AU2018346361B2 - Gluconic acid derivatives for use in the treatment and/or prevention of microbial infections - Google Patents

Gluconic acid derivatives for use in the treatment and/or prevention of microbial infections Download PDF

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Publication number
AU2018346361B2
AU2018346361B2 AU2018346361A AU2018346361A AU2018346361B2 AU 2018346361 B2 AU2018346361 B2 AU 2018346361B2 AU 2018346361 A AU2018346361 A AU 2018346361A AU 2018346361 A AU2018346361 A AU 2018346361A AU 2018346361 B2 AU2018346361 B2 AU 2018346361B2
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AU
Australia
Prior art keywords
compound
formula
vaginal
infection
lactone
Prior art date
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Active
Application number
AU2018346361A
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English (en)
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AU2018346361A1 (en
Inventor
Ulf Ellervik
Sophie MANNER
Olov Sterner
Helena STREVENS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gedea Biotech AB
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Gedea Biotech AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of AU2018346361A1 publication Critical patent/AU2018346361A1/en
Application granted granted Critical
Publication of AU2018346361B2 publication Critical patent/AU2018346361B2/en
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/126—Acids containing more than four carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2018346361A 2017-10-06 2018-10-05 Gluconic acid derivatives for use in the treatment and/or prevention of microbial infections Active AU2018346361B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17195192.4 2017-10-06
EP17195192 2017-10-06
PCT/EP2018/077129 WO2019068862A1 (en) 2017-10-06 2018-10-05 GLUCONIC ACID DERIVATIVES FOR USE IN THE TREATMENT AND / OR PREVENTION OF MICROBIAL INFECTIONS

Publications (2)

Publication Number Publication Date
AU2018346361A1 AU2018346361A1 (en) 2020-05-14
AU2018346361B2 true AU2018346361B2 (en) 2024-07-25

Family

ID=60185986

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018346361A Active AU2018346361B2 (en) 2017-10-06 2018-10-05 Gluconic acid derivatives for use in the treatment and/or prevention of microbial infections

Country Status (21)

Country Link
US (3) US11612584B2 (enExample)
EP (1) EP3691625B1 (enExample)
JP (1) JP7424636B2 (enExample)
KR (1) KR102650182B1 (enExample)
CN (1) CN111182895B (enExample)
AU (1) AU2018346361B2 (enExample)
BR (1) BR112020006931A2 (enExample)
CA (1) CA3078451A1 (enExample)
CL (1) CL2020000859A1 (enExample)
EA (1) EA202090750A1 (enExample)
ES (1) ES3017694T3 (enExample)
HU (1) HUE070746T2 (enExample)
IL (1) IL273297B2 (enExample)
MX (1) MX2020003660A (enExample)
MY (1) MY205944A (enExample)
PH (1) PH12020550222A1 (enExample)
PL (1) PL3691625T3 (enExample)
SG (1) SG11202002494WA (enExample)
UA (1) UA126590C2 (enExample)
WO (1) WO2019068862A1 (enExample)
ZA (1) ZA202001605B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019068862A1 (en) 2017-10-06 2019-04-11 Gedea Biotech Ab GLUCONIC ACID DERIVATIVES FOR USE IN THE TREATMENT AND / OR PREVENTION OF MICROBIAL INFECTIONS
MA56011A (fr) 2019-04-05 2022-04-06 Gedea Biotech Ab Formulation de comprimé vaginal
CN114751878B (zh) * 2022-03-29 2023-06-16 青岛农业大学 一种BcTol1基因靶向剂及其应用
EP4731203A1 (en) * 2023-06-22 2026-04-29 Gedea Biotech AB Compositions for promoting growth of lactobacillus crispatus

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1764100A2 (en) * 2005-09-12 2007-03-21 Johnson & Johnson Consumer Companies, Inc. Compositions and methods for reducing vaginal pH
US20080058421A1 (en) * 2006-09-05 2008-03-06 John Alex Lopes Compositions for cleaning and disinfecting nasal tract and sinus cavity
WO2010129443A2 (en) * 2009-05-05 2010-11-11 The Procter & Gamble Company Hygiene article having calcium sugar acid salt
WO2016141946A1 (en) * 2015-03-11 2016-09-15 Jens Jørgen Pedersen Use of zinc and copper gluconate in the treatment of methicillin-resistant staphylococcus aureus

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IT1278868B1 (it) 1995-10-27 1997-11-28 Sanitaria Scaligera Spa Metodo per l'ottenimento di un materiale riassorbibile atto ad essere utilizzato come elemento di rivestimento per la prevenzione di
AUPP839499A0 (en) 1999-01-29 1999-02-25 Australian National University, The A method for controlling plant pathogens, and agents useful for same
JP3745612B2 (ja) 2000-10-31 2006-02-15 西川ゴム工業株式会社 ポリヒドロキシカルボン酸の製造方法
US20060172007A1 (en) * 2001-05-01 2006-08-03 Nawaz Ahmad Compositions and methods for reducing vaginal pH
US20030017207A1 (en) * 2001-05-01 2003-01-23 Lin Shun Y. Compositions and methods for treating vulvovaginitis and vaginosis
US7569530B1 (en) 2003-06-20 2009-08-04 The Procter & Gamble Company Antimicrobial compositions, products and methods employing same
CA2487270C (en) 2002-06-21 2010-10-26 The Procter & Gamble Company Antimicrobial compositions, products and methods employing same
US7547454B2 (en) * 2002-11-07 2009-06-16 Shyam K Gupta Hydroxy acid complexes for antiaging and skin renovation
US20040126369A1 (en) * 2002-12-30 2004-07-01 Richard Payne Delivery of peroxide-generating enzymes to the vaginal tract
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
US20050260243A1 (en) * 2004-04-26 2005-11-24 The Procter & Gamble Company Method of treating microbial plant diseases
US20050271711A1 (en) 2004-04-26 2005-12-08 The Procter & Gamble Company Therapeutic antimicrobial compositions and methods
AU2006209263A1 (en) 2005-09-12 2007-03-29 Mcneil-Ppc, Inc. Anhydrous composition containing an acid-acid buffer system
US20070059278A1 (en) 2005-09-12 2007-03-15 Nawaz Ahmad Anhydrous composition containing an acid-acid buffer system
WO2008108834A2 (en) * 2006-11-09 2008-09-12 Northwestern University Inhibitors of the mevalonate pathway of streptococcus pneumoniae
JP2008283893A (ja) * 2007-05-16 2008-11-27 Sumitomo Chemical Co Ltd 家禽用コクシジウム感染抑制剤及びそれを用いたコクシジウム感染抑制方法
CN102070774B (zh) 2010-11-25 2012-08-22 华南师范大学 单糖或其糖醇与乳酸的共聚物的制备方法
EP2704694A4 (en) 2011-05-02 2014-11-19 Aptalis Pharmatech Inc RAPID DISSOLUTION TABLET COMPOSITIONS FOR VAGINAL DELIVERY
US9937214B2 (en) 2013-11-08 2018-04-10 Suzhou Osel Bio-Pharm Co., Ltd. Lactobacillus crispatus and application thereof
MX382396B (es) * 2016-04-06 2025-03-13 Gedea Biotech Ab Glucono delta-lactona para el tratamiento de infecciones fúngicas vaginales.
CA3040422A1 (en) 2016-10-13 2018-04-19 Catalent U.K. Swindon Zydis Limited Lyophilized pharmaceutical compositions for vaginal delivery
KR101841976B1 (ko) 2017-06-07 2018-05-14 조영진 식물 추출물을 포함하는 항진균 및 항균 조성물
WO2019068862A1 (en) 2017-10-06 2019-04-11 Gedea Biotech Ab GLUCONIC ACID DERIVATIVES FOR USE IN THE TREATMENT AND / OR PREVENTION OF MICROBIAL INFECTIONS
MA56011A (fr) 2019-04-05 2022-04-06 Gedea Biotech Ab Formulation de comprimé vaginal

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1764100A2 (en) * 2005-09-12 2007-03-21 Johnson & Johnson Consumer Companies, Inc. Compositions and methods for reducing vaginal pH
US20080058421A1 (en) * 2006-09-05 2008-03-06 John Alex Lopes Compositions for cleaning and disinfecting nasal tract and sinus cavity
WO2010129443A2 (en) * 2009-05-05 2010-11-11 The Procter & Gamble Company Hygiene article having calcium sugar acid salt
WO2016141946A1 (en) * 2015-03-11 2016-09-15 Jens Jørgen Pedersen Use of zinc and copper gluconate in the treatment of methicillin-resistant staphylococcus aureus

Also Published As

Publication number Publication date
ZA202001605B (en) 2023-12-20
IL273297B1 (en) 2024-02-01
US11612584B2 (en) 2023-03-28
UA126590C2 (uk) 2022-11-02
EP3691625C0 (en) 2025-02-19
JP7424636B2 (ja) 2024-01-30
PL3691625T3 (pl) 2025-05-12
IL273297A (en) 2020-04-30
BR112020006931A2 (pt) 2020-10-06
EP3691625B1 (en) 2025-02-19
HUE070746T2 (hu) 2025-07-28
ES3017694T3 (en) 2025-05-13
EP3691625A1 (en) 2020-08-12
WO2019068862A1 (en) 2019-04-11
US20200253925A1 (en) 2020-08-13
AU2018346361A1 (en) 2020-05-14
US12226396B2 (en) 2025-02-18
US20230181523A1 (en) 2023-06-15
CL2020000859A1 (es) 2020-10-02
PH12020550222A1 (en) 2021-02-15
MX2020003660A (es) 2020-08-03
IL273297B2 (en) 2024-06-01
JP2020536862A (ja) 2020-12-17
SG11202002494WA (en) 2020-04-29
CN111182895B (zh) 2024-05-14
KR102650182B1 (ko) 2024-03-21
CN111182895A (zh) 2020-05-19
CA3078451A1 (en) 2019-04-11
EA202090750A1 (ru) 2020-11-11
MY205944A (en) 2024-11-21
US20250144070A1 (en) 2025-05-08
KR20200060413A (ko) 2020-05-29

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