CL2019002629A1 - Análogos de deutetrabenazina, su preparación y uso. - Google Patents
Análogos de deutetrabenazina, su preparación y uso.Info
- Publication number
- CL2019002629A1 CL2019002629A1 CL2019002629A CL2019002629A CL2019002629A1 CL 2019002629 A1 CL2019002629 A1 CL 2019002629A1 CL 2019002629 A CL2019002629 A CL 2019002629A CL 2019002629 A CL2019002629 A CL 2019002629A CL 2019002629 A1 CL2019002629 A1 CL 2019002629A1
- Authority
- CL
- Chile
- Prior art keywords
- deutetrabenazine
- analogs
- preparation
- compositions
- same
- Prior art date
Links
- MKJIEFSOBYUXJB-VFJJUKLQSA-N (3r,11br)-3-(2-methylpropyl)-9,10-bis(trideuteriomethoxy)-1,3,4,6,7,11b-hexahydrobenzo[a]quinolizin-2-one Chemical class C1CN2C[C@@H](CC(C)C)C(=O)C[C@@H]2C2=C1C=C(OC([2H])([2H])[2H])C(OC([2H])([2H])[2H])=C2 MKJIEFSOBYUXJB-VFJJUKLQSA-N 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 229950005031 deutetrabenazine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
LA DIVULGACIÓN SE DIRIGE A ANÁLOGOS DE DEUTETRABENAZINA, COMPOSICIONES QUE COMPRENDEN LOS MISMOS Y MÉTODOS PARA DETECTAR LOS MISMOS EN COMPOSICIONES QUE COMPRENDEN DEUTETRABENAZINA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762471484P | 2017-03-15 | 2017-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2019002629A1 true CL2019002629A1 (es) | 2020-01-24 |
Family
ID=61873991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2019002629A CL2019002629A1 (es) | 2017-03-15 | 2019-09-13 | Análogos de deutetrabenazina, su preparación y uso. |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US11813232B2 (es) |
| EP (1) | EP3596077A1 (es) |
| JP (2) | JP2020510073A (es) |
| KR (2) | KR20200003791A (es) |
| CN (1) | CN110709398A (es) |
| AR (1) | AR111182A1 (es) |
| AU (2) | AU2018236336B2 (es) |
| BR (1) | BR112019018966A2 (es) |
| CA (1) | CA3056612A1 (es) |
| CL (1) | CL2019002629A1 (es) |
| CO (1) | CO2019011271A2 (es) |
| EA (1) | EA201992168A1 (es) |
| IL (1) | IL269132A (es) |
| MX (1) | MX2019010913A (es) |
| PE (1) | PE20191819A1 (es) |
| SG (1) | SG11201908477QA (es) |
| TW (1) | TWI772382B (es) |
| UA (1) | UA127052C2 (es) |
| WO (1) | WO2018170214A1 (es) |
| ZA (1) | ZA201906326B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3893876A1 (en) * | 2018-12-13 | 2021-10-20 | Auspex Pharmaceuticals, Inc. | Deutetrabenazine for the treatment of dyskinesia in cerebral palsy |
| WO2020165807A1 (en) * | 2019-02-14 | 2020-08-20 | Dr. Reddy's Laboratories Limited | Solid forms of deutetrabenazine and process for the preparation thereof |
| KR102638424B1 (ko) * | 2020-06-10 | 2024-02-19 | 오스펙스 파마슈티칼스, 인코포레이티드 | 듀테트라베나진을 포함하는 삼투성 제형 및 이의 사용 방법 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2402220T3 (es) | 2006-11-08 | 2013-04-29 | Neurocrine Biosciences, Inc. | Compuestos de 3-isobutil-9,10-dimetoxi-1,3,4,6,7,11b-hexahidro-2H-pirido[2,1-a]isoquinolin-2-ol sustituidos y métodos relacionados con los mismos |
| CN104311552A (zh) * | 2008-09-18 | 2015-01-28 | 奥斯拜客斯制药有限公司 | 囊泡单胺转运体2 的苯并喹啉抑制剂 |
| EP3351247A1 (en) * | 2010-06-01 | 2018-07-25 | Auspex Pharmaceutical, Inc. | Benzoquinolone inhibitors of vmat2 |
| WO2012081031A1 (en) * | 2010-12-15 | 2012-06-21 | Enaltec Labs Pvt. Ltd. | Process for preparing tetrabenazine |
| BR112015005894B1 (pt) * | 2012-09-18 | 2022-03-29 | Auspex Pharmaceuticals, Inc | Composto, composição farmacêutica, método para tratar um distúrbio mediado por vmat2 e formulação farmacêutica de liberação prolongada |
| US9550780B2 (en) * | 2012-09-18 | 2017-01-24 | Auspex Pharmaceuticals, Inc. | Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| BR112016012747B1 (pt) | 2013-12-03 | 2022-07-12 | Auspex Pharmaceuticals, Inc | Processo de preparação de uma mistura racêmica de (rr,ss)-d6-tetrabenazina |
| HUE059747T2 (hu) | 2015-03-06 | 2022-12-28 | Auspex Pharmaceuticals Inc | Eljárások rendellenes, akaratlan mozgással járó zavarok kezelésére |
-
2018
- 2018-03-15 EA EA201992168A patent/EA201992168A1/ru unknown
- 2018-03-15 KR KR1020197030354A patent/KR20200003791A/ko not_active Application Discontinuation
- 2018-03-15 TW TW107108832A patent/TWI772382B/zh active
- 2018-03-15 BR BR112019018966A patent/BR112019018966A2/pt active Search and Examination
- 2018-03-15 WO PCT/US2018/022562 patent/WO2018170214A1/en unknown
- 2018-03-15 AR ARP180100611A patent/AR111182A1/es unknown
- 2018-03-15 KR KR1020227043234A patent/KR20230003308A/ko not_active Application Discontinuation
- 2018-03-15 UA UAA201910309A patent/UA127052C2/uk unknown
- 2018-03-15 PE PE2019001871A patent/PE20191819A1/es unknown
- 2018-03-15 EP EP18715393.7A patent/EP3596077A1/en active Pending
- 2018-03-15 CA CA3056612A patent/CA3056612A1/en active Pending
- 2018-03-15 JP JP2019550774A patent/JP2020510073A/ja active Pending
- 2018-03-15 US US15/922,329 patent/US11813232B2/en active Active
- 2018-03-15 SG SG11201908477Q patent/SG11201908477QA/en unknown
- 2018-03-15 MX MX2019010913A patent/MX2019010913A/es unknown
- 2018-03-15 CN CN201880018609.8A patent/CN110709398A/zh active Pending
- 2018-03-15 AU AU2018236336A patent/AU2018236336B2/en active Active
-
2019
- 2019-09-04 IL IL26913219A patent/IL269132A/en unknown
- 2019-09-13 CL CL2019002629A patent/CL2019002629A1/es unknown
- 2019-09-25 ZA ZA2019/06326A patent/ZA201906326B/en unknown
- 2019-09-25 US US16/582,362 patent/US11179386B2/en active Active
- 2019-10-10 CO CONC2019/0011271A patent/CO2019011271A2/es unknown
-
2021
- 2021-10-21 US US17/507,037 patent/US20220040170A1/en active Pending
- 2021-11-30 US US17/537,663 patent/US20220088006A1/en not_active Abandoned
-
2022
- 2022-05-18 AU AU2022203369A patent/AU2022203369B2/en active Active
- 2022-11-04 JP JP2022177578A patent/JP2023010754A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| UA127052C2 (uk) | 2023-03-29 |
| US20180263972A1 (en) | 2018-09-20 |
| WO2018170214A1 (en) | 2018-09-20 |
| US20200016148A1 (en) | 2020-01-16 |
| CO2019011271A2 (es) | 2020-02-28 |
| TWI772382B (zh) | 2022-08-01 |
| PE20191819A1 (es) | 2019-12-27 |
| TW201840317A (zh) | 2018-11-16 |
| US11813232B2 (en) | 2023-11-14 |
| US20220088006A1 (en) | 2022-03-24 |
| SG11201908477QA (en) | 2019-10-30 |
| KR20200003791A (ko) | 2020-01-10 |
| JP2020510073A (ja) | 2020-04-02 |
| AU2018236336A1 (en) | 2019-10-24 |
| MX2019010913A (es) | 2020-01-20 |
| US11179386B2 (en) | 2021-11-23 |
| KR20230003308A (ko) | 2023-01-05 |
| EP3596077A1 (en) | 2020-01-22 |
| US20220040170A1 (en) | 2022-02-10 |
| EA201992168A1 (ru) | 2020-03-16 |
| AU2022203369A1 (en) | 2022-06-09 |
| AU2022203369B2 (en) | 2024-04-04 |
| BR112019018966A2 (pt) | 2020-04-22 |
| IL269132A (en) | 2019-11-28 |
| CN110709398A (zh) | 2020-01-17 |
| AU2018236336B2 (en) | 2022-02-24 |
| CA3056612A1 (en) | 2018-09-20 |
| JP2023010754A (ja) | 2023-01-20 |
| ZA201906326B (en) | 2022-12-21 |
| AR111182A1 (es) | 2019-06-12 |
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