AU2018230500B2 - Methods of treating Crohn's disease and ulcerative colitis - Google Patents

Methods of treating Crohn's disease and ulcerative colitis Download PDF

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Publication number
AU2018230500B2
AU2018230500B2 AU2018230500A AU2018230500A AU2018230500B2 AU 2018230500 B2 AU2018230500 B2 AU 2018230500B2 AU 2018230500 A AU2018230500 A AU 2018230500A AU 2018230500 A AU2018230500 A AU 2018230500A AU 2018230500 B2 AU2018230500 B2 AU 2018230500B2
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Australia
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weeks
patient
upadacitinib
pharmaceutically acceptable
acceptable salt
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AU2018230500A
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AU2018230500A1 (en
Inventor
Ayman D. Allian
Thomas B. Borchardt
Jose Jeffrey V. ENEJOSA
Jayanthy Jayanth
Steven JUNGERWIRTH
Ben Klünder
Ana Paula MACHADO DE LACERDA
Patrick J. MARROUM
Peter T. Mayer
Mohamed-Eslam MOHAMED
Mathew M. Mulhern
Fredrik Lars Nordstrom
Ahmed Othman
Aileen L. PANGAN
Anne M. ROBINSON
Ahmad Y. Sheikh
Roopal B. Thakkar
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AbbVie Inc
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AbbVie Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
AU2018230500A 2017-03-09 2018-03-09 Methods of treating Crohn's disease and ulcerative colitis Active AU2018230500B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2024203642A AU2024203642B2 (en) 2017-03-09 2024-05-30 Methods of treating Crohn's disease and ulcerative colitis

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762469337P 2017-03-09 2017-03-09
US62/469,337 2017-03-09
US201762470565P 2017-03-13 2017-03-13
US62/470,565 2017-03-13
US201762483289P 2017-04-07 2017-04-07
US62/483,289 2017-04-07
US201762593629P 2017-12-01 2017-12-01
US62/593,629 2017-12-01
PCT/US2018/021800 WO2018165581A1 (en) 2017-03-09 2018-03-09 Methods of treating crohn's disease and ulcerative colitis

Related Child Applications (1)

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AU2024203642A Division AU2024203642B2 (en) 2017-03-09 2024-05-30 Methods of treating Crohn's disease and ulcerative colitis

Publications (2)

Publication Number Publication Date
AU2018230500A1 AU2018230500A1 (en) 2019-09-19
AU2018230500B2 true AU2018230500B2 (en) 2024-03-07

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ID=61750557

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AU2018230500A Active AU2018230500B2 (en) 2017-03-09 2018-03-09 Methods of treating Crohn's disease and ulcerative colitis
AU2024203642A Active AU2024203642B2 (en) 2017-03-09 2024-05-30 Methods of treating Crohn's disease and ulcerative colitis

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Country Status (9)

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US (3) US20190046527A1 (cg-RX-API-DMAC10.html)
EP (2) EP4487908A3 (cg-RX-API-DMAC10.html)
JP (3) JP2020510016A (cg-RX-API-DMAC10.html)
CN (2) CN110392572A (cg-RX-API-DMAC10.html)
AU (2) AU2018230500B2 (cg-RX-API-DMAC10.html)
BR (1) BR112019018576A2 (cg-RX-API-DMAC10.html)
MX (2) MX2019010733A (cg-RX-API-DMAC10.html)
TW (2) TWI851536B (cg-RX-API-DMAC10.html)
WO (2) WO2018165581A1 (cg-RX-API-DMAC10.html)

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US11524964B2 (en) 2015-10-16 2022-12-13 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
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US11512092B2 (en) * 2015-10-16 2022-11-29 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
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US12365689B2 (en) 2015-10-16 2025-07-22 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11564922B2 (en) 2017-03-09 2023-01-31 Abbvie Inc. Methods of treating crohn's disease and ulcerative colitis
CN110392572A (zh) * 2017-03-09 2019-10-29 艾伯维公司 治疗克罗恩病和溃疡性结肠炎的方法
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CN111909160B (zh) * 2019-05-09 2024-05-28 苏州鹏旭医药科技有限公司 一种乌帕替尼盐类化合物及其制备方法
CN110101669A (zh) * 2019-06-11 2019-08-09 南京新酶合医药科技有限公司 一种乌帕替尼颗粒的生产工艺
JP2022549379A (ja) 2019-09-30 2022-11-24 アッヴィ・インコーポレイテッド ウパダシチニブによる脊椎関節炎及び乾癬状態の治療
AU2021303629A1 (en) 2020-07-08 2023-03-09 Crystal Pharmaceutical (Suzhou) Co., Ltd. Crystal form of upadacitinib, preparation method therefor, and use thereof
US20240316040A1 (en) * 2020-12-29 2024-09-26 Abbvie Inc. Extended release upadacitinib formulations
CN114380837B (zh) * 2021-12-27 2023-06-30 上海邈金医药科技有限公司 一种具有Janus激酶抑制活性的化合物、包括该化合物的组合物及其应用
MX2024008557A (es) * 2022-01-13 2024-09-11 Abbvie Inc Método de administración de upadacitinib para evitar interacciones farmacologicas y efectos adversos.
CA3248817A1 (en) * 2022-01-20 2023-07-27 Renata Pharmaceutical (Ireland) Limited Extended-release pharmaceutical composition of Upadacitinib
WO2024052820A1 (en) * 2022-09-09 2024-03-14 Intas Pharmaceuticals Ltd. Upadacitinib formulation
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Also Published As

Publication number Publication date
JP2020510016A (ja) 2020-04-02
JP2026041823A (ja) 2026-03-10
MX2022015499A (es) 2023-01-24
US20210361647A1 (en) 2021-11-25
CN110392572A (zh) 2019-10-29
JP2024009963A (ja) 2024-01-23
TW201840318A (zh) 2018-11-16
US20220233527A1 (en) 2022-07-28
US20190046527A1 (en) 2019-02-14
BR112019018576A2 (pt) 2020-04-14
CA3052873A1 (en) 2018-09-13
WO2022178492A1 (en) 2022-08-25
WO2018165581A1 (en) 2018-09-13
AU2024203642A1 (en) 2024-06-20
TWI851536B (zh) 2024-08-11
TW202517269A (zh) 2025-05-01
AU2024203642B2 (en) 2025-08-21
MX2019010733A (es) 2019-11-01
EP4487908A2 (en) 2025-01-08
US11607411B2 (en) 2023-03-21
CN120661512A (zh) 2025-09-19
EP4487908A3 (en) 2025-01-15
AU2018230500A1 (en) 2019-09-19
EP3592353A1 (en) 2020-01-15

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