AU2018234806A1 - Somatostatin modulators and uses thereof - Google Patents
Somatostatin modulators and uses thereof Download PDFInfo
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- AU2018234806A1 AU2018234806A1 AU2018234806A AU2018234806A AU2018234806A1 AU 2018234806 A1 AU2018234806 A1 AU 2018234806A1 AU 2018234806 A AU2018234806 A AU 2018234806A AU 2018234806 A AU2018234806 A AU 2018234806A AU 2018234806 A1 AU2018234806 A1 AU 2018234806A1
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- 102000005157 Somatostatin Human genes 0.000 title abstract description 20
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Neurology (AREA)
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- Neurosurgery (AREA)
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- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| IL269241B (en) | 2017-03-16 | 2022-09-01 | Crinetics Pharmaceuticals Inc | Somatostatin modulators and uses thereof |
| EP3752498B1 (en) | 2018-02-12 | 2023-06-28 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| WO2019240246A1 (ja) * | 2018-06-15 | 2019-12-19 | 小野薬品工業株式会社 | ピペリジノール誘導体の新規な塩および新規結晶形 |
| EP4548974A3 (en) * | 2018-09-18 | 2025-08-13 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| TWI841768B (zh) | 2019-08-14 | 2024-05-11 | 美商克林提克斯醫藥股份有限公司 | 非肽生長抑制素(somatostatin)5型受體激動劑及其用途 |
| WO2021076448A1 (en) * | 2019-10-14 | 2021-04-22 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators for treating pituitary adenomas |
| AR121682A1 (es) | 2020-03-31 | 2022-06-29 | Takeda Pharmaceuticals Co | Derivados de n-(heterociclil y heterociclilalquil)-3-bencilpiridin-2-amina como agonistas de sstr4 |
| KR20230066379A (ko) | 2020-09-09 | 2023-05-15 | 크리네틱스 파마슈티칼스, 인크. | 소마토스타틴 조절제 제형 |
| IL305011A (en) | 2021-02-17 | 2023-10-01 | Crinetics Pharmaceuticals Inc | Crystalline forms of a somatostatin modulator |
| EP4351654A4 (en) * | 2021-06-09 | 2025-11-12 | Crinetics Pharmaceuticals Inc | Non-peptide targeted therapeutic agents and their uses |
| CN114591326B (zh) * | 2022-02-28 | 2024-02-27 | 上海筛杰生物医药有限公司 | Cct-251921的中间体及其制备方法 |
| PE20251882A1 (es) * | 2022-10-28 | 2025-07-22 | Basecamp Bio Inc | Agonistas del receptor de la somatostatina 2 y usos de estos |
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| US6127343A (en) | 1996-05-14 | 2000-10-03 | Novo Nordisk A/S | Somatostatin agonists and antagonists |
| US6025372A (en) | 1997-04-04 | 2000-02-15 | Merck & Co., Inc. | Somatostatin agonists |
| FR2802206B1 (fr) | 1999-12-14 | 2005-04-22 | Sod Conseils Rech Applic | Derives de 4-aminopiperidine et leur utilisation en tant que medicament |
| US20060281764A1 (en) | 2005-06-10 | 2006-12-14 | Gaul Michael D | Aminopyrimidines as kinase modulators |
| AU2007309708A1 (en) | 2006-03-13 | 2008-05-02 | Merck Sharp & Dohme Corp. | Somatostatin agonists |
| US7754744B2 (en) | 2006-08-15 | 2010-07-13 | Hoffmann-La Roche Inc. | Substituted piperidinamines as somatostatin receptor subtype 5 (SSTR5) antagonists |
| EP2211619A1 (en) | 2007-10-18 | 2010-08-04 | Merck Sharp & Dohme Corp. | Substituted 1,2,4-oxadiazoles and analogs thereof as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases |
| BRPI0914775A2 (pt) | 2008-06-25 | 2015-10-20 | Envivo Pharmaceuticals Inc | compostos de fenila dissubstituídos |
| GB0818241D0 (en) | 2008-10-06 | 2008-11-12 | Cancer Res Technology | Compounds and their use |
| US20120157471A1 (en) * | 2009-09-01 | 2012-06-21 | Pfizer Inc. | Benzimidazole derivatives |
| US20130040978A1 (en) | 2010-05-18 | 2013-02-14 | Joseph L. Duffy | Spiro isoxazoline compounds as sstr5 antagonists |
| GB201008290D0 (en) | 2010-05-18 | 2010-06-30 | Syngenta Ltd | Chemical compounds |
| JP6299591B2 (ja) * | 2012-07-03 | 2018-03-28 | 小野薬品工業株式会社 | ソマトスタチン受容体作動活性を有する化合物およびその医薬用途 |
| PT3053916T (pt) * | 2013-09-30 | 2019-03-26 | Ono Pharmaceutical Co | Composto com atividade agonista do recetor da somatostatina e utiliza ao farmaceutica do mesmo |
| ES2675504T3 (es) | 2013-10-02 | 2018-07-11 | Kuraray Co., Ltd. | Composición de resina, lámina de múltiples capas, material de envasado y recipiente |
| PT3484865T (pt) | 2016-07-14 | 2022-11-03 | Crinetics Pharmaceuticals Inc | Moduladores da somatostatina e suas utilizações |
| TW201835081A (zh) * | 2017-02-08 | 2018-10-01 | 日商小野藥品工業股份有限公司 | 具有體抑素受體促效活性之化合物及其醫藥用途 |
| IL269241B (en) | 2017-03-16 | 2022-09-01 | Crinetics Pharmaceuticals Inc | Somatostatin modulators and uses thereof |
| US11028068B2 (en) | 2017-07-25 | 2021-06-08 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| EP3752498B1 (en) | 2018-02-12 | 2023-06-28 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| EP4548974A3 (en) | 2018-09-18 | 2025-08-13 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
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| EP3596062A1 (en) | 2020-01-22 |
| US11072598B2 (en) | 2021-07-27 |
| SG11201908512YA (en) | 2019-10-30 |
| US20200010453A1 (en) | 2020-01-09 |
| TW201840550A (zh) | 2018-11-16 |
| BR112019019168A2 (pt) | 2020-04-14 |
| MX2019010949A (es) | 2019-10-24 |
| JP7106564B2 (ja) | 2022-07-26 |
| NZ757081A (en) | 2023-03-31 |
| EA201992083A1 (ru) | 2020-03-18 |
| CN110650951B (zh) | 2023-02-24 |
| CA3056131A1 (en) | 2018-09-20 |
| KR20190121404A (ko) | 2019-10-25 |
| WO2018170284A1 (en) | 2018-09-20 |
| EP3596062A4 (en) | 2020-08-26 |
| UA127346C2 (uk) | 2023-07-26 |
| CN110650951A (zh) | 2020-01-03 |
| IL269241A (en) | 2019-11-28 |
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