AU2018212788A1 - Cyclic dinucleotides as STING agonists - Google Patents

Cyclic dinucleotides as STING agonists Download PDF

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Publication number
AU2018212788A1
AU2018212788A1 AU2018212788A AU2018212788A AU2018212788A1 AU 2018212788 A1 AU2018212788 A1 AU 2018212788A1 AU 2018212788 A AU2018212788 A AU 2018212788A AU 2018212788 A AU2018212788 A AU 2018212788A AU 2018212788 A1 AU2018212788 A1 AU 2018212788A1
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AU
Australia
Prior art keywords
compound
mmol
pct
added
mixture
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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AU2018212788A
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English (en)
Inventor
Leonid Beigelman
Gilles Bignan
Peter J. Connolly
James Patrick EDWARDS
Stuart Emanuel
Mark Richter
Wim Schepens
Santhosh Kumar Thatikonda
Johannes Wilhelmus John Fitzgerald Thuring
Marcel Viellevoye
Guangyi Wang
Minghong Zhong
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Janssen Biotech Inc
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Janssen Biotech Inc
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Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of AU2018212788A1 publication Critical patent/AU2018212788A1/en
Abandoned legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2018212788A 2017-01-27 2018-01-26 Cyclic dinucleotides as STING agonists Abandoned AU2018212788A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762451351P 2017-01-27 2017-01-27
US201762451301P 2017-01-27 2017-01-27
US62/451,351 2017-01-27
US62/451,301 2017-01-27
US201762454135P 2017-02-03 2017-02-03
US62/454,135 2017-02-03
PCT/IB2018/050498 WO2018138685A2 (en) 2017-01-27 2018-01-26 Cyclic dinucleotides as sting agonists

Publications (1)

Publication Number Publication Date
AU2018212788A1 true AU2018212788A1 (en) 2019-07-25

Family

ID=61187610

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018212788A Abandoned AU2018212788A1 (en) 2017-01-27 2018-01-26 Cyclic dinucleotides as STING agonists

Country Status (7)

Country Link
US (2) US11492367B2 (https=)
EP (1) EP3573718B1 (https=)
JP (2) JP7275031B2 (https=)
CN (1) CN110234403A (https=)
AU (1) AU2018212788A1 (https=)
ES (1) ES2924186T3 (https=)
WO (1) WO2018138685A2 (https=)

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TWI818007B (zh) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-環二核苷酸
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US20200113912A1 (en) 2018-09-12 2020-04-16 Silverback Therapeutics, Inc. Methods and Compositions for the Treatment of Disease with Immune Stimulatory Conjugates
AU2019371206A1 (en) 2018-10-29 2021-05-27 Venenum Biodesign, LLC Novel sting agonists
US11110106B2 (en) 2018-10-29 2021-09-07 Venenum Biodesign, LLC Sting agonists for treating bladder cancer and solid tumors
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US11766447B2 (en) 2019-03-07 2023-09-26 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
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JP7621974B2 (ja) * 2019-05-09 2025-01-27 アリゴス セラピューティクス インコーポレイテッド Stingモジュレータとしての修飾環状ジヌクレオシド化合物
AU2020310853A1 (en) 2019-07-05 2022-01-27 Tambo, Inc. Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
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TWI794742B (zh) 2020-02-18 2023-03-01 美商基利科學股份有限公司 抗病毒化合物
TWI775313B (zh) 2020-02-18 2022-08-21 美商基利科學股份有限公司 抗病毒化合物
CN112321589B (zh) * 2020-02-18 2022-05-03 山东科巢生物制药有限公司 一种抗病毒药物瑞德西韦及其中间体的合成方法
AU2021224588B2 (en) 2020-02-18 2024-07-18 Gilead Sciences, Inc. Antiviral compounds
JP7735291B2 (ja) 2020-02-21 2025-09-08 エーアールエス ファーマシューティカルズ、インコーポレイテッド ネクチン-4抗体コンジュゲートおよびその使用
WO2021206158A1 (ja) 2020-04-10 2021-10-14 小野薬品工業株式会社 がん治療方法
IL316161A (en) 2020-06-22 2024-12-01 Illumina Cambridge Ltd Nucleotides and nucleosides with a 3' masking group
JP2023532304A (ja) 2020-07-01 2023-07-27 エーアールエス ファーマシューティカルズ オペレーションズ,インク. 抗asgr1抗体コンジュゲートおよびその使用
EP4295917A3 (en) 2020-08-07 2024-02-28 Tambo, Inc. Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
JP7397996B2 (ja) 2020-11-09 2023-12-13 武田薬品工業株式会社 抗体薬物コンジュゲート
EP4323362B1 (en) 2021-04-16 2025-05-07 Gilead Sciences, Inc. Methods of preparing carbanucleosides using amides
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JP2016538344A (ja) 2013-11-19 2016-12-08 ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago 癌処置としてのstingアゴニストの使用
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SG10201912074PA (en) 2016-03-18 2020-02-27 Immune Sensor Llc Cyclic di-nucleotide compounds and methods of use
WO2017186711A1 (en) 2016-04-25 2017-11-02 Invivogen Novel complexes of immunostimulatory compounds, and uses thereof
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WO2018119117A1 (en) * 2016-12-22 2018-06-28 The Regents Of The University Of California Methods of producing cyclic dinucleotides

Also Published As

Publication number Publication date
JP2020505405A (ja) 2020-02-20
CN110234403A (zh) 2019-09-13
US11492367B2 (en) 2022-11-08
EP3573718B1 (en) 2022-06-01
WO2018138685A2 (en) 2018-08-02
US20190375782A1 (en) 2019-12-12
EP3573718A2 (en) 2019-12-04
JP7275031B2 (ja) 2023-05-17
US20230146410A1 (en) 2023-05-11
WO2018138685A3 (en) 2018-10-04
JP2022180398A (ja) 2022-12-06
ES2924186T3 (es) 2022-10-05

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MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application