AU2017338269B2 - Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as PRMT5 inhibitors - Google Patents

Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as PRMT5 inhibitors Download PDF

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AU2017338269B2
AU2017338269B2 AU2017338269A AU2017338269A AU2017338269B2 AU 2017338269 B2 AU2017338269 B2 AU 2017338269B2 AU 2017338269 A AU2017338269 A AU 2017338269A AU 2017338269 A AU2017338269 A AU 2017338269A AU 2017338269 B2 AU2017338269 B2 AU 2017338269B2
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4alkyl
aromatic ring
group
membered
ring
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AU2017338269A1 (en
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Lijs Beke
An Boeckx
Dirk Brehmer
Gaston Stanislas Marcella Diels
Edward Charles LAWSON
Lieven Meerpoel
Vineet PANDE
Marcus Cornelis Bernardus Catharina PARADÉ
Wim Bert Griet Schepens
Weimei SUN
Johannes Wilhelmus John F. Thuring
Marcel Viellevoye
Tongfei Wu
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Janssen Pharmaceutica NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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AU2017338269A 2016-10-03 2017-10-02 Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as PRMT5 inhibitors Active AU2017338269B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662403336P 2016-10-03 2016-10-03
US62/403,336 2016-10-03
EP17157785.1 2017-02-24
EP17157785 2017-02-24
PCT/EP2017/074983 WO2018065365A1 (en) 2016-10-03 2017-10-02 Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as prmt5 inhibitors

Publications (2)

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AU2017338269A1 AU2017338269A1 (en) 2019-04-04
AU2017338269B2 true AU2017338269B2 (en) 2021-03-25

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EP (1) EP3519413A1 (enExample)
JP (2) JP7101171B2 (enExample)
KR (1) KR102531344B1 (enExample)
CN (2) CN115626935B (enExample)
AU (1) AU2017338269B2 (enExample)
BR (1) BR112019006414A2 (enExample)
CA (1) CA3037998A1 (enExample)
IL (1) IL265718B (enExample)
MA (1) MA46341A (enExample)
MX (2) MX2019003843A (enExample)
PE (1) PE20190706A1 (enExample)
PH (1) PH12019500731A1 (enExample)
TN (1) TN2019000087A1 (enExample)
UA (1) UA124074C2 (enExample)

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TWI791251B (zh) * 2015-08-26 2023-02-01 比利時商健生藥品公司 使用作為ｐｒｍｔ５抑制劑之新穎經６-６雙環芳香環取代之核苷類似物
JP7101171B2 (ja) * 2016-10-03 2022-07-14 ヤンセン ファーマシューティカ エヌ．ベー． Ｐｒｍｔ５阻害剤として使用するための新規な単環式および二環式環系置換カルバヌクレオシド類似体
ES2971035T3 (es) 2017-02-27 2024-06-03 Janssen Pharmaceutica Nv Uso de biomarcadores en la identificación de pacientes con cáncer que mostrarán respuesta al tratamiento con un inhibidor de prmt5
CA3084449A1 (en) 2017-12-08 2019-06-13 Janssen Pharmaceutica Nv Novel spirobicyclic analogues
WO2019219805A1 (en) * 2018-05-16 2019-11-21 Ctxone Pty Ltd Combination therapy
TW202112375A (zh) 2019-06-06 2021-04-01 比利時商健生藥品公司 使用ｐｒｍｔ５抑制劑治療癌症之方法
US12414953B2 (en) * 2019-09-18 2025-09-16 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
CN115135651A (zh) * 2019-12-03 2022-09-30 鲁皮恩有限公司 作为prmt5抑制剂的被取代的核苷类似物
CN113186153B (zh) * 2021-04-15 2023-09-08 南方医科大学 Prmt5抑制剂在促进精原干细胞损伤再生和增殖中的应用
CN113234079B (zh) * 2021-04-30 2022-02-01 上海湃隆生物科技有限公司 用作prmt5抑制剂的核苷类似物
CN114740108B (zh) * 2022-03-28 2023-07-14 天津键凯科技有限公司 一种聚合物修饰抗体类药物的修饰度的测定方法

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WO1996040686A1 (en) * 1995-06-07 1996-12-19 Abbott Laboratories Heterocyclic substituted cyclopentane compounds
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CN109803971A (zh) 2019-05-24
US20240124493A1 (en) 2024-04-18
BR112019006414A2 (pt) 2019-06-25
TN2019000087A1 (en) 2020-07-15
MX2019003843A (es) 2019-06-24
JP7101171B2 (ja) 2022-07-14
US11098062B2 (en) 2021-08-24
AU2017338269A1 (en) 2019-04-04
IL265718A (en) 2019-05-30
US20210371433A1 (en) 2021-12-02
JP7576587B2 (ja) 2024-10-31
CN115626935A (zh) 2023-01-20
EP3519413A1 (en) 2019-08-07
JP2022084699A (ja) 2022-06-07
IL265718B (en) 2021-08-31
UA124074C2 (uk) 2021-07-14
JP2019534255A (ja) 2019-11-28
US20190263833A1 (en) 2019-08-29
MX2023005574A (es) 2023-05-29
PE20190706A1 (es) 2019-05-17
US11993614B2 (en) 2024-05-28
KR102531344B1 (ko) 2023-05-10
KR20190056425A (ko) 2019-05-24
CN109803971B (zh) 2022-10-28
MA46341A (fr) 2019-08-07
CN115626935B (zh) 2025-07-15
CA3037998A1 (en) 2018-04-12
PH12019500731A1 (en) 2019-06-24

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