AU2017336363B2 - Methods of treating uterine fibroids and endometriosis - Google Patents

Methods of treating uterine fibroids and endometriosis Download PDF

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Publication number
AU2017336363B2
AU2017336363B2 AU2017336363A AU2017336363A AU2017336363B2 AU 2017336363 B2 AU2017336363 B2 AU 2017336363B2 AU 2017336363 A AU2017336363 A AU 2017336363A AU 2017336363 A AU2017336363 A AU 2017336363A AU 2017336363 B2 AU2017336363 B2 AU 2017336363B2
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Australia
Prior art keywords
estradiol
compound
endometriosis
combination
menopausal woman
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2017336363A
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English (en)
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AU2017336363A1 (en
Inventor
Mark Hibberd
Brendan Mark JOHNSON
Paul N. Mudd Jr.
Vijaykumar Reddy RAJASEKHAR
Lynn Seely
Mayukh Vasant SUKHATME
Masataka TANIMOTO
Susan Wollowitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Switzerland GmbH
Takeda Pharmaceutical Co Ltd
Original Assignee
Sumitomo Pharma Switzerland GmbH
Takeda Pharmaceutical Co Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=60915460&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2017336363(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sumitomo Pharma Switzerland GmbH, Takeda Pharmaceutical Co Ltd filed Critical Sumitomo Pharma Switzerland GmbH
Publication of AU2017336363A1 publication Critical patent/AU2017336363A1/en
Application granted granted Critical
Publication of AU2017336363B2 publication Critical patent/AU2017336363B2/en
Priority to AU2022241582A priority Critical patent/AU2022241582C1/en
Assigned to TAKEDA PHARMACEUTICAL COMPANY LIMITED, SUMITOMO PHARMA SWITZERLAND GMBH reassignment TAKEDA PHARMACEUTICAL COMPANY LIMITED Request to Amend Deed and Register Assignors: MYOVANT SCIENCES GMBH, TAKEDA PHARMACEUTICAL COMPANY LIMITED
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Surgical Instruments (AREA)
AU2017336363A 2016-09-30 2017-09-29 Methods of treating uterine fibroids and endometriosis Active AU2017336363B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022241582A AU2022241582C1 (en) 2016-09-30 2022-09-30 Methods of treating uterine fibroids and endometriosis

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201662402055P 2016-09-30 2016-09-30
US201662402150P 2016-09-30 2016-09-30
US201662402034P 2016-09-30 2016-09-30
US62/402,150 2016-09-30
US62/402,055 2016-09-30
US62/402,034 2016-09-30
US201762492839P 2017-05-01 2017-05-01
US62/492,839 2017-05-01
US201762528409P 2017-07-03 2017-07-03
US62/528,409 2017-07-03
PCT/EP2017/074907 WO2018060501A2 (en) 2016-09-30 2017-09-29 Methods of treating uterine fibroids and endometriosis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022241582A Division AU2022241582C1 (en) 2016-09-30 2022-09-30 Methods of treating uterine fibroids and endometriosis

Publications (2)

Publication Number Publication Date
AU2017336363A1 AU2017336363A1 (en) 2019-05-16
AU2017336363B2 true AU2017336363B2 (en) 2022-08-04

Family

ID=60915460

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2017336363A Active AU2017336363B2 (en) 2016-09-30 2017-09-29 Methods of treating uterine fibroids and endometriosis
AU2022241582A Active AU2022241582C1 (en) 2016-09-30 2022-09-30 Methods of treating uterine fibroids and endometriosis

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2022241582A Active AU2022241582C1 (en) 2016-09-30 2022-09-30 Methods of treating uterine fibroids and endometriosis

Country Status (24)

Country Link
US (4) US11033551B2 (enExample)
EP (2) EP4094766B1 (enExample)
JP (1) JP7043503B2 (enExample)
CN (1) CN110312512B (enExample)
AU (2) AU2017336363B2 (enExample)
BR (1) BR112019006227A2 (enExample)
CA (1) CA3038879A1 (enExample)
CY (1) CY1125254T1 (enExample)
DK (1) DK3518933T4 (enExample)
ES (2) ES2912929T5 (enExample)
FI (1) FI3518933T4 (enExample)
HR (1) HRP20220708T4 (enExample)
HU (2) HUE072130T2 (enExample)
IL (2) IL300580B2 (enExample)
LT (1) LT3518933T (enExample)
MD (1) MD3518933T4 (enExample)
MX (1) MX2019003726A (enExample)
NZ (1) NZ752916A (enExample)
PL (2) PL3518933T5 (enExample)
PT (1) PT3518933T (enExample)
RS (1) RS63300B2 (enExample)
SI (1) SI3518933T2 (enExample)
SM (1) SMT202200254T1 (enExample)
WO (1) WO2018060501A2 (enExample)

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WO2018060501A2 (en) 2016-09-30 2018-04-05 Myovant Sciences Gmbh Methods of treating uterine fibroids and endometriosis
EP3518932B1 (en) 2016-09-30 2024-11-13 Sumitomo Pharma Switzerland GmbH Treatment of prostate cancer
ES3018358T3 (es) 2017-06-05 2025-05-16 Kissei Pharmaceutical Régimen de dosificación que comprende un antagonista de la hormona liberadora de gonadotropina para tratar fibromas uterinos y reducir la pérdida de sangre menstrual
US11980621B2 (en) 2017-06-05 2024-05-14 Kissei Pharmaceutical Co., Ltd. Gonadotropin-releasing hormone antagonist dosing regimens for the treatment of endometriosis
AU2018419533A1 (en) * 2018-04-19 2020-11-12 Abbvie Inc. Methods of treating heavy menstrual bleeding
MA54058A (fr) * 2018-10-29 2021-09-08 ObsEva SA Compositions et méthodes de traitement de l'endométriose interne et de l'endométriose rectovaginale
RU2711658C1 (ru) * 2019-04-16 2020-01-20 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта" Способ лечения наружного генитального эндометриоза
CN110194776B (zh) * 2019-06-27 2021-05-28 四川伊诺达博医药科技有限公司 一种瑞卢戈利的合成方法
JP2022543308A (ja) * 2019-08-08 2022-10-11 オブセヴァ エス．エー． エストロゲン依存性障害の治療のための組成物及び方法
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IL295781A (en) * 2020-02-19 2022-10-01 Aspira Women’S Health Inc Preparations with improved specificity for the evaluation of endometriosis
CN113384581B (zh) * 2020-03-12 2023-11-14 成都倍特药业股份有限公司 一种包含促性腺激素释放激素拮抗剂的药物组合物
AU2021278303A1 (en) * 2020-05-29 2023-02-09 Sumitomo Pharma Switzerland Gmbh Combination solid oral dosage forms of gonadotropin-releasing hormone antagonists
EP4243829A1 (en) 2020-11-11 2023-09-20 Myovant Sciences GmbH Methods of administering relugolix
WO2023066941A1 (en) 2021-10-18 2023-04-27 Myovant Sciences Gmbh Crystalline form of an ethanol solvate of n-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-n'-methoxyurea
CN117069735A (zh) * 2022-05-10 2023-11-17 北京海美源医药科技有限公司 一种高效合成瑞卢戈利的方法和其应用
WO2024015934A2 (en) * 2022-07-13 2024-01-18 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods of diagnostic screening and early detection of adenomyosis
WO2024102620A2 (en) * 2022-11-09 2024-05-16 Tempest Therapeutics, Inc. Triazolone compounds and uses thereof
WO2025106820A1 (en) * 2023-11-16 2025-05-22 University Of South Florida Method of preventing progesterone contraceptive-induced abnormal uterine bleeding (aub)

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CN115279769A (zh) 2019-10-10 2022-11-01 梦欧文科学有限责任公司 N-(4-(1-(2,6-二氟苄基)-5-((二甲基氨基)甲基)-3-(6-甲氧基-3-哒嗪基)-2,4-二氧代-1,2,3,4-四氢噻吩并[2,3-d]嘧啶-6-基)苯基)-n’-甲氧基脲的结晶形式
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Also Published As

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FI3518933T4 (fi) 2025-05-14
CN110312512A (zh) 2019-10-08
AU2022241582B2 (en) 2024-06-13
ES2912929T5 (en) 2025-05-09
ES3018413T3 (es) 2025-05-16
PL3518933T5 (pl) 2025-05-05
RS63300B2 (sr) 2025-05-30
DK3518933T3 (da) 2022-05-30
EP3518933A2 (en) 2019-08-07
JP2019529575A (ja) 2019-10-17
HUE059101T2 (hu) 2022-10-28
NZ752916A (en) 2022-09-30
CA3038879A1 (en) 2018-04-05
US20220370462A1 (en) 2022-11-24
EP3518933B1 (en) 2022-03-16
SI3518933T1 (sl) 2022-06-30
US20240165118A1 (en) 2024-05-23
BR112019006227A2 (pt) 2019-06-18
IL300580B1 (en) 2025-07-01
US20190262346A1 (en) 2019-08-29
CN110312512B (zh) 2023-05-09
PL4094766T3 (pl) 2025-07-28
MX2019003726A (es) 2019-09-26
AU2022241582A1 (en) 2022-10-27
HRP20220708T1 (hr) 2022-07-22
IL265700B2 (en) 2023-07-01
HUE072130T2 (hu) 2025-10-28
RS63300B1 (sr) 2022-07-29
SI3518933T2 (sl) 2025-05-30
IL265700B1 (en) 2023-03-01
MD3518933T2 (ro) 2022-07-31
AU2017336363A1 (en) 2019-05-16
SMT202200254T1 (it) 2022-07-21
EP4094766A1 (en) 2022-11-30
EP3518933B2 (en) 2025-02-26
IL300580B2 (en) 2025-11-01
PL3518933T3 (pl) 2022-06-20
JP7043503B2 (ja) 2022-03-29
US11957684B2 (en) 2024-04-16
US11793812B2 (en) 2023-10-24
AU2022241582C1 (en) 2024-11-28
US20210401841A1 (en) 2021-12-30
IL265700A (en) 2019-05-30
CY1125254T1 (el) 2024-02-16
EP4094766B1 (en) 2025-04-02
PT3518933T (pt) 2022-05-10
WO2018060501A3 (en) 2018-05-11
LT3518933T (lt) 2022-06-10
DK3518933T4 (da) 2025-04-22
US11033551B2 (en) 2021-06-15
IL300580A (en) 2023-04-01
HRP20220708T4 (hr) 2025-04-25
ES2912929T3 (es) 2022-05-30
WO2018060501A2 (en) 2018-04-05
MD3518933T4 (ro) 2025-10-31

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