SG11201908477QA - Analogs of deutetrabenazine, their preparation and use - Google Patents
Analogs of deutetrabenazine, their preparation and useInfo
- Publication number
- SG11201908477QA SG11201908477QA SG11201908477QA SG11201908477QA SG 11201908477Q A SG11201908477Q A SG 11201908477QA SG 11201908477Q A SG11201908477Q A SG 11201908477QA SG 11201908477Q A SG11201908477Q A SG 11201908477QA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- deutetrabenazine
- pct
- analogs
- english
- Prior art date
Links
- MKJIEFSOBYUXJB-VFJJUKLQSA-N (3r,11br)-3-(2-methylpropyl)-9,10-bis(trideuteriomethoxy)-1,3,4,6,7,11b-hexahydrobenzo[a]quinolizin-2-one Chemical compound C1CN2C[C@@H](CC(C)C)C(=O)C[C@@H]2C2=C1C=C(OC([2H])([2H])[2H])C(OC([2H])([2H])[2H])=C2 MKJIEFSOBYUXJB-VFJJUKLQSA-N 0.000 title abstract 4
- 229950005031 deutetrabenazine Drugs 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- FWXAUDSWDBGCMN-DNQXCXABSA-N [(2r,3r)-3-diphenylphosphanylbutan-2-yl]-diphenylphosphane Chemical compound C=1C=CC=CC=1P([C@H](C)[C@@H](C)P(C=1C=CC=CC=1)C=1C=CC=CC=1)C1=CC=CC=C1 FWXAUDSWDBGCMN-DNQXCXABSA-N 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIP0 I PCT omit °nolo mum° oimIE (10) International Publication Number WO 2018/170214 Al (51) International Patent Classification: CO7D 471/04 (2006.01) A61P 25/00 (2006.01) A61K 31/4375 (2006.01) (21) International Application Number: PCT/US2018/022562 (22) International Filing Date: 15 March 2018 (15.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/471,484 15 March 2017 (15.03.2017) US (72) Inventors; and (71) Applicants: ZHANG, Chengzi [US/US]; 5245 South- hampton Cove, San Diego, CA 93130 (US). KERR, Jim [US/US]; 1090 Horsham Road, North Wales, PA 19454 (US). (74) Agent: LODISE, Stephanie, A.; Baker & Hostetler LLP, Cira Centre, 12th Floor, 2929 Arch Street, Philadelphia, PA 19104 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) 1-1 (54) Title: ANALOGS OF DEUTETRABENAZINE, THEIR PREPARATION AND USE (57) : The disclosure is directed to deutetrabenazine analogs, compositions comprising same and methods of detecting same 0 in compositions comprising deutetrabenazine.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762471484P | 2017-03-15 | 2017-03-15 | |
| PCT/US2018/022562 WO2018170214A1 (en) | 2017-03-15 | 2018-03-15 | Analogs of deutetrabenazine, their preparation and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201908477QA true SG11201908477QA (en) | 2019-10-30 |
Family
ID=61873991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201908477Q SG11201908477QA (en) | 2017-03-15 | 2018-03-15 | Analogs of deutetrabenazine, their preparation and use |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US11813232B2 (en) |
| EP (1) | EP3596077A1 (en) |
| JP (3) | JP2020510073A (en) |
| KR (2) | KR20230003308A (en) |
| CN (1) | CN110709398A (en) |
| AR (1) | AR111182A1 (en) |
| AU (2) | AU2018236336B2 (en) |
| BR (1) | BR112019018966A2 (en) |
| CA (1) | CA3056612A1 (en) |
| CL (1) | CL2019002629A1 (en) |
| CO (1) | CO2019011271A2 (en) |
| EA (1) | EA201992168A1 (en) |
| IL (1) | IL269132A (en) |
| MX (1) | MX2019010913A (en) |
| PE (1) | PE20191819A1 (en) |
| SG (1) | SG11201908477QA (en) |
| TW (1) | TWI772382B (en) |
| UA (1) | UA127052C2 (en) |
| WO (1) | WO2018170214A1 (en) |
| ZA (1) | ZA201906326B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11324732B2 (en) * | 2018-12-13 | 2022-05-10 | Auspex Pharmaceuticals, Inc. | Methods for the treatment of dyskinesia in cerebral palsy |
| WO2020165807A1 (en) * | 2019-02-14 | 2020-08-20 | Dr. Reddy's Laboratories Limited | Solid forms of deutetrabenazine and process for the preparation thereof |
| CA3186425A1 (en) * | 2020-06-10 | 2021-12-16 | Auspex Pharmaceuticals, Inc. | Osmotic dosage forms comprising deutetrabenazine and methods of use thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5290185B2 (en) | 2006-11-08 | 2013-09-18 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | Substituted 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido [2,1-a] isoquinolin-2-ol compounds and related methods |
| DK3061760T3 (en) | 2008-09-18 | 2018-02-05 | Auspex Pharmaceuticals Inc | DEUTERATED BENZOQUINOLIZIN DERIVATIVES AS INHIBITORS OF VESICULAR MONOAMIN TRANSPORT 2 |
| WO2011153157A2 (en) * | 2010-06-01 | 2011-12-08 | Auspex Pharmaceutical, Inc. | Benzoquinolone inhibitors of vmat2 |
| WO2012081031A1 (en) * | 2010-12-15 | 2012-06-21 | Enaltec Labs Pvt. Ltd. | Process for preparing tetrabenazine |
| BR112015005894B1 (en) | 2012-09-18 | 2022-03-29 | Auspex Pharmaceuticals, Inc | Compound, pharmaceutical composition, method for treating a vmat2-mediated disorder, and extended-release pharmaceutical formulation |
| US9550780B2 (en) * | 2012-09-18 | 2017-01-24 | Auspex Pharmaceuticals, Inc. | Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| EP3424504A1 (en) | 2013-12-03 | 2019-01-09 | Auspex Pharmaceuticals, Inc. | Methods of manufacturing benzoquinoline compounds |
| IL305352A (en) | 2015-03-06 | 2023-10-01 | Auspex Pharmaceuticals Inc | Methods for the treatment of abnormal involuntary movement disorders |
-
2018
- 2018-03-15 SG SG11201908477Q patent/SG11201908477QA/en unknown
- 2018-03-15 EP EP18715393.7A patent/EP3596077A1/en active Pending
- 2018-03-15 KR KR1020227043234A patent/KR20230003308A/en not_active Application Discontinuation
- 2018-03-15 KR KR1020197030354A patent/KR20200003791A/en not_active Application Discontinuation
- 2018-03-15 WO PCT/US2018/022562 patent/WO2018170214A1/en unknown
- 2018-03-15 UA UAA201910309A patent/UA127052C2/en unknown
- 2018-03-15 US US15/922,329 patent/US11813232B2/en active Active
- 2018-03-15 TW TW107108832A patent/TWI772382B/en active
- 2018-03-15 EA EA201992168A patent/EA201992168A1/en unknown
- 2018-03-15 AU AU2018236336A patent/AU2018236336B2/en active Active
- 2018-03-15 AR ARP180100611A patent/AR111182A1/en unknown
- 2018-03-15 JP JP2019550774A patent/JP2020510073A/en active Pending
- 2018-03-15 CA CA3056612A patent/CA3056612A1/en active Pending
- 2018-03-15 MX MX2019010913A patent/MX2019010913A/en unknown
- 2018-03-15 BR BR112019018966A patent/BR112019018966A2/en active Search and Examination
- 2018-03-15 PE PE2019001871A patent/PE20191819A1/en unknown
- 2018-03-15 CN CN201880018609.8A patent/CN110709398A/en active Pending
-
2019
- 2019-09-04 IL IL26913219A patent/IL269132A/en unknown
- 2019-09-13 CL CL2019002629A patent/CL2019002629A1/en unknown
- 2019-09-25 ZA ZA2019/06326A patent/ZA201906326B/en unknown
- 2019-09-25 US US16/582,362 patent/US11179386B2/en active Active
- 2019-10-10 CO CONC2019/0011271A patent/CO2019011271A2/en unknown
-
2021
- 2021-10-21 US US17/507,037 patent/US20220040170A1/en active Pending
- 2021-11-30 US US17/537,663 patent/US20220088006A1/en not_active Abandoned
-
2022
- 2022-05-18 AU AU2022203369A patent/AU2022203369B2/en active Active
- 2022-11-04 JP JP2022177578A patent/JP2023010754A/en active Pending
-
2024
- 2024-01-30 JP JP2024011974A patent/JP2024050724A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2022203369A1 (en) | 2022-06-09 |
| IL269132A (en) | 2019-11-28 |
| EP3596077A1 (en) | 2020-01-22 |
| JP2020510073A (en) | 2020-04-02 |
| TWI772382B (en) | 2022-08-01 |
| US20220040170A1 (en) | 2022-02-10 |
| US11179386B2 (en) | 2021-11-23 |
| JP2024050724A (en) | 2024-04-10 |
| PE20191819A1 (en) | 2019-12-27 |
| US11813232B2 (en) | 2023-11-14 |
| US20180263972A1 (en) | 2018-09-20 |
| WO2018170214A1 (en) | 2018-09-20 |
| CA3056612A1 (en) | 2018-09-20 |
| EA201992168A1 (en) | 2020-03-16 |
| US20220088006A1 (en) | 2022-03-24 |
| AU2018236336B2 (en) | 2022-02-24 |
| CN110709398A (en) | 2020-01-17 |
| UA127052C2 (en) | 2023-03-29 |
| US20200016148A1 (en) | 2020-01-16 |
| AU2022203369B2 (en) | 2024-04-04 |
| TW201840317A (en) | 2018-11-16 |
| CL2019002629A1 (en) | 2020-01-24 |
| ZA201906326B (en) | 2022-12-21 |
| KR20200003791A (en) | 2020-01-10 |
| AR111182A1 (en) | 2019-06-12 |
| CO2019011271A2 (en) | 2020-02-28 |
| JP2023010754A (en) | 2023-01-20 |
| MX2019010913A (en) | 2020-01-20 |
| KR20230003308A (en) | 2023-01-05 |
| BR112019018966A2 (en) | 2020-04-22 |
| AU2018236336A1 (en) | 2019-10-24 |
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