JP7401312B2 - 抗ヒトパピローマウイルス（ｈｐｖ）抗原結合性タンパク質およびその使用方法 - Google Patents

抗ヒトパピローマウイルス（ｈｐｖ）抗原結合性タンパク質およびその使用方法 Download PDF

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JP7401312B2
JP7401312B2 JP2019571685A JP2019571685A JP7401312B2 JP 7401312 B2 JP7401312 B2 JP 7401312B2 JP 2019571685 A JP2019571685 A JP 2019571685A JP 2019571685 A JP2019571685 A JP 2019571685A JP 7401312 B2 JP7401312 B2 JP 7401312B2
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antigen
hpv16e7
hla
amino acid
peptide
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JP2020529835A (ja
JP2020529835A5 (enExample
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ケビン エー． ブレイ，
フランク デルフィーノ，
マシュー シー． フランクリン，
エレナ エス． ガルノバ，
ジェシカ アール． カーシュナー，
ダグラス マクドナルド，
ウィリアム オルソン，
ギャビン サーストン，
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/084—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • A61K2039/515—Animal cells
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    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
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    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
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    • C07K2317/52—Constant or Fc region; Isotype
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JP2019571685A 2017-06-28 2018-06-27 抗ヒトパピローマウイルス（ｈｐｖ）抗原結合性タンパク質およびその使用方法 Active JP7401312B2 (ja)

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JP2023206822A JP7737440B2 (ja) 2017-06-28 2023-12-07 抗ヒトパピローマウイルス（ｈｐｖ）抗原結合性タンパク質およびその使用方法

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US201762525937P 2017-06-28 2017-06-28
US62/525,937 2017-06-28
PCT/US2018/039654 WO2019005897A1 (en) 2017-06-28 2018-06-27 HUMAN ANTI-PAPILLOMAVIRUS ANTIGEN BINDING PROTEINS AND METHODS OF USE THEREOF

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JP2020529835A5 JP2020529835A5 (enExample) 2021-07-26
JP7401312B2 true JP7401312B2 (ja) 2023-12-19

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JP2023206822A Active JP7737440B2 (ja) 2017-06-28 2023-12-07 抗ヒトパピローマウイルス（ｈｐｖ）抗原結合性タンパク質およびその使用方法

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US (4) US10806780B2 (enExample)
EP (1) EP3645562A1 (enExample)
JP (2) JP7401312B2 (enExample)
KR (2) KR102877389B1 (enExample)
CN (2) CN110914295B (enExample)
AU (1) AU2018290856B2 (enExample)
BR (1) BR112019027211A2 (enExample)
CA (1) CA3066779A1 (enExample)
CL (3) CL2019003802A1 (enExample)
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CA3066779A1 (en) 2017-06-28 2019-01-03 Regeneron Pharmaceuticals, Inc. Anti-human papillomavirus (hpv) antigen-binding proteins and methods of use thereof
US11952408B2 (en) 2017-10-03 2024-04-09 Juno Therapeutics, Inc. HPV-specific binding molecules
BR112020019313A2 (pt) 2018-04-05 2021-01-05 Juno Therapeutics Inc Receptores de células t e células modificadas que expressam os mesmos
MX2022000081A (es) * 2019-07-03 2022-04-27 Regeneron Pharma Proteínas de unión al antígeno anti carcinoma de células escamosas esofágico 1 de nueva york (ny-eso-1) y métodos de uso.
TW202136317A (zh) 2019-12-20 2021-10-01 美商再生元醫藥公司 新穎之ｉｌ２促效劑及其使用方法（二）
SMT202300397T1 (it) 2020-02-26 2024-01-10 Vir Biotechnology Inc Anticorpi contro sars-cov-2
CN111410689B (zh) * 2020-03-16 2021-11-02 重庆理工大学 抗hpv16e7蛋白单抗69e2、杂交瘤细胞株及其制备方法和应用
CN111333720B (zh) * 2020-03-16 2021-11-02 重庆理工大学 抗hpv16e7蛋白单抗79a11、杂交瘤细胞株及其制备方法和应用
CN112433055A (zh) * 2020-11-04 2021-03-02 上海药明生物技术有限公司 一种基于报告基因方法检测pvrig抗体的生物学活性的方法
CN112480217B (zh) * 2020-11-30 2022-04-08 广州阿格纳生物医药制造有限公司 基于SARS-CoV-2的S抗原蛋白的疫苗和组合物
CN114957452B (zh) * 2021-02-18 2025-08-08 江苏瑞科生物技术股份有限公司 一种人乳头瘤病毒11型l1蛋白的抗体及其制备方法
US20250066441A1 (en) 2021-07-19 2025-02-27 Regeneron Pharmaceuticals, Inc. Il12 receptor agonists and methods of use thereof
AU2022331241A1 (en) 2021-08-16 2024-03-28 Regeneron Pharmaceuticals, Inc. Novel il27 receptor agonists and methods of use thereof
WO2023133193A1 (en) * 2022-01-05 2023-07-13 Memorial Sloan-Kettering Cancer Center Anti-hpv antibodies and uses thereof
KR20240163103A (ko) * 2022-03-10 2024-11-18 주식회사 제넥신 두경부암 치료를 위한 삼중 복합약물 투여요법
WO2024151978A1 (en) 2023-01-13 2024-07-18 Regeneron Pharmaceuticals, Inc. Il12 receptor agonists and methods of use thereof
WO2024182540A2 (en) 2023-02-28 2024-09-06 Regeneron Pharmaceuticals, Inc. T cell activators and methods of use thereof

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CN102719402A (zh) 2012-07-05 2012-10-10 时宏珍 Hla-a0201限制性抗hpv抗原特异性ctl的制备方法
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