AU2018316742B2 - Binding agents - Google Patents

Binding agents Download PDF

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Publication number
AU2018316742B2
AU2018316742B2 AU2018316742A AU2018316742A AU2018316742B2 AU 2018316742 B2 AU2018316742 B2 AU 2018316742B2 AU 2018316742 A AU2018316742 A AU 2018316742A AU 2018316742 A AU2018316742 A AU 2018316742A AU 2018316742 B2 AU2018316742 B2 AU 2018316742B2
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AU
Australia
Prior art keywords
seq
amino acid
antigen
mvh
mvl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2018316742A
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English (en)
Other versions
AU2018316742A1 (en
Inventor
Jonathan James William FINLAY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centessa Pharmaceuticals (UK) Ltd
Original Assignee
Centessa Pharmaceuticals (UK) Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1713298.6A external-priority patent/GB201713298D0/en
Priority claimed from GBGB1802595.7A external-priority patent/GB201802595D0/en
Priority claimed from GBGB1808570.4A external-priority patent/GB201808570D0/en
Application filed by Centessa Pharmaceuticals (UK) Ltd filed Critical Centessa Pharmaceuticals (UK) Ltd
Publication of AU2018316742A1 publication Critical patent/AU2018316742A1/en
Assigned to CENTESSA PHARMACEUTICALS (UK) LIMITED reassignment CENTESSA PHARMACEUTICALS (UK) LIMITED Amend patent request/document other than specification (104) Assignors: Ultrahuman Four Limited
Application granted granted Critical
Publication of AU2018316742B2 publication Critical patent/AU2018316742B2/en
Priority to AU2025204808A priority Critical patent/AU2025204808A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001129—Molecules with a "CD" designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2018316742A 2017-08-18 2018-08-17 Binding agents Active AU2018316742B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2025204808A AU2025204808A1 (en) 2017-08-18 2025-06-26 Binding agents

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1713298.6A GB201713298D0 (en) 2017-08-18 2017-08-18 Binding agents
GB1713298.6 2017-08-18
GB1802595.7 2018-02-16
GBGB1802595.7A GB201802595D0 (en) 2018-02-16 2018-02-16 Binding agents
GBGB1808570.4A GB201808570D0 (en) 2018-05-24 2018-05-24 Binding agents
GB1808570.4 2018-05-24
PCT/GB2018/052347 WO2019034895A1 (en) 2017-08-18 2018-08-17 LIAISON AGENTS

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2025204808A Division AU2025204808A1 (en) 2017-08-18 2025-06-26 Binding agents

Publications (2)

Publication Number Publication Date
AU2018316742A1 AU2018316742A1 (en) 2020-03-19
AU2018316742B2 true AU2018316742B2 (en) 2025-04-10

Family

ID=63371721

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2018316742A Active AU2018316742B2 (en) 2017-08-18 2018-08-17 Binding agents
AU2025204808A Pending AU2025204808A1 (en) 2017-08-18 2025-06-26 Binding agents

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2025204808A Pending AU2025204808A1 (en) 2017-08-18 2025-06-26 Binding agents

Country Status (14)

Country Link
US (4) US10683350B2 (enExample)
EP (2) EP4435008A2 (enExample)
JP (4) JP7256580B2 (enExample)
KR (1) KR102781208B1 (enExample)
CN (1) CN111212852A (enExample)
AU (2) AU2018316742B2 (enExample)
BR (1) BR112020003306A2 (enExample)
CA (1) CA3072998A1 (enExample)
ES (1) ES2983651T3 (enExample)
IL (1) IL272643A (enExample)
MX (1) MX2020001873A (enExample)
RU (1) RU2020109544A (enExample)
SG (1) SG11202001425TA (enExample)
WO (1) WO2019034895A1 (enExample)

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WO2019034895A1 (en) 2017-08-18 2019-02-21 Ultrahuman Four Limited LIAISON AGENTS
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GB201906685D0 (en) 2019-05-13 2019-06-26 Ultrahuman Six Ltd Activatable protein constructs and uses thereof
EP3986935A4 (en) 2019-06-19 2023-08-30 Lepu Biopharma Co., Ltd. Anti-cd47 antibodies and uses thereof
AU2020315598B2 (en) 2019-07-16 2024-12-12 Gilead Sciences, Inc. HIV vaccines and methods of making and using
EP4034171A1 (en) * 2019-09-23 2022-08-03 Cytomx Therapeutics Inc. Anti-cd47 antibodies, activatable anti-cd47 antibodies, and methods of use thereof
PH12022550835A1 (en) 2019-10-18 2023-07-03 Forty Seven Inc Combination therapies for treating myelodysplastic syndromes and acute myeloid leukemia
NZ786589A (en) 2019-10-31 2025-03-28 Forty Seven Llc Anti-cd47 and anti-cd20 based treatment of blood cancer
CN115362003B (zh) 2019-12-24 2024-03-22 卡尔那生物科学株式会社 二酰基甘油激酶调节化合物
WO2021142269A1 (en) * 2020-01-10 2021-07-15 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for modulation of genes associated with muscle atrophy
WO2021142331A1 (en) * 2020-01-10 2021-07-15 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for modulation of genes associated with cardiac muscle disease
TWI890283B (zh) 2020-02-14 2025-07-11 美商基利科學股份有限公司 結合ccr8之抗體及融合蛋白及其用途
US12091681B2 (en) 2020-03-27 2024-09-17 Mendus B.V. Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
WO2022003568A1 (en) 2020-06-30 2022-01-06 Dcprime B.V. Use of leukemia-derived cells in ovarian cancer vaccines
CN111733162A (zh) * 2020-07-01 2020-10-02 江苏莱森生物科技研究院有限公司 一种经基因修饰的cd47蛋白及其单克隆抗体和应用
WO2022007947A1 (zh) * 2020-07-10 2022-01-13 信达生物制药(苏州)有限公司 抗cd47抗体或其抗原结合片段和dna甲基化转移酶抑制剂的组合及其用途
KR102757518B1 (ko) * 2020-12-07 2025-01-21 (주)이노베이션바이오 Cd47에 특이적인 항체 및 이의 용도
WO2022140659A2 (en) 2020-12-23 2022-06-30 D-10 Therapeutics, Inc. Anti-cd47 antibodies and uses thereof
WO2022190058A1 (en) 2021-03-12 2022-09-15 Dcprime B.V. Methods of vaccination and use of cd47 blockade
CN112794903B (zh) * 2021-04-14 2021-06-25 广州市雷德生物科技有限公司 一种特异性结合IFN-γ的抗体及其应用
TW202302145A (zh) 2021-04-14 2023-01-16 美商基利科學股份有限公司 ＣＤ４７／ＳＩＲＰα結合及ＮＥＤＤ８活化酶Ｅ１調節次單元之共抑制以用於治療癌症
EP4359413A1 (en) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
JP7651018B2 (ja) 2021-06-23 2025-03-25 ギリアード サイエンシーズ， インコーポレイテッド ジアシルグリセロールキナーゼ調節化合物
MX2023014762A (es) 2021-06-23 2024-01-15 Gilead Sciences Inc Compuestos moduladores de diacilglicerol quinasa.
CN117355531A (zh) 2021-06-23 2024-01-05 吉利德科学公司 二酰基甘油激酶调节化合物
US20250129155A1 (en) * 2021-06-30 2025-04-24 Innobation Bio Co., Ltd. Humanized antibody specific for cd47 and pharmaceutical composition for preventing or treating cd47-related diseases comprising the same
WO2023070353A1 (en) * 2021-10-27 2023-05-04 Adagene Pte. Ltd. Anti-cd47 antibodies and methods of use thereof
EP4423078A1 (en) 2021-10-28 2024-09-04 Gilead Sciences, Inc. Pyridizin-3(2h)-one derivatives
PE20241186A1 (es) 2021-10-29 2024-06-03 Gilead Sciences Inc Compuestos de cd73
US20240124412A1 (en) 2021-12-22 2024-04-18 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
CN118488948A (zh) 2021-12-22 2024-08-13 吉利德科学公司 Ikaros锌指家族降解剂及其用途
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IL314395A (en) 2022-01-31 2024-09-01 Centessa Pharmaceuticals Uk Ltd Bispecific anti-CD47 and anti-PD-L1 activatable proteins and their uses
PL4245756T3 (pl) 2022-03-17 2025-02-17 Gilead Sciences, Inc. Środki degradujące palec cynkowy z rodziny ikaros i ich zastosowania
AU2023240346A1 (en) 2022-03-24 2024-09-19 Gilead Sciences, Inc. Combination therapy for treating trop-2 expressing cancers
WO2023191117A1 (ko) * 2022-03-28 2023-10-05 (주)이노베이션바이오 친화도가 성숙된 cd47에 특이적인 인간화 항체
TWI876305B (zh) 2022-04-05 2025-03-11 美商基利科學股份有限公司 用於治療結腸直腸癌之組合療法
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US20240091351A1 (en) 2022-09-21 2024-03-21 Gilead Sciences, Inc. FOCAL IONIZING RADIATION AND CD47/SIRPa DISRUPTION ANTICANCER COMBINATION THERAPY
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EP4774280A1 (en) 2023-09-08 2026-07-15 Gilead Sciences, Inc. Kras g12d modulating compounds
US20250109147A1 (en) 2023-09-08 2025-04-03 Gilead Sciences, Inc. Kras g12d modulating compounds
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US20250230168A1 (en) 2023-12-22 2025-07-17 Gilead Sciences, Inc. Azaspiro wrn inhibitors
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US20260098049A1 (en) 2024-08-12 2026-04-09 Gilead Sciences, Inc. Kras modulating compounds
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WO2014093678A2 (en) * 2012-12-12 2014-06-19 Frazier William A Therapeutic cd47 antibodies

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Also Published As

Publication number Publication date
US10683350B2 (en) 2020-06-16
JP7564274B2 (ja) 2024-10-08
KR102781208B1 (ko) 2025-03-17
WO2019034895A1 (en) 2019-02-21
CA3072998A1 (en) 2019-02-21
US20220332819A1 (en) 2022-10-20
JP2023073339A (ja) 2023-05-25
ES2983651T3 (es) 2024-10-24
JP2026094226A (ja) 2026-06-09
SG11202001425TA (en) 2020-03-30
RU2020109544A (ru) 2021-09-20
KR20200038533A (ko) 2020-04-13
US11370840B2 (en) 2022-06-28
EP4435008A2 (en) 2024-09-25
IL272643A (en) 2020-03-31
JP7825015B2 (ja) 2026-03-05
US20250109202A1 (en) 2025-04-03
JP2020531048A (ja) 2020-11-05
BR112020003306A2 (pt) 2020-08-25
EP3668897A1 (en) 2020-06-24
US20190375840A1 (en) 2019-12-12
EP3668897B1 (en) 2024-06-05
US20200277375A1 (en) 2020-09-03
AU2018316742A1 (en) 2020-03-19
CN111212852A (zh) 2020-05-29
JP2025000787A (ja) 2025-01-07
JP7256580B2 (ja) 2023-04-12
AU2025204808A1 (en) 2025-07-17
MX2020001873A (es) 2020-10-22

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Owner name: CENTESSA PHARMACEUTICALS (UK) LIMITED

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