |
| US9242085B2 (en) | 2013-06-28 | 2016-01-26 | Boston Scientific Neuromodulation Corporation | Transcutaneous electrical stimulation for treating neurological disorders |
| DE102013011541B3 (de) | 2013-07-10 | 2014-10-16 | Cerbomed Gmbh | Stimulationsvorrichtung |
| DE102013011530B3 (de) | 2013-07-10 | 2014-10-16 | Cerbomed Gmbh | Stimulationsvorrichtung |
| US9662269B2 (en) | 2013-10-22 | 2017-05-30 | Innovative Health Solutions, Inc. | Systems and methods for auricular peripheral nerve field stimulation |
| US10413719B2 (en) | 2016-04-15 | 2019-09-17 | Innovative Health Solutions, Inc. | Methods of treating disease using auricular peripheral nerve field stimulation |
| US20150142082A1 (en) | 2013-11-15 | 2015-05-21 | ElectroCore, LLC | Systems and methods of biofeedback using nerve stimulation |
| US20160263376A1 (en) | 2013-11-27 | 2016-09-15 | The Governing Council Of The University Of Toronto | Systems and methods for improved treatment of overactive bladder |
| DE102013021175B4 (de) | 2013-12-17 | 2015-10-22 | Cerbomed Gmbh | Vorrichtung zur Aufbringung eines transkutanen elektrischen Stimulationsreizes |
| WO2015127476A1 (en) | 2014-02-24 | 2015-08-27 | Setpoint Medial Corporation | Vagus nerve stimulation screening test |
| US10348724B2 (en) * | 2014-04-07 | 2019-07-09 | Barco N.V. | Ad hoc one-time pairing of remote devices using online audio fingerprinting |
| AU2015271774B2 (en) | 2014-06-02 | 2020-04-16 | Cala Health, Inc. | Systems and methods for peripheral nerve stimulation to treat tremor |
| US9782584B2 (en) | 2014-06-13 | 2017-10-10 | Nervana, LLC | Transcutaneous electrostimulator and methods for electric stimulation |
| US10130809B2 (en) * | 2014-06-13 | 2018-11-20 | Nervana, LLC | Transcutaneous electrostimulator and methods for electric stimulation |
| DE102014010882A1 (de) | 2014-07-27 | 2016-01-28 | Cerbomed Gmbh | Vorrichtung zur Aufbringung eines transkutanen elektrischen Stimulationsreizes |
| DE102014216086A1 (de) * | 2014-08-13 | 2016-02-18 | Sivantos Pte. Ltd. | Vorrichtung und Verfahren zur Integration von Hörgerätekomponenten |
| US11311725B2 (en) | 2014-10-24 | 2022-04-26 | Setpoint Medical Corporation | Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation |
| WO2016109851A1 (en) | 2015-01-04 | 2016-07-07 | Thync, Inc. | Methods and apparatuses for transdermal stimulation of the outer ear |
| DE102015002589B4 (de) | 2015-02-27 | 2017-04-27 | Cerbomed Gmbh | Vorrichtung zur Aufbringung eines transkutanen elektrischen Stimulationsreizes |
| US10398902B2 (en) | 2015-03-27 | 2019-09-03 | Equility Llc | Neural stimulation method and system with audio output |
| US10406376B2 (en) | 2015-03-27 | 2019-09-10 | Equility Llc | Multi-factor control of ear stimulation |
| US9987489B2 (en) * | 2015-03-27 | 2018-06-05 | Elwha Llc | Controlling ear stimulation in response to electrical contact sensing |
| US20160279021A1 (en) | 2015-03-27 | 2016-09-29 | Elwha Llc | Vibratory ear stimulation system and method |
| US10589105B2 (en) | 2015-03-27 | 2020-03-17 | The Invention Science Fund Ii, Llc | Method and system for controlling ear stimulation |
| US20160279025A1 (en) | 2015-03-27 | 2016-09-29 | Elwha LLC, a limited liability company of the State of Delaware | Recommendation method and system for treatments including ear stimulation |
| US20190046794A1 (en) | 2015-03-27 | 2019-02-14 | Equility Llc | Multi-factor control of ear stimulation |
| US10327984B2 (en) | 2015-03-27 | 2019-06-25 | Equility Llc | Controlling ear stimulation in response to image analysis |
| US11364380B2 (en) * | 2015-03-27 | 2022-06-21 | Elwha Llc | Nerve stimulation system, subsystem, headset, and earpiece |
| US10512783B2 (en) | 2015-03-27 | 2019-12-24 | Equility Llc | User interface method and system for ear stimulation |
| US10039928B2 (en) | 2015-03-27 | 2018-08-07 | Equility Llc | Ear stimulation with neural feedback sensing |
| US20170027812A1 (en) | 2015-03-27 | 2017-02-02 | Elwha Llc | Nerve stimulation system and related controller |
| US10406363B2 (en) | 2015-04-21 | 2019-09-10 | Livanova Usa, Inc. | Evaluation of efficacy of epilepsy therapy |
| CN119565022A (zh) | 2015-06-10 | 2025-03-07 | 卡拉健康公司 | 用于外周神经刺激以利用可拆卸治疗和监测单元治疗震颤的系统和方法 |
| WO2017023864A1 (en) | 2015-07-31 | 2017-02-09 | Cala Health, Inc. | Systems, devices, and method for the treatment of osteoarthritis |
| EP3352843B1 (en) | 2015-09-23 | 2021-06-23 | Cala Health, Inc. | Device for peripheral nerve stimulation in the finger to treat hand tremors |
| CN108882885A (zh) | 2016-01-20 | 2018-11-23 | 赛博恩特医疗器械公司 | 迷走神经刺激的控制 |
| IL264116B2 (en) | 2016-07-08 | 2024-01-01 | Cala Health Inc | Systems and methods for stimulating n nerves with exactly n electrodes and improved dry electrodes |
| CN109803717B (zh) | 2016-08-25 | 2024-01-09 | 卡拉健康公司 | 通过周围神经刺激治疗心脏机能障碍的系统和方法 |
| WO2018039467A1 (en) | 2016-08-25 | 2018-03-01 | The Regents Of The University Of Michigan | Inhibitors of-bcr-abl mutants and use thereof |
| US10596382B2 (en) | 2016-12-16 | 2020-03-24 | Elwha Llc | System and method for enhancing learning relating to a sound pattern |
| US10695570B2 (en) | 2016-12-16 | 2020-06-30 | Elwha Llc | Prompting system and method for enhancing learning with neural modulation |
| US10736564B2 (en) | 2016-12-16 | 2020-08-11 | Elwha Llc | System and method for enhancing learning of a motor task |
| JP2020525252A (ja) | 2017-06-26 | 2020-08-27 | ヴォルソ コープ | 交感神経および交感神経の活動に影響を与えて治療効果を得るための末梢神経刺激装置 |
| US11794012B2 (en) * | 2017-07-11 | 2023-10-24 | The General Hospital Corporation | Systems and methods for respiratory-gated nerve stimulation |
| US11857778B2 (en) | 2018-01-17 | 2024-01-02 | Cala Health, Inc. | Systems and methods for treating inflammatory bowel disease through peripheral nerve stimulation |
| WO2020068830A1 (en) | 2018-09-24 | 2020-04-02 | Vivek Sharma | Auricular nerve stimulation to address patient disorders, and associated systems and methods |
| AU2020234681B2 (en) | 2019-03-08 | 2025-09-25 | Cala Health, Inc. | Wearable peripheral nerve stimulation for the treatment of diseases utilizing rhythmic biological processes |
-
2019
- 2019-09-24 WO PCT/US2019/052699 patent/WO2020068830A1/en not_active Ceased
- 2019-09-24 EP EP19866172.0A patent/EP3857916A4/en not_active Withdrawn
- 2019-09-24 AU AU2019346417A patent/AU2019346417A1/en not_active Abandoned
- 2019-09-24 CN CN201980077313.8A patent/CN113711623A/zh active Pending
- 2019-09-24 US US16/581,139 patent/US10835747B2/en active Active
- 2019-09-24 JP JP2021516587A patent/JP2022502139A/ja active Pending
-
2020
- 2020-03-13 US US16/818,977 patent/US10806928B2/en active Active
- 2020-10-08 US US17/066,404 patent/US11376430B2/en active Active
- 2020-12-08 US US17/115,665 patent/US11123558B2/en active Active
-
2022
- 2022-06-02 US US17/805,220 patent/US12186557B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20210085972A1 (en) | 2021-03-25 |
| US10806928B2 (en) | 2020-10-20 |
| US20210031036A1 (en) | 2021-02-04 |
| CN113711623A (zh) | 2021-11-26 |
| US11376430B2 (en) | 2022-07-05 |
| EP3857916A4 (en) | 2022-06-15 |
| JP2022502139A (ja) | 2022-01-11 |
| WO2020068830A1 (en) | 2020-04-02 |
| US12186557B2 (en) | 2025-01-07 |
| US20230145581A1 (en) | 2023-05-11 |
| US10835747B2 (en) | 2020-11-17 |
| EP3857916A1 (en) | 2021-08-04 |
| US20200094054A1 (en) | 2020-03-26 |
| US11123558B2 (en) | 2021-09-21 |
| US20200215327A1 (en) | 2020-07-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12186557B2 (en) | Auricular nerve stimulation to address patient disorders, and associated systems and methods | |
| US20210187296A1 (en) | Auricular nerve stimulation to affect brain function and/or improve wellness, and associated systems and methods | |
| US20220168568A1 (en) | Peripheral nerve stimulation device for affecting parasympathetic and sympathetic activity to achieve therapeutic effects | |
| US12551700B2 (en) | Adjustable auricular nerve stimulation devices, and associated systems and methods | |
| US20230364413A1 (en) | Systems and methods for optimizing nerve stimulation | |
| US20200297999A1 (en) | Systems and methods for applying electrical energy to treat psoriasis | |
| EP4299107B1 (en) | Systems for delivering therapy using an auricular stimulation device | |
| JP2022505493A (ja) | 片頭痛および他の頭痛状態を治療するための神経刺激 | |
| US20250152939A1 (en) | Systems and methods for promoting general wellness | |
| US20240216682A1 (en) | Systems and methods for optimizing nerve stimulation therapy | |
| US20250345605A1 (en) | Devices, systems and methods for enhancing sleep | |
| US20260061154A1 (en) | Systems and methods for nerve stimulation | |
| US20250099753A1 (en) | Wearable treatment device for non-invasive nerve stimulation | |
| US20260069863A1 (en) | Devices for nerve stimulation | |
| US20260083960A1 (en) | Devices for nerve stimulation | |
| EP4389192A1 (en) | Neural stimulation system for supporting speech and language skills of a user, especially of a user having aphasia | |
| EP4674467A1 (en) | Device for transcutaneous auricular nerve stimulation | |
| JP2025536251A (ja) | 経皮的耳介枝迷走神経刺激用ニューロ刺激装置およびシステム |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1 | Assignment before grant (sect. 113) |
Owner name: NEXTSENSE, INC. Free format text: FORMER APPLICANT(S): NESOS CORP. |
|
| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |