BR112020003306A2 - agentes de ligação - Google Patents

agentes de ligação Download PDF

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Publication number
BR112020003306A2
BR112020003306A2 BR112020003306-5A BR112020003306A BR112020003306A2 BR 112020003306 A2 BR112020003306 A2 BR 112020003306A2 BR 112020003306 A BR112020003306 A BR 112020003306A BR 112020003306 A2 BR112020003306 A2 BR 112020003306A2
Authority
BR
Brazil
Prior art keywords
seq
amino acid
antigen
lcdr2
lcdr3
Prior art date
Application number
BR112020003306-5A
Other languages
English (en)
Portuguese (pt)
Inventor
William James Jonathan Finlay
Original Assignee
Ultrahuman Four Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1713298.6A external-priority patent/GB201713298D0/en
Priority claimed from GBGB1802595.7A external-priority patent/GB201802595D0/en
Priority claimed from GBGB1808570.4A external-priority patent/GB201808570D0/en
Application filed by Ultrahuman Four Limited filed Critical Ultrahuman Four Limited
Publication of BR112020003306A2 publication Critical patent/BR112020003306A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • A61K39/001129Molecules with a "CD" designation not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BR112020003306-5A 2017-08-18 2018-08-17 agentes de ligação BR112020003306A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB1713298.6 2017-08-18
GBGB1713298.6A GB201713298D0 (en) 2017-08-18 2017-08-18 Binding agents
GBGB1802595.7A GB201802595D0 (en) 2018-02-16 2018-02-16 Binding agents
GB1802595.7 2018-02-16
GBGB1808570.4A GB201808570D0 (en) 2018-05-24 2018-05-24 Binding agents
GB1808570.4 2018-05-24
PCT/GB2018/052347 WO2019034895A1 (en) 2017-08-18 2018-08-17 LIAISON AGENTS

Publications (1)

Publication Number Publication Date
BR112020003306A2 true BR112020003306A2 (pt) 2020-08-25

Family

ID=63371721

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112020003306-5A BR112020003306A2 (pt) 2017-08-18 2018-08-17 agentes de ligação

Country Status (14)

Country Link
US (4) US10683350B2 (enExample)
EP (2) EP4435008A2 (enExample)
JP (3) JP7256580B2 (enExample)
KR (1) KR102781208B1 (enExample)
CN (1) CN111212852A (enExample)
AU (2) AU2018316742B2 (enExample)
BR (1) BR112020003306A2 (enExample)
CA (1) CA3072998A1 (enExample)
ES (1) ES2983651T3 (enExample)
IL (1) IL272643A (enExample)
MX (1) MX2020001873A (enExample)
RU (1) RU2020109544A (enExample)
SG (1) SG11202001425TA (enExample)
WO (1) WO2019034895A1 (enExample)

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EP4435008A2 (en) 2017-08-18 2024-09-25 Centessa Pharmaceuticals (UK) Limited Binding agents
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JP7454645B2 (ja) 2019-07-16 2024-03-22 ギリアード サイエンシーズ, インコーポレイテッド Hivワクチン並びにその作製方法及び使用方法
CN114650844A (zh) * 2019-09-23 2022-06-21 西托姆克斯治疗公司 抗cd47抗体、可活化抗cd47抗体及其使用方法
EP4045083B1 (en) 2019-10-18 2024-01-10 Forty Seven, Inc. Combination therapies for treating myelodysplastic syndromes and acute myeloid leukemia
NZ786589A (en) 2019-10-31 2025-03-28 Forty Seven Llc Anti-cd47 and anti-cd20 based treatment of blood cancer
CN117736207A (zh) 2019-12-24 2024-03-22 卡尔那生物科学株式会社 二酰基甘油激酶调节化合物
WO2021142269A1 (en) * 2020-01-10 2021-07-15 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for modulation of genes associated with muscle atrophy
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CA3172449A1 (en) 2020-03-27 2021-09-30 Erik Hans MANTING Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
CN116133679A (zh) 2020-06-30 2023-05-16 门德斯有限公司 白血病衍生细胞在卵巢癌疫苗中的用途
CN111733162A (zh) * 2020-07-01 2020-10-02 江苏莱森生物科技研究院有限公司 一种经基因修饰的cd47蛋白及其单克隆抗体和应用
WO2022007947A1 (zh) * 2020-07-10 2022-01-13 信达生物制药(苏州)有限公司 抗cd47抗体或其抗原结合片段和dna甲基化转移酶抑制剂的组合及其用途
KR102757518B1 (ko) * 2020-12-07 2025-01-21 (주)이노베이션바이오 Cd47에 특이적인 항체 및 이의 용도
US12071481B2 (en) 2020-12-23 2024-08-27 D-10 Therapeutics, Inc. Anti-CD47 antibodies and uses thereof
WO2022190058A1 (en) 2021-03-12 2022-09-15 Dcprime B.V. Methods of vaccination and use of cd47 blockade
CN112794903B (zh) * 2021-04-14 2021-06-25 广州市雷德生物科技有限公司 一种特异性结合IFN-γ的抗体及其应用
TW202302145A (zh) 2021-04-14 2023-01-16 美商基利科學股份有限公司 CD47/SIRPα結合及NEDD8活化酶E1調節次單元之共抑制以用於治療癌症
EP4359415A1 (en) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
CN117480155A (zh) 2021-06-23 2024-01-30 吉利德科学公司 二酰基甘油激酶调节化合物
CN117377671A (zh) 2021-06-23 2024-01-09 吉利德科学公司 二酰基甘油激酶调节化合物
JP7686091B2 (ja) 2021-06-23 2025-05-30 ギリアード サイエンシーズ, インコーポレイテッド ジアシルグリセロールキナーゼ調節化合物
JP2024527335A (ja) * 2021-06-30 2024-07-24 イノベイション バイオ カンパニー リミテッド Cd47に特異的なヒト化抗体およびそれを含むcd47関連疾患の予防または治療用医薬組成物
WO2023070353A1 (en) * 2021-10-27 2023-05-04 Adagene Pte. Ltd. Anti-cd47 antibodies and methods of use thereof
WO2023076983A1 (en) 2021-10-28 2023-05-04 Gilead Sciences, Inc. Pyridizin-3(2h)-one derivatives
JP7787991B2 (ja) 2021-10-29 2025-12-17 ギリアード サイエンシーズ, インコーポレイテッド Cd73化合物
AU2022419982A1 (en) 2021-12-22 2024-06-06 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
WO2023122615A1 (en) 2021-12-22 2023-06-29 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
TW202340168A (zh) 2022-01-28 2023-10-16 美商基利科學股份有限公司 Parp7抑制劑
AU2023210844A1 (en) 2022-01-31 2024-08-01 Centessa Pharmaceuticals (Uk) Limited Activatable bispecific anti-cd47 and anti-pd-l1 proteins and uses thereof
TW202346277A (zh) 2022-03-17 2023-12-01 美商基利科學股份有限公司 Ikaros鋅指家族降解劑及其用途
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TWI876305B (zh) 2022-04-05 2025-03-11 美商基利科學股份有限公司 用於治療結腸直腸癌之組合療法
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Also Published As

Publication number Publication date
MX2020001873A (es) 2020-10-22
RU2020109544A (ru) 2021-09-20
AU2018316742A1 (en) 2020-03-19
JP2025000787A (ja) 2025-01-07
KR20200038533A (ko) 2020-04-13
JP2020531048A (ja) 2020-11-05
AU2025204808A1 (en) 2025-07-17
US11370840B2 (en) 2022-06-28
KR102781208B1 (ko) 2025-03-17
JP2023073339A (ja) 2023-05-25
EP3668897B1 (en) 2024-06-05
EP4435008A2 (en) 2024-09-25
US20220332819A1 (en) 2022-10-20
CA3072998A1 (en) 2019-02-21
ES2983651T3 (es) 2024-10-24
US20190375840A1 (en) 2019-12-12
AU2018316742B2 (en) 2025-04-10
SG11202001425TA (en) 2020-03-30
US20250109202A1 (en) 2025-04-03
EP3668897A1 (en) 2020-06-24
JP7256580B2 (ja) 2023-04-12
WO2019034895A1 (en) 2019-02-21
US20200277375A1 (en) 2020-09-03
US10683350B2 (en) 2020-06-16
IL272643A (en) 2020-03-31
CN111212852A (zh) 2020-05-29
JP7564274B2 (ja) 2024-10-08

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Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B25G Requested change of headquarter approved

Owner name: ULTRAHUMAN FOUR LIMITED (GB)

B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]