AU2019214358B2 - Modified lipidated Relaxin B chain peptides and their therapeutic use - Google Patents

Modified lipidated Relaxin B chain peptides and their therapeutic use Download PDF

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Publication number
AU2019214358B2
AU2019214358B2 AU2019214358A AU2019214358A AU2019214358B2 AU 2019214358 B2 AU2019214358 B2 AU 2019214358B2 AU 2019214358 A AU2019214358 A AU 2019214358A AU 2019214358 A AU2019214358 A AU 2019214358A AU 2019214358 B2 AU2019214358 B2 AU 2019214358B2
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amino
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AU2019214358A1 (en
Inventor
Elisabetta Bianchi
Olivier Duclos
Stéphane ILLIANO
Raffaele Ingenito
Paola MAGOTTI
Sergio Mallart
Claire MINOLETTI-HOCHEPIED
Alessia Santoprete
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Sanofi SA
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Sanofi SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2221—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2019214358A 2018-01-31 2019-01-30 Modified lipidated Relaxin B chain peptides and their therapeutic use Active AU2019214358B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18305094 2018-01-31
EP18305094.7 2018-01-31
PCT/EP2019/052298 WO2019149782A1 (en) 2018-01-31 2019-01-30 Modified lipidated relaxin b chain peptides and their therapeutic use

Publications (2)

Publication Number Publication Date
AU2019214358A1 AU2019214358A1 (en) 2020-08-20
AU2019214358B2 true AU2019214358B2 (en) 2023-05-25

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AU2019214358A Active AU2019214358B2 (en) 2018-01-31 2019-01-30 Modified lipidated Relaxin B chain peptides and their therapeutic use

Country Status (29)

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US (3) US10961295B2 (https=)
EP (1) EP3746467B1 (https=)
JP (1) JP7295871B2 (https=)
KR (1) KR102755938B1 (https=)
CN (1) CN111770934B (https=)
AR (1) AR114325A1 (https=)
AU (1) AU2019214358B2 (https=)
BR (1) BR112020014834A2 (https=)
CA (1) CA3089657A1 (https=)
CO (1) CO2020008308A2 (https=)
DK (1) DK3746467T3 (https=)
ES (1) ES3058633T3 (https=)
FI (1) FI3746467T3 (https=)
HR (1) HRP20260016T1 (https=)
IL (2) IL316406A (https=)
LT (1) LT3746467T (https=)
MA (1) MA52994A (https=)
MX (1) MX2020008096A (https=)
MY (1) MY199821A (https=)
NZ (1) NZ766762A (https=)
PH (1) PH12020551118A1 (https=)
PL (1) PL3746467T3 (https=)
PT (1) PT3746467T (https=)
RS (1) RS67606B1 (https=)
SG (1) SG11202006903WA (https=)
SI (1) SI3746467T1 (https=)
TW (1) TWI763972B (https=)
UY (1) UY38069A (https=)
WO (1) WO2019149782A1 (https=)

Families Citing this family (10)

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Publication number Priority date Publication date Assignee Title
CN110637027B (zh) 2017-02-08 2024-08-30 百时美施贵宝公司 包含药代动力学增强子的修饰的松弛素多肽及其用途
WO2019149781A1 (en) * 2018-01-31 2019-08-08 Sanofi Modified lipidated relaxin b chain peptides and their therapeutic use
MA52994A (fr) 2018-01-31 2021-05-05 Sanofi Sa Peptides à chaîne b de relaxine lipidés modifiés et leur utilisation thérapeutique
WO2022159395A1 (en) 2021-01-20 2022-07-28 Viking Therapeutics, Inc. Compositions and methods for the treatment of metabolic and liver disorders
US20240400638A1 (en) * 2021-08-23 2024-12-05 Guido MAGNI Combination of relaxin and vasopressin analogues for treatment of renal disorders or conditions
MX2024003236A (es) 2021-09-15 2024-06-19 Viking Therapeutics Inc Composiciones y metodos para el tratamiento de trastornos metabolicos y hepaticos.
WO2023086913A2 (en) 2021-11-11 2023-05-19 Tectonic Therapeutic, Inc. Relaxin-2 fusion protein analogs and methods of using same
CN115998842B (zh) * 2022-09-02 2025-08-26 郑州大学第一附属医院 一种逆转肝星形细胞激活的仿生纳米药物及其应用
KR20260035823A (ko) 2023-05-18 2026-03-13 테크토닉 오퍼레이팅 컴퍼니 인코포레이티드 렐락신-2 융합 단백질 유사체 및 이를 사용하는 방법
KR20250054870A (ko) * 2023-10-16 2025-04-24 (주)케어젠 피부 상태 개선 활성을 갖는 펩타이드 및 이의 용도

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2015157829A1 (en) * 2014-04-17 2015-10-22 The Florey Institute Of Neuroscience And Mental Health Modified relaxin b chain peptides

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BRPI0923283A2 (pt) * 2008-12-05 2017-06-06 Angiochem Inc conjugados terapêuticos de peptídeo e usos dos mesmos
EP2460527A1 (en) * 2010-01-21 2012-06-06 Sanofi Pharmaceutical composition for treating a metabolic syndrome
EP2524915A1 (en) * 2011-05-20 2012-11-21 Sanofi 2-Amino-3-(imidazol-2-yl)-pyridin-4-one derivatives and their use as VEGF receptor kinase inhibitors
TW201315739A (zh) * 2011-07-01 2013-04-16 拜耳智慧財產有限公司 鬆弛素（ｒｅｌａｘｉｎ）融合多肽類及其用途
EP2726502A1 (en) * 2011-07-01 2014-05-07 Bayer Intellectual Property GmbH Relaxin fusion polypeptides and uses thereof
JP6276690B2 (ja) * 2011-08-04 2018-02-07 ファリス バイオテック ゲーエムベーハー ヒトリラキシン−２を調製する方法
US20160152679A1 (en) 2012-05-24 2016-06-02 Angion Biomedica Corp. Relaxin-like compounds and uses thereof
CN105792851B (zh) * 2013-09-13 2023-10-10 斯克利普斯研究所 修饰的治疗剂及其组合物
EP3838285A1 (en) * 2014-04-22 2021-06-23 TXP Pharma GmbH Peptide analogues with branched amino acid probe(s)
CN110637027B (zh) * 2017-02-08 2024-08-30 百时美施贵宝公司 包含药代动力学增强子的修饰的松弛素多肽及其用途
MA52994A (fr) 2018-01-31 2021-05-05 Sanofi Sa Peptides à chaîne b de relaxine lipidés modifiés et leur utilisation thérapeutique
TW201934572A (zh) * 2018-01-31 2019-09-01 法商賽諾菲公司 經修飾之鬆弛素ｂ鏈胜肽及其治療用途
WO2019149781A1 (en) * 2018-01-31 2019-08-08 Sanofi Modified lipidated relaxin b chain peptides and their therapeutic use
TWI844709B (zh) * 2019-07-31 2024-06-11 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
US20240400638A1 (en) * 2021-08-23 2024-12-05 Guido MAGNI Combination of relaxin and vasopressin analogues for treatment of renal disorders or conditions

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2015157829A1 (en) * 2014-04-17 2015-10-22 The Florey Institute Of Neuroscience And Mental Health Modified relaxin b chain peptides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HOSSAIN, M. A. et al, "A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1", Chemical Science, 2016, vol. 7, no. 6, pages 3805-3819 *
HOSSAIN, M. A. et al, "Synthetic relaxins", Current Opinion in Chemical Biology, 2014, vol. 22, pages 47-55 *
HOSSAIN, M. A. et al, "The Minimal Active Structure of Human Relaxin-2", Journal of Biological Chemistry, 2011, vol. 286, no. 43, pages 37555-37565 *

Also Published As

Publication number Publication date
IL276170B1 (en) 2024-11-01
WO2019149782A1 (en) 2019-08-08
KR102755938B1 (ko) 2025-01-20
UY38069A (es) 2019-08-30
IL316406A (en) 2024-12-01
JP7295871B2 (ja) 2023-06-21
ES3058633T3 (en) 2026-03-12
BR112020014834A2 (pt) 2020-12-08
US20190233494A1 (en) 2019-08-01
CN111770934B (zh) 2024-10-18
TW201940505A (zh) 2019-10-16
KR20200116085A (ko) 2020-10-08
US10961295B2 (en) 2021-03-30
IL276170B2 (en) 2025-03-01
TWI763972B (zh) 2022-05-11
DK3746467T3 (da) 2026-01-12
SI3746467T1 (sl) 2026-02-27
PT3746467T (pt) 2026-01-13
RS67606B1 (sr) 2026-01-30
SG11202006903WA (en) 2020-08-28
NZ766762A (en) 2026-03-27
US20210292387A1 (en) 2021-09-23
CN111770934A (zh) 2020-10-13
EP3746467A1 (en) 2020-12-09
CA3089657A1 (en) 2019-08-08
FI3746467T3 (fi) 2026-01-16
RU2020126210A (ru) 2022-02-28
LT3746467T (lt) 2026-01-26
CO2020008308A2 (es) 2020-10-30
PH12020551118A1 (en) 2021-07-05
MY199821A (en) 2023-11-23
PL3746467T3 (pl) 2026-04-13
MA52994A (fr) 2021-05-05
US20240218042A1 (en) 2024-07-04
AU2019214358A1 (en) 2020-08-20
IL276170A (en) 2020-09-30
AR114325A1 (es) 2020-08-19
US11725036B2 (en) 2023-08-15
HRP20260016T1 (hr) 2026-02-27
MX2020008096A (es) 2020-09-24
EP3746467B1 (en) 2025-10-08
JP2021512099A (ja) 2021-05-13

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