AU2019299836B2 - Improvements in immunogenic conjugates - Google Patents

Improvements in immunogenic conjugates

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Publication number
AU2019299836B2
AU2019299836B2 AU2019299836A AU2019299836A AU2019299836B2 AU 2019299836 B2 AU2019299836 B2 AU 2019299836B2 AU 2019299836 A AU2019299836 A AU 2019299836A AU 2019299836 A AU2019299836 A AU 2019299836A AU 2019299836 B2 AU2019299836 B2 AU 2019299836B2
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AU
Australia
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val
glu
gly
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Active
Application number
AU2019299836A
Other languages
English (en)
Other versions
AU2019299836A1 (en
Inventor
Wei Chan
Jeffery Fairman
Jon Heinrichs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vaxcyte Inc
Original Assignee
Vaxcyte Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vaxcyte Inc filed Critical Vaxcyte Inc
Publication of AU2019299836A1 publication Critical patent/AU2019299836A1/en
Application granted granted Critical
Publication of AU2019299836B2 publication Critical patent/AU2019299836B2/en
Priority to AU2025256067A priority Critical patent/AU2025256067A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0216—Bacteriodetes, e.g. Bacteroides, Ornithobacter, Porphyromonas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
AU2019299836A 2018-07-04 2019-07-01 Improvements in immunogenic conjugates Active AU2019299836B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2025256067A AU2025256067A1 (en) 2018-07-04 2025-10-21 Improvements in immunogenic conjugates

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862693981P 2018-07-04 2018-07-04
US62/693,981 2018-07-04
PCT/US2019/040131 WO2020009993A1 (en) 2018-07-04 2019-07-01 Improvements in immunogenic conjugates

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2025256067A Division AU2025256067A1 (en) 2018-07-04 2025-10-21 Improvements in immunogenic conjugates

Publications (2)

Publication Number Publication Date
AU2019299836A1 AU2019299836A1 (en) 2021-02-25
AU2019299836B2 true AU2019299836B2 (en) 2025-08-21

Family

ID=67439412

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2019299836A Active AU2019299836B2 (en) 2018-07-04 2019-07-01 Improvements in immunogenic conjugates
AU2025256067A Pending AU2025256067A1 (en) 2018-07-04 2025-10-21 Improvements in immunogenic conjugates

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2025256067A Pending AU2025256067A1 (en) 2018-07-04 2025-10-21 Improvements in immunogenic conjugates

Country Status (16)

Country Link
EP (2) EP3817775B1 (https=)
JP (2) JP7399934B2 (https=)
KR (1) KR20210042904A (https=)
CN (1) CN112543649B (https=)
AU (2) AU2019299836B2 (https=)
BR (1) BR112020026899A2 (https=)
CA (1) CA3105361A1 (https=)
DK (1) DK3817775T3 (https=)
EA (1) EA202190168A1 (https=)
ES (1) ES2989087T3 (https=)
IL (1) IL279855B2 (https=)
MX (1) MX2020014118A (https=)
PH (1) PH12020552282A1 (https=)
SG (1) SG11202012905PA (https=)
WO (1) WO2020009993A1 (https=)
ZA (1) ZA202100761B (https=)

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WO2022035816A1 (en) * 2020-08-10 2022-02-17 Inventprise, Llc Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24f
EP4200268A4 (en) 2020-08-19 2024-10-16 Vaxcyte, Inc. CARRIER PROTEIN POLYSACCHARIDE CONJUGATION PROCESS
GB202108648D0 (en) * 2021-06-17 2021-08-04 Inst De Medicina Molecular Joaeo Lobo Antunes CRM197 protein carrier

Citations (3)

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WO2010150230A1 (en) * 2009-06-25 2010-12-29 Consorzio Interuniversitario Per Lo Sviluppo Dei Sistemi A Grande Interfase Csgi Bacterial expression of an artificial gene for the production of crm197 and its derivatives
WO2014102265A1 (en) * 2012-12-27 2014-07-03 Glycovaxyn Ag Methods and compositions relating to crm197
WO2017173415A2 (en) * 2016-03-31 2017-10-05 Liffey Biotech Limited Saccharide-polypeptide conjugate compositions and methods of use thereof

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FR2763244B1 (fr) 1997-05-14 2003-08-01 Pasteur Merieux Serums Vacc Composition vaccinale multivalente a porteur mixte
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WO2014102265A1 (en) * 2012-12-27 2014-07-03 Glycovaxyn Ag Methods and compositions relating to crm197
WO2017173415A2 (en) * 2016-03-31 2017-10-05 Liffey Biotech Limited Saccharide-polypeptide conjugate compositions and methods of use thereof

Also Published As

Publication number Publication date
EP3817775B1 (en) 2024-09-04
CN112543649A (zh) 2021-03-23
JP7399934B2 (ja) 2023-12-18
KR20210042904A (ko) 2021-04-20
EP4483896A3 (en) 2025-04-02
IL279855A (en) 2021-03-01
JP2021530468A (ja) 2021-11-11
CN112543649B (zh) 2026-03-31
WO2020009993A1 (en) 2020-01-09
CA3105361A1 (en) 2020-01-09
EP4483896A2 (en) 2025-01-01
ES2989087T3 (es) 2024-11-25
SG11202012905PA (en) 2021-01-28
ZA202100761B (en) 2025-05-28
IL279855B1 (en) 2025-09-01
IL279855B2 (en) 2026-01-01
MX2020014118A (es) 2021-06-18
DK3817775T3 (da) 2024-09-16
PH12020552282A1 (en) 2021-06-28
EP3817775A1 (en) 2021-05-12
JP2024037805A (ja) 2024-03-19
EA202190168A1 (ru) 2021-06-07
AU2025256067A1 (en) 2025-11-13
BR112020026899A2 (pt) 2021-03-30
AU2019299836A1 (en) 2021-02-25
JP7796716B2 (ja) 2026-01-09

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