AU2018297192B2 - Fatty acid derivatives and their use - Google Patents

Fatty acid derivatives and their use Download PDF

Info

Publication number
AU2018297192B2
AU2018297192B2 AU2018297192A AU2018297192A AU2018297192B2 AU 2018297192 B2 AU2018297192 B2 AU 2018297192B2 AU 2018297192 A AU2018297192 A AU 2018297192A AU 2018297192 A AU2018297192 A AU 2018297192A AU 2018297192 B2 AU2018297192 B2 AU 2018297192B2
Authority
AU
Australia
Prior art keywords
compound
cooh
hydroxy
fatty acid
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2018297192A
Other languages
English (en)
Other versions
AU2018297192A1 (en
Inventor
Gregory Keyes
Christopher Ramsden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United States Department of Health and Human Services
Original Assignee
Government of the United States of America
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Government of the United States of America filed Critical Government of the United States of America
Publication of AU2018297192A1 publication Critical patent/AU2018297192A1/en
Application granted granted Critical
Publication of AU2018297192B2 publication Critical patent/AU2018297192B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/02—Acyclic alcohols with carbon-to-carbon double bonds
    • C07C33/025—Acyclic alcohols with carbon-to-carbon double bonds with only one double bond
    • C07C33/03—Acyclic alcohols with carbon-to-carbon double bonds with only one double bond in beta-position, e.g. allyl alcohol, methallyl alcohol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
    • C07D303/42—Acyclic compounds having a chain of seven or more carbon atoms, e.g. epoxidised fats
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2018297192A 2017-07-07 2018-07-06 Fatty acid derivatives and their use Active AU2018297192B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762529846P 2017-07-07 2017-07-07
US62/529,846 2017-07-07
PCT/US2018/041086 WO2019010414A1 (en) 2017-07-07 2018-07-06 FATTY ACID DERIVATIVES AND USE THEREOF

Publications (2)

Publication Number Publication Date
AU2018297192A1 AU2018297192A1 (en) 2019-12-19
AU2018297192B2 true AU2018297192B2 (en) 2022-02-17

Family

ID=63036390

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018297192A Active AU2018297192B2 (en) 2017-07-07 2018-07-06 Fatty acid derivatives and their use

Country Status (9)

Country Link
US (2) US11555021B2 (enExample)
EP (1) EP3649115B1 (enExample)
JP (1) JP7234151B2 (enExample)
KR (1) KR102725883B1 (enExample)
CN (1) CN110869354A (enExample)
AU (1) AU2018297192B2 (enExample)
CA (1) CA3064132C (enExample)
MX (1) MX391168B (enExample)
WO (1) WO2019010414A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112018070164B1 (pt) 2016-04-01 2022-09-27 Sony Corporation Of America Corantes diméricos ou poliméricos ultrabrilhantes
CN109153860B (zh) 2016-04-06 2021-04-23 索尼公司 具有间隔连接体基团的超高亮二聚体或聚合物染料
WO2018022925A1 (en) 2016-07-29 2018-02-01 Sony Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
US12290571B2 (en) 2017-10-05 2025-05-06 Sony Group Corporation Programmable dendritic drugs
KR20260011205A (ko) 2017-10-05 2026-01-22 소니그룹주식회사 프로그램가능한 중합체성 약물
CN111836645A (zh) 2017-11-16 2020-10-27 索尼公司 可编程的聚合药物
US12076407B2 (en) 2018-01-12 2024-09-03 Sony Group Corporation Polymers with rigid spacing groups comprising biologically active compounds
EP3737417B1 (en) 2018-01-12 2025-08-27 Sony Group Corporation Phosphoalkyl ribose polymers comprising biologically active compounds
KR102864292B1 (ko) 2018-03-21 2025-09-26 소니그룹주식회사 링커 군을 갖는 중합체성 텐덤 염료
JP7580689B2 (ja) 2018-06-27 2024-11-12 ソニーグループ株式会社 デオキシリボースを含むリンカー基を有するポリマー色素
US12578342B2 (en) 2018-07-13 2026-03-17 Sony Group Corporation Polymeric dyes having a backbone comprising organophosphate units
EP3861074A2 (en) 2019-09-26 2021-08-11 Sony Group Corporation Polymeric tandem dyes with linker groups
EP4038081A1 (en) 2019-09-30 2022-08-10 Sony Group Corporation Nucleotide probes
EP4256078A1 (en) 2020-12-07 2023-10-11 Sony Group Corporation Spacing linker group design for brightness enhancement in dimeric or polymeric dyes
CN113121475B (zh) * 2021-03-30 2022-12-02 香港科技大学深圳研究院 不饱和脂肪酸类化合物及其制备方法和应用
CN113620923B (zh) * 2021-07-16 2023-03-14 扬州工业职业技术学院 一种低温电解液添加剂的制备方法及应用
CN115073295B (zh) * 2022-07-21 2023-12-26 山东大学 马齿苋中不饱和脂肪酸及其提取分离方法和应用
WO2024237316A1 (ja) * 2023-05-16 2024-11-21 国立大学法人東京大学 エポキシ化不飽和脂肪酸の皮膚線維化改善作用
EP4613730A1 (en) * 2024-03-05 2025-09-10 Centre National de la Recherche Scientifique Lipidic alkynylcarbinols with anti-bacterial and anti-tuberculosis activity

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006106438A2 (en) * 2005-01-11 2006-10-12 Evolva Sa Modulators of ppar activity

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055613A (en) * 1988-02-18 1991-10-08 G. D. Searle & Co. Metabolites of pentanedioic acid derivatives
ATE168372T1 (de) * 1993-03-29 1998-08-15 Hsc Res Dev Lp Hepoxilin analoga verwendbar als entzündungshemmende mittel
IL121165A0 (en) * 1997-06-26 1997-11-20 Yissum Res Dev Co Pharmaceutical compositions containing carboxylic acids and derivatives thereof
US20020037876A1 (en) * 1998-06-25 2002-03-28 Yissum Research Development Company Of Hebrew University Of Jerusalem Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
BR0012447A (pt) * 1999-07-15 2002-04-02 Lilly Co Eli Análogos de pseudomicina de cadeia lateral de n-acila
US7304093B2 (en) * 2000-10-11 2007-12-04 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
US7335689B2 (en) 2003-01-23 2008-02-26 Esperion Therapeutics, Inc. Dihydroxyl compounds and compositions for cholesterol management and related uses
DE102004037118A1 (de) 2004-07-30 2006-03-23 Degussa Ag Titandioxid enthaltende Dispersion
JP5337479B2 (ja) 2005-05-04 2013-11-06 プロノヴァ・バイオファーマ・ノルゲ・アーエス 新規化合物
IL181577A0 (en) * 2007-02-26 2007-07-04 Jacob Bar Tana Combination therapy composition and methods for the treatment of cardiovascular disorders and immune-related disorders
JP5552121B2 (ja) * 2008-09-04 2014-07-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン産生のインドリジン阻害剤
WO2013157926A1 (en) 2012-04-19 2013-10-24 Nyken Holding B.V. Geranyl geranyl acetone analogs and uses thereof
JP6160375B2 (ja) 2013-09-06 2017-07-12 ブラザー工業株式会社 画像記録装置

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006106438A2 (en) * 2005-01-11 2006-10-12 Evolva Sa Modulators of ppar activity

Also Published As

Publication number Publication date
EP3649115B1 (en) 2024-09-04
KR102725883B1 (ko) 2024-11-01
EP3649115A1 (en) 2020-05-13
US20220274940A1 (en) 2022-09-01
JP7234151B2 (ja) 2023-03-07
AU2018297192A1 (en) 2019-12-19
US20210139440A1 (en) 2021-05-13
CN110869354A (zh) 2020-03-06
MX391168B (es) 2025-03-21
WO2019010414A1 (en) 2019-01-10
CA3064132C (en) 2024-06-04
US12479812B2 (en) 2025-11-25
JP2020526505A (ja) 2020-08-31
KR20200027545A (ko) 2020-03-12
CA3064132A1 (en) 2019-01-10
EP3649115C0 (en) 2024-09-04
US11555021B2 (en) 2023-01-17

Similar Documents

Publication Publication Date Title
CA3064132C (en) Fatty acid derivatives and their use
JP6545490B2 (ja) １４−ヒドロキシ−ドコサヘキサエン酸化合物
AU707942B2 (en) New vitamin D derivatives with substituents at C-25, process for their production, intermediate products and use for the production of pharmaceutical agents
HUP9900163A2 (en) Process for the preparation of sterol-and stanol-esters, and use thereof
JPH04506965A (ja) 新規ビタミンｄ類似体
HU213471B (en) Process for producing 1alpha-hydroxy-vitamin d4
JP4010579B2 (ja) ビタミンｄ化合物類およびこれらの化合物の製造方法
JP3725198B2 (ja) ピリピロペン誘導体
JPH06506915A (ja) ビタミンｄ系列の２３−オキサ誘導体、その製造法、該誘導体を含有する製薬学的調剤ならびに医薬品としての該誘導体の使用
US5786380A (en) VPA-analogous antiepileptics
JPH075509B2 (ja) ファルネシルタンパク質トランスフェラーゼの阻害剤
JPS61233681A (ja) 新規置換グルタール酸ラクトン誘導体、およびそれらからなる抗高脂血剤
Ervik et al. Synthesis of the methyl ester of 17 (R/S)-Me-RvD5n-3 DPA and relief of postoperative pain in male mice
JP5309591B2 (ja) キャビコール類縁体化合物、キャビコール類縁体化合物の製造方法、およびｍａｐキナーゼシグナル伝達阻害剤
GB2052500A (en) Pivaloyloxymethyl 2-propyl-pentanoate
Pitt et al. Synthesis of polyunsaturated β-thia and γ-thia fatty acids from naturally derived polyunsaturated fatty alcohols and in vitro evaluation of their susceptibility to β-oxidation
CN104829510A (zh) 23-炔-维生素d3衍生物
US20260022089A1 (en) Quinone-derived compounds and use thereof against leishmania spp
Bathen et al. A modular semi-synthetic approach to form a DHA-like polyunsaturated ether lipid with 15-lipoxygenase-1 substrate activity
Boots et al. Hypocholesterolemic agents I: 3‐methyl‐4‐phenylbutenoic acids
US6331570B1 (en) Active enantiomer of RARγ-specific agonist
WO2024073673A1 (en) Modulators of cd1 protein binding to t cell receptors
US20100172957A1 (en) Eflucimibe medicaments for preventing/treating a disease due to sebaceous gland dysfunction in humans or animals
KR20130119514A (ko) 9,10-세코프레그난 유도체 및 의약
Cozzi et al. Synthesis of 3-hydroxy-3-cyclohexylbutyric acid derivatives. 1. Cyclic homologs of 3-hydroxy-3-methylglutaric acid

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)