AU2017384126B2 - Combination therapy of anti-CD20/anti-CD3 bispecific antibodies and 4-1BB (CD137) agonists - Google Patents

Combination therapy of anti-CD20/anti-CD3 bispecific antibodies and 4-1BB (CD137) agonists Download PDF

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AU2017384126B2
AU2017384126B2 AU2017384126A AU2017384126A AU2017384126B2 AU 2017384126 B2 AU2017384126 B2 AU 2017384126B2 AU 2017384126 A AU2017384126 A AU 2017384126A AU 2017384126 A AU2017384126 A AU 2017384126A AU 2017384126 B2 AU2017384126 B2 AU 2017384126B2
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seq
amino acid
acid sequence
1bbl
antigen binding
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AU2017384126A1 (en
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Marina Bacac
Claudia Ferrara Koller
Christian Klein
Mario PERRO
Johannes Sam
Pablo Umaña
Wei Xu
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • A—HUMAN NECESSITIES
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K39/0005—Vertebrate antigens
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
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    • A61K2039/507—Comprising a combination of two or more separate antibodies
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

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AU2017384126A 2016-12-20 2017-12-18 Combination therapy of anti-CD20/anti-CD3 bispecific antibodies and 4-1BB (CD137) agonists Active AU2017384126B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16205493 2016-12-20
EP16205493.6 2016-12-20
PCT/EP2017/083222 WO2018114748A1 (en) 2016-12-20 2017-12-18 Combination therapy of anti-cd20/anti-cd3 bispecific antibodies and 4-1bb (cd137) agonists

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AU2017384126A1 AU2017384126A1 (en) 2019-05-02
AU2017384126B2 true AU2017384126B2 (en) 2025-01-23

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US (2) US11718680B2 (OSRAM)
EP (1) EP3559034B1 (OSRAM)
JP (1) JP7247091B2 (OSRAM)
KR (1) KR102692708B1 (OSRAM)
CN (1) CN110088135A (OSRAM)
AU (1) AU2017384126B2 (OSRAM)
BR (1) BR112019007267A2 (OSRAM)
CA (1) CA3039446A1 (OSRAM)
ES (1) ES2847973T3 (OSRAM)
IL (1) IL267406B2 (OSRAM)
MX (1) MX2019006954A (OSRAM)
PL (1) PL3559034T3 (OSRAM)
TW (1) TWI773712B (OSRAM)
WO (1) WO2018114748A1 (OSRAM)

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