CA3057849A1 - Quinoline derived small molecule inhibitors of nicotinamide n-methyltransferase (nnmt) and uses thereof - Google Patents

Quinoline derived small molecule inhibitors of nicotinamide n-methyltransferase (nnmt) and uses thereof Download PDF

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Publication number
CA3057849A1
CA3057849A1 CA3057849A CA3057849A CA3057849A1 CA 3057849 A1 CA3057849 A1 CA 3057849A1 CA 3057849 A CA3057849 A CA 3057849A CA 3057849 A CA3057849 A CA 3057849A CA 3057849 A1 CA3057849 A1 CA 3057849A1
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CA
Canada
Prior art keywords
nnmt
cations
cation
alkyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3057849A
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English (en)
French (fr)
Inventor
Stanley Watowich
Harshini NEELAKANTAN
Stanton Mchardy
Hua-yu WANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System filed Critical University of Texas System
Publication of CA3057849A1 publication Critical patent/CA3057849A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/10—Quaternary compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA3057849A 2017-03-30 2018-03-29 Quinoline derived small molecule inhibitors of nicotinamide n-methyltransferase (nnmt) and uses thereof Pending CA3057849A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762479256P 2017-03-30 2017-03-30
US62/479,256 2017-03-30
US201762559417P 2017-09-15 2017-09-15
US62/559,417 2017-09-15
PCT/US2018/025134 WO2018183668A1 (en) 2017-03-30 2018-03-29 Quinoline derived small molecule inhibitors of nicotinamide n-methyltransferase (nnmt) and uses thereof

Publications (1)

Publication Number Publication Date
CA3057849A1 true CA3057849A1 (en) 2018-10-04

Family

ID=63676960

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3057849A Pending CA3057849A1 (en) 2017-03-30 2018-03-29 Quinoline derived small molecule inhibitors of nicotinamide n-methyltransferase (nnmt) and uses thereof

Country Status (6)

Country Link
US (2) US11401243B2 (enExample)
EP (1) EP3600317A4 (enExample)
JP (1) JP7359439B2 (enExample)
AU (1) AU2018244463B2 (enExample)
CA (1) CA3057849A1 (enExample)
WO (1) WO2018183668A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3057849A1 (en) * 2017-03-30 2018-10-04 The Board Of Regents Of The University Of Texas System Quinoline derived small molecule inhibitors of nicotinamide n-methyltransferase (nnmt) and uses thereof
IL290345B2 (en) 2019-08-06 2025-03-01 Lilly Co Eli Pyrimidine-5-carboxamide compound
CN114272236A (zh) * 2020-09-27 2022-04-05 南京施江医药科技有限公司 用于判断线粒体氧化磷酸化通路抑制剂抗癌效果的标志物
CN114644626A (zh) * 2020-12-18 2022-06-21 南京施江医药科技有限公司 一种苯环类化合物及其应用
CN116969885A (zh) * 2023-08-01 2023-10-31 上海升德医药科技有限公司 一种5-氨基-1-烷基喹啉卤代物的合成工艺
WO2025149628A1 (en) 2024-01-12 2025-07-17 Astrazeneca Ab Piperidine derivatives as inhibitors of nicotinamide n-methyl transferase

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB846611A (en) * 1958-02-07 1960-08-31 Ici Ltd Nitroquinolones
FR1588846A (enExample) * 1965-07-25 1970-03-16
US4035367A (en) * 1974-09-09 1977-07-12 Sandoz, Inc. Hydroxyalkyl-substituted-amino-quinolines
US4431774A (en) * 1981-09-14 1984-02-14 Ciba-Geigy Corporation Process for the curing of stoving lacquers
US5817520A (en) * 1991-12-20 1998-10-06 Oxis International S.A. Spectrophotometric methods for assaying total mercaptans, reduced glutathione (GSH) and mercaptans other than GSH in an aqueous medium reagents and kits for implementing same
DE10130144A1 (de) * 2001-06-22 2003-01-02 Wella Ag 1-Benzopyran-Derivate und deren Salze enthaltende Färbemittel
US7977486B2 (en) * 2006-09-08 2011-07-12 Osaka University Quinolinium ion derivatives, process for the production of the derivatives, products made by using the same, and reduction and oxidation methods with the derivatives
WO2012041493A1 (en) * 2010-09-28 2012-04-05 Julius-Maximilians-Universität Würzburg Aminoquinolinium salts, methods of their production and their use as active agents for biotechnological and medical applications against binary toxins
EP2705094B1 (en) * 2011-05-03 2021-12-15 Basf Se Disulfide dyes
CA3057849A1 (en) * 2017-03-30 2018-10-04 The Board Of Regents Of The University Of Texas System Quinoline derived small molecule inhibitors of nicotinamide n-methyltransferase (nnmt) and uses thereof

Also Published As

Publication number Publication date
AU2018244463B2 (en) 2024-04-04
US20200102274A1 (en) 2020-04-02
WO2018183668A1 (en) 2018-10-04
JP7359439B2 (ja) 2023-10-11
US20230107256A1 (en) 2023-04-06
AU2018244463A1 (en) 2019-10-17
EP3600317A4 (en) 2020-12-23
US12071409B2 (en) 2024-08-27
EP3600317A1 (en) 2020-02-05
US11401243B2 (en) 2022-08-02
JP2020512356A (ja) 2020-04-23

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