AU2018244463B2 - Quinoline derived small molecule inhibitors of nicotinamide N-methyltransferase (NNMT) and uses thereof - Google Patents

Quinoline derived small molecule inhibitors of nicotinamide N-methyltransferase (NNMT) and uses thereof Download PDF

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Publication number
AU2018244463B2
AU2018244463B2 AU2018244463A AU2018244463A AU2018244463B2 AU 2018244463 B2 AU2018244463 B2 AU 2018244463B2 AU 2018244463 A AU2018244463 A AU 2018244463A AU 2018244463 A AU2018244463 A AU 2018244463A AU 2018244463 B2 AU2018244463 B2 AU 2018244463B2
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AU
Australia
Prior art keywords
cation
nnmt
alkyl
formula
methyl
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AU2018244463A
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AU2018244463A1 (en
Inventor
Stanton Mchardy
Harshini NEELAKANTAN
Hua-yu WANG
Stanley Watowich
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The University of Texas System
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The University of Texas System
The University of Texas at Austin
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/10—Quaternary compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2018244463A 2017-03-30 2018-03-29 Quinoline derived small molecule inhibitors of nicotinamide N-methyltransferase (NNMT) and uses thereof Active AU2018244463B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762479256P 2017-03-30 2017-03-30
US62/479,256 2017-03-30
US201762559417P 2017-09-15 2017-09-15
US62/559,417 2017-09-15
PCT/US2018/025134 WO2018183668A1 (en) 2017-03-30 2018-03-29 Quinoline derived small molecule inhibitors of nicotinamide n-methyltransferase (nnmt) and uses thereof

Publications (2)

Publication Number Publication Date
AU2018244463A1 AU2018244463A1 (en) 2019-10-17
AU2018244463B2 true AU2018244463B2 (en) 2024-04-04

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AU2018244463A Active AU2018244463B2 (en) 2017-03-30 2018-03-29 Quinoline derived small molecule inhibitors of nicotinamide N-methyltransferase (NNMT) and uses thereof

Country Status (6)

Country Link
US (2) US11401243B2 (enExample)
EP (1) EP3600317A4 (enExample)
JP (1) JP7359439B2 (enExample)
AU (1) AU2018244463B2 (enExample)
CA (1) CA3057849A1 (enExample)
WO (1) WO2018183668A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3057849A1 (en) * 2017-03-30 2018-10-04 The Board Of Regents Of The University Of Texas System Quinoline derived small molecule inhibitors of nicotinamide n-methyltransferase (nnmt) and uses thereof
ES2963560T3 (es) 2019-08-06 2024-03-27 Lilly Co Eli Compuesto piramidin-5-carboxamida
CN114272236A (zh) * 2020-09-27 2022-04-05 南京施江医药科技有限公司 用于判断线粒体氧化磷酸化通路抑制剂抗癌效果的标志物
CN114644626A (zh) * 2020-12-18 2022-06-21 南京施江医药科技有限公司 一种苯环类化合物及其应用
AU2023247721A1 (en) * 2022-03-31 2024-11-14 Shanghai Shijiang Biotechnology Co., Ltd Aromatic ring compound and use thereof
CN116969885A (zh) * 2023-08-01 2023-10-31 上海升德医药科技有限公司 一种5-氨基-1-烷基喹啉卤代物的合成工艺
TW202545926A (zh) 2024-01-12 2025-12-01 瑞典商阿斯特捷利康公司 作為菸鹼醯胺ｎ—甲基轉移酶抑制劑的哌啶衍生物

Citations (1)

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Publication number Priority date Publication date Assignee Title
JP2014514420A (ja) * 2011-05-03 2014-06-19 ビーエーエスエフ ソシエタス・ヨーロピア ジスルフィド染料

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GB846611A (en) * 1958-02-07 1960-08-31 Ici Ltd Nitroquinolones
FR1588846A (enExample) * 1965-07-25 1970-03-16
US4035367A (en) * 1974-09-09 1977-07-12 Sandoz, Inc. Hydroxyalkyl-substituted-amino-quinolines
US4431774A (en) * 1981-09-14 1984-02-14 Ciba-Geigy Corporation Process for the curing of stoving lacquers
US5817520A (en) * 1991-12-20 1998-10-06 Oxis International S.A. Spectrophotometric methods for assaying total mercaptans, reduced glutathione (GSH) and mercaptans other than GSH in an aqueous medium reagents and kits for implementing same
DE10130144A1 (de) * 2001-06-22 2003-01-02 Wella Ag 1-Benzopyran-Derivate und deren Salze enthaltende Färbemittel
US7977486B2 (en) * 2006-09-08 2011-07-12 Osaka University Quinolinium ion derivatives, process for the production of the derivatives, products made by using the same, and reduction and oxidation methods with the derivatives
WO2012041493A1 (en) * 2010-09-28 2012-04-05 Julius-Maximilians-Universität Würzburg Aminoquinolinium salts, methods of their production and their use as active agents for biotechnological and medical applications against binary toxins
CA3057849A1 (en) * 2017-03-30 2018-10-04 The Board Of Regents Of The University Of Texas System Quinoline derived small molecule inhibitors of nicotinamide n-methyltransferase (nnmt) and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014514420A (ja) * 2011-05-03 2014-06-19 ビーエーエスエフ ソシエタス・ヨーロピア ジスルフィド染料

Non-Patent Citations (3)

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Title
ABEYWICKRAMA CHANDIMA ET AL: "Inhibition of protein kinase C by dequalinium analogues: Structure-activity studies on head group variations", BIOORGANIC & MEDICINAL CHEMISTRY, 2006, vol. 14, no. 23, pgs. 7796 - 7803. *
GALANAKIS D ET AL: "Synthesis and Structure-Activity Relationshipsof Dequalinium Analogues as K+ Channel Blockers Investigations on the Role of the Charged Heterocycle", J MED CHEM, AMER CHEM SOCIETY, 1995, vol. 38, no. 4, pgs. 595 - 606. *
HUBERTUS AHLBRECHT ET AL: "Synthese Von Chinolinderivaten Durch Acylierung Von N-Aryl-Carbonsaeureamiden Und N-Aryl-Enaminen Mit Phosgen", CHEM. BER, 1975, vol. 108, pgs. 2300 - 2311. DOI: 10.1002/cber.19751080718 *

Also Published As

Publication number Publication date
EP3600317A1 (en) 2020-02-05
JP2020512356A (ja) 2020-04-23
JP7359439B2 (ja) 2023-10-11
WO2018183668A1 (en) 2018-10-04
AU2018244463A1 (en) 2019-10-17
CA3057849A1 (en) 2018-10-04
EP3600317A4 (en) 2020-12-23
US12071409B2 (en) 2024-08-27
US20230107256A1 (en) 2023-04-06
US20200102274A1 (en) 2020-04-02
US11401243B2 (en) 2022-08-02

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