AU2018290856B2 - Anti-human papillomavirus (HPV) antigen-binding proteins and methods of use thereof - Google Patents

Anti-human papillomavirus (HPV) antigen-binding proteins and methods of use thereof

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Publication number
AU2018290856B2
AU2018290856B2 AU2018290856A AU2018290856A AU2018290856B2 AU 2018290856 B2 AU2018290856 B2 AU 2018290856B2 AU 2018290856 A AU2018290856 A AU 2018290856A AU 2018290856 A AU2018290856 A AU 2018290856A AU 2018290856 B2 AU2018290856 B2 AU 2018290856B2
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AU
Australia
Prior art keywords
antigen
binding
antibody
hpv16e7
hla
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AU2018290856A
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English (en)
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AU2018290856A1 (en
Inventor
Kevin A. BRAY
Frank DELFINO
Matthew C. Franklin
Elena S. GARNOVA
Jessica R. Kirshner
Douglas Macdonald
William Olson
Gavin Thurston
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Application filed by Regeneron Pharmaceuticals Inc filed Critical Regeneron Pharmaceuticals Inc
Publication of AU2018290856A1 publication Critical patent/AU2018290856A1/en
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/11—Antigen recognition domain
    • A61K2239/13—Antibody-based
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
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    • C07K2317/565—Complementarity determining region [CDR]
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AU2018290856A 2017-06-28 2018-06-27 Anti-human papillomavirus (HPV) antigen-binding proteins and methods of use thereof Active AU2018290856B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762525937P 2017-06-28 2017-06-28
US62/525,937 2017-06-28
PCT/US2018/039654 WO2019005897A1 (en) 2017-06-28 2018-06-27 HUMAN ANTI-PAPILLOMAVIRUS ANTIGEN BINDING PROTEINS AND METHODS OF USE THEREOF

Publications (2)

Publication Number Publication Date
AU2018290856A1 AU2018290856A1 (en) 2020-01-02
AU2018290856B2 true AU2018290856B2 (en) 2025-06-26

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US (4) US10806780B2 (enExample)
EP (1) EP3645562A1 (enExample)
JP (2) JP7401312B2 (enExample)
KR (2) KR102877389B1 (enExample)
CN (2) CN110914295B (enExample)
AU (1) AU2018290856B2 (enExample)
BR (1) BR112019027211A2 (enExample)
CA (1) CA3066779A1 (enExample)
CL (3) CL2019003802A1 (enExample)
CO (1) CO2020000733A2 (enExample)
EA (1) EA202090149A1 (enExample)
IL (3) IL317281A (enExample)
MA (1) MA49512A (enExample)
MX (2) MX2019015477A (enExample)
MY (1) MY200131A (enExample)
PH (1) PH12019502763A1 (enExample)
SG (1) SG11201912240QA (enExample)
WO (1) WO2019005897A1 (enExample)

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MX2022000081A (es) * 2019-07-03 2022-04-27 Regeneron Pharma Proteínas de unión al antígeno anti carcinoma de células escamosas esofágico 1 de nueva york (ny-eso-1) y métodos de uso.
TW202136317A (zh) 2019-12-20 2021-10-01 美商再生元醫藥公司 新穎之ｉｌ２促效劑及其使用方法（二）
SMT202300397T1 (it) 2020-02-26 2024-01-10 Vir Biotechnology Inc Anticorpi contro sars-cov-2
CN111410689B (zh) * 2020-03-16 2021-11-02 重庆理工大学 抗hpv16e7蛋白单抗69e2、杂交瘤细胞株及其制备方法和应用
CN111333720B (zh) * 2020-03-16 2021-11-02 重庆理工大学 抗hpv16e7蛋白单抗79a11、杂交瘤细胞株及其制备方法和应用
CN112433055A (zh) * 2020-11-04 2021-03-02 上海药明生物技术有限公司 一种基于报告基因方法检测pvrig抗体的生物学活性的方法
CN112480217B (zh) * 2020-11-30 2022-04-08 广州阿格纳生物医药制造有限公司 基于SARS-CoV-2的S抗原蛋白的疫苗和组合物
CN114957452B (zh) * 2021-02-18 2025-08-08 江苏瑞科生物技术股份有限公司 一种人乳头瘤病毒11型l1蛋白的抗体及其制备方法
US20250066441A1 (en) 2021-07-19 2025-02-27 Regeneron Pharmaceuticals, Inc. Il12 receptor agonists and methods of use thereof
AU2022331241A1 (en) 2021-08-16 2024-03-28 Regeneron Pharmaceuticals, Inc. Novel il27 receptor agonists and methods of use thereof
WO2023133193A1 (en) * 2022-01-05 2023-07-13 Memorial Sloan-Kettering Cancer Center Anti-hpv antibodies and uses thereof
KR20240163103A (ko) * 2022-03-10 2024-11-18 주식회사 제넥신 두경부암 치료를 위한 삼중 복합약물 투여요법
WO2024151978A1 (en) 2023-01-13 2024-07-18 Regeneron Pharmaceuticals, Inc. Il12 receptor agonists and methods of use thereof
WO2024182540A2 (en) 2023-02-28 2024-09-06 Regeneron Pharmaceuticals, Inc. T cell activators and methods of use thereof

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