AU2018233402A1 - Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating ire1-related diseases and disorders - Google Patents
Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating ire1-related diseases and disorders Download PDFInfo
- Publication number
- AU2018233402A1 AU2018233402A1 AU2018233402A AU2018233402A AU2018233402A1 AU 2018233402 A1 AU2018233402 A1 AU 2018233402A1 AU 2018233402 A AU2018233402 A AU 2018233402A AU 2018233402 A AU2018233402 A AU 2018233402A AU 2018233402 A1 AU2018233402 A1 AU 2018233402A1
- Authority
- AU
- Australia
- Prior art keywords
- compound
- oxy
- alkyldiyl
- pyrimidin
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 Cc1cc(N)c2c(NS(*)(=O)=O)c(*)ccc2c1Oc1ncccc1-c1ccnc(NC2CNCC(*)C2)n1 Chemical compound Cc1cc(N)c2c(NS(*)(=O)=O)c(*)ccc2c1Oc1ncccc1-c1ccnc(NC2CNCC(*)C2)n1 0.000 description 9
- AOKOAPNIZCHADH-NUZLPUNMSA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(C)ccc3c2cccc3N[C@H](CCC2)[C@@H]2O)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(C)ccc3c2cccc3N[C@H](CCC2)[C@@H]2O)ccn1)=O AOKOAPNIZCHADH-NUZLPUNMSA-N 0.000 description 2
- WXFFILODGVBTGG-HNNXBMFYSA-N C=C(COCc1ccccc1)N(CCC1)C[C@H]1N Chemical compound C=C(COCc1ccccc1)N(CCC1)C[C@H]1N WXFFILODGVBTGG-HNNXBMFYSA-N 0.000 description 1
- MBTBRHHTOAQKRV-NRFANRHFSA-N CC(C)(C)CC(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)=O Chemical compound CC(C)(C)CC(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)=O MBTBRHHTOAQKRV-NRFANRHFSA-N 0.000 description 1
- MFBMWRPEXAKBBS-IBGZPJMESA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(C)ccc3c2ccc(Br)c3N)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(C)ccc3c2ccc(Br)c3N)ccn1)=O MFBMWRPEXAKBBS-IBGZPJMESA-N 0.000 description 1
- LHRJFOCAQNWALU-QHCPKHFHSA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(C)ccc3c2cccc3NS(N2CCC2)(=O)=O)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(C)ccc3c2cccc3NS(N2CCC2)(=O)=O)ccn1)=O LHRJFOCAQNWALU-QHCPKHFHSA-N 0.000 description 1
- RMBHYNGFIHAFRV-SANMLTNESA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(ccc(F)c3NC(CC4CCCCC4)=O)c3ccc2C)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(ccc(F)c3NC(CC4CCCCC4)=O)c3ccc2C)ccn1)=O RMBHYNGFIHAFRV-SANMLTNESA-N 0.000 description 1
- YUPOBFXMYMPXDF-MHZLTWQESA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(ccc(F)c3NS(Cc(cccc4)c4C#N)(=O)=O)c3ccc2C)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(ccc(F)c3NS(Cc(cccc4)c4C#N)(=O)=O)c3ccc2C)ccn1)=O YUPOBFXMYMPXDF-MHZLTWQESA-N 0.000 description 1
- QFNPHQBVQNKRTD-VWLOTQADSA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(ccc(F)c3NS(Cc(cccc4)c4Cl)(=O)=O)c3ccc2C)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(ccc(F)c3NS(Cc(cccc4)c4Cl)(=O)=O)c3ccc2C)ccn1)=O QFNPHQBVQNKRTD-VWLOTQADSA-N 0.000 description 1
- NLBNPJXDXWYVBC-QHCPKHFHSA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(ccc(F)c3NS(Cc4n[o]c(C)c4)(=O)=O)c3ccc2C)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(ccc(F)c3NS(Cc4n[o]c(C)c4)(=O)=O)c3ccc2C)ccn1)=O NLBNPJXDXWYVBC-QHCPKHFHSA-N 0.000 description 1
- HBUXWCLVBZYCKK-NRFANRHFSA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(ccc(F)c3NS(N(CCO4)C4=O)(=O)=O)c3ccc2C)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(ccc(F)c3NS(N(CCO4)C4=O)(=O)=O)c3ccc2C)ccn1)=O HBUXWCLVBZYCKK-NRFANRHFSA-N 0.000 description 1
- XMMJYSRYFGGRGT-DEOSSOPVSA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3-[n]4nc(C)cc4)c3ccc2C)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3-[n]4nc(C)cc4)c3ccc2C)ccn1)=O XMMJYSRYFGGRGT-DEOSSOPVSA-N 0.000 description 1
- QKIJRJXWHOUMSY-DEOSSOPVSA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3N(CCC45CC4)C5=O)c3ccc2C)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3N(CCC45CC4)C5=O)c3ccc2C)ccn1)=O QKIJRJXWHOUMSY-DEOSSOPVSA-N 0.000 description 1
- ZWFIOPDBKYBEAN-VWLOTQADSA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3N(CCCCC4)C4=O)c3ccc2C)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3N(CCCCC4)C4=O)c3ccc2C)ccn1)=O ZWFIOPDBKYBEAN-VWLOTQADSA-N 0.000 description 1
- APUJBWUYOSCESI-QHCPKHFHSA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3NC(C(C)(C)C#N)=O)c3ccc2C)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3NC(C(C)(C)C#N)=O)c3ccc2C)ccn1)=O APUJBWUYOSCESI-QHCPKHFHSA-N 0.000 description 1
- PKYDZYNIMOVNKC-QFIPXVFZSA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3NC(C4(CC4)F)=O)c3ccc2C)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3NC(C4(CC4)F)=O)c3ccc2C)ccn1)=O PKYDZYNIMOVNKC-QFIPXVFZSA-N 0.000 description 1
- IUNQOCZVUPFUNE-LWAJAQLZSA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3NC(CC(C(F)(F)F)O)=O)c3ccc2C)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3NC(CC(C(F)(F)F)O)=O)c3ccc2C)ccn1)=O IUNQOCZVUPFUNE-LWAJAQLZSA-N 0.000 description 1
- RPBCRIZMXVTWPY-QFIPXVFZSA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3NCC(OC)=O)c3ccc2C)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3NCC(OC)=O)c3ccc2C)ccn1)=O RPBCRIZMXVTWPY-QFIPXVFZSA-N 0.000 description 1
- PQGXNAUKIRYYDM-VWLOTQADSA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3NCCC4CC4)c3ccc2C)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3NCCC4CC4)c3ccc2C)ccn1)=O PQGXNAUKIRYYDM-VWLOTQADSA-N 0.000 description 1
- FVTUOFSNRHWPSA-DEOSSOPVSA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3NCCc4c[s]cn4)c3ccc2C)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3NCCc4c[s]cn4)c3ccc2C)ccn1)=O FVTUOFSNRHWPSA-DEOSSOPVSA-N 0.000 description 1
- DAFNLRIGHUTOKX-XZOQPEGZSA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3NC[C@@H](CF)O)c3ccc2C)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3NC[C@@H](CF)O)c3ccc2C)ccn1)=O DAFNLRIGHUTOKX-XZOQPEGZSA-N 0.000 description 1
- LIPFDIDWTGNCEA-GOTSBHOMSA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3NC[C@H](C4)C4(F)F)c3ccc2C)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3NC[C@H](C4)C4(F)F)c3ccc2C)ccn1)=O LIPFDIDWTGNCEA-GOTSBHOMSA-N 0.000 description 1
- DAFNLRIGHUTOKX-GOTSBHOMSA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3NC[C@H](CF)O)c3ccc2C)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3NC[C@H](CF)O)c3ccc2C)ccn1)=O DAFNLRIGHUTOKX-GOTSBHOMSA-N 0.000 description 1
- RMMWPSILJGDYAK-DEOSSOPVSA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3NS(N4CCCC4)(=O)=O)c3ccc2C)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3NS(N4CCCC4)(=O)=O)c3ccc2C)ccn1)=O RMMWPSILJGDYAK-DEOSSOPVSA-N 0.000 description 1
- AOKOAPNIZCHADH-HDXYBINASA-N CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3N[C@@H](CCC4)[C@H]4O)c3ccc2C)ccn1)=O Chemical compound CC(C)(C)OC(N(CCC1)C[C@H]1Nc1nc(-c2cccnc2Oc2c(cccc3N[C@@H](CCC4)[C@H]4O)c3ccc2C)ccn1)=O AOKOAPNIZCHADH-HDXYBINASA-N 0.000 description 1
- PMBYOHGOIUIJOX-UHFFFAOYSA-N CC(C)(C)OC(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(SC)n1)=O Chemical compound CC(C)(C)OC(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(SC)n1)=O PMBYOHGOIUIJOX-UHFFFAOYSA-N 0.000 description 1
- MNFXVZTUSQUGNS-QHCPKHFHSA-N CC(C)C(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(OC(C)(C)C)=O)n1)=O Chemical compound CC(C)C(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(OC(C)(C)C)=O)n1)=O MNFXVZTUSQUGNS-QHCPKHFHSA-N 0.000 description 1
- NMDNELPKKQBMKA-FPOVZHCZSA-N CC(C)CS(Nc(c1ccc(C)c(Oc2ncccc2-c2ccnc(N[C@@H]3CNC[C@@H](C)C3)n2)c1cc1)c1F)(=O)=O Chemical compound CC(C)CS(Nc(c1ccc(C)c(Oc2ncccc2-c2ccnc(N[C@@H]3CNC[C@@H](C)C3)n2)c1cc1)c1F)(=O)=O NMDNELPKKQBMKA-FPOVZHCZSA-N 0.000 description 1
- NMDNELPKKQBMKA-CTNGQTDRSA-N CC(C)CS(Nc(c1ccc(C)c(Oc2ncccc2-c2ccnc(N[C@@H]3CNC[C@H](C)C3)n2)c1cc1)c1F)(=O)=O Chemical compound CC(C)CS(Nc(c1ccc(C)c(Oc2ncccc2-c2ccnc(N[C@@H]3CNC[C@H](C)C3)n2)c1cc1)c1F)(=O)=O NMDNELPKKQBMKA-CTNGQTDRSA-N 0.000 description 1
- RTOKPVZFMDBRJU-DEOSSOPVSA-N CC(C)CS(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(OC(C)(C)C)=O)n1)(=O)=O Chemical compound CC(C)CS(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(OC(C)(C)C)=O)n1)(=O)=O RTOKPVZFMDBRJU-DEOSSOPVSA-N 0.000 description 1
- QZPFFLUIVKARTL-NRFANRHFSA-N CC(C)CS(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)(=O)=O Chemical compound CC(C)CS(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)(=O)=O QZPFFLUIVKARTL-NRFANRHFSA-N 0.000 description 1
- KKGVSGWRGDBRBV-HEIUKZKOSA-N CC(CC1)CC1C(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(OC(C)(C)C)=O)n1)=O Chemical compound CC(CC1)CC1C(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(OC(C)(C)C)=O)n1)=O KKGVSGWRGDBRBV-HEIUKZKOSA-N 0.000 description 1
- PPBCASUXGWZYPK-LQKDOSGMSA-N CC(CC1)C[C@@H]1C(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)=O Chemical compound CC(CC1)C[C@@H]1C(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)=O PPBCASUXGWZYPK-LQKDOSGMSA-N 0.000 description 1
- CFTFRANIVWBHCA-DHWVBAGJSA-N CC(CCC1)C1C(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(OC(C)(C)C)=O)n1)=O Chemical compound CC(CCC1)C1C(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(OC(C)(C)C)=O)n1)=O CFTFRANIVWBHCA-DHWVBAGJSA-N 0.000 description 1
- YNKBIBRVCPPITQ-LBAQZLPGSA-N CC(CCC1=O)N1c(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 Chemical compound CC(CCC1=O)N1c(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 YNKBIBRVCPPITQ-LBAQZLPGSA-N 0.000 description 1
- VXPMJHMPCKQIGA-CGAIIQECSA-N CC(CCNc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(OC(C)(C)C)=O)n1)O Chemical compound CC(CCNc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(OC(C)(C)C)=O)n1)O VXPMJHMPCKQIGA-CGAIIQECSA-N 0.000 description 1
- MJZQADPEDIELTM-LBAQZLPGSA-N CC(CS(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(O)=O)n1)(=O)=O)OC Chemical compound CC(CS(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(O)=O)n1)(=O)=O)OC MJZQADPEDIELTM-LBAQZLPGSA-N 0.000 description 1
- WANLYVQFPLGAMY-DEOSSOPVSA-N CC1(CC(Nc(c2ccc3C)cccc2c3Oc2ncccc2-c2ccnc(N[C@@H]3CNCCC3)n2)=O)CCCCC1 Chemical compound CC1(CC(Nc(c2ccc3C)cccc2c3Oc2ncccc2-c2ccnc(N[C@@H]3CNCCC3)n2)=O)CCCCC1 WANLYVQFPLGAMY-DEOSSOPVSA-N 0.000 description 1
- RRANPYZHWGYLKU-FQEVSTJZSA-N CC1(CC1)C(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)=O Chemical compound CC1(CC1)C(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)=O RRANPYZHWGYLKU-FQEVSTJZSA-N 0.000 description 1
- LPRDROQFZWPLHC-NRFANRHFSA-N CCCCS(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)(=O)=O Chemical compound CCCCS(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)(=O)=O LPRDROQFZWPLHC-NRFANRHFSA-N 0.000 description 1
- MLZGTAZGGXCPOS-UHFFFAOYSA-N CCCS(Nc(c1c(cc2)c(O)c(C)cc1)c2F)(=O)=O Chemical compound CCCS(Nc(c1c(cc2)c(O)c(C)cc1)c2F)(=O)=O MLZGTAZGGXCPOS-UHFFFAOYSA-N 0.000 description 1
- ZVAQHGOFNVTECH-DEOSSOPVSA-N CCCS(Nc(c1ccc2C)cccc1c2Oc1ncc(C)cc1-c1ccnc(N[C@@H](CCC2)CN2C(OC(C)(C)C)=O)n1)(=O)=O Chemical compound CCCS(Nc(c1ccc2C)cccc1c2Oc1ncc(C)cc1-c1ccnc(N[C@@H](CCC2)CN2C(OC(C)(C)C)=O)n1)(=O)=O ZVAQHGOFNVTECH-DEOSSOPVSA-N 0.000 description 1
- GYPWHIXLSWLYCI-UHFFFAOYSA-N CCCS(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(NC(CCC2C)CN2C(OCc2ccccc2)=O)n1)(=O)=O Chemical compound CCCS(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(NC(CCC2C)CN2C(OCc2ccccc2)=O)n1)(=O)=O GYPWHIXLSWLYCI-UHFFFAOYSA-N 0.000 description 1
- VLQKFLOVVSSCKW-UHFFFAOYSA-N CCCS(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(NC(CN(CC2)C(OC(C)(C)C)=O)C2F)n1)(=O)=O Chemical compound CCCS(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(NC(CN(CC2)C(OC(C)(C)C)=O)C2F)n1)(=O)=O VLQKFLOVVSSCKW-UHFFFAOYSA-N 0.000 description 1
- ZLXOUIWDRLGLHC-UHFFFAOYSA-N CCCS(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc([N]#CC(CCC2)CN2C(OC(C)(C)C)=O)n1)(=O)=O Chemical compound CCCS(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc([N]#CC(CCC2)CN2C(OC(C)(C)C)=O)n1)(=O)=O ZLXOUIWDRLGLHC-UHFFFAOYSA-N 0.000 description 1
- JMTPZVUZLQSGKV-FQEVSTJZSA-N CCCS(Nc(cc1C)c(cccc2)c2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)(=O)=O Chemical compound CCCS(Nc(cc1C)c(cccc2)c2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)(=O)=O JMTPZVUZLQSGKV-FQEVSTJZSA-N 0.000 description 1
- FAXJSCJHZCBHCM-IBGZPJMESA-N CCOC(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)=O Chemical compound CCOC(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)=O FAXJSCJHZCBHCM-IBGZPJMESA-N 0.000 description 1
- KOLOWNQSPUHSFB-IBGZPJMESA-N CCS(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)(=O)=O Chemical compound CCS(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)(=O)=O KOLOWNQSPUHSFB-IBGZPJMESA-N 0.000 description 1
- HJJGYZRUVGVHQZ-PUHATCMVSA-N CC[C@@H](CCN1c(c2ccc3C)cccc2c3Oc2ncccc2-c2ccnc(N[C@@H]3CNC[C@H](C)C3)n2)C1=O Chemical compound CC[C@@H](CCN1c(c2ccc3C)cccc2c3Oc2ncccc2-c2ccnc(N[C@@H]3CNC[C@H](C)C3)n2)C1=O HJJGYZRUVGVHQZ-PUHATCMVSA-N 0.000 description 1
- AADMSXRTEUHZRI-BJKOFHAPSA-N CC[C@H](CNc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(OC(C)(C)C)=O)n1)O Chemical compound CC[C@H](CNc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(OC(C)(C)C)=O)n1)O AADMSXRTEUHZRI-BJKOFHAPSA-N 0.000 description 1
- VLHGRBOSNBSTJT-NRFANRHFSA-N CC[n](cc1)nc1Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 Chemical compound CC[n](cc1)nc1Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 VLHGRBOSNBSTJT-NRFANRHFSA-N 0.000 description 1
- HDKXKCQDSKRZPR-UHFFFAOYSA-N CSc1nc(-c2cccnc2Cl)ccn1 Chemical compound CSc1nc(-c2cccnc2Cl)ccn1 HDKXKCQDSKRZPR-UHFFFAOYSA-N 0.000 description 1
- KSLABJIVMIEMEE-VMODYCNZSA-N C[C@@H](C1)[C@@H]1C(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(OC(C)(C)C)=O)n1)=O Chemical compound C[C@@H](C1)[C@@H]1C(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(OC(C)(C)C)=O)n1)=O KSLABJIVMIEMEE-VMODYCNZSA-N 0.000 description 1
- UFGFFDQDNASRKU-DHFSANGXSA-N C[C@@H](C1)[C@H]1C(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(NC2CNCCC2)n1)=O Chemical compound C[C@@H](C1)[C@H]1C(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(NC2CNCCC2)n1)=O UFGFFDQDNASRKU-DHFSANGXSA-N 0.000 description 1
- QNFDPCGQAIESNL-ILWGZMRPSA-N C[C@@H](CC1)[C@@H]1C(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)=O Chemical compound C[C@@H](CC1)[C@@H]1C(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)=O QNFDPCGQAIESNL-ILWGZMRPSA-N 0.000 description 1
- ZELXPRUBURPWEJ-QUCCMNQESA-N C[C@H](C1)CNC[C@H]1Nc1nc(-c2cccnc2Oc2c(ccc(F)c3NS(CCOC)(=O)=O)c3ccc2C)ccn1 Chemical compound C[C@H](C1)CNC[C@H]1Nc1nc(-c2cccnc2Oc2c(ccc(F)c3NS(CCOC)(=O)=O)c3ccc2C)ccn1 ZELXPRUBURPWEJ-QUCCMNQESA-N 0.000 description 1
- KSLABJIVMIEMEE-KHVXQDHOSA-N C[C@H](C1)[C@H]1C(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(OC(C)(C)C)=O)n1)=O Chemical compound C[C@H](C1)[C@H]1C(Nc(c1ccc2C)cccc1c2Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(OC(C)(C)C)=O)n1)=O KSLABJIVMIEMEE-KHVXQDHOSA-N 0.000 description 1
- OUEQRPCQZKEMFB-AFARHQOCSA-N C[C@H](CC1)CC[C@@H]1Nc1nc(-c2cccnc2Oc(c(C)c2)c(cccc3)c3c2NS(C2CCCC2)(=O)=O)ccn1 Chemical compound C[C@H](CC1)CC[C@@H]1Nc1nc(-c2cccnc2Oc(c(C)c2)c(cccc3)c3c2NS(C2CCCC2)(=O)=O)ccn1 OUEQRPCQZKEMFB-AFARHQOCSA-N 0.000 description 1
- BIOQEFDAIMLTGH-IQGLISFBSA-N C[C@H](CCN(C1)C(OC(C)(C)C)=O)[C@@H]1Nc1nc(-c2cccnc2Oc2c(ccc(F)c3N)c3ccc2C)ccn1 Chemical compound C[C@H](CCN(C1)C(OC(C)(C)C)=O)[C@@H]1Nc1nc(-c2cccnc2Oc2c(ccc(F)c3N)c3ccc2C)ccn1 BIOQEFDAIMLTGH-IQGLISFBSA-N 0.000 description 1
- WFBQCIDONYYHOK-YWEHKCAJSA-N C[C@H](C[C@@H](C1)Nc2nc(-c3cccnc3Oc3c(ccc(F)c4NC(C5CCC5)=O)c4ccc3C)ccn2)CN1C(OCc1ccccc1)=O Chemical compound C[C@H](C[C@@H](C1)Nc2nc(-c3cccnc3Oc3c(ccc(F)c4NC(C5CCC5)=O)c4ccc3C)ccn2)CN1C(OCc1ccccc1)=O WFBQCIDONYYHOK-YWEHKCAJSA-N 0.000 description 1
- VYVROZJEADTTEK-IRXDYDNUSA-N Cc(c(Oc1ncccc1-c1ccnc(N[C@@H](C2)CNC[C@H]2F)n1)c1cc2)ccc1c(NS(CC(F)(F)F)(=O)=O)c2F Chemical compound Cc(c(Oc1ncccc1-c1ccnc(N[C@@H](C2)CNC[C@H]2F)n1)c1cc2)ccc1c(NS(CC(F)(F)F)(=O)=O)c2F VYVROZJEADTTEK-IRXDYDNUSA-N 0.000 description 1
- PGODMMKDERQAEU-GBXCKJPGSA-N Cc(c(Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)c1cc2)ccc1c(NC([C@@H](C1)C11CCC1)=O)c2F Chemical compound Cc(c(Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)c1cc2)ccc1c(NC([C@@H](C1)C11CCC1)=O)c2F PGODMMKDERQAEU-GBXCKJPGSA-N 0.000 description 1
- DWFLOIGGWYROEK-NRFANRHFSA-N Cc(c(Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)c1cc2)ccc1c(NS(C1CCCCC1)(=O)=O)c2F Chemical compound Cc(c(Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)c1cc2)ccc1c(NS(C1CCCCC1)(=O)=O)c2F DWFLOIGGWYROEK-NRFANRHFSA-N 0.000 description 1
- BVBKRYAEKUGHLM-FQEVSTJZSA-N Cc(c(Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)c1cc2)ccc1c(NS(CC1CC1)(=O)=O)c2F Chemical compound Cc(c(Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)c1cc2)ccc1c(NS(CC1CC1)(=O)=O)c2F BVBKRYAEKUGHLM-FQEVSTJZSA-N 0.000 description 1
- GWXHIJTVADNLLH-NRFANRHFSA-N Cc(c(Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)c1cc2)ccc1c(NS(CCC1CC1)(=O)=O)c2F Chemical compound Cc(c(Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)c1cc2)ccc1c(NS(CCC1CC1)(=O)=O)c2F GWXHIJTVADNLLH-NRFANRHFSA-N 0.000 description 1
- HSVUJALKBBGGGF-LEWJYISDSA-N Cc(c(Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)c1cc2)ccc1c(NS(C[C@@H]1OCCC1)(=O)=O)c2F Chemical compound Cc(c(Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)c1cc2)ccc1c(NS(C[C@@H]1OCCC1)(=O)=O)c2F HSVUJALKBBGGGF-LEWJYISDSA-N 0.000 description 1
- CFFBBVUFJSNINS-DEOSSOPVSA-N Cc(c(Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)c1cc2)ccc1c(NS(Cc(cc1)ccc1C#N)(=O)=O)c2F Chemical compound Cc(c(Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)c1cc2)ccc1c(NS(Cc(cc1)ccc1C#N)(=O)=O)c2F CFFBBVUFJSNINS-DEOSSOPVSA-N 0.000 description 1
- JLNFXQBZUDRZBC-SFHVURJKSA-N Cc(c(Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)c1cc2)ccc1c(NS(N(C)C)(=O)=O)c2F Chemical compound Cc(c(Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1)c1cc2)ccc1c(NS(N(C)C)(=O)=O)c2F JLNFXQBZUDRZBC-SFHVURJKSA-N 0.000 description 1
- REYPAQKOWRGBFG-SBUREZEXSA-N Cc(ccc1c2ccc(F)c1NC[C@@H](C(F)(F)F)O)c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 Chemical compound Cc(ccc1c2ccc(F)c1NC[C@@H](C(F)(F)F)O)c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 REYPAQKOWRGBFG-SBUREZEXSA-N 0.000 description 1
- ZEVAILJHSXOUBY-UHFFFAOYSA-N Cc(ccc1c2cccc1N)c2Oc1ncccc1-c1ccnc(SC)n1 Chemical compound Cc(ccc1c2cccc1N)c2Oc1ncccc1-c1ccnc(SC)n1 ZEVAILJHSXOUBY-UHFFFAOYSA-N 0.000 description 1
- SKEWQOVYXDPIKR-PMACEKPBSA-N Cc(ccc1c2cccc1NC[C@H](CF)O)c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 Chemical compound Cc(ccc1c2cccc1NC[C@H](CF)O)c2Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 SKEWQOVYXDPIKR-PMACEKPBSA-N 0.000 description 1
- KSIJJJJLRFVSAN-FQEVSTJZSA-N Cc(ccc1c2cccc1NS(CCOC)(=O)=O)c2Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(O)=O)n1 Chemical compound Cc(ccc1c2cccc1NS(CCOC)(=O)=O)c2Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(O)=O)n1 KSIJJJJLRFVSAN-FQEVSTJZSA-N 0.000 description 1
- LHVUGRACDPDCHI-NRFANRHFSA-N Cc1cc(Nc(c2ccc3C)cccc2c3Oc2ncccc2-c2ccnc(N[C@@H]3CNCCC3)n2)n[n]1C Chemical compound Cc1cc(Nc(c2ccc3C)cccc2c3Oc2ncccc2-c2ccnc(N[C@@H]3CNCCC3)n2)n[n]1C LHVUGRACDPDCHI-NRFANRHFSA-N 0.000 description 1
- PQPDCTWLZKXGOU-UHFFFAOYSA-N Cc1ccc2c(N(CCC34CC3)C4=O)cccc2c1Oc1ncccc1-c1ccnc(NC2CNCCC2)n1 Chemical compound Cc1ccc2c(N(CCC34CC3)C4=O)cccc2c1Oc1ncccc1-c1ccnc(NC2CNCCC2)n1 PQPDCTWLZKXGOU-UHFFFAOYSA-N 0.000 description 1
- SPPXMRNLEUDVMS-KRWDZBQOSA-N Cc1ccc2c(NC(C(Cl)Cl)=O)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 Chemical compound Cc1ccc2c(NC(C(Cl)Cl)=O)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 SPPXMRNLEUDVMS-KRWDZBQOSA-N 0.000 description 1
- HPTWVUWLIAMZLY-FQEVSTJZSA-N Cc1ccc2c(NC(C3CC3)=O)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 Chemical compound Cc1ccc2c(NC(C3CC3)=O)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 HPTWVUWLIAMZLY-FQEVSTJZSA-N 0.000 description 1
- LYNJJOPKUMTLEX-NRFANRHFSA-N Cc1ccc2c(NC(CC3CC3)=O)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 Chemical compound Cc1ccc2c(NC(CC3CC3)=O)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 LYNJJOPKUMTLEX-NRFANRHFSA-N 0.000 description 1
- TXCQFPZDZNAKGH-SANMLTNESA-N Cc1ccc2c(NC(CC3CCCCC3)=O)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(O)=C)n1 Chemical compound Cc1ccc2c(NC(CC3CCCCC3)=O)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H](CCC2)CN2C(O)=C)n1 TXCQFPZDZNAKGH-SANMLTNESA-N 0.000 description 1
- CBXPNEVNLQSBET-SQJMNOBHSA-N Cc1ccc2c(NC([C@@H](C3)C33CCC3)=O)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 Chemical compound Cc1ccc2c(NC([C@@H](C3)C33CCC3)=O)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 CBXPNEVNLQSBET-SQJMNOBHSA-N 0.000 description 1
- JLCDCTBHQHIRQE-FQEVSTJZSA-N Cc1ccc2c(NCc3n[nH]cc3)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 Chemical compound Cc1ccc2c(NCc3n[nH]cc3)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 JLCDCTBHQHIRQE-FQEVSTJZSA-N 0.000 description 1
- DWQIISFNFJOWTN-NRFANRHFSA-N Cc1ccc2c(NS(CC3CC3)(=O)=O)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 Chemical compound Cc1ccc2c(NS(CC3CC3)(=O)=O)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 DWQIISFNFJOWTN-NRFANRHFSA-N 0.000 description 1
- WQFPQVDADJVKDN-HMTLIYDFSA-N Cc1ccc2c(NS(CC3OCCC3)(=O)=O)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 Chemical compound Cc1ccc2c(NS(CC3OCCC3)(=O)=O)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 WQFPQVDADJVKDN-HMTLIYDFSA-N 0.000 description 1
- JTXMLXNVZIAGLO-DEOSSOPVSA-N Cc1ccc2c(NS(Cc(cc3)ccc3Cl)(=O)=O)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 Chemical compound Cc1ccc2c(NS(Cc(cc3)ccc3Cl)(=O)=O)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 JTXMLXNVZIAGLO-DEOSSOPVSA-N 0.000 description 1
- RRAVQYLUVXMTQH-LOSJGSFVSA-N Cc1ccc2c(NS(Cc3ccccc3)(=O)=O)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H](C2)CNC[C@@H]2OC)n1 Chemical compound Cc1ccc2c(NS(Cc3ccccc3)(=O)=O)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H](C2)CNC[C@@H]2OC)n1 RRAVQYLUVXMTQH-LOSJGSFVSA-N 0.000 description 1
- KNVSDBLSJNLCOW-GJJMEYSYSA-N Cc1ccc2c(N[C@H](CCCC3)[C@@H]3O)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 Chemical compound Cc1ccc2c(N[C@H](CCCC3)[C@@H]3O)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 KNVSDBLSJNLCOW-GJJMEYSYSA-N 0.000 description 1
- LTXQWCIBBUHPIW-NRFANRHFSA-N Cc1ccc2c(Oc3ccccn3)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 Chemical compound Cc1ccc2c(Oc3ccccn3)cccc2c1Oc1ncccc1-c1ccnc(N[C@@H]2CNCCC2)n1 LTXQWCIBBUHPIW-NRFANRHFSA-N 0.000 description 1
- WDTVJRYCMIZPMX-UHFFFAOYSA-N Cc1nc(Cl)ccn1 Chemical compound Cc1nc(Cl)ccn1 WDTVJRYCMIZPMX-UHFFFAOYSA-N 0.000 description 1
- VRDAOVQZVXYRNH-UHFFFAOYSA-N OB(c1cccnc1Cl)O Chemical compound OB(c1cccnc1Cl)O VRDAOVQZVXYRNH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2017077059 | 2017-03-17 | ||
CNPCT/CN2017/077059 | 2017-03-17 | ||
PCT/CN2018/079292 WO2018166528A1 (en) | 2017-03-17 | 2018-03-16 | Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating ire1-related diseases and disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2018233402A1 true AU2018233402A1 (en) | 2019-10-10 |
Family
ID=63522807
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2018233402A Abandoned AU2018233402A1 (en) | 2017-03-17 | 2018-03-16 | Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating ire1-related diseases and disorders |
Country Status (17)
Country | Link |
---|---|
US (1) | US10968203B2 (de) |
EP (1) | EP3596063A4 (de) |
JP (1) | JP6925435B2 (de) |
KR (1) | KR20190141145A (de) |
CN (1) | CN111247136A (de) |
AR (1) | AR111281A1 (de) |
AU (1) | AU2018233402A1 (de) |
BR (1) | BR112019019193A2 (de) |
CA (1) | CA3056833A1 (de) |
CL (1) | CL2019002671A1 (de) |
CO (1) | CO2019010078A2 (de) |
CR (1) | CR20190433A (de) |
IL (1) | IL269302A (de) |
PE (1) | PE20191557A1 (de) |
SG (1) | SG11201908517XA (de) |
TW (1) | TW201838981A (de) |
WO (1) | WO2018166528A1 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10392367B2 (en) | 2017-06-01 | 2019-08-27 | Quentis Therapeutics, Inc. | IRE1 small molecule inhibitors |
AU2018278311B2 (en) | 2017-06-01 | 2021-10-07 | Cornell University | IRE1 small molecule inhibitors |
US20210198238A1 (en) * | 2018-08-30 | 2021-07-01 | The Regents Of The University Of California | Ire1 kinase inhibitors and uses thereof |
JP7098826B2 (ja) * | 2018-09-12 | 2022-07-11 | ジェネンテック, インコーポレイテッド | ピリミジニル-ヘテロアリールオキシ-ナフチル化合物および使用方法 |
US11945784B2 (en) | 2018-12-03 | 2024-04-02 | Cornell University | IRE1 small molecule inhibitors |
WO2020117635A1 (en) * | 2018-12-03 | 2020-06-11 | Cornell University | Ire1 small molecule inhibitors |
WO2020232403A1 (en) * | 2019-05-15 | 2020-11-19 | Cornell University | Treatment of fibrosis with ire1 small molecule inhibitors |
CA3188602A1 (en) * | 2020-08-07 | 2022-02-10 | Richard Keenan | Pyrazolopyridine compounds and methods of inhibiting ire1 using same |
JP2023550049A (ja) | 2020-11-13 | 2023-11-30 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | Ire1アルファ阻害剤及びその使用 |
WO2022104151A1 (en) * | 2020-11-13 | 2022-05-19 | The Regents Of The University Of California | Ire1alpha inhibitors and uses thereof |
CN114907350B (zh) * | 2021-02-10 | 2023-12-29 | 上海凌达生物医药有限公司 | 一类含氮稠环类化合物、制备方法和用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA06012613A (es) | 2004-05-07 | 2007-01-31 | Amgen Inc | Derivados heterociclicos nitrogenados como moduladores de proteina cinasa y uso para el tratamiento de angiogenesis y cancer. |
US7868177B2 (en) * | 2006-02-24 | 2011-01-11 | Amgen Inc. | Multi-cyclic compounds and method of use |
EP2340248B1 (de) | 2008-09-15 | 2017-05-31 | The Regents of The University of California | Verfahren und zusammensetzungen zur modulation der ire1-, src- und abl-aktivität |
EP2989091B1 (de) | 2013-04-04 | 2017-05-10 | Janssen Pharmaceutica NV | Neue n-(2,3-dihydro-1h-pyrrolo[2,3-b]pyridin-5-yl)-4-chinazolinamine und n-(2,3-dihydro-1h-indol-5-yl)-4-chinazolinaminederivate als perk inhibitoren |
-
2018
- 2018-03-15 TW TW107108924A patent/TW201838981A/zh unknown
- 2018-03-15 AR ARP180100604A patent/AR111281A1/es unknown
- 2018-03-16 BR BR112019019193A patent/BR112019019193A2/pt not_active Application Discontinuation
- 2018-03-16 CA CA3056833A patent/CA3056833A1/en not_active Abandoned
- 2018-03-16 WO PCT/CN2018/079292 patent/WO2018166528A1/en active Application Filing
- 2018-03-16 CN CN201880032314.6A patent/CN111247136A/zh active Pending
- 2018-03-16 JP JP2019551376A patent/JP6925435B2/ja active Active
- 2018-03-16 EP EP18768363.6A patent/EP3596063A4/de active Pending
- 2018-03-16 CR CR20190433A patent/CR20190433A/es unknown
- 2018-03-16 KR KR1020197030386A patent/KR20190141145A/ko not_active Application Discontinuation
- 2018-03-16 AU AU2018233402A patent/AU2018233402A1/en not_active Abandoned
- 2018-03-16 PE PE2019001893A patent/PE20191557A1/es unknown
- 2018-03-16 SG SG11201908517X patent/SG11201908517XA/en unknown
- 2018-05-24 US US15/989,008 patent/US10968203B2/en active Active
-
2019
- 2019-09-12 IL IL26930219A patent/IL269302A/en unknown
- 2019-09-17 CL CL2019002671A patent/CL2019002671A1/es unknown
- 2019-09-18 CO CONC2019/0010078A patent/CO2019010078A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
CL2019002671A1 (es) | 2019-12-06 |
CA3056833A1 (en) | 2018-09-20 |
IL269302A (en) | 2019-11-28 |
EP3596063A1 (de) | 2020-01-22 |
JP2020514377A (ja) | 2020-05-21 |
PE20191557A1 (es) | 2019-10-24 |
CR20190433A (es) | 2019-11-20 |
JP6925435B2 (ja) | 2021-08-25 |
SG11201908517XA (en) | 2019-10-30 |
BR112019019193A2 (pt) | 2020-04-22 |
CO2019010078A2 (es) | 2020-01-17 |
US10968203B2 (en) | 2021-04-06 |
CN111247136A (zh) | 2020-06-05 |
TW201838981A (zh) | 2018-11-01 |
US20180265497A1 (en) | 2018-09-20 |
AR111281A1 (es) | 2019-06-26 |
KR20190141145A (ko) | 2019-12-23 |
EP3596063A4 (de) | 2020-12-30 |
WO2018166528A1 (en) | 2018-09-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10968203B2 (en) | Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating IRE1-related diseases and disorders | |
AU2019249849B2 (en) | BRM targeting compounds and associated methods of use | |
US9573943B2 (en) | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use | |
RU2665462C2 (ru) | Соединения 5-азаиндазола и способы их применения | |
EP2651899B1 (de) | Substituierte 6,6- kondensierte stickstoffhaltigen heterocyclische verbindungen und anwendungen davon | |
WO2019099868A2 (en) | Degraders and degrons for targeted protein degradation | |
AU2012314518B2 (en) | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use | |
EP3846800A1 (de) | Verbindungen zum abbau von brd9 oder mth1 | |
AU2016282289A1 (en) | HPK1 inhibitors and methods of using same | |
CA2895404A1 (en) | Bet-protein-inhibiting dihydropyridopyrazinones | |
JP2015530975A (ja) | 置換型ピラゾロン化合物及び使用方法 | |
WO2023059581A1 (en) | Heterobifunctional compounds and their use in treating disease | |
TWI831829B (zh) | 苯氧基-吡啶基-嘧啶化合物及使用方法 | |
KR20240018446A (ko) | 돌연변이 braf의 분해를 위한 요법 | |
CN113508115A (zh) | 吡啶并嘧啶酮和蝶啶酮化合物作为需要酶i(ire i α)的内切核糖核酸酶肌醇的抑制剂用于治疗癌症疾病 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |