AU2018306329B8 - Methods of protecting vascular integrity induced by targeted radiation therapy - Google Patents

Methods of protecting vascular integrity induced by targeted radiation therapy Download PDF

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Publication number
AU2018306329B8
AU2018306329B8 AU2018306329A AU2018306329A AU2018306329B8 AU 2018306329 B8 AU2018306329 B8 AU 2018306329B8 AU 2018306329 A AU2018306329 A AU 2018306329A AU 2018306329 A AU2018306329 A AU 2018306329A AU 2018306329 B8 AU2018306329 B8 AU 2018306329B8
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AU
Australia
Prior art keywords
subject
minutes
radiation therapy
tpo mimetic
cancer
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Ceased
Application number
AU2018306329A
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English (en)
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AU2018306329B2 (en
AU2018306329A1 (en
AU2018306329A8 (en
Inventor
Gary Eichenbaum
Alfred Tonelli
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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Publication of AU2018306329A1 publication Critical patent/AU2018306329A1/en
Publication of AU2018306329B2 publication Critical patent/AU2018306329B2/en
Application granted granted Critical
Publication of AU2018306329B8 publication Critical patent/AU2018306329B8/en
Publication of AU2018306329A8 publication Critical patent/AU2018306329A8/en
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Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/196—Thrombopoietin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1094—Shielding, protecting against radiation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Radiation-Therapy Devices (AREA)
  • Medicinal Preparation (AREA)
AU2018306329A 2017-07-26 2018-07-26 Methods of protecting vascular integrity induced by targeted radiation therapy Ceased AU2018306329B8 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762537049P 2017-07-26 2017-07-26
US62/537,049 2017-07-26
PCT/US2018/043821 WO2019023418A1 (en) 2017-07-26 2018-07-26 METHODS FOR PROTECTING VASCULAR INTEGRITY INDUCED BY TARGETED RADIOTHERAPY

Publications (4)

Publication Number Publication Date
AU2018306329A1 AU2018306329A1 (en) 2020-02-13
AU2018306329B2 AU2018306329B2 (en) 2024-09-19
AU2018306329B8 true AU2018306329B8 (en) 2025-02-20
AU2018306329A8 AU2018306329A8 (en) 2025-02-20

Family

ID=63165522

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018306329A Ceased AU2018306329B8 (en) 2017-07-26 2018-07-26 Methods of protecting vascular integrity induced by targeted radiation therapy

Country Status (11)

Country Link
US (1) US12251424B2 (enExample)
EP (1) EP3658191A1 (enExample)
JP (1) JP7481252B2 (enExample)
KR (1) KR102688415B1 (enExample)
CN (1) CN111432845B (enExample)
AU (1) AU2018306329B8 (enExample)
BR (1) BR112020001367A2 (enExample)
CA (1) CA3070442A1 (enExample)
IL (1) IL272213A (enExample)
PH (1) PH12020500166A1 (enExample)
WO (1) WO2019023418A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA54820A (fr) * 2019-01-25 2021-12-01 Janssen Pharmaceutica Nv Méthodes d'atténuation d'une lésion hépatique et de promotion d'une hypertrophie hépatique, de régénération du foie et de prise de greffe de cellules hépatiques conjointement avec des traitements par radiothérapie et/ou radiomimétiques
CN113402614A (zh) * 2021-04-22 2021-09-17 山东泉港药业有限公司 血小板生成素拟肽融合蛋白(fc-tmp)编码基因与应用
EP4525907A2 (en) * 2022-05-20 2025-03-26 JANSSEN Pharmaceutica NV Methods for mitigating lung injury in conjunction with exposure to radiation and/or radiation or radiomimetic treatments
WO2024095178A1 (en) 2022-11-01 2024-05-10 Janssen Pharmaceutica Nv Thrombopoietin mimetic for use in the treatment of acute liver failure
WO2025002113A1 (zh) * 2023-06-26 2025-01-02 上海济煜医药科技有限公司 一种人血小板生成素受体激动剂的融合蛋白

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040750A1 (en) * 1995-06-07 1996-12-19 Glaxo Group Limited Peptides and compounds that bind to a thrombopoietin receptor
WO1998025965A2 (en) * 1996-12-11 1998-06-18 Glaxo Group Limited Peptides and compounds that bind to the thrombopoietin receptor
WO2005023834A2 (en) * 2003-08-28 2005-03-17 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to thrombopoietin receptors
WO2007087428A2 (en) * 2006-01-25 2007-08-02 Amgen Inc. Thrombopoietic compounds
US20080119384A1 (en) * 2004-08-16 2008-05-22 Yurkow Edward J Use of TPO peptide compounds and pharmaceutical compostions in the treatment of anemia
JP2012518408A (ja) * 2009-02-24 2012-08-16 アレクシオン ファーマシューティカルズ， インコーポレイテッド 治療用ｔｐｏ／ｅｐｏ模倣ペプチドを含む抗体

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AU680422B2 (en) 1992-06-11 1997-07-31 Alkermes Controlled Therapeutics, Inc. Erythropoietin drug delivery system
US5354934A (en) 1993-02-04 1994-10-11 Amgen Inc. Pulmonary administration of erythropoietin
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
DK1542714T3 (da) 2002-09-18 2014-05-26 Janssen Pharmaceuticals Inc Fremgangsmåder til forøgelse af produktion af blodplader og hæmatopoietiske stamceller
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
US20060210542A1 (en) 2004-08-16 2006-09-21 Yurkow Edward J Use of TPO mimetic compounds and pharmaceutical compositions in the treatment of anemia
PT1984014E (pt) 2006-02-14 2014-11-13 Janssen Pharmaceutica Nv Utilização de compostos de péptidos tpo e composições farmacêuticas no tratamento da anemia
CN100391474C (zh) * 2006-06-13 2008-06-04 卢建军 用于治疗血小板减少的注射用药物
JP2010511631A (ja) 2006-12-01 2010-04-15 ステイテジックス・インコーポレイテッド トロンボポエチン擬態物
WO2009114725A2 (en) 2008-03-12 2009-09-17 Children's Hospital Medical Center Mobilization of hematopoietic stem cells
KR20110015448A (ko) 2008-06-03 2011-02-15 얀센 파마슈티카 엔.브이. 암 치료와 관련된 혈액 질환을 예방하기 위한 ｔｐｏ 모방 펩티드
JP2012250880A (ja) 2011-06-03 2012-12-20 Semiconductor Energy Lab Co Ltd グラフェン、蓄電装置および電気機器
US20140047572A1 (en) 2012-08-13 2014-02-13 University Of Rochester Thrombopoietin mimetics for the treatment of radiation or chemical induced bone marrow injury
US20140051631A1 (en) 2012-08-17 2014-02-20 Francoise Porteu Pharmaceutical composition comprising tpo or an agonist of the tpo receptor
JP6150374B2 (ja) * 2012-11-15 2017-06-21 国立大学法人弘前大学 放射線被ばく治療剤及び放射線被ばく治療方法
US20200237872A1 (en) 2019-01-25 2020-07-30 Janssen Pharmaceutica Nv Methods of enhancing protection against organ and vascular injury, hematopoietic recovery and survival in response to total body radiation/chemical exposure
MA54820A (fr) 2019-01-25 2021-12-01 Janssen Pharmaceutica Nv Méthodes d'atténuation d'une lésion hépatique et de promotion d'une hypertrophie hépatique, de régénération du foie et de prise de greffe de cellules hépatiques conjointement avec des traitements par radiothérapie et/ou radiomimétiques

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040750A1 (en) * 1995-06-07 1996-12-19 Glaxo Group Limited Peptides and compounds that bind to a thrombopoietin receptor
WO1998025965A2 (en) * 1996-12-11 1998-06-18 Glaxo Group Limited Peptides and compounds that bind to the thrombopoietin receptor
WO2005023834A2 (en) * 2003-08-28 2005-03-17 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to thrombopoietin receptors
US20080119384A1 (en) * 2004-08-16 2008-05-22 Yurkow Edward J Use of TPO peptide compounds and pharmaceutical compostions in the treatment of anemia
WO2007087428A2 (en) * 2006-01-25 2007-08-02 Amgen Inc. Thrombopoietic compounds
JP2012518408A (ja) * 2009-02-24 2012-08-16 アレクシオン ファーマシューティカルズ， インコーポレイテッド 治療用ｔｐｏ／ｅｐｏ模倣ペプチドを含む抗体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YAMAGUCHI MASARU ET AL, BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 126, no. 23, 30 November 2015 (2015-11-30), pages 2390, XP009508502, ISSN: 0006-4971 *

Also Published As

Publication number Publication date
AU2018306329B2 (en) 2024-09-19
JP7481252B2 (ja) 2024-05-10
KR20200059213A (ko) 2020-05-28
US20200164039A1 (en) 2020-05-28
CA3070442A1 (en) 2019-01-31
JP2020528903A (ja) 2020-10-01
EP3658191A1 (en) 2020-06-03
KR102688415B1 (ko) 2024-07-24
BR112020001367A2 (pt) 2020-08-11
IL272213A (en) 2020-03-31
AU2018306329A1 (en) 2020-02-13
PH12020500166A1 (en) 2020-09-14
WO2019023418A1 (en) 2019-01-31
US12251424B2 (en) 2025-03-18
CN111432845A (zh) 2020-07-17
CN111432845B (zh) 2024-02-06
AU2018306329A8 (en) 2025-02-20

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FGA Letters patent sealed or granted (standard patent)
TH Corrigenda

Free format text: IN VOL 58 , NO 37 , PAGE(S) 5419 UNDER THE HEADING APPLICATIONS ACCEPTED - NAME INDEX UNDER THE NAME JANSSEN PHARMACEUTICA NV, APPLICATION NO. 2018306329, UNDER INID (72) ADD CO-INVENTOR EICHENBAUM, GARY

Free format text: IN VOL 34 , NO 6 , PAGE(S) 941 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME JANSSEN PHARMACEUTICA NV, APPLICATION NO. 2018306329, UNDER INID (72) ADD CO-INVENTOR EICHENBAUM, GARY

MK14 Patent ceased section 143(a) (annual fees not paid) or expired