AU2018236336B2 - Analogs of deutetrabenazine, their preparation and use - Google Patents

Analogs of deutetrabenazine, their preparation and use Download PDF

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Publication number
AU2018236336B2
AU2018236336B2 AU2018236336A AU2018236336A AU2018236336B2 AU 2018236336 B2 AU2018236336 B2 AU 2018236336B2 AU 2018236336 A AU2018236336 A AU 2018236336A AU 2018236336 A AU2018236336 A AU 2018236336A AU 2018236336 B2 AU2018236336 B2 AU 2018236336B2
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Australia
Prior art keywords
deutetrabenazine
compound
concentration
pharmaceutical composition
area
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AU2018236336A
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English (en)
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AU2018236336A1 (en
Inventor
Jim Kerr
Chengzi ZHANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Auspex Pharmaceuticals Inc
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Auspex Pharmaceuticals Inc
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Publication of AU2018236336A1 publication Critical patent/AU2018236336A1/en
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Priority to AU2022203369A priority Critical patent/AU2022203369B2/en
Assigned to AUSPEX PHARMACEUTICALS LLC reassignment AUSPEX PHARMACEUTICALS LLC Amend patent request/document other than specification (104) Assignors: AUSPEX PHARMACEUTICALS, INC.
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Pens And Brushes (AREA)
  • Machine Translation (AREA)
AU2018236336A 2017-03-15 2018-03-15 Analogs of deutetrabenazine, their preparation and use Active AU2018236336B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022203369A AU2022203369B2 (en) 2017-03-15 2022-05-18 Analogs of deutetrabenazine, their preparation and use

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762471484P 2017-03-15 2017-03-15
US62/471,484 2017-03-15
PCT/US2018/022562 WO2018170214A1 (en) 2017-03-15 2018-03-15 Analogs of deutetrabenazine, their preparation and use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022203369A Division AU2022203369B2 (en) 2017-03-15 2022-05-18 Analogs of deutetrabenazine, their preparation and use

Publications (2)

Publication Number Publication Date
AU2018236336A1 AU2018236336A1 (en) 2019-10-24
AU2018236336B2 true AU2018236336B2 (en) 2022-02-24

Family

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Family Applications (2)

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AU2018236336A Active AU2018236336B2 (en) 2017-03-15 2018-03-15 Analogs of deutetrabenazine, their preparation and use
AU2022203369A Active AU2022203369B2 (en) 2017-03-15 2022-05-18 Analogs of deutetrabenazine, their preparation and use

Family Applications After (1)

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AU2022203369A Active AU2022203369B2 (en) 2017-03-15 2022-05-18 Analogs of deutetrabenazine, their preparation and use

Country Status (20)

Country Link
US (4) US11813232B2 (https=)
EP (1) EP3596077A1 (https=)
JP (3) JP7608050B2 (https=)
KR (2) KR20230003308A (https=)
CN (1) CN110709398A (https=)
AR (1) AR111182A1 (https=)
AU (2) AU2018236336B2 (https=)
BR (1) BR112019018966A2 (https=)
CA (1) CA3056612A1 (https=)
CL (1) CL2019002629A1 (https=)
CO (1) CO2019011271A2 (https=)
EA (1) EA201992168A1 (https=)
IL (1) IL269132A (https=)
MX (1) MX2019010913A (https=)
PE (1) PE20191819A1 (https=)
SG (1) SG11201908477QA (https=)
TW (1) TWI772382B (https=)
UA (1) UA127052C2 (https=)
WO (1) WO2018170214A1 (https=)
ZA (1) ZA201906326B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA127052C2 (uk) 2017-03-15 2023-03-29 Оспекс Фармасьютікалс, Інк. Аналоги деутетрабеназину, їхнє отримання та застосування
TWI784220B (zh) 2018-12-13 2022-11-21 美商奧斯拜客斯製藥有限公司 腦性麻痺運動障礙之治療方法
WO2020165807A1 (en) * 2019-02-14 2020-08-20 Dr. Reddy's Laboratories Limited Solid forms of deutetrabenazine and process for the preparation thereof
US12599598B2 (en) 2020-06-10 2026-04-14 Auspex Pharmaceuticals Llc Osmotic dosage forms comprising deutetrabenazine and methods of use thereof
US11311488B2 (en) * 2020-06-10 2022-04-26 Auspex Pharmaceuticals, Inc. Osmotic dosage forms comprising deutetrabenazine and methods of use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010044981A2 (en) * 2008-09-18 2010-04-22 Auspex Pharmaceutical ,Inc. Benzoquinoline inhibitors of vesicular monoamine transporter 2
WO2011153157A2 (en) * 2010-06-01 2011-12-08 Auspex Pharmaceutical, Inc. Benzoquinolone inhibitors of vmat2
US20160222008A1 (en) * 2012-09-18 2016-08-04 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2081929T3 (pl) 2006-11-08 2013-06-28 Neurocrine Biosciences Inc Podstawione związki 3-izobutylo-9,10-dimetoksy-1,3,4,6,7,11b-heksahydro-2H-pirydo[2,1-a]izochinolin-2-olowe i ich wytwarzania
WO2012081031A1 (en) * 2010-12-15 2012-06-21 Enaltec Labs Pvt. Ltd. Process for preparing tetrabenazine
CN104684555A (zh) * 2012-09-18 2015-06-03 奥斯拜客斯制药有限公司 囊泡单胺转运体2的氘化苯并喹啉抑制剂的制剂药代动力学
EA201791466A1 (ru) * 2013-12-03 2017-11-30 Оспекс Фармасьютикалз, Инк. Способы получения соединений бензохинолина
HRP20221106T1 (hr) 2015-03-06 2022-11-25 Auspex Pharmaceuticals, Inc. Postupci liječenja abnormalnih nevoljnih poremećaja pokreta
UA127052C2 (uk) 2017-03-15 2023-03-29 Оспекс Фармасьютікалс, Інк. Аналоги деутетрабеназину, їхнє отримання та застосування

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010044981A2 (en) * 2008-09-18 2010-04-22 Auspex Pharmaceutical ,Inc. Benzoquinoline inhibitors of vesicular monoamine transporter 2
WO2011153157A2 (en) * 2010-06-01 2011-12-08 Auspex Pharmaceutical, Inc. Benzoquinolone inhibitors of vmat2
US20160222008A1 (en) * 2012-09-18 2016-08-04 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2

Also Published As

Publication number Publication date
EA201992168A1 (ru) 2020-03-16
JP7631572B2 (ja) 2025-02-18
AU2018236336A1 (en) 2019-10-24
SG11201908477QA (en) 2019-10-30
JP2023010754A (ja) 2023-01-20
BR112019018966A2 (pt) 2020-04-22
US20220040170A1 (en) 2022-02-10
MX2019010913A (es) 2020-01-20
TW201840317A (zh) 2018-11-16
EP3596077A1 (en) 2020-01-22
AU2022203369A1 (en) 2022-06-09
AU2022203369B2 (en) 2024-04-04
PE20191819A1 (es) 2019-12-27
WO2018170214A1 (en) 2018-09-20
US20200016148A1 (en) 2020-01-16
UA127052C2 (uk) 2023-03-29
US20220088006A1 (en) 2022-03-24
CA3056612A1 (en) 2018-09-20
CN110709398A (zh) 2020-01-17
KR20200003791A (ko) 2020-01-10
CO2019011271A2 (es) 2020-02-28
US11813232B2 (en) 2023-11-14
JP2020510073A (ja) 2020-04-02
IL269132A (en) 2019-11-28
US11179386B2 (en) 2021-11-23
TWI772382B (zh) 2022-08-01
JP7608050B2 (ja) 2025-01-06
KR20230003308A (ko) 2023-01-05
NZ757789A (en) 2024-08-30
JP2024050724A (ja) 2024-04-10
AR111182A1 (es) 2019-06-12
US20180263972A1 (en) 2018-09-20
US12502385B2 (en) 2025-12-23
CL2019002629A1 (es) 2020-01-24
ZA201906326B (en) 2022-12-21

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Owner name: AUSPEX PHARMACEUTICALS LLC

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