AU2019263294B2 - Substituted heterocyclic inhibitors of PTPN11 - Google Patents
Substituted heterocyclic inhibitors of PTPN11 Download PDFInfo
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- AU2019263294B2 AU2019263294B2 AU2019263294A AU2019263294A AU2019263294B2 AU 2019263294 B2 AU2019263294 B2 AU 2019263294B2 AU 2019263294 A AU2019263294 A AU 2019263294A AU 2019263294 A AU2019263294 A AU 2019263294A AU 2019263294 B2 AU2019263294 B2 AU 2019263294B2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862665818P | 2018-05-02 | 2018-05-02 | |
| US62/665,818 | 2018-05-02 | ||
| US201862773915P | 2018-11-30 | 2018-11-30 | |
| US62/773,915 | 2018-11-30 | ||
| PCT/US2019/030277 WO2019213318A1 (en) | 2018-05-02 | 2019-05-01 | Substituted heterocyclic inhibitors of ptpn11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2019263294A1 AU2019263294A1 (en) | 2020-12-17 |
| AU2019263294B2 true AU2019263294B2 (en) | 2024-03-21 |
Family
ID=68386765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2019263294A Active AU2019263294B2 (en) | 2018-05-02 | 2019-05-01 | Substituted heterocyclic inhibitors of PTPN11 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10954243B2 (enExample) |
| EP (1) | EP3787627A4 (enExample) |
| JP (1) | JP7297871B2 (enExample) |
| KR (1) | KR102611661B1 (enExample) |
| CN (1) | CN112351780B (enExample) |
| AU (1) | AU2019263294B2 (enExample) |
| BR (1) | BR112020022224A2 (enExample) |
| CA (1) | CA3099151A1 (enExample) |
| IL (1) | IL278297B2 (enExample) |
| MX (1) | MX2020011528A (enExample) |
| NZ (1) | NZ770260A (enExample) |
| SG (1) | SG11202010822SA (enExample) |
| WO (1) | WO2019213318A1 (enExample) |
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| CN116003321A (zh) | 2018-05-09 | 2023-04-25 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
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| AR117200A1 (es) | 2018-11-30 | 2021-07-21 | Syngenta Participations Ag | Derivados de tiazol microbiocidas |
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| CR20210271A (es) | 2018-11-30 | 2021-07-14 | Merck Sharp & Dohme | Derivados de amino triazolo quinazolina 9-sustituidos como antagonistas del receptor de adenosina, composiciones farmacéuticas y su uso |
| AR117206A1 (es) | 2018-11-30 | 2021-07-21 | Glaxosmithkline Ip Dev Ltd | Derivados de octahidropirrolo[2,1-b][1,3]tiazepin-7-carboxamido útiles en la terapia para el vih y para el tratamiento del cáncer |
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- 2019-05-01 EP EP19796849.8A patent/EP3787627A4/en active Pending
- 2019-05-01 KR KR1020207034430A patent/KR102611661B1/ko active Active
- 2019-05-01 CN CN201980029408.2A patent/CN112351780B/zh active Active
- 2019-05-01 BR BR112020022224-0A patent/BR112020022224A2/pt not_active Application Discontinuation
- 2019-05-01 SG SG11202010822SA patent/SG11202010822SA/en unknown
- 2019-05-01 WO PCT/US2019/030277 patent/WO2019213318A1/en not_active Ceased
- 2019-05-01 US US16/401,047 patent/US10954243B2/en active Active
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| Publication number | Publication date |
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| WO2019213318A1 (en) | 2019-11-07 |
| BR112020022224A2 (pt) | 2021-06-08 |
| IL278297B1 (en) | 2023-08-01 |
| JP7297871B2 (ja) | 2023-06-26 |
| CN112351780A (zh) | 2021-02-09 |
| CA3099151A1 (en) | 2019-11-07 |
| AU2019263294A1 (en) | 2020-12-17 |
| EP3787627A1 (en) | 2021-03-10 |
| SG11202010822SA (en) | 2020-11-27 |
| US20190389867A1 (en) | 2019-12-26 |
| IL278297B2 (en) | 2023-12-01 |
| CN112351780B (zh) | 2023-12-01 |
| EP3787627A4 (en) | 2021-12-01 |
| US20210317122A1 (en) | 2021-10-14 |
| US10954243B2 (en) | 2021-03-23 |
| KR20210003901A (ko) | 2021-01-12 |
| NZ770260A (en) | 2024-12-20 |
| IL278297A (enExample) | 2020-12-31 |
| MX2020011528A (es) | 2021-02-09 |
| KR102611661B1 (ko) | 2023-12-08 |
| JP2021523221A (ja) | 2021-09-02 |
| US11932643B2 (en) | 2024-03-19 |
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