AU2018303836B2 - Treatment of CD20-positive B-cell lymphoma with obituzumab - Google Patents

Treatment of CD20-positive B-cell lymphoma with obituzumab Download PDF

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Publication number
AU2018303836B2
AU2018303836B2 AU2018303836A AU2018303836A AU2018303836B2 AU 2018303836 B2 AU2018303836 B2 AU 2018303836B2 AU 2018303836 A AU2018303836 A AU 2018303836A AU 2018303836 A AU2018303836 A AU 2018303836A AU 2018303836 B2 AU2018303836 B2 AU 2018303836B2
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Australia
Prior art keywords
obinutuzumab
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administration
hour
speed
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AU2018303836A
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AU2018303836A1 (en
Inventor
Chin-Yu Lin
Mehrdad Mobasher
Michael Wenger
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU2018303836A1 publication Critical patent/AU2018303836A1/en
Application granted granted Critical
Publication of AU2018303836B2 publication Critical patent/AU2018303836B2/en
Priority to AU2025205481A priority Critical patent/AU2025205481A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
AU2018303836A 2017-10-19 2018-10-19 Treatment of CD20-positive B-cell lymphoma with obituzumab Active AU2018303836B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2025205481A AU2025205481A1 (en) 2017-10-19 2025-07-15 Treatment of CD20-positive B-cell lymphoma with obituzumab

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762574297P 2017-10-19 2017-10-19
US62/574,297 2017-10-19
PCT/JP2018/038924 WO2019017499A2 (en) 2017-10-19 2018-10-19 PHARMACEUTICAL COMPOSITION

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2025205481A Division AU2025205481A1 (en) 2017-10-19 2025-07-15 Treatment of CD20-positive B-cell lymphoma with obituzumab

Publications (2)

Publication Number Publication Date
AU2018303836A1 AU2018303836A1 (en) 2020-05-14
AU2018303836B2 true AU2018303836B2 (en) 2025-04-17

Family

ID=64362606

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2018303836A Active AU2018303836B2 (en) 2017-10-19 2018-10-19 Treatment of CD20-positive B-cell lymphoma with obituzumab
AU2025205481A Pending AU2025205481A1 (en) 2017-10-19 2025-07-15 Treatment of CD20-positive B-cell lymphoma with obituzumab

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2025205481A Pending AU2025205481A1 (en) 2017-10-19 2025-07-15 Treatment of CD20-positive B-cell lymphoma with obituzumab

Country Status (14)

Country Link
US (2) US12129304B2 (cg-RX-API-DMAC10.html)
EP (2) EP3697818B1 (cg-RX-API-DMAC10.html)
JP (2) JP6860652B2 (cg-RX-API-DMAC10.html)
KR (3) KR20260011191A (cg-RX-API-DMAC10.html)
CN (2) CN111212854A (cg-RX-API-DMAC10.html)
AU (2) AU2018303836B2 (cg-RX-API-DMAC10.html)
BR (1) BR112020007731A2 (cg-RX-API-DMAC10.html)
CA (1) CA3079374A1 (cg-RX-API-DMAC10.html)
ES (1) ES3005784T3 (cg-RX-API-DMAC10.html)
IL (2) IL273909B2 (cg-RX-API-DMAC10.html)
MX (2) MX419643B (cg-RX-API-DMAC10.html)
PL (1) PL3697818T3 (cg-RX-API-DMAC10.html)
TW (2) TWI828593B (cg-RX-API-DMAC10.html)
WO (1) WO2019017499A2 (cg-RX-API-DMAC10.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3697818T3 (pl) * 2017-10-19 2025-03-24 F. Hoffmann-La Roche Ag Leczenie CD20-dodatniego chłoniaka z limfocytów B obinutuzumabem
AU2020356896B2 (en) * 2019-10-04 2026-07-30 Chugai Seiyaku Kabushiki Kaisha Inhibitor of cell proliferation in obinutuzumab resistant CD20-positive cancer, and medicinal composition, medicine, production, method for inhibiting cell proliferation, therapeutic method, type II anti-CD20 antibody, compounds, combination of same, enhancer and inducer, each relating thereto
WO2023042679A1 (ja) 2021-09-17 2023-03-23 キヤノン株式会社 送電装置および受電装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016024228A1 (en) * 2014-08-11 2016-02-18 Acerta Pharma B.V. Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor, a pd-1 inhibitor and/or a pd-l1 inhibitor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE038955T2 (hu) 2003-11-05 2018-12-28 Roche Glycart Ag Antigén-kötõ molekulák fokozott Fc receptor-kötõ affinitással és effektor funkcióval
WO2009080541A1 (en) 2007-12-21 2009-07-02 F. Hoffmann-La Roche Ag Antibody formulation
US11149091B2 (en) * 2015-12-09 2021-10-19 Cedars-Sinai Medical Center Methods for treating nephrotic syndrome
CN108395482B (zh) * 2017-02-08 2021-02-05 西比曼生物科技（香港）有限公司 一种靶向cd20抗原嵌合抗原受体的构建及其工程化t细胞的活性鉴定
US12377681B2 (en) 2017-07-21 2025-08-05 The Yokohama Rubber Co., Ltd. Pneumatic tire
PL3697818T3 (pl) * 2017-10-19 2025-03-24 F. Hoffmann-La Roche Ag Leczenie CD20-dodatniego chłoniaka z limfocytów B obinutuzumabem

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016024228A1 (en) * 2014-08-11 2016-02-18 Acerta Pharma B.V. Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor, a pd-1 inhibitor and/or a pd-l1 inhibitor

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Cartron, G. et al., "Obinutuzumab (GA101) in relapsed/refractory chronic lymphocytic leukemia: final data from the phase 1/2 GAUGUIN study", Blood 2014; 124 (14): 2196–2202. doi: https://doi.org/10.1182/blood-2014-07-586610 *
FDA, HIGHLIGHTS OF PRESCRIBING INFORMATION (GAYZVA), 2014 (Year: 2014) *
Tobinai, K. et al., (2017). A Review of Obinutuzumab (GA101), a Novel Type II Anti-CD20 Monoclonal Antibody, for the Treatment of Patients with B-Cell Malignancies. Advances in therapy, 34(2), 324–356. *
Tsujimura, H. et al., "Safety and Tolerability of Obinutuzumab (GA101) with Shorter Duration of Infusion in Japanese Patients with Previously Untreated CD20-Positive B-Cell Non-Hodgkin's Lymphomas...", Blood 2016; 128 (22): 5389 *

Also Published As

Publication number Publication date
WO2019017499A2 (en) 2019-01-24
MX2020003418A (es) 2020-07-20
CN120983618A (zh) 2025-11-21
TWI828593B (zh) 2024-01-01
TW202342099A (zh) 2023-11-01
JP2019528282A (ja) 2019-10-10
JP6860652B2 (ja) 2021-04-21
IL321935A (en) 2025-09-01
KR20200067196A (ko) 2020-06-11
TW201922284A (zh) 2019-06-16
JP2021152002A (ja) 2021-09-30
EP3697818B1 (en) 2024-11-27
CA3079374A1 (en) 2019-01-24
KR20240157135A (ko) 2024-10-31
IL273909B1 (en) 2025-08-01
BR112020007731A2 (pt) 2020-10-20
IL273909A (en) 2020-05-31
WO2019017499A3 (en) 2019-02-21
EP4520347A3 (en) 2025-06-04
EP4520347A2 (en) 2025-03-12
US20250026847A1 (en) 2025-01-23
MX419643B (es) 2025-01-14
KR20260011191A (ko) 2026-01-22
IL273909B2 (en) 2025-12-01
US12129304B2 (en) 2024-10-29
MX2024009217A (es) 2024-11-08
KR102766089B1 (ko) 2025-02-13
JP7370357B2 (ja) 2023-10-27
TWI805630B (zh) 2023-06-21
AU2025205481A1 (en) 2025-08-07
KR102906969B1 (ko) 2026-01-05
PL3697818T3 (pl) 2025-03-24
US20200299398A1 (en) 2020-09-24
ES3005784T3 (en) 2025-03-17
CN111212854A (zh) 2020-05-29
AU2018303836A1 (en) 2020-05-14
EP3697818A2 (en) 2020-08-26

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