AU2018278332B2 - Methods and compositions for treating excessive sleepiness - Google Patents

Methods and compositions for treating excessive sleepiness Download PDF

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Publication number
AU2018278332B2
AU2018278332B2 AU2018278332A AU2018278332A AU2018278332B2 AU 2018278332 B2 AU2018278332 B2 AU 2018278332B2 AU 2018278332 A AU2018278332 A AU 2018278332A AU 2018278332 A AU2018278332 A AU 2018278332A AU 2018278332 B2 AU2018278332 B2 AU 2018278332B2
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apc
dose
daily dose
once
dosing regimen
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AU2018278332A1 (en
Inventor
Lawrence Patrick CARTER
Yuan Lu
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Jazz Pharmaceuticals Ireland Ltd
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Jazz Pharmaceuticals Ireland Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
AU2018278332A 2017-06-02 2018-06-01 Methods and compositions for treating excessive sleepiness Active AU2018278332B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762514176P 2017-06-02 2017-06-02
US62/514,176 2017-06-02
PCT/US2018/035532 WO2018222954A1 (en) 2017-06-02 2018-06-01 Methods and compositions for treating excessive sleepiness

Publications (2)

Publication Number Publication Date
AU2018278332A1 AU2018278332A1 (en) 2020-01-30
AU2018278332B2 true AU2018278332B2 (en) 2022-05-19

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ID=64455104

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018278332A Active AU2018278332B2 (en) 2017-06-02 2018-06-01 Methods and compositions for treating excessive sleepiness

Country Status (12)

Country Link
US (7) US10959976B2 (OSRAM)
EP (1) EP3630072A4 (OSRAM)
JP (1) JP2020528075A (OSRAM)
KR (3) KR20240162165A (OSRAM)
CN (1) CN111201014A (OSRAM)
AU (1) AU2018278332B2 (OSRAM)
BR (1) BR112019025286A2 (OSRAM)
CA (1) CA3065522A1 (OSRAM)
MX (1) MX390786B (OSRAM)
MY (1) MY203401A (OSRAM)
PH (1) PH12019502723A1 (OSRAM)
WO (1) WO2018222954A1 (OSRAM)

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US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12478604B1 (en) 2016-07-22 2025-11-25 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US10195151B2 (en) 2016-09-06 2019-02-05 Jazz Pharmaceuticals International Iii Limited Formulations of (R)-2-amino-3-phenylpropyl carbamate
WO2018222954A1 (en) 2017-06-02 2018-12-06 Jazz Pharmaceuticals International Iii Limited Methods and compositions for treating excessive sleepiness
WO2020178695A1 (en) 2019-03-01 2020-09-10 Flamel Ireland Limited Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state
WO2021001457A1 (en) * 2019-07-04 2021-01-07 Sandoz Ag Crystalline (r)-2-amino-3-phenylpropylcarbamate acid addition salts
US10940133B1 (en) 2020-03-19 2021-03-09 Jazz Pharmaceuticals Ireland Limited Methods of providing solriamfetol therapy to subjects with impaired renal function
WO2023034944A1 (en) * 2021-09-03 2023-03-09 Axsome Therapeutics Methods and compositions for ameliorating biomarkers associated with cardiovascular risk using (r)-2-amino-3-phenylpropyl carbamate
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
AU2023375326A1 (en) * 2022-11-07 2025-05-22 Axsome Therapeutics Compositions and methods for treating insomnia
EP4626417A1 (en) * 2022-11-30 2025-10-08 Axsome Therapeutics Methods and compositions for improving driving performance
US12005036B1 (en) 2022-12-30 2024-06-11 Axsome Malta Ltd. Methods of administering solriamfetol to lactating women
US12036194B1 (en) 2022-12-30 2024-07-16 Axsome Malta Ltd. Methods of administering solriamfetol to lactating women
US12090126B2 (en) 2022-12-30 2024-09-17 Axsome Malta Ltd. Methods of administering solriamfetol to lactating women
US12102609B2 (en) 2022-12-30 2024-10-01 Axsome Malta Ltd. Methods of administering solriamfetol to lactating women
US12064411B1 (en) * 2022-12-30 2024-08-20 Axsome Malta Ltd. Methods of administering solriamfetol to lactating women
EP4642446A2 (en) * 2022-12-30 2025-11-05 Axsome Malta Ltd. Methods of administering solriamfetol to lactating women
US11771666B1 (en) 2022-12-30 2023-10-03 Axsome Malta Ltd. Methods of administering solriamfetol to lactating women
WO2024249560A1 (en) * 2023-05-30 2024-12-05 Axsome Therapeutics, Inc. Solriamfetol for treating cognitive impairment in a subject with impaired cognition associated with obstructive sleep apnea and excessive daytime sleepiness
WO2025042959A1 (en) * 2023-08-21 2025-02-27 Axsome Therapeutics, Inc. Use of solriamfetol for the treatment of orphan diseases
WO2025064549A1 (en) * 2023-09-18 2025-03-27 Axsome Therapeutics, Inc. Solriamfetol for improving cognitive health in apnea patients

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Also Published As

Publication number Publication date
US11865098B1 (en) 2024-01-09
US20200281886A1 (en) 2020-09-10
KR20200016889A (ko) 2020-02-17
KR20240162165A (ko) 2024-11-14
MX2019014409A (es) 2022-03-17
US20200163927A1 (en) 2020-05-28
US11648232B2 (en) 2023-05-16
WO2018222954A1 (en) 2018-12-06
US20210205257A1 (en) 2021-07-08
US10912754B2 (en) 2021-02-09
MY203401A (en) 2024-06-26
US10959976B2 (en) 2021-03-30
KR20230145525A (ko) 2023-10-17
BR112019025286A2 (pt) 2020-06-23
CA3065522A1 (en) 2018-12-06
JP2020528075A (ja) 2020-09-17
NZ760594A (en) 2025-05-02
US20240033243A1 (en) 2024-02-01
MX390786B (es) 2025-03-21
CN111201014A (zh) 2020-05-26
US20240180866A1 (en) 2024-06-06
KR102726728B1 (ko) 2024-11-05
US20240189270A1 (en) 2024-06-13
US20250114322A1 (en) 2025-04-10
EP3630072A4 (en) 2021-03-10
PH12019502723A1 (en) 2020-07-13
AU2018278332A1 (en) 2020-01-30
EP3630072A1 (en) 2020-04-08

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