JP7359439B2 - ニコチンアミドｎ－メチルトランスフェラーゼ（ｎｎｍｔ）のキノリン由来小分子阻害剤及びその使用 - Google Patents

ニコチンアミドｎ－メチルトランスフェラーゼ（ｎｎｍｔ）のキノリン由来小分子阻害剤及びその使用 Download PDF

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JP7359439B2
JP7359439B2 JP2019553173A JP2019553173A JP7359439B2 JP 7359439 B2 JP7359439 B2 JP 7359439B2 JP 2019553173 A JP2019553173 A JP 2019553173A JP 2019553173 A JP2019553173 A JP 2019553173A JP 7359439 B2 JP7359439 B2 JP 7359439B2
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nnmt
cations
amino
cells
inhibitors
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JP2020512356A5 (enExample
JP2020512356A (ja
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ワトウィッチ、スタンレー
ニーラカンタン、ハラシニ
マクハーディ、スタントン
ワン、ファ－ユー
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ザ ボード オブ レジェンツ オブ ザ ユニバーシティ オブ テキサス システム
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/10—Quaternary compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
JP2019553173A 2017-03-30 2018-03-29 ニコチンアミドｎ－メチルトランスフェラーゼ（ｎｎｍｔ）のキノリン由来小分子阻害剤及びその使用 Active JP7359439B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762479256P 2017-03-30 2017-03-30
US62/479,256 2017-03-30
US201762559417P 2017-09-15 2017-09-15
US62/559,417 2017-09-15
PCT/US2018/025134 WO2018183668A1 (en) 2017-03-30 2018-03-29 Quinoline derived small molecule inhibitors of nicotinamide n-methyltransferase (nnmt) and uses thereof

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JP2020512356A JP2020512356A (ja) 2020-04-23
JP2020512356A5 JP2020512356A5 (enExample) 2021-05-06
JP7359439B2 true JP7359439B2 (ja) 2023-10-11

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US (2) US11401243B2 (enExample)
EP (1) EP3600317A4 (enExample)
JP (1) JP7359439B2 (enExample)
AU (1) AU2018244463B2 (enExample)
CA (1) CA3057849A1 (enExample)
WO (1) WO2018183668A1 (enExample)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
CA3057849A1 (en) * 2017-03-30 2018-10-04 The Board Of Regents Of The University Of Texas System Quinoline derived small molecule inhibitors of nicotinamide n-methyltransferase (nnmt) and uses thereof
EP4010324B1 (en) 2019-08-06 2023-09-06 Eli Lilly and Company Pyrimidine-5-carboxamide compound
CN114272236A (zh) * 2020-09-27 2022-04-05 南京施江医药科技有限公司 用于判断线粒体氧化磷酸化通路抑制剂抗癌效果的标志物
CN114644626A (zh) * 2020-12-18 2022-06-21 南京施江医药科技有限公司 一种苯环类化合物及其应用
CN116969885A (zh) * 2023-08-01 2023-10-31 上海升德医药科技有限公司 一种5-氨基-1-烷基喹啉卤代物的合成工艺
WO2025149628A1 (en) 2024-01-12 2025-07-17 Astrazeneca Ab Piperidine derivatives as inhibitors of nicotinamide n-methyl transferase

Citations (1)

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Publication number Priority date Publication date Assignee Title
JP2014514420A (ja) 2011-05-03 2014-06-19 ビーエーエスエフ ソシエタス・ヨーロピア ジスルフィド染料

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GB846611A (en) * 1958-02-07 1960-08-31 Ici Ltd Nitroquinolones
FR1588846A (enExample) * 1965-07-25 1970-03-16
US4035367A (en) * 1974-09-09 1977-07-12 Sandoz, Inc. Hydroxyalkyl-substituted-amino-quinolines
US4431774A (en) * 1981-09-14 1984-02-14 Ciba-Geigy Corporation Process for the curing of stoving lacquers
US5817520A (en) * 1991-12-20 1998-10-06 Oxis International S.A. Spectrophotometric methods for assaying total mercaptans, reduced glutathione (GSH) and mercaptans other than GSH in an aqueous medium reagents and kits for implementing same
DE10130144A1 (de) * 2001-06-22 2003-01-02 Wella Ag 1-Benzopyran-Derivate und deren Salze enthaltende Färbemittel
US7977486B2 (en) * 2006-09-08 2011-07-12 Osaka University Quinolinium ion derivatives, process for the production of the derivatives, products made by using the same, and reduction and oxidation methods with the derivatives
WO2012041493A1 (en) * 2010-09-28 2012-04-05 Julius-Maximilians-Universität Würzburg Aminoquinolinium salts, methods of their production and their use as active agents for biotechnological and medical applications against binary toxins
CA3057849A1 (en) * 2017-03-30 2018-10-04 The Board Of Regents Of The University Of Texas System Quinoline derived small molecule inhibitors of nicotinamide n-methyltransferase (nnmt) and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014514420A (ja) 2011-05-03 2014-06-19 ビーエーエスエフ ソシエタス・ヨーロピア ジスルフィド染料

Non-Patent Citations (5)

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Title
GABRIEL, S. et al.，Berichte der Deutschen Chemischen Gesellschaft [Abteilung] B: Abhandlungen ，1919年，pp. 1079-1092
GALANAKIS, D. et al.，Journal of Medicinal Chemistry，1995年，Vol. 38，pp. 595-606
MEGUELLATI, K. et al.，Molecular BioSystems ，2010年，Vol. 6，pp. 1694-1699
RUSINOV, G. L. et al.，Russian Journal of Organic Chemistry，1998年，Vol. 34，pp. 263-270
VAN HAREN, M. J. et al.，Biochemistry，2016年，Vol. 55，pp. 5307-5315

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AU2018244463B2 (en) 2024-04-04
US20230107256A1 (en) 2023-04-06
US20200102274A1 (en) 2020-04-02
CA3057849A1 (en) 2018-10-04
WO2018183668A1 (en) 2018-10-04
AU2018244463A1 (en) 2019-10-17
EP3600317A1 (en) 2020-02-05
US12071409B2 (en) 2024-08-27
EP3600317A4 (en) 2020-12-23
US11401243B2 (en) 2022-08-02
JP2020512356A (ja) 2020-04-23

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