AU2017376445B2 - Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use - Google Patents

Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use Download PDF

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AU2017376445B2
AU2017376445B2 AU2017376445A AU2017376445A AU2017376445B2 AU 2017376445 B2 AU2017376445 B2 AU 2017376445B2 AU 2017376445 A AU2017376445 A AU 2017376445A AU 2017376445 A AU2017376445 A AU 2017376445A AU 2017376445 B2 AU2017376445 B2 AU 2017376445B2
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fluoro
thiazin
fluorophenyl
fluorovinyl
amino
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AU2017376445A1 (en
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Jennifer R. Allen
Matthew P. Bourbeau
Ning Chen
Qingyian Liu
Liping H. Pettus
Aaron C. Siegmund
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Amgen Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
AU2017376445A 2016-12-15 2017-12-13 Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use Active AU2017376445B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662434719P 2016-12-15 2016-12-15
US62/434,719 2016-12-15
US201762570429P 2017-10-10 2017-10-10
US62/570,429 2017-10-10
PCT/US2017/066180 WO2018112084A1 (en) 2016-12-15 2017-12-13 Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use

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AU2017376445A1 AU2017376445A1 (en) 2019-07-04
AU2017376445B2 true AU2017376445B2 (en) 2021-09-30

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US (1) US11548903B2 (https=)
EP (1) EP3555106B1 (https=)
JP (1) JP7148518B2 (https=)
AU (1) AU2017376445B2 (https=)
CA (1) CA3047285A1 (https=)
ES (1) ES2910367T3 (https=)
MA (1) MA54101A (https=)
MX (1) MX394391B (https=)
WO (1) WO2018112084A1 (https=)

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JP7149271B2 (ja) 2016-12-15 2022-10-06 アムジエン・インコーポレーテツド β－セクレターゼ阻害剤としての１，４－チアジンジオキシドおよび１，２，４－チアジアジンジオキシド誘導体ならびに使用方法
WO2018112084A1 (en) 2016-12-15 2018-06-21 Amgen Inc. Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use
US10947223B2 (en) 2016-12-15 2021-03-16 Amgen Inc. Substituted oxazines as beta-secretase inhibitors
JP7149272B2 (ja) 2016-12-15 2022-10-06 アムジエン・インコーポレーテツド β－セクレターゼ阻害剤としてのチアジン誘導体および使用方法

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US20100093999A1 (en) * 2008-09-30 2010-04-15 Eisai R&D Management Co., Ltd. Novel fused aminodihydrothiazine derivative
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Also Published As

Publication number Publication date
EP3555106B1 (en) 2022-03-09
AU2017376445A1 (en) 2019-07-04
JP7148518B2 (ja) 2022-10-05
CA3047285A1 (en) 2018-06-21
US11548903B2 (en) 2023-01-10
MA54101A (fr) 2021-10-27
MX2019007100A (es) 2019-12-16
WO2018112084A1 (en) 2018-06-21
JP2020503294A (ja) 2020-01-30
EP3555106A1 (en) 2019-10-23
US20200199153A1 (en) 2020-06-25
MX394391B (es) 2025-03-24
ES2910367T3 (es) 2022-05-12

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