AU2019247842B2 - Opioid receptor modulators and products and methods related thereto - Google Patents

Opioid receptor modulators and products and methods related thereto Download PDF

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AU2019247842B2
AU2019247842B2 AU2019247842A AU2019247842A AU2019247842B2 AU 2019247842 B2 AU2019247842 B2 AU 2019247842B2 AU 2019247842 A AU2019247842 A AU 2019247842A AU 2019247842 A AU2019247842 A AU 2019247842A AU 2019247842 B2 AU2019247842 B2 AU 2019247842B2
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compound
mmol
int
methyl
synthesis
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AU2019247842A1 (en
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Ulhas Bhatt
Pingyu Ding
Jason Duquette
Yihong Li
Larry Mcgee
Julio Cesar Medina
Alok NERURKAR
Thomas Nguyen
Corinne SADLOWSKI
Frederick SEIDL
David Sperandio
Xiaodong Wang
Zhi-Liang Wei
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Epiodyne Inc
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Epiodyne Inc
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    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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AU2019247842B2 (en) 2018-04-04 2023-08-31 Epiodyne, Inc. Opioid receptor modulators and products and methods related thereto
CN112159401B (zh) * 2019-11-05 2022-06-03 中国人民解放军军事科学院军事医学研究院 偏向性激动剂及其医药用途
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017007695A1 (en) * 2015-07-09 2017-01-12 The Regents Of The University Of California Mu opioid receptor modulators
WO2018129393A1 (en) * 2017-01-06 2018-07-12 The Regents Of The University Of California Mu opioid receptor modulators

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ210669A (en) 1983-12-27 1988-05-30 Syntex Inc Benzoxazin-4-one derivatives and pharmaceutical compositions
JPH05194406A (ja) 1991-11-12 1993-08-03 Yoshitomi Pharmaceut Ind Ltd 新規アミド化合物
IL115420A0 (en) * 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
SE9600769D0 (sv) 1996-02-28 1996-02-28 Astra Ab Compounds useful as analgesic
AU4674797A (en) 1996-10-22 1998-05-15 Ortho Pharmaceutical Corporation Phenylalaninol derivatives for the treatment of central nervous system disorders
US6900228B1 (en) 1998-03-10 2005-05-31 Research Triangle Institute Opiate compounds, methods of making and methods of use
EP1055665B1 (en) 1999-05-28 2003-10-22 Pfizer Products Inc. 3-(3-Hydroxyphenyl)-3-amino-propionamide derivatives
AU2001268951A1 (en) 2000-07-07 2002-01-21 Novo-Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
DE10252666A1 (de) 2002-11-11 2004-08-05 Grünenthal GmbH N-Piperidyl-cyclohexan-Derivate
WO2005009315A1 (fr) 2003-06-27 2005-02-03 Applications Technologiques Avancees, A.T.A. Caisson de confinement ou d'isolement d'un nouveau type
WO2005063704A1 (ja) 2003-12-25 2005-07-14 Ono Pharmaceutical Co., Ltd. アゼチジン環化合物およびその医薬
EP1598341A1 (en) 2004-05-21 2005-11-23 Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft DPP-IV inhibitors
EP1604662A1 (en) 2004-06-08 2005-12-14 Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft 1-[(3R)-Amino-4-(2-fluoro-phenyl)-butyl]-pyrrolidine-(2R)-carboxylic acid benzyl amine derivatives and related compounds as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes mellitus
WO2007076423A2 (en) 2005-12-22 2007-07-05 Smithkline Beecham Corporation INHIBITORS OF Akt ACTIVITY
US7807704B2 (en) 2006-03-30 2010-10-05 Chemocentryx, Inc. Bicyclic, nitrogen-containing compounds modulating CXCR4 and/or CCXCKR2
KR20080071476A (ko) 2007-01-30 2008-08-04 주식회사 엘지생명과학 신규한 디펩티딜 펩티데이즈 ｉｖ(ｄｐｐ-ｉｖ) 저해제
GB0813740D0 (en) 2008-07-28 2008-09-03 Angeletti P Ist Richerche Biologica Therapeutic compounds
CN101823987B (zh) 2009-03-06 2014-06-04 中国科学院上海药物研究所 一类新的dpp-ⅳ抑制剂及其制备方法和用途
GB0919426D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
CA2787037C (en) 2010-02-24 2018-04-10 Research Triangle Institute Arylpiperazine opioid receptor antagonists
EP2632897B1 (en) 2010-10-29 2014-10-01 Merz Pharma GmbH & Co. KGaA Indole derivatives and process for their preparation
WO2013006734A1 (en) 2011-07-05 2013-01-10 St. Jude Children's Research Hospital Substituted 4-phenoxyphenol analogs as modulators of proliferating cell nuclear antigen activity
CA2840317C (en) 2011-07-13 2016-11-01 Pfizer Limited Enkephalin analogues
WO2013033310A1 (en) 2011-08-31 2013-03-07 Theodore Mark Kamenecka Modulators of rev-erb
WO2013068467A1 (en) 2011-11-09 2013-05-16 Grünenthal GmbH Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with a co-containing group as vanilloid receptor ligands
WO2016067143A1 (en) * 2014-10-28 2016-05-06 Pfizer Inc. N-(2-alkyleneimino-3-phenylpropyl)acetamide compounds and their use against pain and pruritus via inhibition of trpa1 channels
US10053465B2 (en) 2015-08-26 2018-08-21 Incyte Corporation Pyrrolopyrimidine derivatives as TAM inhibitors
EP3668852A1 (en) 2017-08-17 2020-06-24 The Regents of The University of California Mu opioid receptor modulators
AU2019247842B2 (en) 2018-04-04 2023-08-31 Epiodyne, Inc. Opioid receptor modulators and products and methods related thereto

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017007695A1 (en) * 2015-07-09 2017-01-12 The Regents Of The University Of California Mu opioid receptor modulators
WO2018129393A1 (en) * 2017-01-06 2018-07-12 The Regents Of The University Of California Mu opioid receptor modulators

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